47 completed, 12 unknown, 10 recruiting, 9 withdrawn. 92 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 92 | Completed 47, Unknown 12, Recruiting 10, Withdrawn 9, Not yet recruiting 6, Terminated 6, Active not recruiting 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial Guanfacine (GFC), Cromolyn Sodium, Placebo - Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia | Early Phase 1 | Not yet recruiting | Johns Hopkins University | 25 | 2026-11-15 | 2026-10-09 |
| Individualized fMRI-guided TMS for Depression Active Repetitive Transcranial Magnetic Stimulation (rTMS), Sham Transcranial Magnetic Stimulation (TMS) - Depression, Major Depressive Disorder (MDD) | Early Phase 1 | Not yet recruiting | University of Pennsylvania | 60 | 2026-09-15 | 2026-09-09 |
| Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101 TMS, NRX-101 - Major Depression | Early Phase 1 | Not yet recruiting | Mclean Hospital | 30 | 2026-09-01 | 2026-09-22 |
| FLOAT for Healthcare PTSS Floatation-REST, Documentary - Posttraumatic Stress Symptoms, Burnout | Early Phase 1 | Recruiting | Laureate Institute for Brain Research, Inc. | 15 | 2026-06-10 | 2026-07-17 |
| A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression repetetive transcranial magnetic stimulation - Knee Osteoarthritis, Depression | Early Phase 1 | Recruiting | University of California, Los Angeles | 30 | 2026-06-04 | 2026-07-06 |
| Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression D-Cycloserine (DCS), Continuous theta-burst stimulation (cTBS), Transcranial Magnetic Stimulation Sham - Major Depression | Early Phase 1 | Recruiting | Mclean Hospital | 80 | 2026-03-11 | 2026-05-13 |
| Efficacy of Digital Problem Solving Application in Reduction of Anxiety, Depression and Substance Use Disorder Symptoms DSPT - Digital Support for Problem-solving Therapy - Anxiety, Depressive Symptoms | Early Phase 1 | Not yet recruiting | 7 Generation Games | 100 | 2026-03-01 | 2024-04-04 |
| Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study Esketamine injection group (0.25 mg/kg), Saline injection group (Consistent with esketamine injection volume) - Esketamine, ECT | Early Phase 1 | Recruiting | Min Su | 220 | 2025-11-25 | 2026-01-07 |
| Examining the Impact of the Parenting Young Children Check-up The Parenting Young Children Check-up - Behavioral Health, Disruptive Behaviors | Early Phase 1 | Recruiting | Wayne State University | 40 | 2025-11-06 | 2026-07-29 |
| Testing the Impact of the Parenting Young Children Check-up Parenting Young Children Check-up - Behavioral Health, Disruptive Behaviors | Early Phase 1 | Recruiting | Wayne State University | 50 | 2025-11-01 | 2026-08-06 |
| Integrating Inuit Knowledge Principles in Multi-Level Mental Health Clinical Trials Traditional Country Foods, Cultural Workshops - Depression, Anxiety | Early Phase 1 | Completed | University of Alberta | 29 | 2025-10-15 | 2026-10-23 |
| PsiloIMAGINE: A Psychedelic-augmented Mental Imagery-based Intervention for Young People With Self-harm Psilocybin 5 mg with cognitive behavioural therapy intervention, Placebo with cognitive behavioural therapy intervention - Self Harm | Early Phase 1 | Recruiting | Imperial College London | 30 | 2025-10-01 | 2025-12-05 |
| Mood Effects of Serotonin Agonists: Depression LSD, Placebo - LSD, Major Depressive Disorder | Early Phase 1 | Completed | University of Chicago | 41 | 2025-06-09 | 2026-07-10 |
| Probiotic Administration for Adolescent Depression Visbiome, Placebo - Depression | Early Phase 1 | Recruiting | University of California, San Francisco | 77 | 2025-05-15 | 2026-07-14 |
| Effects of Intranasal Ketamine on Depression and Anxiety in Palliative Care Cancer Patients Intranasal ketamine hydrochloride - Depressive Symptoms Mild to Moderate in Severity, Anxiety | Early Phase 1 | Not yet recruiting | University of Zurich | 100 | 2025-04-01 | 2025-05-01 |
| Effects of Cannabidiol on Burnout Syndrome and Empathy of Caregivers of Older Adults Intervention1: Cannabidiol, Intervention 2: Placebo - Burnout Syndrome | Early Phase 1 | Not yet recruiting | University of Sao Paulo | 26 | 2024-12-01 | 2024-10-01 |
| Testing a Transdiagnostic TMS Treatment Target transcranial magnetic stimulation - Major Depressive Disorder, Depression | Early Phase 1 | Completed | Brigham and Women's Hospital | 10 | 2024-09-09 | 2026-07-13 |
| Losartan and Emotional Learning Losartan potassium 50mg, Placebo - Emotional Processing | Early Phase 1 | Unknown | University of Oxford | 60 | 2024-08-14 | 2024-10-04 |
| Effect of Kava on Anxiety and Stress in Cancer Survivors Kava, Placebo - Kava, Anxiety | Early Phase 1 | Withdrawn | Masonic Cancer Center, University of Minnesota | 2024-06-20 | 2026-10-16 | |
| Confirmatory Efficacy Trial of Attention Bias Modification for Depression Traditional Attention Bias Modification, Gamified Attention Bias Modification, Sham Attention Bias Modification - Depression | Early Phase 1 | Recruiting | University of Texas at Austin | 600 | 2024-05-01 | 2025-09-15 |
Showing 20 of 92. Sign in to see all of them.
