24 completed, 7 not yet recruiting, 7 recruiting, 4 unknown. 24 Not applicable, 5 Phase 2, 1 Early Phase 1, 1 Phase 1, 1 Phase 3.
Follow TBI: new trials by email Literature Review of TBI trials Research Report on TBI
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND) Memantine - Traumatic Brain Injury, Mild Traumatic Brain Injury | Phase 2 | Not yet recruiting | Nova Scotia Health Authority | 45 | 2027-06-01 | 2026-10-09 |
| Assessment of Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments SSMD, Functional Electrical Stimulation (FES) - Stroke, TBI | Not applicable | Not yet recruiting | Motion Informatics LTD | 120 | 2026-12-30 | 2026-02-11 |
| fREMS for Mortality Prediction in TBI TBI, TBI Traumatic Brain Injury | Not yet recruiting | Al-Nahrain University | 2000 | 2026-09-01 | 2026-09-15 | |
| Comparing Approaches to Helping People With Chronic Traumatic Brain Injury Manage Their Health Care Patient Priorities Care (PPC), Resource Education - Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients | Not applicable | Enrolling by invitation | Indiana University | 142 | 2026-07-29 | 2026-08-06 |
| A Pilot Study of Home-Based Rhythmic Auditory Stimulation to Evaluate Mobility, Balance, and Patient-Reported Outcomes After Traumatic Brain Injury Home-Based Rhythmic Auditory Stimulation - Traumatic Brain Injury, Traumatic Brain Injury | Patient | Not applicable | Not yet recruiting | Craig Hospital | 33 | 2026-07-15 | 2026-07-14 |
| Effects of Neurofeedback Training and tRNS on Attentional Deficits in Patients With Acquired Brain Injury verum tRNS + Neurofeedback, sham tRNS + Neurofeedback - Acquired Brain Injury Including Stroke, TBI | Not applicable | Recruiting | Hospitales Nisa | 30 | 2026-06-26 | 2026-09-14 |
| INSIGHT: Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention NightWare smartwatch configured to detect physiological signs of sympathetic activation during sleep, such as heart-rate spikes and movement patterns., Sham (No Treatment) - Nightmare, Insomnia | Not applicable | Not yet recruiting | Uniformed Services University of the Health Sciences | 180 | 2026-06-01 | 2026-04-28 |
| NEUROBALANCE Training to Improve Postural Control in Individuals With Traumatic Brain Injury Combined (Robotic balance training and high-definition transcranial direct current stimulation), Standard of Care Balance Training - Traumatic Brain Injury, TBI | Not applicable | Recruiting | Kessler Foundation | 45 | 2025-08-01 | 2025-08-06 |
| Understanding Patient Engagement Trends in TBI Clinical Research TBI | Not yet recruiting | Power Life Sciences Inc. | 500 | 2025-03-01 | 2024-03-01 | |
| Reduced-dose Conditioning Regimen Containing TBI in HSCT Treating Elderly Patients With Aplastic Anemia reduced-dose conditioning regimen containing TBI in hematopoietic stem cell transplantation treating elderly patients with aplastic anemia - Aplastic Anaemia, HSCT | Phase 2 | Not yet recruiting | Institute of Hematology & Blood Diseases Hospital, China | 20 | 2025-01-31 | 2025-01-10 |
| Novel Intervention for Chronic Complex TBI in OEF/OIF/OND Veterans Pregnenolone, Placebo - Traumatic Brain Injury, TBI | Phase 2 | Suspended | Christine Marx, MD | 108 | 2024-09-06 | 2026-05-13 |
| Strengthening Neuro-Cognitive Skills for Success in School, Work and Beyond BrainStrong-BSR, BrainStrong-OPT - TBI, Cognitive Dysfunction | Not applicable | Recruiting | VA Office of Research and Development | 20 | 2024-06-10 | 2026-10-21 |
| Walking After Traumatic Brain Injury in Older Adults Planning, Reminders, and Micro-Incentives, Health Education - Traumatic Brain Injury, TBI | Not applicable | Completed | Timothy Morris | 57 | 2024-04-10 | 2026-01-07 |
| A Mixed Methods Pilot Trial of the STEP Home Workshop to Improve Reintegration and Reduce Suicide Risk for Recently Transitioned Veterans STEP-Home-SP, Transition Assistance Program, VA Solid Start - TBI, Suicide Prevention | Not applicable | Recruiting | VA Office of Research and Development | 120 | 2024-03-01 | 2026-03-06 |
| Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury Traumatic Brain Injury With Loss of Consciousness, Brain Injury Traumatic Severe | Recruiting | University of Texas Southwestern Medical Center | 130 | 2023-09-01 | 2026-07-02 | |
| The Exercise and Concussion Health Study Aerobic Exercise, Balance Exercise - Concussion, Mild, Concussion, Brain | Not applicable | Completed | Northeastern University | 37 | 2023-02-01 | 2026-01-07 |
| Virtual Reality and Social Cognition After Acquired Brain Injury VR TASIT, DT TASIT - TBI, Stroke | Unknown | Sunnaas Rehabilitation Hospital | 200 | 2022-09-15 | 2022-11-10 | |
| Art Therapy QEEG Study for Service Members with a Traumatic Brain Injury and Posttraumatic Stress Symptoms Art Therapy - Post-Traumatic Headache, PTSD | Not applicable | Completed | Walter Reed National Military Medical Center | 2 | 2021-10-30 | 2024-11-06 |
| Tracheostomy With Bedside Simultaneous Gastrostomy Vs Usual Care Tracheostomy And Delayed Gastrostomy Placement Timing of placement - Stroke, Acute, TBI | Not applicable | Withdrawn | University of Mississippi Medical Center | 2021-03-31 | 2021-06-09 | |
| Longitudinal Cognitive Assessment by BoCA Boston Cognitive Assessment (BoCA) - Alzheimer Disease, Mild Cognitive Impairment | Recruiting | Alzheimer's Light LLC | 10000 | 2019-10-01 | 2024-08-01 |
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Brain Injuries, Traumatic (19) · Brain Concussion (8) · Stress Disorders, Post-Traumatic (8) · Brain Injuries (7) · Stroke (6) · Cognitive Dysfunction (4) · Alzheimer Disease (3) · Attention Deficit Disorder with Hyperactivity (3) · Dementia (3) · Depression (3) · Hypoxia-Ischemia, Brain (3) · Anxiety Disorders (2) · Craniocerebral Trauma (2) · Dementia, Vascular (2) · Depressive Disorder, Major (2)
Nervous System Diseases (34) · Brain Diseases (32) · Central Nervous System Diseases (32) · Trauma, Nervous System (26) · Wounds and Injuries (26) · Craniocerebral Trauma (24) · Brain Injuries (19) · Mental Disorders (19) · Pathological Conditions, Signs and Symptoms (15) · Cardiovascular Diseases (12) · Signs and Symptoms (12) · Vascular Diseases (12) · Cerebrovascular Disorders (11) · Stress Disorders, Traumatic (8) · Trauma and Stressor Related Disorders (8)
Exercise (2) · Sugars (2) · Art Therapy (1) · Cognitive Behavioral Therapy (1) · Diagnostic Imaging (1) · Escitalopram (1) · Fatty Acids, Omega-3 (1) · Magnetic Resonance Imaging (1) · Memantine (1) · Methylphenidate (1) · Neurofeedback (1) · Neuropsychological Tests (1) · Omacor (1) · Pliability (1) · Pregnenolone (1)
Johns Hopkins University (3) · VA Office of Research and Development (3) · Children's Hospital Medical Center, Cincinnati (2) · University of Pennsylvania (2) · Al-Nahrain University (1) · Alzheimer's Light LLC (1) · Baylor College of Medicine (1) · Carrick Institute for Graduate Studies (1) · Children's Hospital Los Angeles (1) · Christine Marx, MD (1) · Clionsky Neuro Systems Inc. (1) · Craig Hospital (1) · Danderyd Hospital (1) · Hospitales Nisa (1) · Indiana University (1)
United States (33) · Canada (1) · China (1) · Denmark (1) · Iraq (1) · Israel (1) · Italy (1) · Norway (1) · Poland (1) · Spain (1) · Sweden (1)
Ramon Diaz-Arrastia, MD, PhD (2) · Alon Friedman, MD PhD (1) · Anne G Sadler, Ph.D. (1) · Anthony J. W. Chen, MD MA (1) · Brad Kurowski, MS, MD (1) · Candace Tefertiller, PT, DPT, PhD, NCS (1) · Carlos A Jaramillo, M.D., Ph.D. (1) · Catherine B Fortier, PhD (1) · Chris Marx, MD (1) · David B Clarke, MDCM PhD (1) · Deborah Stein, MD, MPH (1) · Ellen Parker, MD PhD (1) · Emily F Clionsky, M.D. (1) · Flora Hammond, MD (1) · Frantz Rom Poulsen, MD, PhD (1)
PMID 26082920, PMID 27774033, PMID 30169436, PMID 31556652, PMID 33459040, PMID 33635325, PMID 37139182, PMID 39479003, PMID 40614040, PMID 41988967
I01RX003141 (1), K25HL153954 (1), P30AG048785 (1), R01NS129934 (1)