21 completed. 21 Phase 2, 4 Phase 3, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 21 | Completed 21 |
| Phase 3 | 4 | Completed 4 |
| Phase 1 | 3 | Completed 3 |
Follow Sleep: new trials by email Literature Review of Sleep trials Research Report on Sleep
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nurse-Led Elderly Sleep Intervention Otago programme, Otago programme + Cognifit, Control - Sleep, Gerontology | Phase 1 / Phase 2 | Completed | University of Castilla-La Mancha | 66 | 2025-09-01 | 2026-05-22 |
| Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin melatonin, placebo - Traumatic Brain Injury, Critical Illness | Phase 2 | Completed | Oregon Health and Science University | 21 | 2023-01-02 | 2025-08-20 |
| The Lived Experiences Measured Using Rings Pilot Study Moodlifters, Physical Activity, Nature Experiences - Depression, Stress | Phase 2 | Completed | University of Vermont | 188 | 2022-12-01 | 2025-04-17 |
| The Effectiveness of a Caralluma Fimbriata Extract on Stress, Sleep and Neurotransmitters Caralluma Fimbriata, Placebo comparator - Microcrystalline cellulose - Stress, Sleep | Phase 2 / Phase 3 | Completed | RDC Clinical Pty Ltd | 129 | 2022-02-10 | 2023-10-24 |
| Efficacy and Safety of Valerian Root Extract and Lavender Essential Oil Combination, Over 4 Weeks in Subjects With Sleep Complaints Valerian - lavender, Placebo - Sleep | Phase 2 / Phase 3 | Completed | University Hospital, Bordeaux | 114 | 2022-02-02 | 2023-03-14 |
| Prospective Randomized Trial of CPAP for SDB in Patients Who Use Opioids Positive Airway Pressure (PAP) - Sleep Disorder; Breathing-Related, Pain | Phase 2 | Completed | University of California, San Diego | 62 | 2021-08-10 | 2024-12-02 |
| Do Endotypes Predict Response and Sequelae in OSA Patients Eszopiclone, Supplemental Oxygen, Continuous Positive Airway Pressure (CPAP) - Obstructive Sleep Apnea, Sleep Apnea | Phase 2 | Completed | University of California, San Diego | 233 | 2020-08-01 | 2026-06-18 |
| A Personalized Behavioral Intervention to Improve Physical Activity, Sleep and Cognition in Sedentary Older Adults ELDERFITNESS, Control - Sleep | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 129 | 2019-07-11 | 2023-03-08 |
| The Impact of Ashwagandha on Perceived Stress, Sleep and Food Cravings in College Students Ashwagandha, Placebo - Stress, Sleep | Phase 2 | Completed | University of Colorado, Colorado Springs | 60 | 2019-05-29 | 2022-06-24 |
| Investigation of Sleep in the Intensive Care Unit Dexmedetomidine, Placebo - Delirium, Sleep | Phase 2 | Completed | Massachusetts General Hospital | 522 | 2018-05-29 | 2024-10-08 |
| Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep Dexmedetomidine, Placebo - Postoperative Delirium, Sleep | Phase 2 / Phase 3 | Completed | Massachusetts General Hospital | 469 | 2017-03-06 | 2026-09-01 |
| Repurposing Dexmedetomidine as an Orally Administered Sleep Therapeutic Dexmedetomidine, Saline Placebo - Sleep, Insomnia | Phase 1 / Phase 2 | Completed | Massachusetts General Hospital | 15 | 2016-10-01 | 2019-10-02 |
| Essential Oils for Enhancing QOL in ASD Reconnect, Coconut oil Comparator - Autism Spectrum Disorder, Quality of Life | Phase 2 | Completed | Jill Hollway | 28 | 2015-07-01 | 2021-04-01 |
| Progressive Muscle Relaxation Effect on Sleep Quality, Depression and Stress in People With Multiple Sclerosis Progressive muscle relaxation - Multiple Sclerosis, Depression | Phase 2 | Completed | Federal University of Espirito Santo | 40 | 2014-04-01 | 2016-02-04 |
| Mission Reconnect: Promoting Resilience and Reintegration of Post-Deployment Veterans and Their Families Mission Reconnect, PREP - Stress, Depression | Phase 2 | Completed | Collinge and Associates, Inc. | 320 | 2012-09-01 | 2015-08-04 |
