128 completed, 41 unknown, 28 recruiting, 28 terminated. 257 Phase 2, 47 Phase 1, 36 Phase 3.
Follow Cardiovascular Abnormalities: new trials by email Literature Review of Cardiovascular Abnormalities trials Research Report on Cardiovascular Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2027-01-01 | 2026-10-15 |
| Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids 2 mL SunButyrate-TG, Placebo, 4 mL SunButyrate-TG - Congenital Heart Disease (CHD) | Phase 1 / Phase 2 | Recruiting | University of Nebraska | 105 | 2026-11-01 | 2026-10-30 |
| ATR 1072 in Participants With PRKAG2 Syndrome ATR 1072 - Cardiac Glycogenosis, Cardiomyopathy | Phase 1 / Phase 2 | Recruiting | Atrium Therapeutics | 37 | 2026-09-14 | 2026-09-18 |
| Treatment of Low-flow Vascular Malformations With Bleomycin Electrosclerotherapy (BEST) Bleomycin Sulfate - Vascular Malformations | Phase 2 | Recruiting | Institute of Oncology Ljubljana | 140 | 2026-09-10 | 2026-10-09 |
| Pre-pubertal Low Dose Transdermal Estradiol in Turner Syndrome Estradiol transdermal patch 0.025mg/24 hours- 1/8th fractionated patch - Turner Syndrome, Primary Ovarian Insufficiency | Phase 2 | Not yet recruiting | Children's National Research Institute | 15 | 2026-09-01 | 2026-08-25 |
| Sota-ES - Sotatercept in Patients With Congenital Heart Disease and Eisenmenger´s Syndrome Sotatercept - Congenital Heart Disease (CHD), Eisenmenger Syndrome | Phase 2 | Not yet recruiting | Philipps University Marburg | 40 | 2026-09-01 | 2026-03-27 |
| Harmony-HHT: ATV-1601 in Participants With Hereditary Hemorrhagic Telangiectasia (HHT) ATV-1601, Placebo - Hereditary Hemorrhagic Telangiectasia (HHT), Osler Weber Rendu Disease | Phase 1 / Phase 2 | Recruiting | Atavistik Bio, Inc | 100 | 2026-07-27 | 2026-10-29 |
| DIAG723 in Adults With Hereditary Hemorrhagic Telangiectasia DIAG723, Placebo - Hereditary Hemorrhagic Telangiectasia, Pulmonary Arterial Hypertension | Phase 1 / Phase 2 | Recruiting | Diagonal Therapeutics, Inc. | 93 | 2026-06-04 | 2026-09-08 |
| Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD) Hematopoietic stem cell transplant (HSCT) - Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder | Phase 2 | Recruiting | Paul Szabolcs | 25 | 2026-05-04 | 2026-05-15 |
| A Study to Evaluate the Efficacy and Safety of Everolimus in Patients With Teratment-refractory Vascular Anomalies Everolimus - Vascular Malformations, Arteriovenous Malformations | Phase 2 | Not yet recruiting | Yonsei University | 67 | 2026-04-01 | 2026-03-17 |
| Evaluation of the Efficacy and Safety of THRV-1268 in Participants With Long QT Syndrome Type 2 (LQTS2) and Type 3 (LQTS3) baseline lead-in, THRV-1268 - Long QT Syndrome (LQTS) 2 | Phase 2 / Phase 3 | Recruiting | Thryv Therapeutics, Inc. | 84 | 2026-03-07 | 2026-09-21 |
| A Study Comparing Different Treatment Approaches for the Initiation of Puberty in Girls With Turner Syndrome Using a TRIFECTA-DARED Approach for Rare Diseases Oral estradiol valerate, Transdermal 17β estradiol - Turner Syndrome | Phase 2 | Not yet recruiting | Universiti Kebangsaan Malaysia Medical Centre | 24 | 2026-02-15 | 2026-02-02 |
| Efficacy and Safety of Anti-angiogenic Therapy With IV Bevacizumab in Patients With Symptomatic Cerebral Arteriovenous Malformations Bevacizumab, Placebo - Cerebral AV Malformation | Phase 2 / Phase 3 | Recruiting | Fondation Ophtalmologique Adolphe de Rothschild | 54 | 2026-01-16 | 2026-01-22 |
| Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Recruiting | Charite University, Berlin, Germany | 80 | 2025-12-05 | 2026-10-15 |
| Propranolol Treatment for Postoperative Chylothorax Propranolol Hydrochloride, Placebo - Postoperative Chylothorax, Congenital Heart Disease | Phase 1 / Phase 2 | Suspended | June Wu | 50 | 2025-09-09 | 2026-05-15 |
| 24VA022; VATCH Alpelisib for TIE2/PIK3CA Pathway VAs alpelisib (BYL719) - Vascular Anomalies, Vascular Anomaly | Phase 2 | Recruiting | Children's Hospital of Philadelphia | 61 | 2025-08-27 | 2026-10-19 |
| 24VA021; VATCH Trametinib for Ras/MAPK Pathway VAs Trametinib - Ras/MAPK Pathway Vascular Anomalies, Vascular Anomalies | Phase 2 | Recruiting | Children's Hospital of Philadelphia | 45 | 2025-08-27 | 2026-10-19 |
| Trametinib Treatment for Complicated Vascular Anomalies Trametinib tablet - Vascular Anomalies | Phase 1 / Phase 2 | Active not recruiting | West China Hospital | 20 | 2025-07-07 | 2025-07-22 |
| An Open-Label, Single-Arm Exploratory Clinical Study of Everolimus for the Treatment of Vascular Malformations Everolimus 10mg daily - Vascular Malformations | Phase 2 | Recruiting | Xuanwu Hospital, Beijing | 10 | 2025-07-01 | 2025-09-05 |
| A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study) RLY-2608, Placebo - PIK3CA-Related Overgrowth Spectrum (PROS), Lymphatic Malformations | Phase 2 | Recruiting | Relay Therapeutics, Inc. | 277 | 2025-06-13 | 2026-08-25 |
Showing 20 of 257. Sign in to see all of them.
