45 completed, 2 not yet recruiting, 2 recruiting, 1 enrolling by invitation. 20 Phase 1, 15 Not applicable, 7 Early Phase 1, 7 Phase 2, 2 Phase 3.
Follow Endotoxins: new trials by email Literature Review of Endotoxins trials Research Report on Endotoxins
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Endotoxin Exposure to Examine the Role of Inflammation in Alcohol Use Endotoxin, Placebo saline - Alcohol Use Disorder, Inflammatory Response | Phase 2 | Not yet recruiting | University of California, Los Angeles | 64 | 2026-09-01 | 2026-08-28 |
| Inflammatory Challenge in Human Aggression. Endotoxin (E. coli O:113, Reference Endotoxin), Saline (Placebo) - Intermittent Explosive Disorder | Phase 2 | Recruiting | Ohio State University | 112 | 2026-02-16 | 2026-03-27 |
| Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function Short-Chain Fatty Acid Colon-Delivery Capsules, Placebo capsules, Lipopolysaccharide (LPS) - Endotoxemia, Inflammation | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 56 | 2025-10-24 | 2026-07-20 |
| Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia Dexamethasone, Tocilizumab, Anakinra - Sepsis, Neuroinflammatory Response | Phase 4 | Unknown | Radboud University Medical Center | 52 | 2024-10-24 | 2025-04-04 |
| Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma Lipopolysaccharides - Asthma; Eosinophilic, Asthma | Phase 1 | Not yet recruiting | National Jewish Health | 60 | 2024-04-01 | 2024-02-21 |
| Aging and Reward System Response to Inflammation and Anxiety Study Endotoxin, Placebo - Anhedonia, Inflammation | Phase 1 | Completed | University of California, Los Angeles | 40 | 2023-03-29 | 2025-12-11 |
| Effect of Endotoxin on Alcohol Consumption Endotoxin - Alcohol Use Disorder | Phase 2 | Completed | Yale University | 27 | 2022-02-27 | 2025-11-03 |
| An Inflammatory Challenge Using Endotoxin Placebo, Endotoxin - Alcohol Use Disorder, Inflammatory Response | Phase 2 | Completed | University of California, Los Angeles | 20 | 2021-10-19 | 2025-05-01 |
| The Innate Central Nervous System Immune Response to an Experimental Immune Challenge in People With Fibromyalgia Endotoxin, Escherichia Coli, Magnetic Resonance Spectroscopy - Fibromyalgia | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 36 | 2020-03-11 | 2023-04-14 |
| Sleep and Healthy Aging Research on Depression for Younger Women Endotoxin, Placebo - Anhedonia, Depression | Phase 1 | Completed | University of California, Los Angeles | 40 | 2019-10-02 | 2026-01-27 |
| Determining the Fingerprint of Endotoxin Tolerance Endotoxin (E. coli O:113, Reference Endotoxin) - Endotoxemia, Sepsis | Not applicable | Completed | Radboud University Medical Center | 110 | 2019-05-27 | 2025-02-07 |
| A Study Exploring the Use of Vaccine and Antigen Challenges for Immune Monitoring in Healthy Participants Imvanex, Shingrix, LPS - Healthy | Early Phase 1 | Completed | Janssen Research & Development, LLC | 48 | 2019-04-08 | 2025-02-03 |
| Effects of 20,000 EU of Clinical Center Reference Endotoxin (CCRE) Versus Placebo(ENDOHEART) Clinical Center Reference Endotoxin (CCRE), Normal saline - Healthy | Phase 1 | Completed | University of North Carolina, Chapel Hill | 15 | 2018-10-17 | 2019-09-20 |