| Auricular Acupuncture in Substance Abuse: Effects on Anxiety, Sleep, Drug Use. NADA Acupuncture, LP acupuncture, Relaxation - Substance Abuse, Anxiety | Phase 2 | Completed | Örebro Läns Landsting | 280 | 2010-10-01 | 2015-11-16 |
| Differential Effects of Zolpidem Versus Ramelteon in Burned Children zolipidem, ramelteon - Sleep, Burns | Phase 2 | Completed | Shriners Hospitals for Children | 10 | 2009-12-01 | 2016-07-27 |
| The Long-term Effects of Body-mind-spirit Group Therapy body-mind-spirit group therapy - Depression, Sleep | Phase 2 / Phase 3 | Completed | National Taiwan University Hospital | 60 | 2009-10-01 | 2012-11-16 |
| Efficacy and Safety of SR46349B in Patients With Sleep Disorders in Fibromyalgia eplivanserin (SR46349), placebo - Fibromyalgia, Sleep | Phase 2 | Completed | Sanofi | 205 | 2004-04-01 | 2010-11-30 |
| Hangover, Congeners, Sleep and Occupational Performance Ethanol (Bourbon or Vodka) - Sleep, Neurobehavioral Manifestations | Phase 2 | Completed | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 140 | 2003-09-01 | 2006-12-06 |
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Depression (4) · Anxiety Disorders (3) · Chronic Pain (2) · Sleep Apnea Syndromes (2) · Sleep Apnea, Obstructive (2) · Sleep Wake Disorders (2) · Alcohol Drinking (1) · Alcoholism (1) · Autism Spectrum Disorder (1) · Brain Injuries, Traumatic (1) · Breast Neoplasms (1) · Burns (1) · Critical Illness (1) · Delirium (1) · Dementia (1)
Mental Disorders (11) · Nervous System Diseases (10) · Pathological Conditions, Signs and Symptoms (7) · Behavior (6) · Neurologic Manifestations (6) · Signs and Symptoms (6) · Behavioral Symptoms (4) · Dyssomnias (3) · Neurocognitive Disorders (3) · Sleep Disorders, Intrinsic (3) · Apnea (2) · Brain Diseases (2) · Central Nervous System Diseases (2) · Chemically-Induced Disorders (2) · Confusion (2)
Dexmedetomidine (3) · Saline Solution (2) · Sodium Chloride (2) · Ashwagandha (1) · Autogenic Training (1) · Continuous Positive Airway Pressure (1) · Eszopiclone (1) · Ethanol (1) · Exercise (1) · Glycerol (1) · Melatonin (1) · Psychotherapy, Group (1) · SR 46349B (1) · Walking (1) · Zolpidem (1)
Massachusetts General Hospital (3) · University of California, San Diego (2) · Collinge and Associates, Inc. (1) · Federal University of Espirito Santo (1) · Jill Hollway (1) · Johns Hopkins University (1) · National Institute of Nursing Research (NINR) (1) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (1) · National Taiwan University Hospital (1) · Oregon Health and Science University (1) · RDC Clinical Pty Ltd (1) · Sanofi (1) · Shriners Hospitals for Children (1) · University Hospital, Bordeaux (1) · University of Castilla-La Mancha (1)
United States (14) · Australia (1) · Canada (1) · France (1) · Spain (1) · Sweden (1) · Taiwan (1)
Amanda Rao, PhD (1) · Atul Malhotra, MD (1) · Chris Danforth, PhD (1) · Christopher Schmickl (1) · Cydni Williams, MD (1) · Ellen McGinnis, PhD (1) · Eugene Arnold, M.D.,M.A. (1) · Fei Hsiao, PhD (1) · Janet R Kahn, PhD, LMT (1) · Jeremy Orr, MD (1) · Jill A Hollway, Ph.D., M.A. (1) · Jonathan Howland, PhD, MPH, MPA (1) · Junxin Li, PhD (1) · Laura Bloomfield, MD, PhD (1)
PMID 21314643, PMID 22617163, PMID 25294621, PMID 27451854, PMID 27598379, PMID 27678169, PMID 28795452, PMID 29678977, PMID 35984870, PMID 35984871, PMID 36590787, PMID 37144470, PMID 37535937, PMID 37722484, PMID 39921932, PMID 40705710, PMID 41925207
K23HL150229 (1), K23HL151880 (1), R00NR016484 (1), R01AG053582 (1), R01NR007771 (1), R01NS102190 (1)