22 completed, 5 recruiting, 3 not yet recruiting, 2 unknown. 21 Phase 2, 6 Phase 1, 5 Not applicable, 5 Phase 4, 1 Early Phase 1.
Follow Pregnenolone: new trials by email Literature Review of Pregnenolone trials Research Report on Pregnenolone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Investigating Novel Interventions for Low Back Pain in US Military Veterans: A Randomized Controlled Adaptive Phase II Trial Pregnenolone, DHEA, Placebo - Chronic Low Back Pain | Phase 2 | Not yet recruiting | VA Office of Research and Development | 108 | 2026-12-01 | 2026-09-08 |
| Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder Pregnenolone, Placebo - Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD) | Phase 2 | Not yet recruiting | Sherwood Brown, MD, PhD | 100 | 2026-10-01 | 2026-08-24 |
| Pregnenolone for Cannabis Use Disorder and Depression Pregnenolone - Cannabis Use Disorder, Major Depressive Disorder (MDD) | Phase 1 / Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 20 | 2026-09-01 | 2026-07-06 |
| Study on Allopregnanolone and Depression in Women Across the Menopause Transition pregnenolone, placebo - Depression | Not applicable | Recruiting | Beth Israel Deaconess Medical Center | 80 | 2026-05-01 | 2026-08-26 |
| Pregnenolone as a Treatment for Cannabis Intoxication Cannabis, Pregnenolone 250 mg, Pregnenolone 500 mg - Cannabis Intoxication | Phase 2 | Recruiting | Johns Hopkins University | 20 | 2026-04-24 | 2026-09-29 |
| A New Intervention to Improve Function in Veterans With Anxiety and Depression Pregnenolone, Placebo - Anxiety and Depression | Phase 2 | Recruiting | VA Office of Research and Development | 84 | 2025-08-14 | 2026-10-14 |
| Novel Intervention for Chronic Complex TBI in OEF/OIF/OND Veterans Pregnenolone, Placebo - Traumatic Brain Injury, TBI | Phase 2 | Suspended | Christine Marx, MD | 108 | 2024-09-06 | 2026-05-13 |
| Pregnenolone for the Treatment of Alcohol Use Disorder Pregnenolone, Placebo - Alcohol Use Disorder | Phase 2 | Recruiting | Yale University | 150 | 2024-01-08 | 2026-02-02 |
| Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV Placebo, Pregnenolone - Major Depressive Disorder, Anxiety Depression | Phase 2 | Recruiting | Massachusetts General Hospital | 120 | 2023-03-03 | 2025-09-12 |
| Feasibility Trial of Pregnenolone for Posttraumatic Stress Disorder and Alcohol Use Disorder Pregnenolone 250 mg, Pregnenolone 400 mg - Post Traumatic Stress Disorder, Alcohol Use Disorder | Phase 1 | Withdrawn | University of Texas Southwestern Medical Center | 2021-12-01 | 2021-08-23 | |
| Development of Pregnenolone as a Treatment for Depression Pregnenolone 500 mg, Pregnenolone 800 mg, Placebo - Major Depressive Disorder | Phase 1 | Completed | University of Texas Southwestern Medical Center | 34 | 2019-09-01 | 2024-05-01 |
| Neurosteroids for Treatment of PTSD in Veterans Pregnenolone, Placebo - Posttraumatic Stress Disorder | Phase 2 | Completed | VA Office of Research and Development | 97 | 2019-06-27 | 2026-08-26 |
| The Role of Neuroactive Steroids in Stress, Drug Craving and Drug Use in Cocaine Use Disorders Pregnenolone (PREG), Placebos - Cocaine-Related Disorders | Early Phase 1 | Completed | Yale University | 58 | 2019-03-12 | 2024-07-03 |
