7 completed, 3 not yet recruiting, 1 active not recruiting, 1 withdrawn. 12 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 12 | Completed 7, Not yet recruiting 3, Active not recruiting 1, Withdrawn 1 |
Follow Sleep: new trials by email Literature Review of Sleep trials Research Report on Sleep
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reducing Days DELirious With DEXmedetomidine as Part of an Intensive Care Unit Sleep Promotion Bundle Dexmedetomidine, Control (placebo) group - Sleep, Delirium | Early Phase 1 | Not yet recruiting | University of Alberta | 50 | 2026-12-01 | 2026-10-13 |
| reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care Unit Sleep chronobundle, Control - Sleep, Circadian Dysregulation | Early Phase 1 | Not yet recruiting | University of Alberta | 50 | 2026-11-30 | 2026-10-21 |
| Dexmedetomidine Trial for Effects on Rhythms, Sleep Architecture, and Biomarker Dynamics in Older Adults Dexmedetomidine sublingual film, Placebo Sublingual Film - Sleep, Circadian Rhythm | Early Phase 1 | Not yet recruiting | Massachusetts General Hospital | 12 | 2026-09-01 | 2026-09-02 |
| Effect of Kava on Anxiety and Stress in Cancer Survivors Kava, Placebo - Kava, Anxiety | Early Phase 1 | Withdrawn | Masonic Cancer Center, University of Minnesota | 2024-06-20 | 2026-10-16 | |
| Investigating the Efficacy of Sleepgift Blanket on Sleep Quality and Heart Health Active sleepgift blanket, Sham Sleepgift Blanket - Sleep | Early Phase 1 | Completed | University of Manitoba | 31 | 2023-01-01 | 2025-04-03 |
| Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease Time in Bed Restriction, Sleep Schedule - Alzheimer Disease, Late Onset, Mild Cognitive Impairment | Early Phase 1 | Completed | University of Pittsburgh | 99 | 2022-01-03 | 2026-07-06 |
| Lavender vs Zolpidem Sleep Quality During Diagnostic PSG Lavender Aromatherapy, Zolpidem - Sleep | Early Phase 1 | Completed | HealthPartners Institute | 58 | 2019-09-04 | 2021-03-17 |
| Electrical Synchronization of Slow Oscillations to Enhance Deep Sleep Transcranial Electrical Stimulation - Sleep, Sleep Hygiene | Early Phase 1 | Completed | Brain Electrophysiology Laboratory Company | 13 | 2019-09-01 | 2020-07-08 |
| Tetrahydrocannabinol (THC) and Sleep Dronabinol - Sleep, THC | Early Phase 1 | Completed | Oregon Health and Science University | 18 | 2018-09-01 | 2026-02-05 |
| Effects of Sleep Deprivation and Adrenergic Inhibition on Glymphatic Flow in Humans Carvedilol 25mg, Placebo oral capsule - Sleep Deprivation, Sleep Wake Disorders | Early Phase 1 | Completed | Gitte Moos Knudsen | 22 | 2018-08-28 | 2022-11-23 |
| Sleep and Inflammatory Resolution Pathway Aspirin, Placebo - Inflammatory Response, Inflammation | Early Phase 1 | Active not recruiting | Beth Israel Deaconess Medical Center | 66 | 2018-06-06 | 2026-10-26 |
| Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude. Melatonin, Hypoxia - Altitude Hypoxia, Ventilation | Early Phase 1 | Completed | University of California, San Diego | 20 | 2017-07-04 | 2019-01-31 |
Delirium (2) · Sleep Hygiene (2) · Altitude Sickness (1) · Alzheimer Disease (1) · Anxiety Disorders (1) · Chronobiology Disorders (1) · Cognition Disorders (1) · Cognitive Dysfunction (1) · Critical Illness (1) · Depression (1) · Inflammation (1) · Marijuana Abuse (1) · Neoplasms (1) · Respiratory Aspiration (1) · Sleep Deprivation (1)
Mental Disorders (8) · Nervous System Diseases (5) · Pathological Conditions, Signs and Symptoms (5) · Neurocognitive Disorders (4) · Behavior (3) · Neurologic Manifestations (3) · Pathologic Processes (3) · Signs and Symptoms (3) · Confusion (2) · Dyssomnias (2) · Health Behavior (2) · Neurobehavioral Manifestations (2) · Behavioral Symptoms (1) · Brain Diseases (1) · Central Nervous System Diseases (1)
Anti-Inflammatory Agents, Non-Steroidal (1) · Aspirin (1) · Carvedilol (1) · Dexmedetomidine (1) · Dronabinol (1) · Melatonin (1) · Population Groups (1) · Time (1) · Transcranial Direct Current Stimulation (1) · Ultraviolet Therapy (1) · Zolpidem (1)
University of Alberta (2) · Beth Israel Deaconess Medical Center (1) · Brain Electrophysiology Laboratory Company (1) · Gitte Moos Knudsen (1) · HealthPartners Institute (1) · Masonic Cancer Center, University of Minnesota (1) · Massachusetts General Hospital (1) · Oregon Health and Science University (1) · University of California, San Diego (1) · University of Manitoba (1) · University of Pittsburgh (1)
United States (8) · Canada (2) · Denmark (1)
Charlene E McEvoy, MD, MPH (1) · Monika Haack, PhD (1) · Sebastian C Sebastian, PhD (1) · Steven A Shea, PhD (1) · Zahra Moussavi, Ph.D. (1)
PMID 39043348, PMID 41264592, PMID 41686719, PMID 41715219, PMID 42017829, PMID 42781832
R01AG068001 (1)