13 completed, 6 terminated, 3 active not recruiting, 3 recruiting. 14 Phase 2, 5 Phase 1, 5 Phase 3, 3 Not applicable.
Follow Immunosuppression Therapy: new trials by email Literature Review of Immunosuppression Therapy trials Research Report on Immunosuppression Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sirolimus With corTicOsteroid TheraPy for Rapid rEcurrences of Coronary Unexplained In-stent Restenosis Immunosuppressive therapy, Placebo - In-stent Restenosis Lesion, Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)) | Not applicable | Not yet recruiting | China National Center for Cardiovascular Diseases | 52 | 2025-06-01 | 2025-05-21 |
| Immunosuppressive Therapy Alone Versus Plus Oral Anticoagulation in the Treatment of VT Associated With Behcet's Disease Placebo plus immunosuppression, Rivaroxaban plus immunosupression - Behcet Disease, Behcet Disease and Vascular Involvement | Phase 3 | Not yet recruiting | Marmara University | 110 | 2025-04-30 | 2025-04-13 |
| UI-Romi-02; Romiplostim Added to Standard of Care for Treatment Naive and Relapsed or Refractory Severe Aplastic Anemia Romiplostim, Immunosuppressive therapy (IST) - Aplastic Anemia | Phase 2 | Withdrawn | Anjali Sharathkumar | 2025-04-10 | 2026-10-16 | |
| Clinical Features, Current Treatment and Clinical Outcomes in Patients With INR-CAD: a Cohort Study Healthy life style, Secondary prevention for atherosclerotic coronary artery disease, Immunosuppressive Therapy - Coronary Artery Disease, Coronary Artery Disease Progression | Recruiting | Peking Union Medical College Hospital | 120 | 2025-04-01 | 2025-11-19 | |
| Efficacy and Safety of Comprehensive Treatment in Patients With IR-CAD: a Self-controlled Cohort Study Healthy life style, Secondary prevention for atherosclerotic coronary artery disease, Immunosuppressive therapy - Coronary Artery Disease, Coronary Artery Stenosis | Recruiting | Peking Union Medical College Hospital | 39 | 2023-05-17 | 2025-11-19 | |
| A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202) cyclosporine, Matched Unrelated Donor Hematopoetic Stem Cell Transplant, horse anti-thymocyte globulin (ATG) - Severe Aplastic Anemia | Phase 3 | Terminated | Boston Children's Hospital | 53 | 2023-01-25 | 2026-10-19 |
| Incidence, Course and Outcome of ABMR in Kidney Transplantation Kidney Transplantation, Immunosuppression, Nephrectomy (kidney donation) - Antibody-mediated Rejection, Kidney Transplantation | Unknown | University Medical Center Groningen | 225 | 2022-01-01 | 2023-05-11 | |
| COVID Protection After Transplant-Immunosuppression Reduction Pfizer-BioNTech COVID-19 Vaccine 2023-2024, Moderna COVID-19 Vaccine 2023-2024, SOC IS Regimen - Kidney Transplant Recipients, Liver Transplant Recipients | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 48 | 2021-12-06 | 2026-04-23 |
| Donor-derived Cell-free DNA in Kidney Transplant Recipients Biopsy, Blood Biomarkers - cfDNA, Antirejection therapy - Kidney Transplantation, Acute Rejection of Renal Transplant | Completed | Institute for Clinical and Experimental Medicine | 143 | 2021-10-21 | 2025-05-01 | |
| Discontinuation or Continuation of Immunosuppressive Therapy in Participants With Chronic Graft Versus Host Disease Immunosuppressive Therapy, Survey Administration - Chronic Graft Versus Host Disease | Phase 2 | Completed | Fred Hutchinson Cancer Center | 21 | 2018-06-06 | 2021-06-23 |
| Maintaining or Stopping Immunosuppressive Therapy in Patients With ANCA Vasculitis and End-stage Renal Disease Discontinuation (or not initiation) of Immunosuppressive Therapy, Maintenance (or initiation) of immunosuppressive treatment: Imurel®, Mabthera®,Cellcept®, Cortancyl® - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, End Stage Renal Disease | Phase 3 | Active not recruiting | Centre Hospitalier Departemental Vendee | 136 | 2018-02-02 | 2026-03-20 |
| Evaluate the Clinical Benefits of EnvarsusXR in Post Liver Transplant EnvarsusXR, Tacrolimus - Post Liver Transplant | Phase 2 / Phase 3 | Active not recruiting | Albert Einstein Healthcare Network | 35 | 2017-12-13 | 2021-01-08 |
| Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia cyclosporine, Matched Unrelated Donor Hematopoietic Stem Cell Transplant, horse anti-thymocyte globulin (ATG) - Severe Aplastic Anemia | Not applicable | Completed | Michael Pulsipher | 40 | 2016-08-01 | 2025-05-11 |
| Donor Alloantigen Reactive Tregs (darTregs) for Calcineurin Inhibitor (CNI) Reduction darTregs, Acetaminophen, Diphenhydramine - Liver Transplant Recipient, Living Donor (of the Respective Liver Transplant Recipient) | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 15 | 2016-06-06 | 2021-02-09 |
| Early Immunosuppressive Therapy on the Course of Vogt-Koyanagi-Harada Disease Early high-dose corticosteroid and immunosuppressive therapy - Vogt Koyanagi Harada Disease | Not applicable | Recruiting | University of Sao Paulo | 40 | 2015-03-23 | 2026-05-07 |
| Thiotepa, Busulfan and Fludarabin for pt With Refractory/Early Relapsed Aggressive B-cell Non Hodgkin Lymphomas Thiotepa, Busulfan, Fludarabin - B-cell Lymphoma Refractory | Phase 2 | Unknown | Azienda Ospedaliera San Giovanni Battista | 42 | 2013-02-01 | 2014-07-08 |
| Multicenter Study of Peritransplantation Immunosuppression for Mismatched Hematopoietic Cell Transplantation After Reduced Intensity Conditioning immunosuppression - Patients Receiving Mismatched Allogeneic HCT | Phase 2 | Terminated | Prof. Dr. med. Wolfgang Bethge | 9 | 2012-04-01 | 2022-07-05 |
| Liver Cell Transplant for Phenylketonuria Preparative Radiation Therapy, Hepatocyte Transplant, Immunosuppression - Phenylketonuria | Phase 1 / Phase 2 | Terminated | Ira Fox | 1 | 2011-10-12 | 2023-08-16 |
| An Observational Study on Renal Function in Kidney Transplant Participants on Immunosuppressive Therapy Containing Mycophenolate Mofetil Mycophenolate Mofetil, Immunosuppressive Therapy - Kidney Transplantation | Completed | Hoffmann-La Roche | 128 | 2011-09-01 | 2016-10-11 | |
| Rituximab in Preventing Acute Graft-Versus-Host Disease in a Donor Stem Cell Transplant for Hematologic Cancer rituximab, mycophenolate mofetil, tacrolimus - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Terminated | University of Nebraska | 20 | 2009-12-10 | 2023-09-06 |
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Anemia, Aplastic (4) · Coronary Artery Disease (3) · Blast Crisis (2) · Burkitt Lymphoma (2) · Coronary Restenosis (2) · Coronary Stenosis (2) · Diabetes Mellitus (2) · Diabetes Mellitus, Type 1 (2) · Disease Progression (2) · Graft vs Host Disease (2) · Inflammation (2) · Leukemia (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Leukemia, Myeloid, Accelerated Phase (2) · Leukemia, Myeloid, Acute (2)
National Institute of Allergy and Infectious Diseases (NIAID) (3) · City of Hope Medical Center (2) · Peking Union Medical College Hospital (2) · University of Sao Paulo (2) · Albert Einstein Healthcare Network (1) · Anjali Sharathkumar (1) · Azienda Ospedaliera San Giovanni Battista (1) · Boston Children's Hospital (1) · Centre Hospitalier Departemental Vendee (1) · China National Center for Cardiovascular Diseases (1) · Fred Hutchinson Cancer Center (1) · Hoffmann-La Roche (1) · Institute for Clinical and Experimental Medicine (1) · Ira Fox (1) · Marmara University (1)
United States (14) · China (3) · Brazil (2) · Germany (2) · Canada (1) · Czechia (1) · France (1) · Hungary (1) · Italy (1) · Netherlands (1) · Turkey (Türkiye) (1)
Michael Pulsipher, MD (2) · Anil Chandraker, MD (1) · Anjali Sharathkumar, MD (1) · Arthur Matas, MD (1) · Benedetto Bruno, MD (1) · Bronwen Shaw, MD (1) · Christian P. Larsen, MD, DPhil (1) · Dalong Zhu, MD,PhD (1) · David A Williams, MD (1) · David Senitzer, PhD (1) · David Williams, MD (1) · Dorry L. Segev, MD, PhD (1) · Faird Boulad, MD (1) · Fatma Alibaz-Oner, Prof (1)
PMID 17426276, PMID 18587715, PMID 18992868, PMID 19366777, PMID 19668980, PMID 19781687, PMID 22419704, PMID 22889440, PMID 23099292, PMID 24440284, PMID 24548697, PMID 25592477, PMID 26032537, PMID 26630142, PMID 27008848, PMID 27368955, PMID 27844182, PMID 28179273, PMID 28346714, PMID 31851762, PMID 35819312, PMID 36322627, PMID 38299639, PMID 38864363, PMID 39780302, PMID 39881535
1UG3HL157564-01A1 (1), K12HD043494 (1), P30CA015704 (1), P30CA033572 (1), P30CA036727 (1), R01AI047040 (1), R01AI054843 (1), U01AI138897 (1), U01HL068091 (1), U24HL157560 (1)