31 completed, 8 unknown, 7 recruiting, 7 terminated. 31 Not applicable, 11 Phase 4, 5 Phase 3, 3 Phase 2, 1 Early Phase 1.
Follow Spine Surgery: new trials by email Literature Review of Spine Surgery trials Research Report on Spine Surgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes Vancomycin (local, via calcium sulfate beads), Morphine (local, via calcium sulfate beads), Bupivacaine (local, via calcium sulfate beads) - Spine Surgery, Postoperative Pain Management | Phase 2 | Not yet recruiting | Ganesh M. Shankar | 100 | 2027-01-01 | 2026-04-16 |
| Investigation of the PREVENTIA® Irrigation Solution for Reducing Bacteria in Spinal Surgery With Implants - A Comparative Study Preventia Surgical Solution, 0.9 % NaCl - Surgical Site Infection (SSI), Spine Surgery | Phase 4 | Not yet recruiting | Universität Luzern | 114 | 2027-01-01 | 2026-06-29 |
| Spine Registration Using 3D-Scanning Optical 3D Scanner - Spine Surgery | Enrolling by invitation | Advanced Scanners Inc. | 10 | 2026-11-01 | 2025-10-06 | |
| SpinePal Open Pilot SpinePal - Spine Surgery | Not applicable | Enrolling by invitation | Trustees of Dartmouth College | 10 | 2026-10-21 | 2026-10-15 |
| Low-Dose Rocuronium Maintenance During Spine Surgery With Intraoperative Neurophysiological Monitoring Low-Dose Rocuronium Maintenance, Rocuronium - Spine Surgery, Intraoperative Neurophysiological Monitoring | Not applicable | Recruiting | Bach Mai Hospital | 62 | 2026-10-07 | 2026-10-16 |
| Superiority of Phenylephrine Versus Norepinephrine in Complex Spine Surgery (SPiNeS) Phenylephrine hydrochloride infusion, Norepinephrine bitartrate infusion - Spine Surgery, Intraoperative Hypotension | Phase 4 | Not yet recruiting | Mayo Clinic | 50 | 2026-09-01 | 2026-09-02 |
| Ciprofol and Remimazolam for Intraoperative Neurophysiological Monitoring During Spine Surgery Ciprofol, Remimazolam - Intraoperative Neurophysiological Monitoring, Spine Surgery | Phase 4 | Not yet recruiting | Affiliated 2 Hospital of Nantong University | 60 | 2026-08-01 | 2026-07-21 |
| Impact of NOL - Nociception Level Index Intraoperative Monitoring on Perioperative Outcomes in Spine Surgery - a Quality Improvement Pilot NOL guided intraoperative analgesia - Spine Surgery, Pain After Surgery | Not applicable | Not yet recruiting | Medasense Biometrics Ltd | 100 | 2026-05-01 | 2026-05-27 |
| The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries. Methadone-dexmedetomidine-ketamine combination - Spine Surgery | Phase 4 | Enrolling by invitation | University of Missouri-Columbia | 248 | 2026-04-24 | 2026-06-11 |
| ORI-Guided FiO₂ Titration in Prone Spine Surgery: Impact on Postoperative Atelectasis Assessed by Lung Ultrasound Titrated Oxygen, Fixed oxygen - Atelectases, Postoperative Pulmonary, Prone Position | Not applicable | Not yet recruiting | Ankara Etlik City Hospital | 74 | 2026-03-15 | 2026-01-29 |
| An Open, Parallel-group, Randomized, Medical Device Study to Assess the Usability and Performance of Surgify HaloTM in Spine Surgery Versus State-of-art (Rosen Burr) A burr used in spine surgery - Spine Surgery | Not applicable | Recruiting | Surgify Medical Oy | 30 | 2026-02-19 | 2026-04-30 |
| Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery Placebo capsule, Melatonin capsule, Pregabalin capsule - Oral, Melatonin | Not applicable | Recruiting | Tanta University | 105 | 2026-01-17 | 2026-01-21 |
| Dependence, Frailty, and Kinesiophobia on Early Postoperative Mobilization and Self-Care Ability in Patients Undergoing Lumbar Disc Herniation Surgery Nursing Care, Spine Surgery | Completed | Aydin Adnan Menderes University | 221 | 2025-12-15 | 2026-08-13 | |
| Telerehabilitation After Spine Surgery Telerehabilitation method, Nurse instructions, Physiotherapy after surgery, personal - Spine Surgery, Telerehabilitation | Not applicable | Recruiting | Kuopio University Hospital | 300 | 2025-11-01 | 2026-08-31 |
| Effect of Magnesium on Neuromonitoring Magnesium sulfate administration - Spine, Pain | Phase 4 | Recruiting | University of California, San Francisco | 40 | 2025-07-01 | 2026-08-21 |