Heart Defects, Congenital (68) · Telangiectasia, Hereditary Hemorrhagic (32) · Ductus Arteriosus, Patent (26) · Vascular Malformations (21) · Epistaxis (16) · Arteriovenous Fistula (11) · Hypoplastic Left Heart Syndrome (11) · Turner Syndrome (11) · Univentricular Heart (11) · Arteriovenous Malformations (10) · DiGeorge Syndrome (9) · Noonan Syndrome (9) · Foramen Ovale, Patent (7) · Premature Birth (7) · Alagille Syndrome (6)
Congenital Abnormalities (257) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (257) · Cardiovascular Diseases (252) · Heart Diseases (169) · Heart Defects, Congenital (111) · Pathological Conditions, Signs and Symptoms (72) · Vascular Diseases (70) · Pathologic Processes (56) · Hemic and Lymphatic Diseases (55) · Vascular Malformations (53) · Hematologic Diseases (41) · Genetic Diseases, Inborn (38) · Hemorrhagic Disorders (38) · Hemostatic Disorders (35)
Acetaminophen (14) · Sodium Chloride (10) · Bevacizumab (9) · Ibuprofen (8) · Saline Solution (8) · Dexmedetomidine (5) · Sirolimus (5) · Thalidomide (5) · Indomethacin (4) · Milrinone (4) · Propranolol (4) · Standard of Care (4) · maralixibat (4) · trametinib (4) · Bosentan (3)
Hospices Civils de Lyon (7) · Children's Hospital of Philadelphia (6) · Mirum Pharmaceuticals, Inc. (6) · Shaare Zedek Medical Center (5) · The Hospital for Sick Children (5) · Boston Children's Hospital (4) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (4) · Unity Health Toronto (4) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (3) · Assiut University (3) · Oslo University Hospital (3) · Shanghai Jiao Tong University School of Medicine (3) · Stanford University (3) · Sumitomo Pharma Switzerland GmbH (3) · University of California, San Diego (3)
United States (123) · Canada (31) · France (23) · China (16) · Italy (14) · United Kingdom (14) · Germany (10) · Israel (10) · Netherlands (9) · Australia (8) · Belgium (8) · Spain (8) · Sweden (7) · Austria (6) · Denmark (4)
Cathy Hammerman, MD (5) · M. Louise Markert, MD, PhD (3) · Marie E Faughnan, MD MSc FRCPC (3) · Christoph Male, Prof,MD,PhD (2) · David P Bichell, MD (2) · Ida Jovanovic, Prof,MD,PhD (2) · James Gossage, MD (2) · Mark Reisman, MD (2) · Michael Burch, Prof,MD,PhD (2) · Michiel Dalinghaus, MD,PhD (2) · Sayed K Abd-Elshafy, MD (2)
PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 42002216, PMID 17284531, PMID 22065264, PMID 36519620, PMID 37979797, PMID 12702512, PMID 15701582, PMID 16219273, PMID 16322159, PMID 17307530, PMID 17662768, PMID 18155964, PMID 18195173, PMID 18254095, PMID 18812735, PMID 19128748, PMID 19217726, PMID 20978268, PMID 21051670, PMID 21106014, PMID 21317433, PMID 21382896, PMID 21449786, PMID 21565561, PMID 21774843, PMID 21914136, PMID 21926656, PMID 22089267, PMID 22396517, PMID 22417252, PMID 22611117, PMID 22943074, PMID 23102686, PMID 23172172, PMID 23228403, PMID 23234752, PMID 23258386, PMID 23263337, PMID 23321647, PMID 23462260, PMID 23543702, PMID 23607606, PMID 23663658, PMID 23771484, PMID 23796341
2015 (4), K12HD043494 (3), R01AI047040 (3), R01AI054843 (3), 2017 (2), 2019 (2), 2023 (2), 2025 (2), R56AI047040 (2), 2009 (1), 2016 (1), 2018 (1), 5UH3HL148693 (1), 7UG3HL148318-02 (1), K23HL093024 (1)