74 completed, 17 terminated, 11 recruiting, 10 unknown. 130 Phase 1, 47 Phase 2.
Follow Cardiovascular Abnormalities: new trials by email Literature Review of Cardiovascular Abnormalities trials Research Report on Cardiovascular Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2027-01-01 | 2026-10-15 |
| Phase 1b Study of TX002100 in Participants With Hematologic Support-Dependent Hereditary Hemorrhagic Telangiectasia (HHT) TX002100 - Hereditary Hemorrhagic Telangiectasia (HHT) | Phase 1 | Not yet recruiting | Tectonic Operating Company, Inc. | 20 | 2026-12-31 | 2026-10-15 |
| Study to Establish Safety, Tolerability and Pharmacokinetics of NRL-1049 in Healthy Adult Participants Following Multiple-Dose Administration NRL-1049, Placebo - Cerebral Cavernous Malformation | Phase 1 | Not yet recruiting | Neurelis, Inc. | 40 | 2026-11-11 | 2026-10-30 |
| Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids 2 mL SunButyrate-TG, Placebo, 4 mL SunButyrate-TG - Congenital Heart Disease (CHD) | Phase 1 / Phase 2 | Recruiting | University of Nebraska | 105 | 2026-11-01 | 2026-10-30 |
| Topical TOR-582 Treatment of Epistaxis in HHT Topical sirolimus ointment - Hereditary Hemorrhagic Telangiectasia (HHT), Epistaxis | Phase 1 | Not yet recruiting | Columbia University | 27 | 2026-10-01 | 2026-08-21 |
| ATR 1072 in Participants With PRKAG2 Syndrome ATR 1072 - Cardiac Glycogenosis, Cardiomyopathy | Phase 1 / Phase 2 | Recruiting | Atrium Therapeutics | 37 | 2026-09-14 | 2026-09-18 |
| Harmony-HHT: ATV-1601 in Participants With Hereditary Hemorrhagic Telangiectasia (HHT) ATV-1601, Placebo - Hereditary Hemorrhagic Telangiectasia (HHT), Osler Weber Rendu Disease | Phase 1 / Phase 2 | Recruiting | Atavistik Bio, Inc | 100 | 2026-07-27 | 2026-10-29 |
| DIAG723 in Adults With Hereditary Hemorrhagic Telangiectasia DIAG723, Placebo - Hereditary Hemorrhagic Telangiectasia, Pulmonary Arterial Hypertension | Phase 1 / Phase 2 | Recruiting | Diagonal Therapeutics, Inc. | 93 | 2026-06-04 | 2026-09-08 |
| A Multiple Baseline Feasibility Trial of Social Management Training for People With Sex Chromosome Aneuploidies Social Management Training - Sex Chromosome Disorders | Phase 1 | Recruiting | University of Oslo | 30 | 2026-06-01 | 2026-07-22 |
| A Trial of TER-1754 in Patients With Hereditary Hemorrhagic Telangiectasia TER-1754, Placebo - Hereditary Hemorrhagic Telangiectasia (HHT) | Phase 1 | Withdrawn | Terremoto Biosciences Inc. | 2025-12-15 | 2026-04-13 | |
| Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Recruiting | Charite University, Berlin, Germany | 80 | 2025-12-05 | 2026-10-15 |
| In Situ Injection of Anti-angiogenics in Patients With Brain Arteriovenous Malformations Not Eligible for Exclusion Treatment Single in situ intra-arterial injection of bevacizumab - Brain Arteriovenous Malformations | Phase 1 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 20 | 2025-10-01 | 2025-07-20 |
| Propranolol Treatment for Postoperative Chylothorax Propranolol Hydrochloride, Placebo - Postoperative Chylothorax, Congenital Heart Disease | Phase 1 / Phase 2 | Suspended | June Wu | 50 | 2025-09-09 | 2026-05-15 |
| Study of Intramyocardial Injection of Ventrix Bio Extracellular Matrix (VentriGel) to Assess the Safety and Feasibility in Pediatric Patients with Hypoplastic Left Heart Syndrome (HLHS) Ventrix Bio Extracellular Matrix - Hypoplastic Left Heart Syndrome | Phase 1 | Not yet recruiting | Emory University | 12 | 2025-08-01 | 2025-03-10 |
| Trametinib Treatment for Complicated Vascular Anomalies Trametinib tablet - Vascular Anomalies | Phase 1 / Phase 2 | Active not recruiting | West China Hospital | 20 | 2025-07-07 | 2025-07-22 |
| A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT) ALN-6400, Placebo - Hereditary Hemorrhagic Telangiectasia | Phase 1 / Phase 2 | Active not recruiting | Alnylam Pharmaceuticals | 89 | 2024-11-07 | 2026-10-15 |
| Study of Inhaled RCT1100 in Adults With PCD Caused by Pathogenic Mutations in the DNAI1 Gene to Measure Mucociliary Clearance RCT1100 - Primary Ciliary Dyskinesia (PCD) | Phase 1 | Completed | ReCode Therapeutics | 14 | 2024-10-22 | 2026-04-30 |
| PK/PD of Digoxin in Infants With SVHD PK/PD Model Based Dosing of Digoxin in Infants with Single Ventricle Heart Disease - Single-ventricle, Infant Conditions | Phase 1 / Phase 2 | Completed | Duke University | 24 | 2024-10-10 | 2026-08-14 |
| A Study to Assess the Safety, Tolerability, Ciliary Rescue, and Pharmacodynamics of RCT1100 in Adults With PCD RCT1100 - Primary Ciliary Dyskinesia | Phase 1 | Completed | ReCode Therapeutics | 7 | 2024-09-20 | 2025-10-08 |
| IC14 (Atibuclimab) in Arrhythmogenic Cardiomyopathy IC14 - Arrhythmogenic Right Ventricular Dysplasia, Arrhythmogenic Left Ventricular Cardiomyopathy | Phase 1 / Phase 2 | Completed | Implicit Bioscience | 1 | 2024-03-29 | 2026-04-22 |
Showing 20 of 130. Sign in to see all of them.
