44 completed, 4 terminated, 3 recruiting, 2 not yet recruiting. 26 Phase 1, 14 Not applicable, 6 Early Phase 1, 6 Phase 2, 4 Phase 4.
Follow Lipopolysaccharides: new trials by email Literature Review of Lipopolysaccharides trials Research Report on Lipopolysaccharides
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Endotoxin Exposure to Examine the Role of Inflammation in Alcohol Use Endotoxin, Placebo saline - Alcohol Use Disorder, Inflammatory Response | Phase 2 | Not yet recruiting | University of California, Los Angeles | 64 | 2026-09-01 | 2026-08-28 |
| Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function Short-Chain Fatty Acid Colon-Delivery Capsules, Placebo capsules, Lipopolysaccharide (LPS) - Endotoxemia, Inflammation | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 56 | 2025-10-24 | 2026-07-20 |
| Mechanisms of Pain Hypersensitivity in a Human Skin Inflammation Model Synthetic interstitial fluid (SIF) / SIF neutral pH, Synthetic interstitial fluid (SIF) / SIF acidic pH, Synthetic interstitial fluid (SIF) / SIF acidic pH + BCTC 1 µM - Pain | Early Phase 1 | Completed | Stefan Heber | 42 | 2025-06-17 | 2025-07-29 |
| Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia Dexamethasone, Tocilizumab, Anakinra - Sepsis, Neuroinflammatory Response | Phase 4 | Unknown | Radboud University Medical Center | 52 | 2024-10-24 | 2025-04-04 |
| Individual Differences in Acute Response to Experimental Inflammation: Microcirculatory Changes and Psychological Predictors endotoxin escherichia coli (E. coli) lipopolysaccharide (LPS), Placcebo - Inflammation Biomarkers, Inflammation | Not applicable | Completed | University Hospital, Linkoeping | 25 | 2024-09-17 | 2026-05-08 |
| Mapping the Effect of (neuro)inflammation on Stress Sensitivity in the Brain of Healthy Men Lipopolysaccharide (LPS), Placebo - Inflammation, Stress | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 20 | 2024-05-03 | 2024-10-01 |
| Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma Lipopolysaccharides - Asthma; Eosinophilic, Asthma | Phase 1 | Not yet recruiting | National Jewish Health | 60 | 2024-04-01 | 2024-02-21 |
| A Study of Adalimumab on Inflammatory Mediators Following a Systemic Endotoxin Challenge Adalimumab, Lipopolysaccharide (LPS) - Healthy | Phase 1 | Completed | Janssen Research & Development, LLC | 20 | 2023-05-22 | 2025-03-30 |
| Feasibility Study of Intra-Tumoral Lipopolysaccharide Immunotherapy for Intra-Abdominal Tumors Lipopolysaccharide - Abdominal Cancer, Malignancy | Phase 1 | Completed | Patrick Wagner, MD, FACS | 12 | 2023-03-16 | 2026-06-15 |
| Theophylline for Depression Study Theophylline ER, PO placebo, Lipopolysaccharide (LPS) - Depression | Early Phase 1 | Withdrawn | University of California, Los Angeles | 2023-03-01 | 2021-11-05 | |
| Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR Lipopolysaccharide, PET/MR with [11C]PBR28 - Neurodegenerative Diseases, Parkinson Disease | Recruiting | University of Exeter | 30 | 2022-02-28 | 2025-10-07 | |
| Effect of Endotoxin on Alcohol Consumption Endotoxin - Alcohol Use Disorder | Phase 2 | Completed | Yale University | 27 | 2022-02-27 | 2025-11-03 |
| CBD-Microglia PET Study [11C]PBR28, Low-dose lipopolysaccharide, Intradermal Capsaicin - CBD, Healthy | Early Phase 1 | Completed | Yale University | 28 | 2021-05-07 | 2026-04-29 |
