64 completed, 14 unknown, 13 recruiting, 9 terminated. 22 Not applicable, 14 Phase 1, 8 Phase 2, 5 Phase 4, 2 Phase 3.
Follow Long QT Syndrome: new trials by email Literature Review of Long QT Syndrome trials Research Report on Long QT Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Physical Activity and Functional Capacity in Patients With Congenital Long QT Syndrome Questionnaires, Cardiopulmonary exercise testing, 24-hour Holter monitoring - Long QT Syndrome, Channelopathies | Not yet recruiting | University of Sao Paulo | 120 | 2026-11-01 | 2026-10-07 | |
| Evaluation of the Efficacy and Safety of THRV-1268 in Participants With Long QT Syndrome Type 2 (LQTS2) and Type 3 (LQTS3) baseline lead-in, THRV-1268 - Long QT Syndrome (LQTS) 2 | Phase 2 / Phase 3 | Recruiting | Thryv Therapeutics, Inc. | 84 | 2026-03-07 | 2026-09-21 |
| AI-powered ECG Analysis for Deadly Arrhythmias and ICI Myocarditis Arrhythmia, Long QT Syndrome | Recruiting | Groupe Hospitalier Pitie-Salpetriere | 127000 | 2026-01-01 | 2026-06-12 | |
| National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry whole genome sequencing - Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated | Recruiting | Hospital do Coracao | 1211 | 2025-04-30 | 2026-05-08 | |
| Wearable Devices for Patient Monitoring in Long QT Syndrome Wearable device - Long QT Syndrome | Recruiting | Queen Mary University of London | 80 | 2025-04-01 | 2026-05-19 | |
| Evaluation of Exercise Testing and Physical Activity in Children and Adolescents Living With Inherited Arrhythmias Exercise tolerance test, Physical activity & heart rate monitoring - Long QT Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia Type 1 | Completed | Royal Brompton & Harefield NHS Foundation Trust | 55 | 2025-03-18 | 2026-09-01 | |
| N-of-1 in ATS and MEPPC Flecainide, Flecainide + beta-blocker - Andersen Tawil Syndrome, Multifocal Ectopic Purkinje-related Premature Contractions | Phase 2 | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 10 | 2025-03-01 | 2025-01-29 |
| Do QT-Prolonging Drugs Cause Major Adverse Cardiac Events in Hospitalized Adults? Acquired Long QT, Ventricular Arrhythmias | Recruiting | St. Joseph's Healthcare Hamilton | 990000 | 2025-02-01 | 2026-01-28 | |
| Frequency of Hypoglycemia in Children With Beta-blocker Treated Long QT-syndrome Continuous Glucose Monitoring - Long QT Syndrome, Hypoglycemia | Not applicable | Enrolling by invitation | Helsinki University Central Hospital | 40 | 2024-12-09 | 2025-11-18 |
| Breath-holding Spells and Its Management Study Guidelines - Breath-holding Spell | Not applicable | Recruiting | Region Skane | 120 | 2024-12-02 | 2026-05-05 |
| COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C - Cardiopulmonary Failure, Myocardial Infarction (MI) | Enrolling by invitation | Peerbridge Health, Inc | 15000 | 2024-11-16 | 2025-01-08 | |
| Diltiazem in Jervell and Lange-Nielsen Syndrome diltiazem - Jervell and Lange Nielsen Syndrome | Phase 4 | Completed | Vanderbilt University Medical Center | 1 | 2024-10-16 | 2025-10-14 |
| Risk of Sudden Cardiac Death in UN Athletes Death, Sudden, Cardiac, Electrocardiogram QT Prolonged | Unknown | Universidad Nacional de Colombia | 250 | 2023-11-24 | 2024-07-24 | |
| Continuous Versus Intermittent cARdiac Electrical moNitorinG BodyGuardian Mini Plus - Torsades de Pointe Caused by Drug, Long QT Syndrome | Not applicable | Recruiting | Washington University School of Medicine | 60 | 2023-11-21 | 2025-12-30 |
| A Study to Evaluate Accuracy and Validity of the Chang Gung ECG Abnormality Detection Software Chang Gung ECG Abnormality Detection Software - Long QT Syndrome, Sinus Bradycardia | Unknown | Chang Gung Memorial Hospital | 4306 | 2023-10-06 | 2024-01-11 | |
| Comparing Direct vs Indirect Methods for Cascade Screening Direct contact of family members for cascade screening of relevant variants - Long QT Syndrome, Familial Hypercholesterolemia | Not applicable | Recruiting | University of Maryland, Baltimore | 200 | 2023-05-15 | 2026-04-14 |
| QT Changes in Geriatric Patients: a Comparison of Spinal and General Anesthesia QT and QTc interval - Anesthesia, Spinal, Sevoflurane | Not applicable | Completed | Haseki Training and Research Hospital | 58 | 2023-03-29 | 2024-04-19 |
