23 completed, 5 recruiting, 4 unknown, 3 withdrawn. 18 Not applicable, 9 Phase 3, 7 Phase 4, 2 Phase 2, 1 Phase 1.
Follow Analgesics, Opioid: new trials by email Literature Review of Analgesics, Opioid trials Research Report on Analgesics, Opioid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Quality of Recovery-15 After Opioid-free Versus Opioid-based General Anesthesia in Major Urological Surgery Remifentanil-based general anesthesia, Opioid-free general anesthesia - Postoperative Recovery, Anesthesia, General | Not applicable | Recruiting | Jagiellonian University | 200 | 2026-09-02 | 2026-09-08 |
| Optimizing Pain Treatment in Children On Mechanical Ventilation Acetaminophen, Ketorolac, Placebo - Mechanical Ventilation, Pediatric Acute Respiratory Failure | Phase 3 | Recruiting | Weill Medical College of Cornell University | 644 | 2025-12-29 | 2026-07-30 |
| The Effects of TFPB on Opioid Consumption in Patients Undergoing HLDN Ultrasound-guided transversalis fascia plane block - Postoperative Pain, Analgesics, Opioid | Not applicable | Completed | Koç University | 50 | 2025-07-25 | 2026-09-30 |
| Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery Spinal Anesthesia (bupivacaine), Postoperative pain management with acetaminophen, PCA IV Oxycodone - Analgesics, Opioid, Anesthesia, Spinal | Phase 4 | Recruiting | Medical University of Silesia | 120 | 2025-03-04 | 2026-02-12 |
| Asleep Fiberoptic vs Direct Laryngoscopy Effect on Hemodynamic Stability Using Opioid Free Anesthesia Induction direct conventional laryngoscopy, fiberoptic guided intubation - Analgesics, Opioid, Anesthesia, General | Not applicable | Completed | American University of Beirut Medical Center | 68 | 2024-09-11 | 2026-10-08 |
| Comparison of Total Intravenous Anesthesia and Inhalational Anesthesia in Opioid-Free Anesthesia for Bariatric Surgery: A Randomized Controlled Trial TIVA versus Inhalation - Analgesics, Opioid, Anesthesia; Adverse Effect | Not applicable | Completed | Jagiellonian University | 280 | 2024-04-30 | 2026-05-05 |
| Opioid-free Anesthesia as an Alternative to General Anesthesia in Abdominal Surgery anesthesia without opioids - Analgesics, Opioid, Anesthesia, Endotracheal | Not applicable | Recruiting | Jagiellonian University | 600 | 2024-04-29 | 2026-08-26 |
| Alternatives to Dental Opioid Prescribing After Tooth Extraction Multicomponent intervention, Usual care - Analgesics, Opioid, Acute Pain | Not applicable | Enrolling by invitation | Douglas Oyler | 38159 | 2024-04-16 | 2026-09-10 |
| IPACK on Early Pain Scores After ACL Reconstruction IPACK, PLACEBO - Pain, Postoperative, Anterior Cruciate Ligament Injuries | Phase 4 | Unknown | Loyola University | 78 | 2023-08-03 | 2023-08-14 |
| Opioid Use of Local Anaesthetic Agents in Open Heart Surgery and Its Effect on Recovery LIDOFAST 40 mg/2 ml + 0.025 mg/2 ml - Analgesics, Opioid, Anesthetics, Local | Not applicable | Completed | Yuzuncu Yil University | 60 | 2023-08-01 | 2024-10-15 |
| Patient-centred Deprescribing of Psychotropic, Sedative and Anticholinergic Medication in Elderly Patients With Polypharmacy PARTNER intervention, Control intervention - Deprescriptions, Antidepressive Agents | Not applicable | Recruiting | Ludwig-Maximilians - University of Munich | 352 | 2023-03-25 | 2025-05-04 |
| Perioperative Methadone in Hip Fracture Patients Methadone (Dose1), Methadone (Dose 2), Methadone (Dose 3) - Methadone, Pain, Post Operative | Phase 4 | Completed | University of Southern Denmark | 31 | 2023-01-12 | 2023-04-18 |
| Dexmedetomine as Adjuvant for Spinal Anesthesia in Elective Cesarian Sections : a Pilot Study Dexmedetomidine 0.004 MG/ML [Precedex], Opioids - Analgesia, Analgesics, Opioid | Phase 3 | Completed | St. Justine's Hospital | 42 | 2022-03-15 | 2023-05-09 |
| Rescue Quadratus Lumborum Blocks for Post-cesarean Pain Saline, Bupivacaine, Dexamethasone - Morphine, Analgesics | Phase 4 | Withdrawn | The University of Texas Health Science Center, Houston | 2022-01-01 | 2023-11-03 | |
