92 completed, 23 unknown, 17 recruiting, 16 terminated. 159 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 159 | Completed 92, Unknown 23, Recruiting 17, Terminated 16, Withdrawn 7, Active not recruiting 2, Not yet recruiting 2 |
Follow Apnea: new trials by email Literature Review of Apnea trials Research Report on Apnea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment Trazodone + positive airway pressure (PAP) therapy, Oxygen + positive airway pressure (PAP) therapy - Sleep Disordered Breathing, Able Bodied | Phase 4 | Recruiting | VA Office of Research and Development | 200 | 2026-09-16 | 2026-10-13 |
| A Comparative Effectiveness Study of Positive Airway Pressure (PAP) Therapy, Dental Device, and Atomoxetine-Oxybutynin for Treatment of Obstructive Sleep Apnea in Adults Positive airway pressure (PAP) therapy, Sleep dental device, Atomoxetine-oxybutynin - Obstructive Sleep Apnea (OSA) | Phase 4 | Recruiting | Sairam Parthasarathy | 2400 | 2026-09-04 | 2026-10-19 |
| Fentanyl and Rocuronium for Tracheal Intubation in Newborns Rocuronium Bromide 10 MG/ML, Fentanyl 1 mcg/kg IV, single dose, administered before non-emergent tracheal intubation. - Infant, Premature, Intubation, Intratracheal | Phase 4 | Not yet recruiting | UEA - Universidade Do Estado Do Amazonas | 102 | 2026-09-01 | 2026-07-01 |
| Caffeine Citrate in Preterm Infants at Risk of Apnea in Zambia Caffeine citrate 20mg/kg/day, Placebo-Sterile water 1ml/kg/day - Premature Infant Disease, Apnea of Prematurity | Phase 4 | Recruiting | University of Alabama at Birmingham | 340 | 2026-06-17 | 2026-06-23 |
| INFORMing Patients With Oximetry Data to Improve MAD Engagement Narval MRD device, MyNarval intervention (Narval CC MAD + O2 ring + MyNarval smartphone application), - Obstructive Sleep Apnea (OSA) | Phase 4 | Not yet recruiting | ResMed | 120 | 2026-06-01 | 2026-05-04 |
| Endotype DIrected Treatment for OSA in Down Syndrome ato-oxy, Oxygen - Obstructive Sleep Apnea (OSA), Down Syndrome | Phase 4 | Recruiting | University of Arizona | 200 | 2026-03-14 | 2026-09-03 |
| Combination of Remimazolam and Propofol During Drug-induced Sleep Endoscopy Remimazolam and Propofol, Propofol, Midazolam and propofol - Sedative Effect During Drug-induced Sleep Endoscopy, Obstructive Sleep Apnea (OSA) | Phase 4 | Active not recruiting | Dan Liu | 174 | 2025-03-01 | 2026-02-24 |
| Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia Methadone, Fentanyl/Hydromorphone - Pain, Postoperative, Tonsillar Hypertrophy | Phase 4 | Recruiting | Duke University | 440 | 2024-11-21 | 2025-12-05 |
| Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA Dexmedetomidine-esketamine combination, Placebo - Obstructive Sleep Apnea, Surgery | Phase 4 | Completed | Peking University First Hospital | 100 | 2024-09-11 | 2026-09-04 |
| f Adding Ketamine to Propofol For Drug-induced Sleep Endoscopy in Adult Patients With Obstructive Sleep Apnea Ketamine + propofol, propofol - Sleep Apnea Syndromes | Phase 4 | Completed | Zagazig University | 30 | 2024-07-30 | 2026-09-10 |
| HighCycle Study: Effect of Acetazolamide on Sleep Disordered Breathing in Women Compared to Men Acetazolamide, Placebo - Sleep-Disordered Breathing | Phase 4 | Completed | University of Zurich | 303 | 2024-07-15 | 2026-06-05 |
| CPAP Effect on Lipid Profile and Hyperuricemia in Patients With Dyslipidemia and Moderate-severe Obstructive Sleep Apnea Continuous positive airway pressure, Hygienic-dietary recommendations and daily physical activity promotion - Sleep Apnea, Dyslipidemias | Phase 4 | Recruiting | Hospital Universitario La Paz | 220 | 2024-07-12 | 2024-07-15 |
| Muscle Relaxation for Pediatric Adenotonsillectomy Rocuronium, Sugammadex, Anesthesia without neuromuscular blockade - Tonsillectomy | Phase 4 | Completed | University of Texas Southwestern Medical Center | 172 | 2024-04-10 | 2025-07-28 |
| Adipose Dysfunction, Imaging, Physiology, and Outcomes With Sodium Glucose Cotransporter 2 Inhibitor (SGLT2i) for Sleep Apnea: The ADIPOSA Study Bexagliflozin 20 mg, Placebo - Sleep Apnea | Phase 4 | Recruiting | Yale University | 164 | 2024-03-27 | 2026-08-27 |
| Impact GLP-1 Agonists Following Bariatric GLP-1 receptor agonist - Morbid Obesity, Metabolic Syndrome | Phase 4 | Recruiting | University of Missouri-Columbia | 150 | 2024-02-01 | 2026-10-21 |
| Impact of Obstructive Sleep Apnea (OSA) Treatment on Blood Pressure Control in Chronic Kidney Disease CPAP, Usual care - Sleep Apnea, Chronic Kidney Diseases | Phase 4 | Unknown | University of Sao Paulo | 150 | 2024-01-08 | 2024-06-11 |
| The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate Caffeine citrate - Apnea of Prematurity, Premature Birth | Phase 4 | Recruiting | Semmelweis University | 226 | 2023-12-21 | 2024-05-06 |
| CPAP Effect on the Polycythemia in Patients With Obstructive Sleep Apnea Continuous positive airway pressure, Conventional pharmacological treatment, Sleep ,diet and life style recomendations - Sleep Apnea, Obstructive, Polycythemia | Phase 4 | Recruiting | Hospital Universitario Ramon y Cajal | 182 | 2023-11-01 | 2025-09-17 |
| Zolpidem on CPAP Acclimatization in OSA Zolpidem, Placebo - Obstructive Sleep Apnea | Phase 4 | Unknown | Siriraj Hospital | 30 | 2023-10-15 | 2023-10-16 |
| Effect of Eszopiclone on Adherence to CPAP and Severity of Insomnia in Patients With COMISA Eszopiclone 3 mg, Placebo - Obstructive Sleep Apnea, Insomnia | Phase 4 | Completed | University of Sao Paulo General Hospital | 60 | 2023-08-24 | 2026-05-29 |
Showing 20 of 159. Sign in to see all of them.
