72 completed, 22 unknown, 15 terminated, 6 not yet recruiting. 30 Phase 3, 29 Phase 2, 26 Phase 4, 23 Not applicable, 22 Phase 1.
Follow Indomethacin: new trials by email Literature Review of Indomethacin trials Research Report on Indomethacin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pain Control During Hysterosalpingography: A Three-Arm Randomized Trial Indomethacin 100Mg Suppository, Lidocaine %2 ampoule - Hysterosalpingography-Related Pain | Phase 4 | Not yet recruiting | Balikesir University | 180 | 2026-11-01 | 2026-10-15 |
| Rectal Indomethacin With or Without Papillary Ice Water Irrigation to Prevent Post-ERCP Pancreatitis Rectal Indomethacin, Papillary Ice Water Irrigation - Pancreatitis | Not applicable | Not yet recruiting | Unity Health Toronto | 120 | 2026-10-01 | 2026-09-21 |
| Human Cerebrovascular Blood Flow and Sex Differences in Metabolic Syndrome Indomethacin, Placebo, MRI - Metabolic Syndrome | Early Phase 1 | Not yet recruiting | University of Wisconsin, Madison | 72 | 2026-10-01 | 2026-09-29 |
| Indomethacin for Biliary ERCP Patients indomethacin - Pancreatitis Biliary, Pancreatitis Acute Biliary | Phase 4 | Not yet recruiting | University of California, San Francisco | 860 | 2026-07-01 | 2026-06-22 |
| Preoperative Indomethacin and Paracetamol for Pain Management During Oocyte Retrieval in IVF Patients Indomethacin 100Mg Suppository, Paracetamol / Acetaminophen - Pain, Oocyte Retrieval | Phase 4 | Not yet recruiting | Western Galilee Hospital-Nahariya | 177 | 2026-04-13 | 2026-05-04 |
| SHIELD: Sorafenib Hand-foot Syndrome Inhibition With Pre-Emptive Local Delivery of Topical Indomethacin Topical Indomethacin - Hepato Cellular Carcinoma (HCC), Hand Foot Skin Syndrome | Phase 2 | Recruiting | National Taiwan University Hospital | 39 | 2025-12-09 | 2026-05-01 |
| Single-dose Prophylactic INdomethacin in Extremely Preterm Infants Indomethacin, Placebo - Extreme Prematurity, Intraventricular Hemorrhage | Phase 2 | Not yet recruiting | University of British Columbia | 500 | 2025-11-01 | 2025-09-03 |
| Low-Dose vs Standard-Dose Indomethacin for Preventing Post-ERCP Pancreatitis standard dose indomethacin, low dose indomethacin - Post-ERCP Pancreatitis | Phase 4 | Recruiting | Changhai Hospital | 1366 | 2025-09-15 | 2025-11-18 |
| Indomethacin vs Diclofenac for Preventing PEP Indomethacin 100 MG, Diclofenac 100mg - ERCP, Pancreatitis | Not applicable | Recruiting | Air Force Military Medical University, China | 4050 | 2025-06-01 | 2026-06-15 |
| Brain Blood Flow Responses to Stress: Sex Differences Indomethacin, Placebo, Orilissa - Cerebrovascular Disorders | Phase 4 | Completed | University of Wisconsin, Madison | 22 | 2024-07-24 | 2026-09-24 |
| Three Dimensional Ultrasonographic Detection of Human Ovulation Indomethacin 50 MG, Transvaginal ultrasound scans, Finger prick blood test - Ovulation Disorder | Phase 4 | Unknown | University of Saskatchewan | 30 | 2024-04-22 | 2024-05-29 |
| A First Time in Human Study to Evaluate the Safety and Tolerability of GSK4381406 in Healthy Participants GSK4381406, Placebo, Indomethacin - Colitis, Ulcerative | Phase 1 | Withdrawn | GlaxoSmithKline | 2023-10-31 | 2023-12-15 | |
| Prevention of Post-ERCP Pancreatitis by Indomethacin vs Diclofenac 100mg diclofenac, 100mg indomethacin - Post-ERCP Acute Pancreatitis, NSAIDs | Not applicable | Terminated | Air Force Military Medical University, China | 1204 | 2023-06-01 | 2024-10-28 |
| Saccharomyces Boulardii CNCM I-745 on Intestinal Barrier Function Indomethacin, S. boulardii CNCM I-745, Placebo - Healthy | Early Phase 1 | Completed | Mayo Clinic | 56 | 2023-04-13 | 2026-05-11 |
| Rectal Indomethacin and Oral Tacrolimus Versus Combination to Prevent Post-ERCP Pancreatitis Tacrolimus capsule, Placebo, Rectal Indomethacin - Post-ERCP Acute Pancreatitis | Phase 3 | Recruiting | Johns Hopkins University | 4874 | 2023-01-18 | 2025-12-09 |