| Composition for Treating Uterine Fibroid (SB-UF) SB-UF, SB-UF Placebo - Uterine Fibroids Affecting Pregnancy | Phase 4 | Completed | Trieu, Nguyen Thi, M.D. | 66 | 2019-01-01 | 2026-06-08 |
| A Neurosteroid Intervention for Menopausal and Perimenopausal Depression Pregnenolone, Placebo - Major Depressive Disorder, Menopause | Phase 1 / Phase 2 | Completed | University of Texas Southwestern Medical Center | 73 | 2018-09-01 | 2026-01-22 |
| Effects of Pregnenolone on Perceived Social Isolation Pregnenolone 175mg, Pregnenolone 400mg, Placebo - Perceived Social Isolation | Phase 2 | Terminated | University of Chicago | 34 | 2017-05-01 | 2024-05-16 |
| Clinical Medication Development for Bipolar Disorder and Alcohol Use Disorders Placebo, Citicoline, Pregnenolone - Alcohol Use Disorder, Bipolar Disorder | Phase 4 | Completed | Sherwood Brown, MD, PhD | 96 | 2016-05-01 | 2024-10-09 |
| Pilot Trial of Pregnenolone in Autism Pregnenolone, Placebo - Autism Spectrum Disorder, Autism | Phase 2 | Completed | Stanford University | 40 | 2016-01-29 | 2026-03-30 |
| Pregnenolone and Marijuana Dependence Pregnenolone, Placebo - Marijuana Dependence | Phase 2 | Completed | Medical University of South Carolina | 21 | 2015-06-01 | 2018-06-18 |
| Complementary Neurosteroid Intervention in Gulf War Illnesses (GWVI) Pregnenolone, Placebo - Fatigue, Musculoskeletal Pain | Phase 2 | Completed | VA Office of Research and Development | 170 | 2013-10-01 | 2020-05-01 |
Showing 20 of 36. Sign in to see all of them.
Depressive Disorder, Major (8) · Depression (7) · Schizophrenia (6) · Alcoholism (4) · Pain (4) · Stress Disorders, Post-Traumatic (4) · Bipolar Disorder (3) · Brain Injuries, Traumatic (3) · Psychotic Disorders (3) · Anxiety Disorders (2) · Autistic Disorder (2) · Marijuana Abuse (2) · Substance-Related Disorders (2) · Alcoholic Intoxication (1) · Autism Spectrum Disorder (1)
University of Texas Southwestern Medical Center (6) · VA Office of Research and Development (5) · Durham VA Medical Center (4) · Sha'ar Menashe Mental Health Center (3) · Sherwood Brown, MD, PhD (2) · Stanford University (2) · Yale University (2) · Beth Israel Deaconess Medical Center (1) · Christine Marx, MD (1) · Jed E. Rose (1) · Johns Hopkins University (1) · Massachusetts General Hospital (1) · Medical University of South Carolina (1) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (1) · National Research Foundation, Singapore (1)
United States (30) · Israel (2) · Singapore (1) · Vietnam (1)
Christine E. Marx, MD MA (3) · Jennifer C Naylor, PhD (3) · Christine E Marx, MD, MA (2) · Sherwood Brown, MD, PhD (2) · Aimee McRae-Clark, PharmD (1) · Anatoly Kreinin, MD, PhD (1) · Antonio Hardan, MD (1) · Antonio Y. Hardan, MD (1) · Chris Marx, MD (1) · Christine E Marx, MD (1) · Christine E Marx, MD MA (1) · Christine Marx, M.D. (1) · Christine Marx, MD MA (1) · David Wolinsky, MD (1) · E. Sherwood Brown (1)
PMID 20584515, PMID 24849255, PMID 26218236, PMID 32119096
1IK2RX000908-01A1 (1), 1UG3DA066242-01 (1), I01CX001784 (1), I01CX002667 (1), I01RX004287 (1), K01DA046561 (1), R01AA030923 (1), R01AA033156 (1), R01MH131194 (1), R21DA063854 (1), R61AT009625 (1)