139 completed, 54 recruiting, 53 unknown, 29 not yet recruiting. 133 Not applicable, 20 Phase 4, 11 Phase 3, 7 Phase 2, 3 Early Phase 1.
Follow Aortic Stenosis: new trials by email Literature Review of Aortic Stenosis trials Research Report on Aortic Stenosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Regression in Left Ventricular Hypertrophy and Fibrosis in Aortic Stenosis Dapagliflozin (DAPA), Spironolactone (drug), Spironolactone + Dapagliflozin - Aortic Stenosis | Phase 2 | Not yet recruiting | University College, London | 445 | 2026-12-01 | 2026-09-11 |
| Safety and Clinical Performance of the Next-Generation SAFESYNC Transcatheter Heart Valve in Patients With Severe Aortic Stenosis INOVARE® SAFESYNC Next-Generation Bioprosthetic Heart Valve - Aortic Stenosis Senile, Aortic Stenosis Symptomatic | Not applicable | Not yet recruiting | Braile Biomedica Ind. Com. e Repr. Ltda. | 40 | 2026-11-01 | 2026-09-08 |
| Same-Day Versus Standard Hospital Discharge After TAVI (HOME-TAVI) Same-Day Discharge Strategy, Standard-of-Care Discharge Strategy - Aortic Stenosis, Severe, Aortic Stenosis | Not applicable | Not yet recruiting | Hospital Clinic of Barcelona | 764 | 2026-09-01 | 2026-07-31 |
| TAVI Without On-Site Cardiac Surgery in Poland: A Randomized Multicenter Trial Protocol transcathter aortic valve implantation - Aortic Stenosis | Not applicable | Not yet recruiting | Medical University of Warsaw | 404 | 2026-09-01 | 2026-04-07 |
| Remote Monitoring for Patients With Aortic Stenosis Aortic Stenosis | Not yet recruiting | Baker Heart and Diabetes Institute | 160 | 2026-09-01 | 2026-07-08 | |
| Quality of Life After Transcatheter Aortic Valve Implantation Aortic Stenosis, Heart Failure | Active not recruiting | Aalborg University Hospital | 200 | 2026-08-26 | 2026-09-01 | |
| ECG-based AI Screening for Cases of Undiagnosed Moderate-to-Severe Aortic Stenosis in the Primary Care Setting AK-AVS - Aortic Stenosis | Enrolling by invitation | AccurKardia, Inc. | 4000 | 2026-08-21 | 2026-09-18 | |
| Application of TAVI at Experienced Interventional Cardiac Centers Without On-site Cardiac Surgery (ATLAS Study) Transcatheter Aortic Valve Replacement (TAVR) with surgical oversight, Transcatheter Aortic Valve Replacement (TAVR) without surgical oversight - Aortic Stenosis, Severe Aortic Stenosis | Phase 4 | Not yet recruiting | University of Alberta | 600 | 2026-08-01 | 2026-06-02 |
| Systematic Ambulatory ECG Monitoring Following TAVI Ambulatory ECG monitoring - Aortic Stenosis, Conduction Disturbances | Not applicable | Not yet recruiting | Institut universitaire de cardiologie et de pneumologie de Québec, University Laval | 754 | 2026-08-01 | 2026-07-31 |
| Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE) Kosmos Torso-One AI-guided Point-of-Care Ultrasound (EchoNous, Inc.) - Valvular Heart Disease Patients, Aortic Stenosis | Not applicable | Not yet recruiting | University of Texas Southwestern Medical Center | 1088 | 2026-08-01 | 2026-08-17 |
| Evaluation of a Management Algorithm for TAVI Patients With Concomitant Mitral or Tricuspid Regurgitation Aortic Stenosis, Mitral Regurgitation | Not yet recruiting | Josep Rodes-Cabau | 300 | 2026-06-05 | 2026-06-03 | |
| Cerebral Microembolization During Transcatheter Aortic Valve Implantation: Comparing Balloon-expandable and Self-expanding Valves Balloon-expandable transcatheter aortic valve, Self-expanding transcatheter aortic valve - Aortic Stenosis | Not applicable | Not yet recruiting | Ivan Zeljkovic | 80 | 2026-06-01 | 2026-05-29 |
| TRanscatheter Aortic-Valve Implantation Without On-site Cardiac Surgery Transcatheter Aortic Valve Implantation - Aortic Stenosis | Not applicable | Recruiting | University Hospital of Ferrara | 1612 | 2026-05-25 | 2026-08-21 |
| CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material EmStop Embolic Protection System, Boston Scientific Sentinel - Aortic Valve Stenosis, Aortic Stenosis | Not applicable | Recruiting | EmStop Inc | 663 | 2026-05-12 | 2026-08-26 |
| Active Post-Market Surveillance of Innovative Devices for Valvular Heart Disease Transcatheter Aortic Valve Replacement, Transcatheter Edge-to-Edge Repair, Transcatheter Tricuspid Valve Annuloplasty - Aortic Stenosis, Aortic Regurgitation | Not yet recruiting | Beijing Anzhen Hospital | 5500 | 2026-05-10 | 2026-05-26 | |
