Immunologic Deficiency Syndromes: Clinical Trials

5517 completed, 633 unknown, 420 recruiting, 393 terminated. 2099 Not applicable, 1397 Phase 1, 1378 Phase 2, 875 Phase 3, 613 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	2099	Completed 1524, Unknown 181, Recruiting 142, Active not recruiting 67, Terminated 66, Not yet recruiting 61, Withdrawn 40, Enrolling by invitation 16, Suspended 2
Phase 1	1397	Completed 1119, Terminated 79, Unknown 55, Recruiting 49, Withdrawn 43, Active not recruiting 29, Not yet recruiting 13, Enrolling by invitation 7, Suspended 3
Phase 2	1378	Completed 974, Terminated 127, Recruiting 73, Unknown 72, Withdrawn 60, Active not recruiting 37, Not yet recruiting 20, Suspended 8, Enrolling by invitation 7
Phase 3	875	Completed 686, Terminated 52, Unknown 49, Withdrawn 26, Active not recruiting 25, Recruiting 23, Not yet recruiting 8, Enrolling by invitation 4, Suspended 2
Phase 4	613	Completed 422, Unknown 74, Terminated 64, Recruiting 21, Withdrawn 14, Not yet recruiting 8, Active not recruiting 6, Enrolling by invitation 3, Suspended 1
Early Phase 1	40	Completed 25, Active not recruiting 4, Unknown 4, Terminated 3, Not yet recruiting 2, Recruiting 1, Withdrawn 1

Follow Immunologic Deficiency Syndromes: new trials by email Literature Review of Immunologic Deficiency Syndromes trials Research Report on Immunologic Deficiency Syndromes

