17 terminated. 17 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 17 | Terminated 17 |
| Phase 2 | 4 | Terminated 4 |
Follow Cardiovascular Abnormalities: new trials by email Literature Review of Cardiovascular Abnormalities trials Research Report on Cardiovascular Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of LQT-1213 on QTc-induced Prolongation in Healthy Adult Subjects (Part1) and on Congenital Long QT in Patients Diagnosed With Type 2 or 3 Long QT Syndrome (Part 2). LQT-1213, Placebo, Dofetilide 250 μg Cap - Long QT Syndrome | Phase 1 / Phase 2 | Terminated | Thryv Therapeutics, Inc. | 42 | 2023-03-12 | 2025-07-24 |
| Topical Rapamycin/Sirolimus for Complicated Vascular Anomalies and Other Susceptible Lesions Topical Sirolimus - Vascular Anomaly | Phase 1 | Terminated | Nemours Children's Clinic | 5 | 2020-04-01 | 2025-12-31 |
| Cold Heart Study: A Randomized Pilot Trial of Surfactant Therapy Curosurf, Sham - Congenital Heart Disease, Hypoplastic Left Heart Syndrome | Phase 1 | Terminated | University of Michigan | 2 | 2020-02-25 | 2023-09-13 |
| Use of Oxandrolone to Promote Growth in Infants With HLHS Oxandrolone - Hypoplastic Left Heart, Congenital Heart Disease | Phase 1 / Phase 2 | Terminated | Carelon Research | 34 | 2019-12-20 | 2024-05-23 |
| Acute Effects of the Prostaglandin (Alprostadil) on Cerebral and Pulmonary Flow Alprostadil 5 MCG Injection - Congenital Heart Disease | Phase 1 | Terminated | The Hospital for Sick Children | 10 | 2019-07-23 | 2023-02-08 |
| Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus Paracetamol 10Mg/mL, 0.45% Sodium Chloride, Ibuprofen - Patent Ductus Arteriosus | Phase 1 | Terminated | University of Oulu | 22 | 2018-09-03 | 2024-10-18 |
| Pharmacokinetic Study of Intranasal Dexmedetomidine in Pediatric Patients With Congenital Heart Disease Dexmedetomidine - Dexmedetomidine, Congenital Heart Disease | Phase 1 | Terminated | Children's Hospital of Philadelphia | 28 | 2018-06-14 | 2024-03-22 |
| Dose Finding Study of TNO155 in Adult Patients With Advanced Solid Tumors TNO155, TNO155 in combination with EGF816 (nazartinib) - Advanced EGFR Mutant Non Small Cell LungCancer (NSCLC), KRAS G12-mutant NSCLC | Phase 1 | Terminated | Novartis Pharmaceuticals | 227 | 2017-05-26 | 2026-07-09 |
| Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome Allo-hMSCs, Placebo - Hypoplastic Left Heart Syndrome | Phase 1 | Terminated | Longeveron Inc. | 5 | 2015-04-01 | 2021-07-19 |
| Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery: Proposal for Pilot Investigation Dexrazoxane - Heart Defects, Congenital | Phase 1 | Terminated | Medical City Children's Hospital | 12 | 2014-09-01 | 2018-07-26 |
| Antithrombin III in Infants With Cardiopulmonary Bypass (CPB) Antithrombin III, Placebo - Congenital Heart Disease | Phase 1 | Terminated | University of Rochester | 6 | 2012-07-01 | 2016-03-22 |
| Safety and Feasibility Study of Umbilical Cord Blood Cells for Infants With Hypoplastic Left Heart Syndrome Autologous Umbilical Cord Blood - Hypoplastic Left Heart Syndrome | Phase 1 | Terminated | Michael Cotten | 7 | 2011-09-01 | 2024-05-16 |
| Mechanisms of Dysfunction and the Influence of Exercise on Cardiac and Musculoskeletal Function Exercise Program - Congenital Heart Disease | Phase 1 / Phase 2 | Terminated | The Hospital for Sick Children | 10 | 2010-01-01 | 2016-02-01 |