| Deep Learning-enhanced Personalized Monitoring of Aortic Stenosis - The DETECT-AS Prognostic Study Transthoracic echocardiogram - Aortic Stenosis | Enrolling by invitation | Yale University | 210 | 2026-05-06 | 2026-05-08 | |
| Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis Impedance Cardiography Upright/Supine Test - Aortic Stenosis | Not applicable | Recruiting | Dermed Diagnostics, Inc. | 6 | 2026-04-30 | 2026-05-05 |
| Multicenter Study for the Validation of Willem AI: Aortic StenoSis Early Diagnosis With AI-electrocardiogram Study Willem AI ECG assessment - Aortic Stenosis | Recruiting | Idoven 1903 S.L. | 5000 | 2026-04-28 | 2026-07-20 | |
| Echo-Guided vs Fluoroscopy-Guided Transcatheter Aortic Valve Replacement in Patients With Aortic Stenosis（ECHO-TAVR） Echocardiographic guidance, Fluoroscopic guidance - Aortic Stenosis, TAVI | Phase 4 | Not yet recruiting | China National Center for Cardiovascular Diseases | 212 | 2026-04-26 | 2026-04-21 |
| Alternative Peripheral TAVI Accesses TAVI procedures with an alternative access - Aortic Stenosis | Not yet recruiting | Medical University of Silesia | 600 | 2026-04-15 | 2026-04-23 |
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Aortic Valve Stenosis (325) · Aortic Valve Insufficiency (27) · Mitral Valve Insufficiency (17) · Heart Valve Diseases (16) · Aortic Valve Disease (15) · Heart Failure (15) · Cardiovascular Diseases (14) · Coronary Artery Disease (11) · Heart Diseases (8) · Aortic Valve, Calcification of (7) · Frailty (7) · Hypertrophy, Left Ventricular (7) · Tricuspid Valve Insufficiency (7) · Inflammation (6) · Bicuspid Aortic Valve Disease (5)
Ventricular Outflow Obstruction (325) · Heart Diseases (317) · Cardiovascular Diseases (311) · Aortic Valve Disease (310) · Heart Valve Diseases (309) · Pathological Conditions, Signs and Symptoms (48) · Vascular Diseases (41) · Pathologic Processes (32) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (16) · Myocardial Ischemia (15) · Coronary Disease (12) · Nervous System Diseases (12) · Arterial Occlusive Diseases (11) · Arteriosclerosis (10) · Pathological Conditions, Anatomical (10)
Transcatheter Aortic Valve Replacement (40) · Echocardiography (6) · Hematologic Tests (4) · Anesthesia, General (3) · Aspirin (3) · Control Groups (3) · Magnetic Resonance Imaging (3) · Anesthesia, Local (2) · Bisoprolol (2) · Conscious Sedation (2) · Methylprednisolone (2) · Rivaroxaban (2) · Saline Solution (2) · Tadalafil (2) · dapagliflozin (2)
Edwards Lifesciences (14) · Boston Scientific Corporation (7) · Symetis SA (7) · University of Edinburgh (7) · The Cleveland Clinic (6) · Mayo Clinic (5) · Oslo University Hospital (5) · Baylor Research Institute (4) · China National Center for Cardiovascular Diseases (4) · Institut für Pharmakologie und Präventive Medizin (4) · Second Affiliated Hospital, Zhejiang University, School of Medicine (4) · Abbott Medical Devices (3) · Anteris Technologies Ltd. (3) · Beijing Anzhen Hospital (3) · Chinese Academy of Medical Sciences, Fuwai Hospital (3)
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Francis Duhay, MD (3) · Xiangbin Pan (3) · Barathi Sethuraman (2) · Brian R. Lindman, MD (2) · Duk-Hyun Kang, M.D. (2) · Marco Barbanti, MD (2) · Rohan Khera, MD, MS (2) · Russell J Everett, MBBS (2) · Sean Brady, JD (2) · Sven Erik Ricksten, Professor (2) · Tuomas Kiviniemi, MD, PhD (2) · Vinod Thourani, MD (2) · Xiangbin Pan, MD (2) · Yoshiki Sawa (2)
PMID 35321859, PMID 29555836, PMID 37526194, PMID 37832606, PMID 12538380, PMID 12831818, PMID 15212337, PMID 15817019, PMID 17350221, PMID 17502643, PMID 18219161, PMID 18625866, PMID 18765432, PMID 19580719, PMID 20031890, PMID 20139439, PMID 20413039, PMID 20435842, PMID 20961243, PMID 21149862, PMID 21570860, PMID 21639811, PMID 22090163, PMID 22092012, PMID 22147903, PMID 22155702, PMID 22362502, PMID 22440214, PMID 22447809, PMID 22516444, PMID 22649517, PMID 23149669, PMID 23329150, PMID 23349346, PMID 23357717, PMID 23391586, PMID 23720379, PMID 23727214, PMID 23916928, PMID 24014619, PMID 24237764, PMID 24276881, PMID 24353258, PMID 24474596, PMID 24508669, PMID 24681140, PMID 24682026, PMID 24780909, PMID 24903982, PMID 24939033
R01AG089981 (2), 2009 (1), 2016 (1), 2019 (1), U01HL088942 (1)