23 completed, 9 recruiting, 8 terminated, 4 unknown. 12 Not applicable, 9 Phase 2, 5 Phase 1, 1 Phase 3, 1 Phase 4.
Follow DiGeorge Syndrome: new trials by email Literature Review of DiGeorge Syndrome trials Research Report on DiGeorge Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD) Hematopoietic stem cell transplant (HSCT) - Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder | Phase 2 | Recruiting | Paul Szabolcs | 25 | 2026-05-04 | 2026-05-15 |
| Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD) | Recruiting | Healing Hope International | 100 | 2026-03-01 | 2026-03-25 | |
| The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk Assessment Pregnant Individuals, Aneuploidy | Recruiting | BillionToOne Inc. | 1000 | 2026-01-10 | 2026-10-15 | |
| Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders Sertraline, Placebo - Neurodevelopmental Disorders, Autism | Phase 2 | Recruiting | Holland Bloorview Kids Rehabilitation Hospital | 130 | 2024-09-16 | 2026-07-27 |
| Early Scoliotic Changes in Children at Increased Risk for Scoliosis Development MRI, Scolioscan, Skeletal maturity assessment - Adolescent Idiopathic Scoliosis, 22q11.2 Deletion Syndrome | Recruiting | UMC Utrecht | 120 | 2023-06-16 | 2023-06-29 | |
| NB-001 in Children and Adolescents With 22q11 Deletion Syndrome NB-001, Placebo - 22q11 Deletion Syndrome | Phase 2 | Completed | Nobias Therapeutics, Inc. | 37 | 2022-02-10 | 2025-02-10 |
| Understanding of Psychotic Disorders in Children With 22q11.2DS neuropsychological testing, questionnaires and experimental tasks - 22q11.2 Deletion Syndrome | Not applicable | Recruiting | Hôpital le Vinatier | 80 | 2020-11-13 | 2025-07-30 |
| Arithmetic Abilities in Children With 22q11.2DS Magnitude comparison tasks and neuropsychological testing - 22q11.2 Deletion Syndrome | Not applicable | Terminated | Hôpital le Vinatier | 41 | 2020-09-16 | 2025-03-07 |
| Is Thymus Size of Infants Who Born to COVID-19 Positive Mothers Associated With Neonatal Morbidities? chest x-ray - Covid19, Thymic Hypoplasia | Not applicable | Unknown | Kanuni Sultan Suleyman Training and Research Hospital | 20 | 2020-05-30 | 2020-07-14 |
| Molecular Variants Associated With Schizophrenia: Differential Analysis of Monozygotic Twins With Variable Phenotypic 22q11 Molecular analyses - Di George Syndrome | Not applicable | Completed | Hôpital le Vinatier | 2 | 2020-03-27 | 2021-02-09 |
| Open-Label Study of ZYN002 Administered as a Transdermal Gel to Children and Adolescents With 22q11.2 Deletion Syndrome (INSPIRE) ZYN002 - 22Q11.2 Deletion Syndrome | Phase 2 | Completed | Harmony Biosciences Management, Inc. | 20 | 2020-02-19 | 2026-03-09 |
| Parent and Infant Inter(X)Action Intervention (PIXI) Parent-Infant Inter(X)action Intervention (PIXI) - Fragile X Syndrome, Angelman Syndrome | Not applicable | Enrolling by invitation | RTI International | 120 | 2018-11-30 | 2026-07-13 |
| GROWing Up With Rare GENEtic Syndromes Retrospective file studies - Prader-Willi Syndrome, PWS-like Syndrome | Recruiting | dr. Laura C. G. de Graaff-Herder | 600 | 2018-10-01 | 2023-09-06 | |
| Social Cognition Training and Cognitive Remediation Cognitive remediation program - 22q11.2 Deletion Syndrome | Not applicable | Terminated | Hôpital le Vinatier | 3 | 2017-10-11 | 2020-01-09 |
| Neuroprotective Effects of Risperdal on Brain and Cognition in 22q11 Deletion Syndrome Risperdal, Placebo - 22q11.2 Deletion Syndrome | Not applicable | Terminated | University of Geneva, Switzerland | 16 | 2017-09-29 | 2024-12-06 |
| Safety and Efficacy Study of NFC-1 in Subjects Aged 12-17 Years With 22q11.2DS & Associated Neuropsychiatric Conditions NFC-1 - 22q11.2 Deletion Syndrome | Phase 1 | Completed | Aevi Genomic Medicine, LLC, a Cerecor company | 2 | 2016-11-28 | 2022-03-25 |
| Effects of Methylphenidate on Brain and Cognition in 22q11 Deletion Syndrome Concerta - 22q11.2 Deletion Syndrome | Not applicable | Completed | University of Geneva, Switzerland | 45 | 2016-08-26 | 2022-10-07 |
| Examining Genetic Factors That Affect the Severity of 22q11.2 Deletion Syndrome DiGeorge Syndrome, 22q11.2 Deletion Syndrome | Recruiting | Albert Einstein College of Medicine | 1000 | 2016-07-01 | 2026-07-29 | |
| Expanded Noninvasive Genomic Medical Assessment: The Enigma Study Blood sampling for Laboratory Developed Test (LDT) analysis - Down Syndrome, Edwards Syndrome | Completed | Progenity, Inc. | 760 | 2015-10-01 | 2019-08-21 | |
| Non-Invasive Chromosomal Evaluation of 22q11.2 22q.11.2 Deletion/Duplication | Completed | Cindy Cisneros | 420 | 2015-06-01 | 2020-04-30 |
Showing 20 of 46. Sign in to see all of them.
