8 completed, 1 terminated. 3 Phase 1, 3 Phase 2, 2 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 3 |
| Phase 2 | 3 | Completed 3 |
| Not applicable | 2 | Completed 1, Terminated 1 |
| Phase 4 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Harmine in Healthy Subjects Harmine Hydrochloride Capsules - Diabetes Mellitus | Phase 1 | Completed | James Murrough | 27 | 2022-09-13 | 2025-01-16 |
| XEN1101 for Major Depressive Disorder XEN1101, Placebo - Major Depressive Disorder | Phase 2 | Completed | James Murrough | 60 | 2021-10-19 | 2026-11-06 |
| Study to Treat Major Depressive Disorder With a New Medication Ezogabine, Placebos - Depressive Disorder, Anhedonia | Phase 2 | Completed | James Murrough | 45 | 2017-09-25 | 2020-10-23 |
| Nuedexta in Treatment-Resistant Major Depression dextromethorphan/quinidine - Major Depressive Disorder, Treatment Resistant | Phase 2 | Completed | James Murrough | 20 | 2013-07-01 | 2018-06-11 |
| A Dose Escalation Study of Intranasal Neuropeptide Y in Post Traumatic Stress Disorder (PTSD) Neuropeptide Y - Posttraumatic Stress Disorder | Phase 1 | Completed | James Murrough | 26 | 2012-12-01 | 2016-04-14 |
| Ketamine For Suicidal Ideation Ketamine, Midazolam - Suicidal Ideation | Phase 4 | Completed | James Murrough | 24 | 2012-01-01 | 2017-02-08 |
| Intranasal Ketamine in Treatment-Resistant Depression Ketamine, placebo - Major Depressive Disorder | Not applicable | Completed | James Murrough | 20 | 2011-10-01 | 2017-02-08 |
| Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in Depression Ketamine, Methohexital - Major Depression, Bipolar Depression | Not applicable | Terminated | James Murrough | 3 | 2010-04-01 | 2013-08-30 |
| Continuation Ketamine in Major Depression Lithium, Ketamine - Major Depressive Disorder | Phase 1 | Completed | James Murrough | 36 | 2007-10-01 | 2014-05-23 |
Depressive Disorder, Major (6) · Depression (5) · Anhedonia (2) · Bipolar Disorder (1) · Depressive Disorder (1) · Diabetes Mellitus (1) · Stress Disorders, Post-Traumatic (1) · Suicidal Ideation (1) · Wounds and Injuries (1)
Ketamine (4) · Excitatory Amino Acid Antagonists (1) · Lithium (1) · Lithium Carbonate (1) · Methohexital (1) · Midazolam (1) · N-Methylaspartate (1) · Neuropeptide Y (1) · XEN1101 (1) · dextromethorphan - quinidine combination (1) · ezogabine (1)
United States (9)
James W Murrough, MD (3) · James W Murrough, MD, PhD (1)
PMID 19545857, PMID 19897179, PMID 21450159, PMID 24821196, PMID 25271445, PMID 26266877, PMID 28478356, PMID 29186416, PMID 33653118, PMID 34510411, PMID 39301926, PMID 41001561
R01DK128242 (1), R33MH111932 (1), R61MH111932 (1)