71 completed, 19 unknown, 15 terminated, 11 recruiting. 132 Phase 3, 31 Phase 2.
Follow Shock, Septic: new trials by email Literature Review of Shock, Septic trials Research Report on Shock, Septic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial of Adjunctive Fludrocortisone (50mcg, 100mcg or Placebo) in Critically Ill Patients With Septic Shock Receiving Hydrocortisone, Evaluating Survival and Functional Recovery and the Influence of Transcriptomic Response Fludrocortisone 50 mcg daily, Fludrocortisone 100 mcg daily, Placebo - Septic Shock | Phase 3 | Recruiting | The George Institute | 2200 | 2026-10-16 | 2026-10-30 |
| Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock Dexmedetomidine 100 µg/mL, intravenous solution, Stardard care - Septic Shock, Vasopressor Resistance | Phase 3 | Not yet recruiting | Hospices Civils de Lyon | 360 | 2026-09-01 | 2026-05-06 |
| Assessing the Efficacy of Dapagliflozin as a Vasculoprotective Treatment in Septic Shock Patients With Microcirculatory Dysfunction Dapaglifozin, Placebo - Septic Shock | Phase 3 | Not yet recruiting | University Hospital, Strasbourg, France | 568 | 2026-07-01 | 2026-03-27 |
| Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation Ketofol, propofol (drug) - The Critically Ill Patient is Requiring Intubation, Septic Shock | Phase 3 | Active not recruiting | Helwan University | 70 | 2026-05-13 | 2026-10-15 |
| Systematic Adjunction of Vasopressine in Septic Shock Vasopressin administration, Sodium chloride administration - Septic Shock | Phase 3 | Recruiting | Assistance Publique Hopitaux De Marseille | 120 | 2026-03-24 | 2026-10-26 |
| Early Methylene Blue in the Microhemodynamics of Septic Patients Methylene blue infusion - Septic Shock, Hypoperfusion | Phase 2 / Phase 3 | Recruiting | Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva | 50 | 2026-01-09 | 2026-03-27 |
| Human Albumin for Resuscitation in Surgical Septic Shock: A Randomized Controlled Trial (ALBUS Study) Human Albumin 20% Solution, Standard Care (in control arm) - Critical Illness, Septic Shock | Phase 3 | Not yet recruiting | Mahidol University | 304 | 2025-12-01 | 2025-11-19 |
| Weaning Approaches for Vasopressin in Sepsis Titrated weaning of vasopressin., Abrupt weaning of vasopressin. - Septic Shock | Phase 3 | Recruiting | Hospital Nossa Senhora da Conceicao | 82 | 2025-10-01 | 2026-01-02 |
| A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patients With Suspected Severe Gram-negative Bacterial Infections Ceftazidime± avibactam with fosfomycin, Ceftazidime± avibactam with placebo - Gram Negative Infections, Sepsis and Septic Shock | Phase 3 | Recruiting | Angela HUTTNER | 100 | 2025-08-25 | 2025-09-26 |
| Adjunctive Methylene Blue in Septic Shock Methylene Blue, Usual Care - Septic Shock | Phase 3 | Completed | Dr. Shannon M. Fernando | 50 | 2025-06-02 | 2026-03-19 |
| Evaluation of Early Administration of Levetiracetam in the Prevention and Treatment Encephalopathy in Septic Shock: Randomized, Double-blind, Placebo-controlled Trial Levetiracetam IV, Placebo control - Septic Shock | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 280 | 2025-03-15 | 2025-03-12 |
| Venous Excess Ultrasound for Personalized Resuscitation in Septic Shock Venous Excess Ultrasound (VEXUS)-Guided Management - Septic Shock, Sepsis | Phase 3 | Not yet recruiting | Western University, Canada | 80 | 2024-12-01 | 2024-11-20 |
| Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis Early Vasopressin, Norepinephrine and Vasopressin for Rescue - Septic Shock | Phase 3 | Recruiting | Hospital do Coracao | 2800 | 2024-11-21 | 2026-01-30 |
| A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02) VBI-S - Septic Shock, Sepsis | Phase 3 | Completed | Vivacelle Bio | 39 | 2024-08-06 | 2026-10-26 |