Sleep Apnea, Obstructive (95) · Sleep Apnea Syndromes (66) · Hypertension (11) · Heart Failure (9) · Sleep Apnea, Central (9) · Cardiovascular Diseases (6) · Hypoxia (6) · Diabetes Mellitus (4) · Disorders of Excessive Somnolence (4) · Metabolic Syndrome (4) · Premature Birth (4) · Sleep Wake Disorders (4) · Agnosia (3) · Obesity (3)
Respiration Disorders (159) · Respiratory Tract Diseases (159) · Nervous System Diseases (148) · Dyssomnias (147) · Sleep Disorders, Intrinsic (147) · Sleep Wake Disorders (143) · Sleep Apnea Syndromes (81) · Pathological Conditions, Signs and Symptoms (54) · Signs and Symptoms (45) · Cardiovascular Diseases (30) · Signs and Symptoms, Respiratory (28) · Vascular Diseases (21) · Mental Disorders (16) · Heart Diseases (15)
Continuous Positive Airway Pressure (21) · Acetazolamide (8) · Propofol (8) · Dexmedetomidine (5) · caffeine citrate (5) · Ketamine (4) · Occlusal Splints (4) · Saline Solution (4) · Sodium Chloride (4) · Sugammadex (4) · Trazodone (4) · Zolpidem (4) · Donepezil (3) · Eszopiclone (3) · Fentanyl (3)
Hospital Universitario La Paz (7) · University of Sao Paulo (7) · University of Zurich (5) · VA Office of Research and Development (5) · University Hospital, Antwerp (4) · University Hospital, Grenoble (4) · University of California, San Diego (4) · Centre Hospitalier Universitaire Vaudois (3) · Hospital de Clinicas de Porto Alegre (3) · University of Chicago (3) · Associacao Fundo de Incentivo a Psicofarmcologia (2) · Associação Fundo de Incentivo à Pesquisa (2) · Chang Gung Memorial Hospital (2) · Children's Hospital Medical Center, Cincinnati (2) · Duke University (2)
United States (54) · Brazil (18) · Spain (12) · Canada (10) · France (10) · Switzerland (8) · Belgium (7) · Italy (7) · Germany (6) · China (5) · Netherlands (3) · Australia (2) · Denmark (2) · Kyrgyzstan (2) · South Korea (2)
Francisco Garcia-Rio, MD (4) · Konrad E Bloch, MD (4) · Armin Steffen, PD Dr. med. (2) · Christopher J Lettieri, MD (2) · Clemens Heiser, Dr. med. (2) · David L Steward, MD (2) · Denis Martinez, MD, PhD (2) · Erling B Pedersen, Professor (2) · Luciano F Drager, MD, PhD (2) · M Safwan Badr, MD (2) · Olivier Vanderveken, MD, PhD (2) · Sairam Parthasarathy, MD (2) · Alberto Alonso, MD (1)
PMID 34739082, PMID 38862381, PMID 10450601, PMID 10678860, PMID 10908222, PMID 10940788, PMID 11208620, PMID 11422885, PMID 11587154, PMID 12748199, PMID 14500166, PMID 15187032, PMID 16376782, PMID 16494088, PMID 16579514, PMID 17452537, PMID 17494787, PMID 17496462, PMID 17556718, PMID 17920917, PMID 17921053, PMID 17925431, PMID 17936040, PMID 17975198, PMID 1798888, PMID 18172212, PMID 18198262, PMID 18292756, PMID 18347202, PMID 18404673, PMID 18413499, PMID 18452788, PMID 18458174, PMID 18539753, PMID 18584016, PMID 18595959, PMID 18647805, PMID 18663661, PMID 18710420, PMID 18788656, PMID 19018977, PMID 19101028, PMID 19171788, PMID 19225527, PMID 19249441, PMID 19357147, PMID 19567493, PMID 19920270, PMID 20007932, PMID 20016520
2019 (1), I01CX001944 (1), I01RD001576 (1), R01HD057098 (1), R01HD114678 (1), R01HL075079 (1), R01HL130552 (1), U19AI057229 (1)