| Benefits of Opioid Free Anesthesia on Morphine Consumption in Gastric Bypass Dexmedetomidine Injection [Precedex], Remifentanil - Analgesics, Opioid | Not applicable | Completed | matthieu clanet | 183 | 2021-10-05 | 2023-11-30 |
| Phase 1: Randomized Evaluation of a System to Deliver Mobile Cognitive Behavioral Therapy InCaveo's EOA system with integrated mobile CBT - Pain, Postoperative, Analgesics, Opioid | Not applicable | Unknown | InCaveo | 30 | 2021-10-01 | 2021-04-08 |
| Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery Acetaminophen, Gabapentin, Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine, Dexamethasone, Ondansetron - Anesthesia, General Anesthesia | Phase 3 | Unknown | University of Saskatchewan | 60 | 2021-05-15 | 2023-12-20 |
| Totally Transdermal Sedation in the Weaning From Remifentanil Infusion Fentanyl Transdermal System, Remifentanil - Respiratory Insufficiency, Ventilator Weaning | Phase 2 | Completed | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 24 | 2021-02-15 | 2024-05-17 |
| Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine 2% lidocaine with 1:200,000 epinephrine and epidural morphine, 3% 2-chloroprocaine and epidural morphine - Physiological Effect of Drugs, Morphine | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 44 | 2020-05-11 | 2022-05-26 |
| A RCT of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture INF2.0 + IBU, INF1.0 + IBU - Emergency Service, Hospital, Child/Adolescent Problem | Phase 4 | Withdrawn | St. Justine's Hospital | 2020-01-01 | 2022-11-23 |
Showing 20 of 36. Sign in to see all of them.
Pain, Postoperative (10) · Pain (8) · Agnosia (7) · Acute Pain (3) · Chronic Pain (2) · Respiratory Insufficiency (2) · Anterior Cruciate Ligament Injuries (1) · Cancer Pain (1) · Emergencies (1) · Fractures, Closed (1) · Hernia, Ventral (1) · Hyperalgesia (1) · Nociceptive Pain (1) · Pathologic Processes (1) · Patient Satisfaction (1)
Pathological Conditions, Signs and Symptoms (23) · Neurologic Manifestations (22) · Signs and Symptoms (22) · Pathologic Processes (11) · Pain (10) · Postoperative Complications (10) · Nervous System Diseases (9) · Neurobehavioral Manifestations (7) · Perceptual Disorders (7) · Wounds and Injuries (3) · Respiration Disorders (2) · Respiratory Tract Diseases (2) · Apnea (1) · Behavior (1) · Chemically-Induced Disorders (1)
Acetaminophen (4) · Dexmedetomidine (4) · Dexamethasone (3) · Lidocaine (3) · Analgesics, Opioid (2) · Bupivacaine (2) · Gabapentin (2) · Ketamine (2) · Ondansetron (2) · Remifentanil (2) · Sevoflurane (2) · Sodium Chloride (2) · Anesthesia (1) · Anesthesia, Spinal (1) · Buprenorphine (1)
Alza Corporation, DE, USA (5) · Jagiellonian University (3) · Medical University of Silesia (2) · St. Justine's Hospital (2) · The University of Texas Health Science Center, Houston (2) · University of Saskatchewan (2) · American University of Beirut Medical Center (1) · Carilion Clinic (1) · Christopher Anthony (1) · Douglas Oyler (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Hospital Italiano de Buenos Aires (1) · InCaveo (1) · Koç University (1) · Loyola University (1)
United States (10) · Poland (5) · Canada (4) · Turkey (Türkiye) (2) · Argentina (1) · Belgium (1) · Chile (1) · Denmark (1) · Germany (1) · Italy (1) · Lebanon (1) · New Zealand (1) · Sweden (1)
Linden Lee, MD (2) · Andrew G Hill, MD, EdD, FACS, FRACS (1) · Canan Demir (1) · Cassandra Mierisch, MD (1) · Chani Traube, MD (1) · Christian Rouphael, MD (1) · Christina Lamontagne (1) · Christopher A Anthony, MD (1) · Douglas R Oyler, PharmD (1) · Hoyman Hong, MD (1) · Jon Gamble, MD (1)
PMID 14508326, PMID 14665996, PMID 19402781, PMID 19507806, PMID 20705642, PMID 21620344, PMID 23945010, PMID 24267631, PMID 24566643, PMID 26247858, PMID 28594762, PMID 30322458, PMID 31417264, PMID 32584934, PMID 32723723, PMID 33523457, PMID 34184312, PMID 34321058, PMID 36473717, PMID 36534717, PMID 38047142, PMID 38435809, PMID 39893373, PMID 41522713, PMID 42472775, PMID 42867736
1UG3DE032621-01 (1), 2019 (1), 4UH3DE032621-02 (1), U01HD116260 (1)