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Evaluating a Clinical Decision Support Tool for Antiretroviral Therapy Optimization smART (Smart Antiretroviral Therapy Assistant), Traditional Prescribing resources - HIV (Human Immunodeficiency Virus), Clinical Decision Support System (CDSS)	Not applicable	Not yet recruiting	Keck School of Medicine of USC	250	2028-09-01	2025-10-22
Social Contact-Based Brief Video Interventions To Reduce Stigma and ImproVe Engagement in HIV Prevention and Care and Mental Health Care for Youth Living With and Vulnerable to HIV Brief Videos for HIV Stigma - HIV, Mental Health	Not applicable	Not yet recruiting	City University of New York, School of Public Health	3900	2028-01-01	2026-10-01
Same-Day Antiretroviral Therapy as a Behavioral Design Intervention to Reduce Stigma in Key Affected Populations SD-ART - Hiv	Not applicable	Not yet recruiting	Yale University	139	2027-10-01	2026-08-31
Lentiviral Gene Therapy for CGD Infusion of lentiviral TYF-CGD-modified autologous stem cells - Chronic Granulomatous Disease	Not applicable	Not yet recruiting	Shenzhen Geno-Immune Medical Institute	10	2027-07-01	2026-11-02
SCID-X1 Gene Therapy Via Intravenous Lentiviral (Ivlv-X1) Injection Direct intravenous injection of ivlv-X1 lentiviral vector - SCID, X-Linked	Phase 1 / Phase 2	Not yet recruiting	Shenzhen Geno-Immune Medical Institute	10	2027-06-30	2026-11-03
Scaling Up Implementation Strategies to Improve the DIAGNOSE and PREVENT Pillars for Young MSM in Florida Workforce Development (WD) strategies, Quality Management (QM) and Mystery Shopper (MS) Feedback - Hiv	Not applicable	Not yet recruiting	Florida State University	81	2027-06-01	2026-10-13
HC-HMP: Healthy Choices Implementation Trial Healthy Choices (HC), HealthMpowerment (HMP), Low-Touch: Video Introduction - Alcohol Drinking, HIV Infections	Not applicable	Not yet recruiting	Florida State University	360	2027-06-01	2026-11-06
Advanced HIV Re-engagement in Care ARC - Advanced HIV Disease	Not applicable	Not yet recruiting	University of Alabama at Birmingham	724	2027-05-01	2026-07-23
Incidence of HIV Infection in Screening Indian Men Who Have Sex With Men Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis, Medical Examination - HIV Infection		Withdrawn	AIDS Malignancy Consortium		2027-04-30	2025-06-06
Incidence of HPV Infection and HPV-Associated Disease in Screening Indian Men Who Have Sex With HIV-Positive Men Cytology Specimen Collection Procedure, High Resolution Anoscopy with Biopsy, Laboratory Biomarker Analysis - HIV Infection, Human Papillomavirus Infection		Withdrawn	AIDS Malignancy Consortium		2027-04-30	2025-06-06
Telenursing-Based Sleep Coaching for Adults Living With HIV With Insomnia Symptoms Telenursing-based sleep coaching - Insomnia, HIV Infections	Not applicable	Not yet recruiting	Universitas Indonesia	50	2027-04-01	2026-10-23
Integrating Supports to Promote PrEP for Black Adolescents Working With Apps- Atlanta Health MPowerment App - HIV Infections	Not applicable	Not yet recruiting	Emory University	10	2027-04-01	2026-09-22
PrEPwise Pilot Among Black Women in Eastern Virginia PrEPwise, Usual care - HIV Infections, Sexually Transmitted Infection	Not applicable	Not yet recruiting	Boston University	108	2027-04-01	2026-02-11
PositiveLinks for Youth (PL4Y) for Texas PositiveLinks for Youth Smartphone App - Human Immunodeficiency Virus, HIV	Not applicable	Not yet recruiting	The University of Texas Health Science Center at San Antonio	600	2027-04-01	2026-09-04
Safety & Immunogenicity of 426c.Mod.Core-C4b Vaccine With 3M-052-AF+Alum in Infants Perinatally Exposed to HIV But Uninfected 426c.Mod.Core-C4b, 3M-052-AF, Aluminum hydroxide suspension (Alum) - HIV Infections	Phase 1	Not yet recruiting	HIV Vaccine Trials Network	22	2027-03-30	2026-09-18
Testing a Multi-Level Approach to Reduce Stigma for Women Living With HIV Labda Siku Moja, Total Facility Approach - HIV (Human Immunodeficiency Virus)	Not applicable	Not yet recruiting	RTI International	680	2027-03-01	2026-10-26
AI-Powered Sleep Hygiene Mentor for Adults Living With HIV AI-powered sleep hygiene mentor - Sleep Wake Disorders, Sleep Initiation and Maintenance Disorders	Not applicable	Not yet recruiting	Universitas Indonesia	100	2027-03-01	2026-10-26
Reducing Arterial Inflammation Using Eplerenone and Statins in HIV Eplerenone, Placebo - HIV (Human Immunodeficiency Virus), Cardiovascular Diseases (CVD)	Phase 2 / Phase 3	Not yet recruiting	Massachusetts General Hospital	124	2027-03-01	2026-10-23
Medical Mistrust Among Hispanic/Latino Gay, Bisexual and Other Men Who Have Sex With Men (HLMSM) Navigators (peer navigator) training, delayed-intervention - Human Immunodeficiency Virus	Not applicable	Not yet recruiting	Wake Forest University Health Sciences	144	2027-03-01	2026-04-30
Improving TelePrEP Initiation and Retention Outcomes in the US: The MISTR+ Study No Marginal Cost Interventions, Low-Marginal Cost Interventions, Standard of Care - Human Immunodeficiency Virus	Not applicable	Not yet recruiting	Emory University	223165	2027-03-01	2026-09-16

Showing 20 of 7584. Sign in to see all of them.

