104 completed, 22 recruiting, 16 unknown, 12 withdrawn. 175 Phase 2, 38 Phase 1, 27 Phase 3.
Follow Sleep Apnea Syndromes: new trials by email Literature Review of Sleep Apnea Syndromes trials Research Report on Sleep Apnea Syndromes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs Intranasal Oxytocin 40 i.u., Intranasal Placebo Spray - Obesity & Overweight, Respiratory Depression | Phase 2 | Not yet recruiting | George Washington University | 100 | 2027-05-15 | 2026-10-29 |
| Study to Examine the Effect of Silicone Mouth Tape on Snoring and Mild Sleep Apnea. Mouth Tape - Mild Obstructive Sleep Apnea, Snoring | Phase 2 | Recruiting | Johns Hopkins University | 100 | 2027-03-01 | 2026-06-23 |
| Supplemental Oxygen for Sleep-Disordered Breathing in Adults With Chronic Opioid Use. Sham Air, Supplemental Oxygen - Sleep-disordered Breathing, Chronic Opioid Use | Phase 2 | Not yet recruiting | University of California, San Diego | 62 | 2026-12-01 | 2026-11-06 |
| A Study Of Synthetic THC And Sleep Dronabinol, Placebo - Obstructive Sleep Apnea | Phase 2 / Phase 3 | Not yet recruiting | Mayo Clinic | 72 | 2026-11-01 | 2026-09-18 |
| Tirzepatide Versus Positive Airway Pressure for the Treatment of Obstructive Sleep Apnoea Continuous Positive Airway Pressure, Tirzepatide - Sleep Apnoea, Obesity & Overweight | Phase 2 / Phase 3 | Not yet recruiting | Woolcock Institute of Medical Research | 256 | 2026-10-01 | 2026-11-02 |
| Combination Upper-Airway Electrical and Pharmacological Stimulation for Obstructive Sleep Apnea Combination device and drug: Unilateral hypoglossal nerve stimulation & atomoxetine-plus-oxybutynin (HGNS+AtoOxy), Unilateral hypoglossal nerve stimulation (HGNS), active comparator condition, Atomoxetine-plus-oxybutynin (80/5 mg) (AtoOxy), active comparator condition - Obstructive Sleep Apnea, Sleep-disordered Breathing | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 24 | 2026-09-01 | 2026-09-21 |
| The Optimal One-Month Dosing of Lemborexant for Moderate Obstructive Sleep Apnea (OSA) Patients With Low Arousal Threshold Lemborexant 5 MG [Dayvigo] Period 1, Placebo Period 1, Lemborexant 5 MG [Dayvigo] Period 2 - OSA - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Not yet recruiting | Chulalongkorn University | 36 | 2026-09-01 | 2026-07-06 |
| DReAMzz- Dronabinol and Acetazolamide Medication for Sleep Apnea (ZZ). Dose Confirmation Crossover Study for IHL-42X in Subjects With Obstructive Sleep Apnea. IHL-42X: 2.5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 7.5 mg dronabinol + 125 mg acetazolamide - Obstructive Sleep Apnea (OSA) | Phase 2 | Recruiting | Incannex Healthcare Ltd | 120 | 2026-07-21 | 2026-10-13 |
| Post-Operative Steroids After Sleep Surgery 8mg dexamethasone - Obstructive Sleep Apnea | Phase 2 | Withdrawn | Medical University of South Carolina | 2026-07-01 | 2026-10-06 | |
| Botulinum Toxin in the Palatopharyngeal Muscle for the Treatment of Obstructive Sleep Apnea BOTULINUM TOXIN IN THE PALATOPHARYGEUS MUSCLE - Sleep Apnea Syndrome, Obstructive, Sleep Apnea Syndrome (OSAS) | Phase 2 | Not yet recruiting | Hospital Felicio Rocho | 20 | 2026-04-05 | 2026-02-10 |
| Low-Tech Treatments for Obstructive Sleep Apnea High-Resistance Breathing and Drinking Exercises, Low-Resistance Breathing and Drinking Exercises - Obstructive Sleep Apnea (OSA), Traumatic Brain Injury (TBI) | Phase 1 / Phase 2 | Recruiting | Uniformed Services University of the Health Sciences | 60 | 2026-01-29 | 2026-09-10 |
| Effects of Eszopiclone and Lemborexant in People With OSA With a Low Arousal Threshold Who Have Difficulty Sleeping Eszopiclone 3 mg, Placebo, Lemborexant 10mg - OSA - Obstructive Sleep Apnea | Phase 2 | Recruiting | Flinders University | 15 | 2025-10-31 | 2026-09-02 |
| DRonabinol Treatment of OSA Dronabinol - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Recruiting | VA Office of Research and Development | 120 | 2025-08-25 | 2026-11-05 |
| Safety and Efficacy Study of Sivopixant, Acetazolamide and SASS-001 in Sleep Apnea Sivopixant, Placebo, Acetazolamide - Sleep Apnea | Phase 2 | Active not recruiting | Shionogi | 60 | 2025-04-02 | 2026-05-06 |
| Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples With Implications for Alzheimer's Disease Risk Couples-based treatment- Patient, Couples-based treatment- Partner, Information control- Patient - Sleep Apnea, Sleep Disturbance | Phase 2 | Enrolling by invitation | University of Utah | 80 | 2025-03-20 | 2026-08-07 |
