26 completed, 12 terminated, 8 recruiting, 6 active not recruiting. 24 Phase 2, 19 Phase 3, 15 Phase 1, 2 Not applicable.
Follow Dexrazoxane: new trials by email Literature Review of Dexrazoxane trials Research Report on Dexrazoxane
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The CARDIOPROTECT Trial Dexrazoxane, Dexrazoxane placebo, Doxorubicin - Diffuse Large B-cell Lymphoma (DLBCL), Cardiotoxicity | Phase 2 | Recruiting | Beth Israel Deaconess Medical Center | 60 | 2026-08-31 | 2026-07-27 |
| Dexrazoxane to Protect Against Hemorrhagic STEMI Dexrazoxane, Normal Saline - Acute Myocardial Infarction (AMI) | Phase 2 | Completed | Rohan Dharmakumar | 50 | 2025-08-30 | 2026-05-26 |
| Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma Biospecimen Collection, Bone Scan, Computed Tomography - Pleuropulmonary Blastoma | Phase 3 | Recruiting | Children's Oncology Group | 110 | 2025-03-21 | 2026-08-25 |
| Prevention of Anthracycline-Induced Cardiac Dysfunction With Dexrazoxane in Patients With Diffuse Large-B Cell Lymphoma Dexrazoxane, Rituximab, Cyclophosphamide - DLBCL - Diffuse Large B Cell Lymphoma | Phase 3 | Recruiting | Stichting Hemato-Oncologie voor Volwassenen Nederland | 324 | 2024-08-15 | 2026-09-23 |
| CHIP-AML22/Quizartinib: Quizartinib + Chemotherapy in Newly Diagnosed Pediatric FLT3-ITD+ and NPM1wt AML Patients Quizartinib, Etoposide, Dexrazoxane - Acute Myeloid Leukemia in Children | Phase 2 | Recruiting | Princess Maxima Center for Pediatric Oncology | 60 | 2024-02-06 | 2025-08-05 |
| Study of DPPG2-TSL-DOX Combined With Hyperthermia in Soft Tissue Sarcoma DPPG2-TSL-DOX, Dexrazoxane - Sarcoma, Soft Tissue | Phase 1 | Completed | Thermosome GmbH | 8 | 2023-04-19 | 2025-07-28 |
| Venetoclax Basket Trial for High Risk Hematologic Malignancies Venetoclax, Azacitidine, Cytarabine - Myelodysplastic Syndromes, de Novo, Myelodysplastic Syndromes, Secondary | Phase 1 | Recruiting | Andrew E. Place, MD | 30 | 2023-03-29 | 2026-03-12 |
| Prevention of Heart Failure Induced by Doxorubicin With Early Administration of Dexrazoxane Dexrazoxane - Degradation of Top2b and Top2a in Human by Dexrazoxane, Time Course and Degradation of Top2b in Human by Dexrazoxane | Phase 1 | Completed | University of Arkansas | 25 | 2021-09-14 | 2025-07-08 |
| Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery Dexrazoxane - Heart Defects, Congenital | Phase 1 | Unknown | University of Texas at Austin | 12 | 2021-04-09 | 2021-08-09 |
| A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations Allogeneic Hematopoietic Stem Cell Transplantation, Asparaginase Erwinia chrysanthemi, Biospecimen Collection - Acute Myeloid Leukemia | Phase 3 | Recruiting | Children's Oncology Group | 1400 | 2020-07-21 | 2026-09-17 |
| Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Autologous Hematopoietic Stem Cell Transplantation, Carboplatin, Cisplatin - Ganglioneuroblastoma, High Risk Neuroblastoma | Phase 2 | Completed | National Cancer Institute (NCI) | 42 | 2019-03-04 | 2026-06-02 |
| OlaReDo - Olaratumab and Rechallenge With Doxorubicin in Soft Tissue Sarcoma Patients Olaratumab, Dexrazoxane, Doxorubicin - Advanced Soft Tissue Sarcoma | Phase 2 | Terminated | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | 2 | 2018-11-12 | 2020-07-15 |
| Dexrazoxane Hydrochloride in Preventing Heart-Related Side Effects of Chemotherapy in Participants With Blood Cancers Cladribine, Cytarabine, Dexrazoxane Hydrochloride - Acute Myeloid Leukemia, Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 100 | 2018-09-19 | 2026-05-22 |
| Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL) Autologous Hematopoietic Stem Cell Transplantation, Biospecimen Collection, Bone Marrow Aspiration and Biopsy - Ganglioneuroblastoma, Ganglioneuroblastoma, Nodular | Phase 3 | Recruiting | Children's Oncology Group | 750 | 2018-05-14 | 2026-08-25 |
| Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Allogeneic Hematopoietic Stem Cell Transplantation, Calaspargase Pegol, Cyclophosphamide - Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia | Phase 3 | Active not recruiting | Children's Oncology Group | 352 | 2017-08-08 | 2026-10-05 |
| A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia Azacitidine, Decitabine, Cytarabine - Acute Myeloid Leukemia, Myelodysplastic Syndromes | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 206 | 2017-06-15 | 2026-04-23 |
| Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents Pegaspargase, Erwinia asparaginase, Cyclophosphamide - Acute Lymphoblastic Leukemia, Pediatric | Phase 3 | Active not recruiting | Dana-Farber Cancer Institute | 560 | 2017-03-03 | 2026-07-16 |
| Marched Pair Study Conventional Doxorubicin(DOX) Versus Pegylated Liposomal Doxorubicin(PLD) Neoadjuvant Chemotherapy Pegylated Liposomal Doxorubicin, Cyclophosphamide, Taxotere - Antineoplastic Combined Chemotherapy Protocols | Phase 2 | Unknown | Jilin University | 160 | 2016-11-01 | 2017-12-29 |
| Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma Dexrazoxane, Doxorubicin - Sarcoma, Soft Tissue, Soft Tissue Sarcoma | Phase 2 | Completed | Washington University School of Medicine | 73 | 2016-02-22 | 2023-11-07 |
| Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery: Proposal for Pilot Investigation Dexrazoxane - Heart Defects, Congenital | Phase 1 | Terminated | Medical City Children's Hospital | 12 | 2014-09-01 | 2018-07-26 |
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Sarcoma (11) · Cardiotoxicity (10) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (10) · Osteosarcoma (5) · Lymphoma (4) · Recurrence (4) · Breast Neoplasms (3) · Leukemia (3) · Leukemia, Biphenotypic, Acute (3) · Leukemia, Myeloid, Acute (3) · Lymphoma, Large B-Cell, Diffuse (3) · Neuroblastoma (3) · Neuroectodermal Tumors, Primitive, Peripheral (3) · Rhabdomyosarcoma (3) · Blast Crisis (2)
Children's Oncology Group (13) · National Cancer Institute (NCI) (7) · Dana-Farber Cancer Institute (6) · M.D. Anderson Cancer Center (4) · Memorial Sloan Kettering Cancer Center (3) · City of Hope Medical Center (2) · St. Jude Children's Research Hospital (2) · Valerio Therapeutics (2) · Andrew E. Place, MD (1) · Beth Israel Deaconess Medical Center (1) · Fudan University (1) · Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest (1) · Jilin University (1) · Kissei Pharmaceutical Co., Ltd. (1) · Medical City Children's Hospital (1)
United States (41) · Canada (16) · Australia (9) · Puerto Rico (9) · Germany (5) · Netherlands (5) · New Zealand (3) · Switzerland (3) · China (2) · Denmark (2) · Italy (2) · Japan (2) · Saudi Arabia (2) · Austria (1) · Belgium (1)
Cindy Schwartz, MD (2) · Henning T Mouridsen, MD, Dr. med. (2) · Lewis Silverman, MD (2) · A. van Rhenen, MD (1) · Aiping Shi, Doctor (1) · Andrea Biondi (1) · Andres Morales, MD (1) · Andrew Chan, PD Dr. (1) · Andrew E Place, MD, PhD (1) · Barbara L. Asselin, MD (1) · Brian A Van Tine, M.D., Ph.D. (1) · Cameron K. Tebbi, MD (1) · Daniel Stromberg, MD (1) · Elizabeth Raetz, MD (1) · Emily Greengard (1)
PMID 17185744, PMID 15226337, PMID 15247354, PMID 19064966, PMID 19584400, PMID 20007809, PMID 20850381, PMID 22689804, PMID 22911615, PMID 23358966, PMID 23393050, PMID 23664013, PMID 26549586, PMID 29090520, PMID 29941458, PMID 30975630, PMID 32154021, PMID 33026184, PMID 33095287, PMID 33843815, PMID 34028986, PMID 34652968, PMID 34874751, PMID 34933343, PMID 35483358, PMID 37073741, PMID 38107263, PMID 38947228, PMID 39875951, PMID 40317097, PMID 40905823, PMID 41469545, PMID 41920422, PMID 42321916, PMID 42497367
U10CA180886 (7), 2023 (3), U10CA098543 (3), P30CA006516 (2), P30CA033572 (2), U01CA097452 (2), 2017 (1), P01CA068484 (1), P30CA013330 (1), P30CA016672 (1), R01HL151993 (1), U10CA030969 (1), U10CA031946 (1), U10CA180830 (1), UM1CA097452 (1)