12 completed, 2 withdrawn, 1 recruiting, 1 suspended. 17 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 17 | Completed 12, Withdrawn 2, Recruiting 1, Suspended 1, Terminated 1 |
Follow Suicidal Ideation: new trials by email Literature Review of Suicidal Ideation trials Research Report on Suicidal Ideation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression Ketamine, Esketamine - Major Depressive Disorder | Phase 4 | Recruiting | Massachusetts General Hospital | 100 | 2022-10-13 | 2026-11-10 |
| IM Ketamine vs Midazolam for Suicidal ER Patients Ketamine hydrochloride injection, Midazolam injection - Depression, Unipolar, Depression, Bipolar | Phase 4 | Suspended | New York State Psychiatric Institute | 90 | 2021-02-09 | 2026-05-26 |
| Cyclical Neuroactive Steroid Changes, Arousal, and Proximal Suicide Risk: An Experimental Approach Estradiol Transdermal Patch 0.1 mg/24 hrs, Oral Micronized Progesterone 200mg, Inactive Clear Patch - Suicidal Ideation | Phase 4 | Completed | University of Illinois at Chicago | 124 | 2020-09-15 | 2025-12-19 |
| Anti-suicidal Effects of Buprenorphine in Opioid Use Disorder Buprenorphine/Naloxone 8/2 milligram (mg) Sublingual Film, Morphine Sulfate 30 mg - Opioid-use Disorder, Suicidal Ideation | Phase 4 | Withdrawn | New York State Psychiatric Institute | 2020-01-20 | 2021-06-18 | |
| Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department Ketamine, Sodium Chloride 0.9% - Depression, Depression Severe | Phase 4 | Completed | MercyOne Des Moines Medical Center | 29 | 2019-10-18 | 2020-09-01 |
| Unique Effects of Perimenstrual Estradiol or Progesterone Supplementation on Perimenstrual Suicidality Transdermal Estradiol + Placebo, Oral Micronized Progesterone + Placebo, Placebos - Suicidal Ideation | Phase 4 | Completed | University of Illinois at Chicago | 60 | 2018-07-27 | 2022-09-14 |
| Clinical and Imaging Trial of Uridine for Veterans With Suicidal Ideation Uridine, Placebo - Suicidal Ideation | Phase 4 | Completed | VA Office of Research and Development | 75 | 2018-04-02 | 2025-08-15 |
| The Effect of Ketamine on the Length of Hospital Stay of Patients Hospitalized With Suicidal Ideation. Ketamine, Normal Saline - Suicidal Ideation | Phase 4 | Terminated | Allen Richert | 4 | 2017-03-02 | 2020-06-02 |
| Effect of Perimenstrual Ovarian Steroid Supplementation on Perimenstrual Suicidality Estradiol Transdermal Patch 0.1 mg/24 hrs, Oral Micronized Progesterone, Inactive Clear Patch - Suicidal Ideation | Phase 4 | Completed | University of North Carolina, Chapel Hill | 30 | 2016-12-31 | 2019-02-04 |
| Ketamine Infusion for Adolescent Depression and Anxiety Ketamine, Midazolam - Major Depressive Disorder, Anxiety Disorder | Phase 4 | Completed | Yale University | 17 | 2015-10-01 | 2020-07-14 |
| Intranasal Ketamine for Late-Life Depression and Suicidal Ideation Ketamine, Placebo - Depression, Suicide | Phase 4 | Withdrawn | Massachusetts General Hospital | 2015-07-01 | 2017-03-03 | |
| Reducing Suicidal Ideation Through Treatment of Nightmares-Post Traumatic Stress Disorder (PTSD) Prazosin, Placebo - Post Traumatic Stress Disorder, Suicidal Ideation | Phase 4 | Completed | Augusta University | 20 | 2014-03-01 | 2018-09-18 |
