21 completed, 6 recruiting, 3 not yet recruiting, 3 unknown. 37 Phase 2, 8 Phase 3, 4 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CBD Supplementation in Brazilian Jiu-Jitsu Athletes CBD Isolate 100mg BID, Placebo - Pro and Anti Inflamatory Cytokines, Pain | Phase 2 / Phase 3 | Not yet recruiting | Associação Pan-Americana Multidisciplinar de Endocanabinologia | 100 | 2027-01-01 | 2026-07-27 |
| Mechanisms of Cannabidiol and Sleep in the Context of Alcohol Use Cannabidiol, Placebo - Sleep, Alcohol Misuse | Phase 2 | Not yet recruiting | University of Colorado, Boulder | 58 | 2026-07-01 | 2026-06-11 |
| Sleep Health in U.S. Marines Sleep Leadership, Circadian, Light, and Sleep Skills in Shipboard Military (CLASS-MC) Personnel Program, Insomnia Coach - Depression, Suicidality | Phase 2 | Recruiting | San Diego State University | 860 | 2026-03-31 | 2026-04-16 |
| NADream: Effects of Nicotinamide Adenine Dinucleotide Supplementation on Sleep Quality in Healthy Individuals Nicotinamide Riboside (NR), Placebo - Sleep | Phase 2 | Recruiting | Haukeland University Hospital | 16 | 2025-10-13 | 2025-09-15 |
| Nurse-Led Elderly Sleep Intervention Otago programme, Otago programme + Cognifit, Control - Sleep, Gerontology | Phase 1 / Phase 2 | Completed | University of Castilla-La Mancha | 66 | 2025-09-01 | 2026-05-22 |
| Lemborexant to Prevent Post-operative Delirium in Cardiac Surgery Patients Lemborexant 5 mg, Control (placebo) group - Delirium - Postoperative, Cardiac Surgery | Phase 2 | Not yet recruiting | University of British Columbia | 60 | 2025-05-01 | 2025-04-23 |
| Impact of Exogenous Ketones on Sleep Apnea Ketone-IQ, Placebo - Obstructive Sleep Apnea, Sleep | Phase 1 / Phase 2 | Withdrawn | Johns Hopkins University | 2025-01-29 | 2026-09-21 | |
| Cannabis for Palliative Care in Cancer fsCBD Cannabidiol, Placebo, bsCBD Cannabidiol - Sleep, Anxiety | Phase 2 | Recruiting | University of Colorado, Boulder | 185 | 2024-09-16 | 2025-08-01 |
| Cannabidiol and Older Adult Cannabis Users fsCBD Cannabidiol, bsCBD Cannabidiol, Placebo - Sleep, Anxiety | Phase 2 | Recruiting | University of Colorado, Boulder | 385 | 2024-05-01 | 2026-06-10 |
| Implementation of Digital Vital Sign Monitoring to Decrease Sleep Interruption and Enhance Recovery in Phase II of the PROmoting Sleep, Patient Engagement and Recovery (PROSPER) Project ViSi Mobile device, Sleep enhancement intervention - Sleep | Phase 2 / Phase 3 | Terminated | M.D. Anderson Cancer Center | 89 | 2023-03-01 | 2024-12-18 |
| Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin melatonin, placebo - Traumatic Brain Injury, Critical Illness | Phase 2 | Completed | Oregon Health and Science University | 21 | 2023-01-02 | 2025-08-20 |
| The Lived Experiences Measured Using Rings Pilot Study Moodlifters, Physical Activity, Nature Experiences - Depression, Stress | Phase 2 | Completed | University of Vermont | 188 | 2022-12-01 | 2025-04-17 |
| Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer Melatonin, Placebo for Melatonin, Methylphenidate - Sleep, Fatigue | Phase 2 / Phase 3 | Active not recruiting | M.D. Anderson Cancer Center | 169 | 2022-11-21 | 2026-09-25 |
| Sleep Trial to Prevent Alzheimer's Disease Suvorexant 20 mg, Placebo - Sleep, Alzheimer Disease | Phase 2 | Recruiting | University of Minnesota | 120 | 2022-05-25 | 2026-07-13 |
| Acute Effect of Exogenous Ketosis on Sleep Architecture Following Strenuous Exercise Ketone ester, Placebo, Exercise - Sleep | Phase 2 | Unknown | KU Leuven | 11 | 2022-05-15 | 2022-06-30 |
| Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype Cannabidiol (CBD), Tetrahydrocannabinol (THC), Placebo CBD - Multiple Sclerosis, Sleep | Phase 2 | Recruiting | Tiffany J. Braley, MD, MS | 166 | 2022-03-25 | 2026-07-17 |