Narrower conditions

HIV Infections (4680)  ·  Acquired Immunodeficiency Syndrome (3037)  ·  AIDS-Related Complex (283)  ·  Infections (232)  ·  Primary Immunodeficiency Diseases (207)  ·  Sexually Transmitted Diseases (201)  ·  HIV Seropositivity (194)  ·  Hepatitis C (188)  ·  Angioedemas, Hereditary (169)  ·  AIDS-Related Opportunistic Infections (167)  ·  Tuberculosis (166)  ·  Substance-Related Disorders (151)  ·  Depression (94)  ·  Hepatitis B (85)

Broader conditions

Immune System Diseases (7537)  ·  Virus Diseases (6776)  ·  RNA Virus Infections (6775)  ·  Urogenital Diseases (6759)  ·  Retroviridae Infections (6751)  ·  Genital Diseases (6748)  ·  Blood-Borne Infections (6744)  ·  Lentivirus Infections (6735)  ·  Sexually Transmitted Diseases, Viral (6725)  ·  Communicable Diseases (6723)  ·  Infections (6651)  ·  Sexually Transmitted Diseases (6542)  ·  Slow Virus Diseases (3083)  ·  HIV Infections (2066)

Interventions

Zidovudine (320)  ·  Ritonavir (307)  ·  Lamivudine (260)  ·  efavirenz (213)  ·  Tenofovir (208)  ·  Raltegravir Potassium (152)  ·  Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination (147)  ·  Emtricitabine (146)  ·  Lopinavir (146)  ·  Nevirapine (139)  ·  Didanosine (132)  ·  dolutegravir (126)  ·  Stavudine (124)  ·  abacavir (107)  ·  Darunavir (98)

Sponsors

National Institute of Allergy and Infectious Diseases (NIAID) (1142)  ·  ViiV Healthcare (248)  ·  University of California, San Francisco (140)  ·  University of North Carolina, Chapel Hill (113)  ·  National Cancer Institute (NCI) (91)  ·  Merck Sharp & Dohme LLC (90)  ·  ANRS, Emerging Infectious Diseases (87)  ·  Bristol-Myers Squibb (82)  ·  University of Washington (82)  ·  Gilead Sciences (80)  ·  Glaxo Wellcome (72)  ·  Boehringer Ingelheim (71)  ·  Columbia University (70)  ·  Johns Hopkins University (68)  ·  French National Agency for Research on AIDS and Viral Hepatitis (66)

Countries

United States (4127)  ·  France (481)  ·  South Africa (440)  ·  Canada (385)  ·  Spain (377)  ·  Puerto Rico (376)  ·  United Kingdom (330)  ·  Germany (291)  ·  Italy (275)  ·  Uganda (227)  ·  Thailand (218)  ·  Brazil (193)  ·  Kenya (183)  ·  Australia (169)  ·  China (162)

Top investigators

Pablo Tebas, MD (14)  ·  Kiat Ruxrungtham, MD (13)  ·  Corey L (12)

Results publications

PMID 36326435, PMID 32779730, PMID 40190112, PMID 25820067, PMID 39324693, PMID 24326304, PMID 25075835, PMID 33901188, PMID 34817414, PMID 34843602, PMID 34895272, PMID 36408587, PMID 39903535, PMID 40655875, PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20004776, PMID 20236866, PMID 20818886, PMID 23312695, PMID 23349878, PMID 23818196, PMID 23878046, PMID 24139498, PMID 24290292, PMID 24331379, PMID 24712435, PMID 24979445, PMID 27262745, PMID 27572401, PMID 32031570, PMID 32171076, PMID 32838558, PMID 39101506, PMID 16220994, PMID 17284531, PMID 17666313, PMID 18657709, PMID 19571722, PMID 20024643, PMID 22288567, PMID 23548529, PMID 24077845, PMID 24086319, PMID 24870935, PMID 25295500, PMID 25992639, PMID 26743093

NIH funding

U01AI068636 (25), U01CA121947 (25), 2008 (24), 2009 (22), UM1CA121947 (19), 2015 (18), 2014 (17), 2023 (15), 2019 (14), 2005 (13), 2018 (13), 2004 (12), U01AI068632 (12), 2016 (11), 2017 (10)