| Reducing Suicidal Ideation Through Insomnia Treatment Zolpidem-CR, Placebo - Insomnia, Depression | Phase 4 | Completed | Augusta University | 103 | 2012-12-06 | 2022-02-16 |
| Ketamine in the Treatment of Suicidal Depression Ketamine, Midazolam - Major Depressive Disorder, Suicidal Ideation | Phase 4 | Completed | New York State Psychiatric Institute | 82 | 2012-06-01 | 2020-03-11 |
| Ketamine For Suicidal Ideation Ketamine, Midazolam - Suicidal Ideation | Phase 4 | Completed | James Murrough | 24 | 2012-01-01 | 2017-02-08 |
| Paroxetine/Bupropion in Depression With Suicide Attempt or Thoughts: fMRI Study Paroxetine CR for Major Depressive Episode, Bupropion XL for Major Depressive Episode - Depression, Suicidal Ideation | Phase 4 | Completed | New York State Psychiatric Institute | 15 | 2010-06-01 | 2017-11-21 |
| Paliperidone and Lithium in the Treatment of Suicidality - Treatment Indication and Epigenetic Regulation paliperidone, lithium, Placebo - Major Depressive Disorder, Suicidal Ideation | Phase 4 | Completed | University of Alabama at Birmingham | 54 | 2010-05-01 | 2016-03-03 |
Depression (11) · Suicide (7) · Depressive Disorder, Major (6) · Anxiety Disorders (1) · Bipolar Disorder (1) · Depressive Disorder (1) · Emergencies (1) · Generalized Anxiety Disorder (1) · Opioid-Related Disorders (1) · Phobia, School (1) · Sleep Initiation and Maintenance Disorders (1) · Stress Disorders, Post-Traumatic (1)
Behavior (17) · Behavioral Symptoms (17) · Self-Injurious Behavior (17) · Mental Disorders (10) · Suicide (10) · Mood Disorders (7) · Depressive Disorder (6) · Bipolar and Related Disorders (1) · Chemically-Induced Disorders (1) · Disease Attributes (1) · Dyssomnias (1) · Narcotic-Related Disorders (1) · Nervous System Diseases (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1)
Ketamine (8) · Midazolam (4) · Estradiol (3) · Progesterone (3) · Sugars (3) · Saline Solution (2) · Buprenorphine (1) · Bupropion (1) · Esketamine (1) · Excitatory Amino Acid Antagonists (1) · Lithium (1) · Morphine (1) · N-Methylaspartate (1) · Paliperidone Palmitate (1) · Paroxetine (1)
New York State Psychiatric Institute (4) · Augusta University (2) · Massachusetts General Hospital (2) · University of Illinois at Chicago (2) · Allen Richert (1) · James Murrough (1) · MercyOne Des Moines Medical Center (1) · University of Alabama at Birmingham (1) · University of North Carolina, Chapel Hill (1) · VA Office of Research and Development (1) · Yale University (1)
United States (16)
Michael F. Grunebaum, M.D. (2) · Tory A Eisenlohr-Moul, PhD (2) · William V McCall, MD, MS (2) · Adnan Iqbal, MD (1) · Allen C Richert, MD (1) · Dawn F Ionescu, MD (1) · Douglas Gavin Kondo, MD (1) · James Murrough, MD (1) · Kathryn Bress, PharmD (1) · Michael Grunebaum, MD (1) · Michael H. Bloch, MD MS (1) · Mina M Rizk, MD (1) · Richard C Shelton, M.D. (1) · Susan Girdler, PhD (1) · Tory A Eisenlohr-Moul, Ph.D (1)
PMID 26266877, PMID 29202655, PMID 31238203, PMID 31537089, PMID 32329435, PMID 32918323, PMID 33884617, PMID 33897480, PMID 34727422, PMID 34953926, PMID 36585408, PMID 36799961, PMID 37326562, PMID 37611527, PMID 38170185, PMID 39119911, PMID 41913970
K23MH076049 (1), K99MH109667 (1), R00MH109667 (1), R01MH095776 (1), R01MH096784 (1), R01MH125155 (1)