| Determining the Fingerprint of Endotoxin Tolerance Endotoxin (E. coli O:113, Reference Endotoxin) - Endotoxemia, Sepsis | Not applicable | Completed | Radboud University Medical Center | 110 | 2019-05-27 | 2025-02-07 |
| Intradermal LPS and Antibiotics Erythromycin 4% topical gel formulation:, Clindamycin 1% lotion formulation:, Prednisolone tablet (0.5mg/kg; parallel comparison): - Inflammation; Skin | Not applicable | Completed | Centre for Human Drug Research, Netherlands | 32 | 2018-10-12 | 2021-08-03 |
| Leucine for Depression Study (L-DEP) leucine, PO placebo, lipopolysaccharide (LPS) - Depression | Early Phase 1 | Terminated | University of California, Los Angeles | 59 | 2018-09-01 | 2023-06-08 |
| The Effects of Human Endotoxemia on Functional Capacity of Hematopoietic Stem and Progenitor Cells LPS, Placebo - Sepsis, Endotoxemia, Immunosuppression | Not applicable | Completed | Radboud University Medical Center | 12 | 2018-01-05 | 2022-10-06 |
| Systemic Inflammatory Response to CCRE CCRE - Healthy | Phase 1 | Completed | University of North Carolina, Chapel Hill | 25 | 2017-12-11 | 2019-09-20 |
| Lipopolysaccharide (LPS) Challenge in Depression Lipopolysaccharide, Placebo - Major Depressive Disorder | Phase 1 | Completed | Laureate Institute for Brain Research, Inc. | 64 | 2017-09-07 | 2025-07-02 |
| Lipopolysaccharide (LPS) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Challenge Study on Healthy Subjects Cantharidin, Lipopolysaccharide, Granulocyte-Macrophage Colony-Stimulating Factor - Arthritis, Rheumatoid | Phase 1 | Completed | GlaxoSmithKline | 12 | 2017-08-11 | 2019-08-08 |
Showing 20 of 56. Sign in to see all of them.
Inflammation (12) · Endotoxemia (10) · Sepsis (4) · Illness Behavior (3) · Pneumonia (3) · Alcoholism (2) · Asthma (2) · Depression (2) · Escherichia coli Infections (2) · Arthritis, Rheumatoid (1) · Autoimmune Diseases (1) · Blister (1) · Cardiovascular Diseases (1) · Depressive Disorder, Major (1) · Dermatitis (1)
Radboud University Medical Center (8) · Medical University of Vienna (6) · Yale University (4) · Boehringer Ingelheim (3) · Karolinska Institutet (3) · Rutgers, The State University of New Jersey (3) · University of California, Los Angeles (3) · Washington University School of Medicine (3) · Universitaire Ziekenhuizen KU Leuven (2) · University of North Carolina, Chapel Hill (2) · Adrenomed AG (1) · Baylor Research Institute (1) · Bernd Jilma (1) · Centre for Human Drug Research, Netherlands (1) · Craig L Slingluff, Jr (1)
United States (22) · Netherlands (10) · Austria (8) · Belgium (3) · United Kingdom (2) · Canada (1) · Denmark (1) · Sweden (1)
Michael Wolzt, MD (3) · Peter Pickkers, MD, PhD (3) · Siobhan Corbett, MD (3) · Bernd Jilma, MD (2) · Boushra Dalile, PhD (2) · Kelly Cosgrove, PhD (2) · Lukas Van Oudenhove, MD, PhD (2) · Craig L Slingluff, MD (1) · David B Peden, MD, MS (1) · Delphine Chen, MD (1) · Delphine L Chen, MD (1) · Delphine L. Chen, MD (1) · Gerhard Garhofer, MD (1)
PMID 10191237, PMID 18299127, PMID 18433844, PMID 19387330, PMID 19574441, PMID 19684008, PMID 20562702, PMID 21270403, PMID 22106246, PMID 24568613, PMID 24576874, PMID 25525163, PMID 25525182, PMID 25883989, PMID 28062311, PMID 29298938, PMID 30217536, PMID 30782041, PMID 30908082, PMID 30919998, PMID 31248461, PMID 32107360, PMID 32350119, PMID 33548580, PMID 33863932, PMID 34293819, PMID 34935141, PMID 42706575, PMID 42830319, PMID 5781321
2023 (2), K24AA025704 (1), P50HL084934 (1), R01HL073278 (1), R01MH110674 (1), R03AA028361 (1), R21MH113915 (1)