| Methylene Blue for the Treatment of Septic Shock Methylene Blue, Placebo - Septic Shock | Phase 3 | Completed | Northern Jiangsu People's Hospital | 88 | 2024-08-05 | 2026-02-04 |
| The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock Norepinephrine, Ringer's Lactate - Septic Shock, Sepsis | Phase 2 / Phase 3 | Completed | Universitas Indonesia | 42 | 2024-03-25 | 2024-06-20 |
| Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock Methylene Blue, Placebo - Neonatal Sepsis, Shock, Septic | Phase 2 / Phase 3 | Not yet recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 130 | 2024-03-15 | 2024-03-12 |
| Extracorporal Cytokin Removal in Septic Shock: a Prospective, Randomized, Multicenter Clinical Trial Standard medical therapy, Standard medical therapy plus cytokine removal treatment using Cytosorb, with the adsorber changed in every 12 hours, Standard medical therapy plus cytokine removal treatment using Cytosorb, with the adsorber changed in every 24 hours - Septic Shock | Phase 3 | Suspended | University of Pecs | 135 | 2024-01-01 | 2023-04-20 |
| Multimodal Vasopressor Strategy in Septic Shock Simultaneous administration of vasopressors, Successive administration of vasopressors - Shock, Septic | Phase 2 / Phase 3 | Completed | University Medical Centre Maribor | 79 | 2023-12-23 | 2026-03-31 |
| Early Initiated Vasopressor Therapy in the Emergency Department Noradrenaline - Shock, Shock, Septic | Phase 3 | Recruiting | Odense University Hospital | 320 | 2023-12-08 | 2025-07-01 |
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Sepsis (66) · Shock (8) · Acute Kidney Injury (5) · Critical Illness (5) · Diabetes Insipidus (5) · Hypotension (3) · Infections (3) · Neoplasms (3) · Systemic Inflammatory Response Syndrome (3) · Adrenal Insufficiency (2) · Hypovolemia (2) · Pneumonia (2) · Shock, Cardiogenic (2) · Toxemia (2)
Inflammation (132) · Pathologic Processes (132) · Pathological Conditions, Signs and Symptoms (132) · Infections (129) · Systemic Inflammatory Response Syndrome (129) · Shock (124) · Sepsis (66) · Cardiovascular Diseases (10) · Female Urogenital Diseases (10) · Female Urogenital Diseases and Pregnancy Complications (10) · Kidney Diseases (10) · Male Urogenital Diseases (10) · Urogenital Diseases (10) · Urologic Diseases (10) · Vascular Diseases (8)
Saline Solution (17) · Norepinephrine (12) · Hydrocortisone (11) · Ascorbic Acid (9) · Methylene Blue (8) · Sodium Chloride (7) · Fludrocortisone (5) · Ringer's Lactate (5) · Thiamine (5) · Albumins (4) · Dexmedetomidine (4) · Terlipressin (4) · Ketamine (3) · Meropenem (3) · Vasopressins (3)
Assistance Publique - Hôpitaux de Paris (8) · Cairo University (6) · University of Versailles (3) · Beth Israel Deaconess Medical Center (2) · Centre Hospitalier Universitaire Dijon (2) · Centre Hospitalier Universitaire de Nīmes (2) · Centre Hospitalier Universitaire, Amiens (2) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (2) · Frisius Medisch Centrum (2) · Hospices Civils de Lyon (2) · Kompetenznetz Sepsis (2) · McMaster University (2) · Northern Jiangsu People's Hospital (2) · Post Graduate Institute of Medical Education and Research, Chandigarh (2) · Ramathibodi Hospital (2)
France (32) · United States (17) · Italy (11) · Brazil (10) · Canada (10) · Egypt (10) · Netherlands (9) · Spain (9) · Australia (8) · Germany (8) · Belgium (7) · Denmark (6) · United Kingdom (6) · Finland (5) · Israel (5)
Ahmed Mukhtar, Professor (3) · Anders Perner, MD, PhD (2) · Andrea Morelli, MD (2) · Djillali Annane, MD (2) · Konrad Reinhart, MD (2) · Luciano Gattinoni, MD (2) · Michael W Donnino, MD (2) · Pietro Caironi, MD (2) · Qingquan Lyu, Master (2) · Thomas Deufel, MD (2) · Abdelrhman Hussein (1) · Adham Mohamed, PharmD (1) · Ahmed Hasanin, Professor (1)
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