7 completed, 1 recruiting, 1 terminated, 1 unknown. 5 Phase 1, 4 Phase 2, 1 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Completed 3, Recruiting 1, Terminated 1 |
| Phase 2 | 4 | Completed 3, Recruiting 1 |
| Not applicable | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Thymic aplasia: new trials by email Literature Review of Thymic aplasia trials Research Report on Thymic aplasia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Single-arm, Dose-escalation Trial of Long-acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia Recombinant human interleukin (IL) 7-hyFc - Idiopathic CD4 Lymphopenia | Phase 1 / Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 60 | 2024-11-06 | 2026-10-19 |
| Functional Exhaustion of T Cells in COVID19 Patients Flow cytometry - T Cell Deficiency | Unknown | Assiut University | 100 | 2020-07-22 | 2020-08-06 | |
| Expanded Access Protocol Thymus Transplantation Cultured Thymus Tissue, Blood Draw, Rabbit Anti-Thymocyte Globulin and Cyclosporine or Tacrolimus - Poor Thymic Function, Immunodeficiency | Phase 4 | Completed | Sumitomo Pharma Switzerland GmbH | 11 | 2014-08-01 | 2025-01-16 |
| Thymus Transplantation Safety-Efficacy Cultured Thymus Tissue - Complete DiGeorge Anomaly, DiGeorge Syndrome | Not applicable | Completed | Sumitomo Pharma Switzerland GmbH | 29 | 2010-12-01 | 2025-01-16 |
| Serum-Free Thymus Transplantation in DiGeorge Anomaly Serum Free Thymus Transplantation with Immunosuppression, Serum Free Thymus Transplantation without immunosuppression - DiGeorge Anomaly | Phase 1 | Terminated | Sumitomo Pharma Switzerland GmbH | 2 | 2008-04-01 | 2022-04-01 |
| Phase I/II Thymus Transplantation With Immunosuppression #950 Cultured Thymus Tissue for Implantation (CTTI), Cultured Thymus Tissue Implantation and Parental Parathyroid Transplantation, Blood Draw - DiGeorge Anomaly, Complete DiGeorge Anomaly | Phase 1 / Phase 2 | Completed | Sumitomo Pharma Switzerland GmbH | 14 | 2005-12-19 | 2022-03-25 |
| Parathyroid and Thymus Transplantation in DiGeorge #931 Thymus/Parathyroid Transplantation - DiGeorge Syndrome, Hypoparathyroidism | Phase 1 | Completed | Sumitomo Pharma Switzerland GmbH | 25 | 2005-01-01 | 2022-04-04 |
| Thymus Transplantation Dose in DiGeorge #932 Cultured Thymus Tissue Implantation (CTTI), Cultured Thymus Tissue Implantation with Parathyroid Transplantation - DiGeorge Anomaly, DiGeorge Syndrome | Phase 2 | Completed | Sumitomo Pharma Switzerland GmbH | 7 | 2004-09-02 | 2022-03-25 |
| Thymus Transplantation With Immunosuppression Thymus Tissue for Transplantation - DiGeorge Syndrome, DiGeorge Anomaly | Phase 1 | Completed | Sumitomo Pharma Switzerland GmbH | 15 | 2002-07-01 | 2022-04-04 |
| Thymus Transplantation in DiGeorge Syndrome #668 Cultured Thymus Tissue for Implantation (CTTI) - DiGeorge Syndrome, Complete Typical DiGeorge Anomaly | Phase 2 | Completed | Sumitomo Pharma Switzerland GmbH | 26 | 1991-10-01 | 2022-03-25 |
DiGeorge Syndrome (7) · Immunologic Deficiency Syndromes (6) · Hypoparathyroidism (3) · Hypocalcemia (2) · Opportunistic Infections (1) · Primary Immunodeficiency Diseases (1) · T-Lymphocytopenia, Idiopathic CD4-Positive (1)
Hemic and Lymphatic Diseases (8) · Immune System Diseases (8) · 22q11 Deletion Syndrome (7) · Abnormalities, Multiple (7) · Cardiovascular Abnormalities (7) · Cardiovascular Diseases (7) · Chromosome Disorders (7) · Congenital Abnormalities (7) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (7) · Craniofacial Abnormalities (7) · Endocrine System Diseases (7) · Genetic Diseases, Inborn (7) · Heart Defects, Congenital (7) · Heart Diseases (7) · Lymphatic Abnormalities (7)
Thymus Extracts (3) · Antilymphocyte Serum (2) · Blood Specimen Collection (2) · Cyclosporine (2) · Cyclosporins (2) · Drug Implants (2) · Phlebotomy (2) · Tacrolimus (2) · Transplantation (2) · Daclizumab (1) · Flow Cytometry (1) · Immunosuppression Therapy (1) · Methylprednisolone (1) · Mycophenolic Acid (1) · Prednisolone (1)
Sumitomo Pharma Switzerland GmbH (8) · Assiut University (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1)
United States (7) · Egypt (1)
M. Louise Markert, MD, PhD (5) · John W. Sleasman, M.D. (2) · Andrea Lisco, M.D. (1) · M. Louise Markert, M.D., Ph.D (1)
PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 17284531, PMID 15100156, PMID 18155964, PMID 20978268, PMID 23607606, PMID 12702512, PMID 15100681, PMID 18333898, PMID 21565561, PMID 22590644, PMID 23914737
K12HD043494 (7), R01AI047040 (7), R01AI054843 (6), R56AI047040 (4)