| Study of LQT-1213 on QTc-induced Prolongation in Healthy Adult Subjects (Part1) and on Congenital Long QT in Patients Diagnosed With Type 2 or 3 Long QT Syndrome (Part 2). LQT-1213, Placebo, Dofetilide 250 μg Cap - Long QT Syndrome | Phase 1 / Phase 2 | Terminated | Thryv Therapeutics, Inc. | 42 | 2023-03-12 | 2025-07-24 |
| Beat to Beat A Study in Paediatric, Adolescent and Young Adult Patients Who Are Undergoing or Have Undergone Cancer Therapy to Evaluate the Agreement Between QTc Measured Using 12 Lead Electrocardiogram (ECG) and a Wearable Device ECG ECG application, 12 lead ECG - Neoplasms, Cardiac Arrhythmia | Not applicable | Completed | Murdoch Childrens Research Institute | 45 | 2023-02-07 | 2025-04-01 |
| Phase 1 Study of LQT-1213 in Healthy Adults LQT-1213, Placebo - Long QT Syndrome | Phase 1 | Completed | Thryv Therapeutics, Inc. | 50 | 2022-09-14 | 2023-09-26 |
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Death, Sudden, Cardiac (13) · Brugada Syndrome (12) · Arrhythmias, Cardiac (11) · Polymorphic Catecholaminergic Ventricular Tachycardia (11) · Arrhythmogenic Right Ventricular Dysplasia (8) · Torsades de Pointes (8) · Cardiomyopathy, Hypertrophic (7) · Cardiovascular Diseases (6) · Channelopathies (6) · Jervell-Lange Nielsen Syndrome (5) · Motor Activity (5) · Tachycardia, Ventricular (5) · Andersen Syndrome (4) · Cardiomyopathy, Dilated (4)
Pathological Conditions, Signs and Symptoms (107) · Cardiac Conduction System Disease (106) · Cardiovascular Abnormalities (106) · Pathologic Processes (106) · Congenital Abnormalities (105) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (105) · Heart Defects, Congenital (104) · Heart Diseases (103) · Cardiovascular Diseases (101) · Arrhythmias, Cardiac (96) · Tachycardia (23) · Tachycardia, Ventricular (17) · Genetic Diseases, Inborn (15) · Death (14) · Death, Sudden (13)
Moxifloxacin (5) · eleclazine (5) · Progesterone (4) · ibutilide (4) · Exercise Test (3) · dofetilide (3) · Adrenergic beta-Antagonists (2) · Electrocardiography (2) · Haloperidol (2) · Methadone (2) · Ondansetron (2) · Ranolazine (2) · Surveys and Questionnaires (2) · Testosterone (2) · 1-(1-(imidazo(1,2-a)pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-(1,2,3)triazolo(4,5-b)pyrazine (1)
Gilead Sciences (5) · University of British Columbia (5) · Indiana University (4) · University of Rochester (4) · KU Leuven (3) · Nantes University Hospital (3) · Tel-Aviv Sourasky Medical Center (3) · Thryv Therapeutics, Inc. (3) · University Hospital, Montpellier (3) · Istituto Auxologico Italiano (2) · Massachusetts General Hospital (2) · Mayo Clinic (2) · Pediatrix (2) · University of Maryland, Baltimore (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1)
United States (48) · France (14) · Canada (10) · United Kingdom (6) · Israel (5) · Belgium (4) · Germany (4) · Italy (4) · Brazil (3) · Denmark (3) · Turkey (Türkiye) (3) · Australia (2) · China (2) · New Zealand (2) · Romania (2)
Eline Vandael, PhD-student (3) · James E Tisdale, PharmD (3) · Andrew D Krahn, MD (2) · Christopher Newton-Cheh, MD, MPH (2) · Ana CG Oliveira, S (1) · Andreas Barth, MD (1) · Andreas Metzner, MD (1) · Andreas Rillig, MD (1) · Andrew A Grace, MD PhD (1) · Andrew D Krahn, Dr. (1) · Anne M Holbrook (1) · Arnold Fenrich, MD (1) · Arthur Moss (1)
PMID 10716483, PMID 11136691, PMID 16105845, PMID 16203906, PMID 18940888, PMID 19597050, PMID 20855658, PMID 21816308, PMID 21955300, PMID 22841828, PMID 22944906, PMID 23337247, PMID 23675554, PMID 23694966, PMID 24666686, PMID 25205533, PMID 26305685, PMID 26783233, PMID 27635072, PMID 27733495, PMID 28083030, PMID 28235848, PMID 28281228, PMID 28600387, PMID 28800628, PMID 28912187, PMID 31075442, PMID 31315600, PMID 31319747, PMID 32882399, PMID 33020898, PMID 33400845, PMID 33512057, PMID 33733338, PMID 33960826, PMID 34531279, PMID 35142618, PMID 35661239, PMID 37638409, PMID 38704288, PMID 38997778, PMID 39051104, PMID 39998828, PMID 40810874, PMID 41732243
2014 (3), 2023 (1), R01HL033843 (1), R01HL041035 (1), R01HL049432 (1), R01HL063174 (1), R01HL125918 (1), R01HL128743 (1), R01HL143070 (1), R01HL143485 (1), R01HL153114 (1), R21HG010412 (1), U10HD045986 (1), U54NS059065 (1), U54RR019482 (1)