Heart Defects, Congenital (32) · Hypoplastic Left Heart Syndrome (16) · Telangiectasia, Hereditary Hemorrhagic (15) · Long QT Syndrome (13) · Noonan Syndrome (11) · Carcinoma, Non-Small-Cell Lung (8) · Vascular Malformations (8) · Arteriovenous Malformations (7) · Epistaxis (7) · Colorectal Neoplasms (6) · Squamous Cell Carcinoma of Head and Neck (6) · DiGeorge Syndrome (5) · Tetralogy of Fallot (5) · Univentricular Heart (5) · Arrhythmogenic Right Ventricular Dysplasia (4)
Congenital Abnormalities (130) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (130) · Cardiovascular Diseases (127) · Heart Diseases (92) · Heart Defects, Congenital (66) · Pathological Conditions, Signs and Symptoms (39) · Pathologic Processes (35) · Vascular Diseases (28) · Hemic and Lymphatic Diseases (26) · Respiratory Tract Diseases (21) · Vascular Malformations (21) · Hematologic Diseases (17) · Hemorrhagic Disorders (17) · Hemostatic Disorders (17)
Acetaminophen (4) · Dexmedetomidine (4) · Moxifloxacin (4) · eleclazine (4) · Saline Solution (3) · Capsules (2) · Dexrazoxane (2) · Doxycycline (2) · Ibuprofen (2) · Injections (2) · Propranolol (2) · Sildenafil Citrate (2) · Sodium Chloride (2) · Standard of Care (2) · Sugars (2)
Gilead Sciences (4) · Sumitomo Pharma Switzerland GmbH (4) · Boston Children's Hospital (3) · Jacobio Pharmaceuticals Co., Ltd. (3) · ReCode Therapeutics (3) · The Hospital for Sick Children (3) · Timothy J Nelson, MD, PhD (3) · University of California, San Francisco (3) · Albireo (2) · Assistance Publique - Hôpitaux de Paris (2) · Athena Zuppa (2) · Carelon Research (2) · Charite University, Berlin, Germany (2) · Children's Hospital of Philadelphia (2) · Duke University (2)
United States (88) · Canada (8) · China (8) · Australia (5) · France (5) · Germany (5) · Spain (5) · New Zealand (3) · United Kingdom (3) · Finland (2) · Italy (2) · Japan (2) · Netherlands (2) · Romania (2) · Singapore (2)
John Matthews, MBBS, MCRP, PhD (3) · M. Louise Markert, MD, PhD (3) · Muhammad Y Qureshi, MBBS (3) · Timothy J Nelson, M.D., Ph.D. (3) · Outi Aikio, MD, PhD (2) · Revolution Medicines, Inc. (2) · William Mahle, MD (2) · Yuankai Shi, MD (2) · Adelina Pellicer, PhD (1) · Aditya K Kaza (1) · Alfred T Lane, MD (1) · Allan Doctor, MD (1) · Ana Paula CP Carlotti, 1 (1)
PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 15100156, PMID 17284531, PMID 23607606, PMID 15100681, PMID 17662768, PMID 18155964, PMID 18212521, PMID 18333898, PMID 19217726, PMID 20978268, PMID 22590644, PMID 23102686, PMID 23172172, PMID 23228403, PMID 23771484, PMID 23823195, PMID 24201857, PMID 24252784, PMID 24481211, PMID 24656411, PMID 24666686, PMID 25403163, PMID 26232942, PMID 26951240, PMID 28750642, PMID 28800628, PMID 29367212, PMID 30501611, PMID 30542204, PMID 31623840, PMID 32083653, PMID 32894644, PMID 33400845, PMID 33733338, PMID 34217109, PMID 34265312, PMID 34479739, PMID 35394149, PMID 35690720, PMID 37120522, PMID 37264205, PMID 37527726, PMID 37979797, PMID 38629477, PMID 39510938
K12HD043494 (4), R01AI047040 (4), R01AI054843 (4), 2014 (2), 2023 (2), R56AI047040 (2), 2016 (1), 2025 (1), R01HD106588 (1), R01HL073317 (1), R01HL149139 (1), R01HL155597 (1), R21HD055501 (1), R56HL128813 (1), U10HD045986 (1)