Thymic aplasia (7) · Down Syndrome (6) · Immunologic Deficiency Syndromes (6) · Hypoparathyroidism (5) · Turner Syndrome (5) · Williams Syndrome (5) · 22q11 Deletion Syndrome (4) · Chromosome Aberrations (4) · Fragile X Syndrome (4) · Genetic Diseases, Inborn (4) · Heart Defects, Congenital (4) · Klinefelter Syndrome (4) · Prader-Willi Syndrome (4) · Trisomy 13 Syndrome (4)
Cardiovascular Abnormalities (46) · Cardiovascular Diseases (46) · Chromosome Disorders (46) · Craniofacial Abnormalities (46) · Heart Diseases (46) · Hemic and Lymphatic Diseases (46) · Lymphatic Abnormalities (46) · Lymphatic Diseases (46) · Musculoskeletal Abnormalities (46) · Musculoskeletal Diseases (46) · Parathyroid Diseases (46) · Abnormalities, Multiple (45) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (45) · Endocrine System Diseases (45) · Congenital Abnormalities (44)
Thymus Extracts (3) · Blood Specimen Collection (2) · Drug Implants (2) · Methylphenidate (2) · Neuropsychological Tests (2) · Risperidone (2) · Transplantation (2) · 5-((2-(6-Amino-9H-purin-9-yl) ethyl) amino)-1-pentanol (1) · Antilymphocyte Serum (1) · Calcium Gluconate (1) · Cyclosporine (1) · Cyclosporins (1) · Daclizumab (1) · Diagnostic Imaging (1) · Exercise (1)
Sumitomo Pharma Switzerland GmbH (7) · Hôpital le Vinatier (4) · Children's Healthcare of Atlanta (2) · National Center for Research Resources (NCRR) (2) · Progenity, Inc. (2) · State University of New York - Upstate Medical University (2) · UMC Utrecht (2) · University of Geneva, Switzerland (2) · Aevi Genomic Medicine, LLC, a Cerecor company (1) · Albert Einstein College of Medicine (1) · Bausch Health Americas, Inc. (1) · BillionToOne Inc. (1) · Cindy Cisneros (1) · Duke University (1) · Hannover Medical School (1)
United States (29) · France (5) · Netherlands (3) · Australia (2) · Canada (2) · Switzerland (2) · Belgium (1) · Germany (1) · Ireland (1) · Israel (1) · Spain (1) · Sweden (1) · Thailand (1) · Turkey (Türkiye) (1) · United Kingdom (1)
M. Louise Markert, MD, PhD (5) · Robert J Shprintzen, PhD (2) · Stephan Eliez, Professor (2) · Anne Wheeler, PhD (1) · Bernice E. Morrow, PhD (1) · Bernice Morrow, PhD (1) · Craig B. Langman (1) · Dr. Evdokia Anagnostou (1) · Dr. Tina Casoglos-Adamopoulos, OT, OTD, BCP (1) · Frank Ong, MD (1) · Gerd P Meyer, MD (1) · Helmut Drexler, MD (1)
PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 17284531, PMID 15100156, PMID 18155964, PMID 20978268, PMID 23607606, PMID 10417280, PMID 12642839, PMID 12702512, PMID 12820840, PMID 15100681, PMID 16282778, PMID 16814942, PMID 18333898, PMID 20375405, PMID 21310373, PMID 21519036, PMID 21565561, PMID 22005709, PMID 22281937, PMID 22464072, PMID 22590644, PMID 22617594, PMID 22742782, PMID 23215555, PMID 23613152, PMID 23711443, PMID 23712453, PMID 23914737, PMID 24135152, PMID 24207068, PMID 24388429, PMID 24785862, PMID 25004354, PMID 25111587, PMID 25479548, PMID 26044111, PMID 27629273, PMID 31599480, PMID 31823380, PMID 35033576, PMID 35085538, PMID 35690720, PMID 36386982, PMID 36965866, PMID 37120522
K12HD043494 (7), R01AI047040 (7), R01AI054843 (6), R56AI047040 (4), R01HL084410 (1), R01HL157157 (1), R33MH085901 (1), R34MH091314 (1)