| The Effectiveness of a Caralluma Fimbriata Extract on Stress, Sleep and Neurotransmitters Caralluma Fimbriata, Placebo comparator - Microcrystalline cellulose - Stress, Sleep | Phase 2 / Phase 3 | Completed | RDC Clinical Pty Ltd | 129 | 2022-02-10 | 2023-10-24 |
| Efficacy and Safety of Valerian Root Extract and Lavender Essential Oil Combination, Over 4 Weeks in Subjects With Sleep Complaints Valerian - lavender, Placebo - Sleep | Phase 2 / Phase 3 | Completed | University Hospital, Bordeaux | 114 | 2022-02-02 | 2023-03-14 |
| Phase II Study - Trial of a Phototherapy Light Device to Improve Sleep Health Phototherapy device - Sleep | Phase 2 | Unknown | University of Arizona | 30 | 2021-09-02 | 2021-11-11 |
| Prospective Randomized Trial of CPAP for SDB in Patients Who Use Opioids Positive Airway Pressure (PAP) - Sleep Disorder; Breathing-Related, Pain | Phase 2 | Completed | University of California, San Diego | 62 | 2021-08-10 | 2024-12-02 |
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Depression (9) · Anxiety Disorders (6) · Pain (5) · Sleep Apnea Syndromes (3) · Sleep Apnea, Obstructive (3) · Sleep Initiation and Maintenance Disorders (3) · Chronic Pain (2) · Delirium (2) · Emergence Delirium (2) · Ketosis (2) · Motor Activity (2) · Multiple Sclerosis (2) · Psychological Well-Being (2) · Sleep Wake Disorders (2) · Alcohol Drinking (1)
Mental Disorders (17) · Nervous System Diseases (14) · Pathological Conditions, Signs and Symptoms (14) · Behavior (12) · Signs and Symptoms (12) · Neurologic Manifestations (11) · Behavioral Symptoms (9) · Dyssomnias (6) · Sleep Disorders, Intrinsic (6) · Neurocognitive Disorders (5) · Sleep Wake Disorders (4) · Apnea (3) · Brain Diseases (3) · Central Nervous System Diseases (3) · Chemically-Induced Disorders (3)
Dexmedetomidine (3) · Cannabidiol (2) · Exercise (2) · Melatonin (2) · Saline Solution (2) · Sodium Chloride (2) · suvorexant (2) · Ashwagandha (1) · Autogenic Training (1) · BID protein, human (1) · Cognitive Behavioral Therapy (1) · Continuous Positive Airway Pressure (1) · Dronabinol (1) · Eszopiclone (1) · Ethanol (1)
Massachusetts General Hospital (3) · University of Colorado, Boulder (3) · Johns Hopkins University (2) · M.D. Anderson Cancer Center (2) · National Taiwan University Hospital (2) · University of California, San Diego (2) · Associação Pan-Americana Multidisciplinar de Endocanabinologia (1) · Collinge and Associates, Inc. (1) · Federal University of Espirito Santo (1) · Haukeland University Hospital (1) · Jill Hollway (1) · KU Leuven (1) · National Institute of Nursing Research (NINR) (1) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (1) · Oregon Health and Science University (1)
United States (24) · Canada (2) · Taiwan (2) · Australia (1) · Belgium (1) · Brazil (1) · France (1) · Norway (1) · Spain (1) · Sweden (1)
Fei Hsiao, PhD (2) · Amanda Rao, PhD (1) · Atul Malhotra, MD (1) · Brendan Lucey, MD (1) · Charalampos Tzoulis, PhD (1) · Chris Danforth, PhD (1) · Christopher Schmickl (1) · Cydni Williams, MD (1) · Ellen McGinnis, PhD (1) · Emily Schmied, PhD (1) · Eugene Arnold, M.D.,M.A. (1) · Janet R Kahn, PhD, LMT (1) · Jeremy Orr, MD (1)
PMID 21314643, PMID 22617163, PMID 25294621, PMID 27451854, PMID 27598379, PMID 27678169, PMID 28795452, PMID 29678977, PMID 35984870, PMID 35984871, PMID 36590787, PMID 37141002, PMID 37144470, PMID 37259248, PMID 37535937, PMID 37722484, PMID 39921932, PMID 40640892, PMID 40705710, PMID 41925207, PMID 42063312
2025 (1), K23HL150229 (1), K23HL151880 (1), R00NR016484 (1), R01AG053582 (1), R01AT011341 (1), R01NR007771 (1), R01NS102190 (1)