| Initiating Transdermal Estradiol Therapy in Turner's Syndrome Norditropin, Menostar 14mcg patch, Vivelle dot 25mcg patch - Turner's Syndrome | Phase 1 | Terminated | University of Chicago | 1 | 2009-04-01 | 2014-03-11 |
| Effect of Potassium and Acetazolamide on People With Andersen-Tawil Syndrome Potassium, Acetazolamide - Andersen-Tawil Syndrome | Phase 1 | Terminated | University of Rochester | 3 | 2008-12-01 | 2012-01-20 |
| Serum-Free Thymus Transplantation in DiGeorge Anomaly Serum Free Thymus Transplantation with Immunosuppression, Serum Free Thymus Transplantation without immunosuppression - DiGeorge Anomaly | Phase 1 | Terminated | Sumitomo Pharma Switzerland GmbH | 2 | 2008-04-01 | 2022-04-01 |
| Nesiritide Use Following Cardiac Surgery in Infants nesiritide, Placebo - Heart Defects, Congenital, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Terminated | Boston Children's Hospital | 9 | 2006-04-08 | 2020-08-27 |
Heart Defects, Congenital (8) · Hypoplastic Left Heart Syndrome (4) · Andersen Syndrome (1) · DiGeorge Syndrome (1) · Ductus Arteriosus, Patent (1) · Esophageal Squamous Cell Carcinoma (1) · Immunologic Deficiency Syndromes (1) · Long QT Syndrome (1) · Melanoma (1) · Noonan Syndrome (1) · Premature Birth (1) · Reperfusion Injury (1) · Squamous Cell Carcinoma of Head and Neck (1) · Thymic aplasia (1) · Turner Syndrome (1)
Cardiovascular Diseases (17) · Congenital Abnormalities (17) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (17) · Heart Diseases (16) · Heart Defects, Congenital (8) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Arrhythmias, Cardiac (2) · Cardiac Conduction System Disease (2) · Chromosome Disorders (2) · Craniofacial Abnormalities (2) · Endocrine System Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Genetic Diseases, Inborn (2)
Injections (2) · Acetaminophen (1) · Acetazolamide (1) · Alprostadil (1) · Antithrombin III (1) · Capsules (1) · Dexmedetomidine (1) · Dexrazoxane (1) · Estradiol (1) · Human Growth Hormone (1) · Ibuprofen (1) · Immunosuppression Therapy (1) · Indomethacin (1) · Natriuretic Peptide, Brain (1) · Oxandrolone (1)
The Hospital for Sick Children (2) · University of Rochester (2) · Boston Children's Hospital (1) · Carelon Research (1) · Children's Hospital of Philadelphia (1) · Longeveron Inc. (1) · Medical City Children's Hospital (1) · Michael Cotten (1) · Nemours Children's Clinic (1) · Novartis Pharmaceuticals (1) · Sumitomo Pharma Switzerland GmbH (1) · Thryv Therapeutics, Inc. (1) · University of Chicago (1) · University of Michigan (1) · University of Oulu (1)
United States (13) · Canada (4) · Finland (1) · Italy (1) · Japan (1) · Netherlands (1) · Singapore (1) · South Korea (1) · Spain (1) · Taiwan (1)
Anthony Oliva, MD (1) · Brian McCrindle, MD (1) · Charles M Cotten, MD MHS (1) · Craig Johnson, DO (1) · Daniel Stromberg, MD (1) · Jan Matousek, DO (1) · John M Costello, MD (1) · Kelly L Grogan, MD (1) · M. Louise Markert, M.D., Ph.D (1) · Michael Eaton, MD (1) · Outi Aikio, MD, PhD (1) · Paul Twydell, DO (1) · Phillip T Burch, MD (1) · Rajiv Chaturvedi, MD (1)
2023 (1), K12HD043494 (1), R01AI047040 (1), R01AI054843 (1), U54NS059065 (1)