| Product Surveillance Registry; Ear, Nose &Amp; Throat - NIM Vital Cohort Intraoperative Nerve Monitoring - Intracranial Surgery, Extracranial Surgery | Completed | Medtronic | 205 | 2025-01-27 | 2025-09-24 | |
| Minimum Effective Dose of Incisional Local Infiltration Betamethasone for the Prevention of Pain After Spinal Surgery 0.012%diprospan+0.5%ropivacaine, 0.009%diprospan+0.5%ropivacaine, 0.006%diprospan+0.5ropivacaine - Pain Management, Spine Surgery | Not applicable | Recruiting | Beijing Tiantan Hospital | 535 | 2025-01-25 | 2025-07-16 |
| Irrisept Solution for Instrumented Spine Surgery Chlorhexidine gluconate solution, Vancomycin - Post-Op Complication, Spine Surgery | Not applicable | Recruiting | Rhode Island Hospital | 200 | 2024-10-01 | 2026-08-14 |
| Hemodynamic Effects of Fentanyl Vs Dexmedetomidine in Spine Surgery Dexmedetomidine, fentanyl - Spine Surgery, Hemodynamic Stability During Anesthesia | Phase 4 | Completed | Universitas Sumatera Utara | 50 | 2024-05-08 | 2025-11-20 |
| 3rd-year Post-surgical Evaluation of Adjacent Segment Disc Degeneration Onset in Lumbar Spine (Spinal Fusion vs. Lumbar Arthroplasty With Disc Replacement) Consultation involving pain evaluation, questionnaires and the Lasègue Manoeuver, Magnetic Resonance Imaging of the lumbar spine - Spine Surgery | Withdrawn | Centre Hospitalier Universitaire de Nīmes | 2024-02-27 | 2024-02-28 |
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Pain, Postoperative (6) · Agnosia (3) · Pain (3) · Hemorrhage (2) · Low Back Pain (2) · Surgical Wound Infection (2) · Anemia (1) · Ankylosis (1) · Anxiety Disorders (1) · Back Pain (1) · Bradycardia (1) · Chills (1) · Delirium (1) · Emergence Delirium (1) · Fibrosis (1)
Pathological Conditions, Signs and Symptoms (22) · Neurologic Manifestations (16) · Signs and Symptoms (16) · Pathologic Processes (13) · Pain (9) · Postoperative Complications (8) · Nervous System Diseases (6) · Neurobehavioral Manifestations (4) · Musculoskeletal Diseases (3) · Perceptual Disorders (3) · Back Pain (2) · Bone Diseases (2) · Cardiovascular Diseases (2) · Infections (2) · Mental Disorders (2)
Saline Solution (4) · Pregabalin (3) · Tranexamic Acid (3) · Dexmedetomidine (2) · Neostigmine (2) · Rocuronium (2) · Sugammadex (2) · Vancomycin (2) · (2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenol (1) · Acetaminophen (1) · Anesthesia, General (1) · Bupivacaine (1) · Fentanyl (1) · Glycopyrrolate (1) · Intraoperative Neurophysiological Monitoring (1)
University of Missouri-Columbia (3) · Centre Hospitalier Universitaire de Nīmes (2) · Copenhagen University Hospital, Rigshospitalet (2) · Hospital for Special Surgery, New York (2) · Icahn School of Medicine at Mount Sinai (2) · Rothman Institute Orthopaedics (2) · Shahid Beheshti University (2) · Surgify Medical Oy (2) · The University of Texas Health Science Center, Houston (2) · University of California, San Francisco (2) · University of Cologne (2) · Advanced Scanners Inc. (1) · Affiliated 2 Hospital of Nantong University (1) · Ain Shams University (1) · Ajou University School of Medicine (1)
United States (30) · Egypt (4) · France (4) · China (3) · Germany (3) · Canada (2) · Denmark (2) · Finland (2) · Iran (2) · Belgium (1) · Indonesia (1) · Poland (1) · Saudi Arabia (1) · Spain (1) · Switzerland (1)
Aaron Bernstein, PhD (1) · Alaa Mazy (1) · Albert S. Woo, MD (1) · Alphonse Lubansu, MD (1) · Arthur Jenkins, III (1) · Boris Mraovic, MD (1) · Boris Mraovic, MD, FASA (1) · C. David Mazer, MD (1) · Daniel I Sessler, MD (1) · Ehab Farag, MD (1) · Ellen Soffin, MD, PhD (1) · Eric Deloso, MD (1)
PMID 23757474, PMID 26097987, PMID 27510395, PMID 28332374, PMID 30016956, PMID 32240402, PMID 33116789, PMID 33449503, PMID 34981693, PMID 35645714, PMID 35668701, PMID 35863786, PMID 37031893, PMID 37192785, PMID 37204435, PMID 37349841, PMID 38499358, PMID 41022457
2019 (1), P30DA029926 (1), T32GM135118 (1)