| A Study to Assess the Efficacy and Safety of Lorundrostat in Participants With Obstructive Sleep Apnea and Hypertension Lorundrostat, Placebo - Obstructive Sleep Apnea, Hypertension | Phase 2 | Completed | Mineralys Therapeutics Inc. | 48 | 2025-02-28 | 2026-08-21 |
| Impact of Exogenous Ketones on Sleep Apnea Ketone-IQ, Placebo - Obstructive Sleep Apnea, Sleep | Phase 1 / Phase 2 | Withdrawn | Johns Hopkins University | 2025-01-29 | 2026-09-21 | |
| Study That Tests AD109 in Patients Taking GLP-1 Drugs AD109 - OSA | Phase 2 | Completed | Apnimed | 40 | 2024-05-20 | 2025-02-19 |
| RePOSA-Revealing the Efficacy of IHL-42X Use in Patients With OSA IHL-42X Low Dose, IHL-42X High Dose, Placebo - Obstructive Sleep Apnea | Phase 2 / Phase 3 | Completed | Incannex Healthcare Ltd | 121 | 2024-05-02 | 2026-07-27 |
| EFFECT OF A SUBSTANCE P ANTAGONIST ON THE SECRETION OF ALDOSTERONE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME AND ARTERIAL HYPERTENSION Aprepitant 125 and 80Mg Oral Capsule, Placebo - Apnea, Obstructive | Phase 2 | Recruiting | University Hospital, Rouen | 24 | 2024-03-05 | 2026-05-11 |
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Sleep Apnea, Obstructive (127) · Hypertension (13) · Obesity (11) · Sleep Wake Disorders (8) · Sleep Apnea, Central (7) · Stroke (7) · Apnea (5) · Diabetes Mellitus (5) · Heart Failure (5) · Snoring (5) · Pain (4) · Pulmonary Disease, Chronic Obstructive (4) · Disorders of Excessive Somnolence (3) · Down Syndrome (3)
Dyssomnias (175) · Nervous System Diseases (175) · Respiratory Tract Diseases (175) · Sleep Disorders, Intrinsic (175) · Respiration Disorders (173) · Apnea (170) · Sleep Wake Disorders (167) · Pathological Conditions, Signs and Symptoms (41) · Signs and Symptoms (32) · Cardiovascular Diseases (24) · Vascular Diseases (22) · Nutritional and Metabolic Diseases (18) · Neurologic Manifestations (15) · Central Nervous System Diseases (14)
Continuous Positive Airway Pressure (14) · Acetazolamide (12) · Atomoxetine Hydrochloride (12) · Eszopiclone (7) · Dronabinol (5) · Oxygen (5) · oxybutynin (5) · Dexmedetomidine (4) · Occlusal Splints (3) · Sugars (3) · Tablets (3) · Trazodone (3) · lemborexant (3) · Desipramine (2) · Orlistat (2)
Brigham and Women's Hospital (24) · Apnimed (10) · University of California, San Diego (9) · VA Office of Research and Development (9) · Johns Hopkins University (6) · University of Michigan (4) · Bayer (3) · Flinders University (3) · Apnex Medical, Inc. (2) · Chulalongkorn University (2) · Duke University (2) · George Washington University (2) · Göteborg University (2) · Imperial College London (2) · Incannex Healthcare Ltd (2)
United States (108) · Australia (10) · France (9) · Italy (7) · Canada (6) · United Kingdom (6) · Germany (5) · Switzerland (4) · Spain (3) · China (2) · Denmark (2) · Israel (2) · Sweden (2) · Thailand (2) · Austria (1)
Scott A Sands, PhD (6) · Atul Malhotra, MD (3) · Bradley A Edwards, PhD (3) · Carl J Stepnowsky, PhD (3) · Jeremy Orr, MD (3) · Christopher N Schmickl, MD, PhD (2) · Christopher Schmickl, MD, PhD (2) · Darrel P Francis, MD (2) · Dawn M Bravata, MD (2) · Elisa Perger, MD (2) · Jan Hedner, MD. Prof. (2) · Jonathan Jun, MD (2) · Ron Farkas, MD (2) · Sarocha Vivatvakin, MD (2)
PMID 39688178, PMID 12105286, PMID 12126214, PMID 15112907, PMID 17294232, PMID 17441783, PMID 17513285, PMID 18513353, PMID 18711110, PMID 19122865, PMID 19393404, PMID 20086074, PMID 20297950, PMID 21306949, PMID 21557231, PMID 21614467, PMID 21784661, PMID 21801857, PMID 21885958, PMID 21886365, PMID 22043118, PMID 22131599, PMID 22334806, PMID 22547887, PMID 22572632, PMID 22893765, PMID 22968110, PMID 23086863, PMID 23920422, PMID 23941576, PMID 24041858, PMID 24458967, PMID 24815497, PMID 24918372, PMID 25136550, PMID 25221387, PMID 25268234, PMID 25770408, PMID 25805361, PMID 25892349, PMID 26210388, PMID 26567858, PMID 26643404, PMID 26967681, PMID 27092703, PMID 27439031, PMID 28364504, PMID 28387543, PMID 29035093, PMID 29065955
K23HL151880 (2), 1IK2CX000547 (1), 2005 (1), 2009 (1), 2015 (1), 2017 (1), 2019 (1), I01CX002632 (1), K23HL153897 (1), K23HL161336 (1), P30DK072476 (1), R01HL065176 (1), R01HL084139 (1), R01HL106410 (1), R01HL128658 (1)