84 completed, 26 unknown, 14 terminated, 8 withdrawn. 147 Phase 2, 31 Phase 3, 21 Phase 1.
Follow Shock, Septic: new trials by email Literature Review of Shock, Septic trials Research Report on Shock, Septic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulopathy • Sivelestat intravenous infusion, NaCl intravenous infusion - Septic Shock, Coagulopathy | Phase 2 | Not yet recruiting | University Hospital, Strasbourg, France | 120 | 2027-08-01 | 2026-08-20 |
| NAI for Sepsis With Persistent Lymphopenia Nogapendekin alfa inbakicept (NAI), Standard of Care (SOC) - Sepsis, Septic Shock | Phase 2 | Not yet recruiting | ImmunityBio, Inc. | 50 | 2026-07-06 | 2026-05-11 |
| Adjunctive Fludrocortisone in Septic Shock Fludrocortisone 100 mcg daily, Placebo - Sepsis, Septic Shock | Phase 2 | Recruiting | Chinese University of Hong Kong | 32 | 2026-04-01 | 2026-06-02 |
| POCUS-Guided Esmolol in Septic Shock: A Pilot RCT Esmolol - Septic Shock | Phase 1 / Phase 2 | Not yet recruiting | John Basmaji | 100 | 2026-01-15 | 2026-01-06 |
| Early Methylene Blue in the Microhemodynamics of Septic Patients Methylene blue infusion - Septic Shock, Hypoperfusion | Phase 2 / Phase 3 | Recruiting | Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva | 50 | 2026-01-09 | 2026-03-27 |
| Sevoflurane Sedation in Patients With Septic Shock Sevoflurane, Control Group - Shock, Septic | Phase 2 | Not yet recruiting | University of Zurich | 153 | 2026-01-01 | 2025-04-01 |
| Study SOLACE SEPSIS Sodium Lactate, 3% NaCl - Septic Shock, Intracranial Hypertension | Phase 2 | Recruiting | University Hospital Pilsen | 40 | 2024-11-24 | 2026-04-14 |
| Early Resuscitation in Paediatric Sepsis Using Inotropes Fluid, Adrenalin - Sepsis | Phase 2 | Unknown | NATALIA LOPERA MUNERA | 40 | 2024-07-01 | 2024-06-27 |
| Dexmedetomidine and Vasopressin in Septic Shock DEX-PRESSIN, Standard of Care - Sepsis, Septic Shock | Phase 2 | Unknown | Mansoura University | 260 | 2024-06-01 | 2024-03-12 |
| The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock Norepinephrine, Ringer's Lactate - Septic Shock, Sepsis | Phase 2 / Phase 3 | Completed | Universitas Indonesia | 42 | 2024-03-25 | 2024-06-20 |
| Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock Methylene Blue, Placebo - Neonatal Sepsis, Shock, Septic | Phase 2 / Phase 3 | Not yet recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 130 | 2024-03-15 | 2024-03-12 |
| Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock Allogeneic umbilical cord-derived human mesenchymal stromal cells, Placebo - Septic Shock, Sepsis | Phase 2 | Recruiting | Ottawa Hospital Research Institute | 296 | 2024-02-14 | 2024-12-05 |
| Human Albumin Treatment in Adult Septic Shock. A Study Evaluating Immune Response and Organ Failure. Human albumin, Saline solution - Septic Shock | Phase 2 | Withdrawn | Albimmune SL | 2024-02-01 | 2024-07-31 | |
| Multimodal Vasopressor Strategy in Septic Shock Simultaneous administration of vasopressors, Successive administration of vasopressors - Shock, Septic | Phase 2 / Phase 3 | Completed | University Medical Centre Maribor | 79 | 2023-12-23 | 2026-03-31 |
| Strong Albumin Solutions in Patients With Septic Shock hyperoncotic human albumin solution, Buffered crystalloid solutions - Sepsis, Septic Shock | Phase 2 / Phase 3 | Completed | Manchester University NHS Foundation Trust | 47 | 2023-11-10 | 2026-02-09 |