Depression (70) · Anxiety Disorders (24) · Depressive Disorder, Major (9) · Cognitive Dysfunction (5) · Pain (5) · Sleep Initiation and Maintenance Disorders (5) · Suicidal Ideation (5) · Burnout, Psychological (4) · Inflammation (4) · Neoplasms (4) · Occupational Stress (4) · Stress Disorders, Post-Traumatic (4) · Bipolar Disorder (3) · Motor Activity (3) · Suicide (3)
Behavior (92) · Mental Disorders (48) · Pathological Conditions, Signs and Symptoms (21) · Nervous System Diseases (18) · Signs and Symptoms (18) · Neurologic Manifestations (13) · Mood Disorders (12) · Depressive Disorder (10) · Neurocognitive Disorders (9) · Central Nervous System Diseases (8) · Pathologic Processes (8) · Stress, Psychological (8) · Neoplasms (6) · Neurobehavioral Manifestations (6)
Ketamine (11) · Transcranial Magnetic Stimulation (4) · Endotoxins (3) · Psilocybin (3) · Citalopram (2) · Cycloserine (2) · Exercise (2) · Glycopyrrolate (2) · Hydrocortisone (2) · Iontophoresis (2) · Lipopolysaccharides (2) · Midazolam (2) · Sodium Chloride (2) · hydrocortisone acetate (2) · 3-(2'-fluoro-6',7'-dihydrospiro(piperidine-4,4'-thieno(3,2-c)pyran)-1-yl)-2-(2-fluorobenzyl)-N-methylpropanamide (1)
University of California, Los Angeles (6) · Mclean Hospital (4) · Soul Medicine Institute (3) · Boston University (2) · China Academy of Chinese Medical Sciences (2) · James J. Peters Veterans Affairs Medical Center (2) · Johns Hopkins University (2) · Stanford University (2) · University of Texas at Austin (2) · Wayne State University (2) · 7 Generation Games (1) · Ali Rezai, MD (1) · Benten Technologies, Inc. (1) · Bezmialem Vakif University (1) · Brigham and Women's Hospital (1)
United States (60) · Canada (5) · United Kingdom (4) · China (3) · Australia (2) · Brazil (1) · Czechia (1) · Egypt (1) · Germany (1) · Ireland (1) · Israel (1) · Norway (1) · Philippines (1) · Russia (1) · Switzerland (1)
Christopher P Cardozo, MD (2) · Dawson Church, PhD (2) · Keith Sudheimer, Ph.D. (2) · Scott Irwin, MD, PhD (2) · Alan Stanley Apter, MD (1) · Albert Garcia-Romeu, PhD (1) · Ali Rezai, MD (1) · Amber Leaver, PhD (1) · Andrea Reinecke, PhD (1) · Andreas Bechdolf, MD (1) · AnnMaria Demars, Ph.D. (1) · Anthony Bossis, PhD (1) · Benjamin Lewis, MD (1) · Cherry Leung, PhD, RN (1) · Christian J Amlang, MD (1)
PMID 16677714, PMID 19376240, PMID 20719303, PMID 21569488, PMID 22848802, PMID 23599019, PMID 23679917, PMID 25276687, PMID 25770082, PMID 26360770, PMID 26364274, PMID 26540163, PMID 27909164, PMID 27965856, PMID 29283117, PMID 29768360, PMID 31103547, PMID 31567264, PMID 31632316, PMID 31916890, PMID 32627860, PMID 32665041, PMID 34711062, PMID 35488938, PMID 35871638, PMID 36042911, PMID 36186856, PMID 36399169, PMID 36943254, PMID 36977985, PMID 37815563, PMID 39428602, PMID 39435124, PMID 39725004, PMID 40270079
2014 (1), K23MH101498 (1), P30AG072958 (1), R01DA002812 (1), R01MH059668 (1), R01MH091352 (1), R01MH139697 (1), R21CA197023 (1), R21MH113915 (1), R33MH135428 (1), R44MH121219 (1), R61AT012028 (1), UL1TR001412 (1)