| Papillary Epinephrine Injection vs Rectal Indomethacin Epinephrine injection, Indomethacin - Post-ERCP Acute Pancreatitis | Phase 4 | Completed | Duzce University | 504 | 2023-01-01 | 2026-07-17 |
| Clinical Efficacy of Indomethacin in Early Treatment of Acute Pancreatitis Indometacin, conventional treatment - Acute Pancreatitis, Systemic Inflammatory Response Syndrome | Not applicable | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 188 | 2022-12-11 | 2023-02-17 |
| The Optimal Dose of Indomethacin Suppository for Preventing Post-ERCP Pancreatitis Indomethacin Suppository - Pancreatitis, Cholangiopancreatography, Endoscopic Retrograde | Not applicable | Completed | The First Affiliated Hospital of Soochow University | 192 | 2022-11-01 | 2024-03-15 |
| Ketotifen and Indomethacin Combination Treatment Clinical Trial for COVID-19 Ketotifen/Indomethacin, Placebo - COVID-19 Respiratory Infection | Phase 3 | Completed | Sen-Jam Pharmaceutical | 150 | 2022-05-03 | 2024-06-24 |
| T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and Other KK-LC-1 Positive Epithelial Cancers IL-2 (Aldesleukin), Cyclophosphamide, KK-LC-1 TCR - Kita-kyushu Lung Cancer Antigen 1, Human | Phase 1 | Terminated | National Cancer Institute (NCI) | 36 | 2022-03-08 | 2025-12-02 |
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Pancreatitis (15) · Ductus Arteriosus, Patent (13) · Obstetric Labor, Premature (11) · Premature Birth (10) · Inflammation (3) · Pain (3) · Squamous Cell Carcinoma of Head and Neck (3) · Agnosia (2) · Axial Spondyloarthritis (2) · Cardiovascular Diseases (2) · Colonic Neoplasms (2) · Colorectal Neoplasms (2) · Enterocolitis, Necrotizing (2) · Gastrointestinal Diseases (2) · Gout (2)
Air Force Military Medical University, China (5) · University of Wisconsin, Madison (4) · Iroko Pharmaceuticals, LLC (3) · Mayo Clinic (3) · National Cancer Institute (NCI) (3) · Brock University (2) · Brooklyn ImmunoTherapeutics, LLC (2) · Cairo University (2) · First Affiliated Hospital Xi'an Jiaotong University (2) · GlaxoSmithKline (2) · Johns Hopkins University (2) · Radboud University Medical Center (2) · Shaare Zedek Medical Center (2) · Tehran University of Medical Sciences (2) · Thomas Jefferson University (2)
United States (57) · Canada (15) · China (11) · Netherlands (5) · Israel (4) · Taiwan (4) · United Kingdom (4) · Denmark (3) · France (3) · India (3) · Spain (3) · Thailand (3) · Austria (2) · Belgium (2) · Egypt (2)
Cathy Hammerman, MD (2) · Ira Gottlieb, DPM (2) · Kyle Patrick, DO (2) · Michael Golf, DPM (2) · Scott M Norberg, D.O. (2) · William Schrage, PhD (2) · Aisling Murphy, MD (1) · Alexander Nadas (1) · Alexander T Limkakeng, MD (1) · Amish Jain, MBBS, PhD (1) · Amuchou S Soraisham, MD, DM (1) · Angela R Baerwald, PhD,MD,CCFP (1) · Anthony R Godfrey, Pharm. D. (1) · Avroy A. Fanaroff, MD (1)
PMID 35947046, PMID 22494121, PMID 10655301, PMID 10662747, PMID 11430325, PMID 11904109, PMID 11927685, PMID 11927799, PMID 12119802, PMID 12122152, PMID 12237259, PMID 12622582, PMID 12793996, PMID 12806612, PMID 12832331, PMID 15066944, PMID 15153776, PMID 15173799, PMID 15217999, PMID 15498811, PMID 15563538, PMID 15710782, PMID 15738343, PMID 15911704, PMID 16009161, PMID 16284067, PMID 16322159, PMID 16647401, PMID 16677640, PMID 16769377, PMID 16777920, PMID 16895628, PMID 16895634, PMID 16935285, PMID 17188612, PMID 17307535, PMID 17355281, PMID 17515447, PMID 17515448, PMID 17883296, PMID 18213383, PMID 18245398, PMID 18284881, PMID 18427974, PMID 18628265, PMID 19117897, PMID 19687359, PMID 19909587, PMID 20539208, PMID 2070995
R01HL150361 (2), 2019 (1), M01RR000070 (1), M01RR000997 (1), P30CA014089 (1), P30CA015704 (1), P30CA093373 (1), R00HL118154 (1), R01HD070792 (1), R01HL179276 (1), R21DK117212 (1), U01DK104833 (1), U10HD021364 (1), U10HD021373 (1), U10HD021385 (1)