| The Effects of Human Endotoxemia on Functional Capacity of Hematopoietic Stem and Progenitor Cells LPS, Placebo - Sepsis, Endotoxemia, Immunosuppression | Not applicable | Completed | Radboud University Medical Center | 12 | 2018-01-05 | 2022-10-06 |
| Systemic Inflammatory Response to CCRE CCRE - Healthy | Phase 1 | Completed | University of North Carolina, Chapel Hill | 25 | 2017-12-11 | 2019-09-20 |
| Lipopolysaccharide (LPS) Challenge in Depression Lipopolysaccharide, Placebo - Major Depressive Disorder | Phase 1 | Completed | Laureate Institute for Brain Research, Inc. | 64 | 2017-09-07 | 2025-07-02 |
| Sleep and Healthy Aging Research for Depression (SHARE-D) Study Endotoxin, Placebo - Depression in Old Age | Phase 1 | Completed | Michael Irwin, MD | 160 | 2017-08-23 | 2024-09-05 |
| Adrecizumab-LPS Study Endotoxin, Placebo, Adrecizumab - Healthy Volunteers | Phase 1 | Completed | Adrenomed AG | 24 | 2017-01-04 | 2021-02-01 |
| Dose-Related Inflammatory Effects of Intravenous Endotoxin in Humans Endotoxin, Placebo - Healthy | Phase 1 | Completed | Robert J Noveck, M.D. | 23 | 2016-08-01 | 2017-04-11 |
| Effects of Bronchial Segmental Endotoxin Instillation in Humans Saline, Endotoxin - Acute Lung Inflammation | Phase 2 | Enrolling by invitation | National Institutes of Health Clinical Center (CC) | 58 | 2015-06-18 | 2026-10-16 |
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Endotoxemia (11) · Inflammation (9) · Sepsis (7) · Depression (6) · Pneumonia (4) · Alcoholism (3) · Illness Behavior (3) · Anhedonia (2) · Asthma (2) · Insulin Resistance (2) · Neuroinflammatory Diseases (2) · Systemic Inflammatory Response Syndrome (2) · Aggression (1) · Anemia (1) · Anxiety Disorders (1)
Radboud University Medical Center (10) · University of California, Los Angeles (7) · Karolinska Institutet (3) · Rutgers, The State University of New Jersey (3) · University of North Carolina, Chapel Hill (3) · Washington University School of Medicine (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · National Institutes of Health Clinical Center (CC) (2) · University of Pennsylvania (2) · Aarhus University Hospital (1) · Adrenomed AG (1) · Copenhagen University Hospital, Rigshospitalet (1) · Janssen Research & Development, LLC (1) · Laureate Institute for Brain Research, Inc. (1) · Michael Irwin, MD (1)
United States (28) · Netherlands (11) · Denmark (3) · Belgium (2) · United Kingdom (2)
Peter Pickkers, MD, PhD (4) · Siobhan Corbett, MD (3) · Anthony F Suffredini, M.D. (2) · Lara Ray, PhD (2) · Michael R Irwin, MD (2) · Michelle Hernandez, MD (2) · Boushra Dalile, PhD (1) · Chloe C Boyle, PHD (1) · Chloe C Boyle, PhD (1) · David Peden, MD (1) · Delphine Chen, MD (1) · Delphine L Chen, MD (1) · Delphine L. Chen, MD (1) · Emil F. Coccaro, MD (1)
PMID 41298372, PMID 16864730, PMID 19376240, PMID 19387330, PMID 19574441, PMID 20719303, PMID 22106246, PMID 23060625, PMID 23497455, PMID 23835341, PMID 24504737, PMID 24875672, PMID 25525182, PMID 25579865, PMID 25770082, PMID 26360770, PMID 26515417, PMID 27307305, PMID 28515092, PMID 29298938, PMID 30217536, PMID 30239561, PMID 30418539, PMID 30571184, PMID 30919998, PMID 31103547, PMID 31632316, PMID 35868533, PMID 35871638, PMID 37256193, PMID 40668551, PMID 41192236
2023 (1), K01AG072049 (1), K24AA025704 (1), R01HL073278 (1), R01MH091352 (1), R01MH133925 (1), R03AA028361 (1)