| Safety and Feasibility of Metformin for Sepsis Induced AKI Metformin low dose, Metformin high dose, Placebo - Sepsis, Septic Shock | Phase 2 | Completed | Hernando Gomez | 80 | 2023-11-08 | 2026-06-09 |
| Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis apigenin, sterilized water - Sepsis, Septic Shock | Phase 1 / Phase 2 | Completed | Zhujiang Hospital | 20 | 2023-09-01 | 2024-03-13 |
| Low Dose Versus High Dose Methylene Blue in Septic Patients Normal saline, Methylene Blue low dose, Methylene Blue high dose - Septic Shock | Phase 2 / Phase 3 | Completed | National Cancer Institute, Egypt | 90 | 2023-08-01 | 2024-07-05 |
| Early Versus Conventional Cessation of Hydrocortisone in Septic Shock normal saline solution, Hydrocortisone and normal saline solution - Septic Shock, Adverse Event | Phase 2 | Unknown | Mahidol University | 160 | 2023-07-05 | 2024-04-05 |
| Effects of Paroxetine on Cardiovascular Function in Septic Patients Paroxetine - Septic Shock, Sepsis | Phase 2 | Completed | Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude | 130 | 2023-06-10 | 2026-08-24 |
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Sepsis (80) · Systemic Inflammatory Response Syndrome (8) · Shock (7) · Infections (6) · Acute Kidney Injury (4) · Critical Illness (4) · Diabetes Insipidus (4) · Disease (4) · Inflammation (4) · Hypotension (3) · Hyperglycemia (2) · Multiple Organ Failure (2) · Neonatal Sepsis (2) · Pathologic Processes (2)
Pathological Conditions, Signs and Symptoms (147) · Pathologic Processes (145) · Inflammation (143) · Infections (141) · Shock (140) · Systemic Inflammatory Response Syndrome (139) · Sepsis (67) · Urogenital Diseases (9) · Female Urogenital Diseases (8) · Female Urogenital Diseases and Pregnancy Complications (8) · Kidney Diseases (8) · Male Urogenital Diseases (8) · Urologic Diseases (8) · Cardiovascular Diseases (7) · Disease Attributes (6)
Saline Solution (13) · Ascorbic Acid (11) · Thiamine (8) · esmolol (8) · Sodium Chloride (7) · Hydrocortisone (6) · Methylene Blue (6) · Standard of Care (6) · Norepinephrine (5) · Terlipressin (5) · AZD9773 (3) · Bronchoscopy (3) · CytoFab (3) · Dobutamine (3) · Epinephrine (3)
University of Roma La Sapienza (6) · Beth Israel Deaconess Medical Center (5) · Dascena (5) · AstraZeneca (3) · Ferring Pharmaceuticals (3) · King Abdul Aziz Specialist Hospital (3) · Mahidol University (3) · Mansoura University (3) · Ottawa Hospital Research Institute (3) · University of Manitoba (3) · Zhujiang Hospital (3) · Inotrem (2) · Jinhua Central Hospital (2) · M.D. Anderson Cancer Center (2) · McMaster University (2)
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Andrea Morelli, MD (5) · Eric Bellissant, MD, PhD (3) · Michael W Donnino, MD (3) · Ritankar Das, MSc (3) · Wayne Dankner, MD (3) · Andrea Morelli, M.D. (2) · Justin Lindemann, MD (2) · Lauralyn McIntyre, MD (2) · Ryan Zarychanski, MD MSc (2) · Warren Botnick, MD (2) · Zhanguo Liu, M.D.PhD (2) · Abele Donati, MD (1) · Adham Mohamed, PharmD (1) · Ahmed Mohamed Mukhtar, M,D (1)
PMID 23001587, PMID 24484547, PMID 26903338, PMID 36915146, PMID 10722036, PMID 1138591, PMID 11502226, PMID 11588440, PMID 12454520, PMID 12500513, PMID 12519925, PMID 12545007, PMID 12700374, PMID 14759425, PMID 15231405, PMID 1607900, PMID 16134000, PMID 16134766, PMID 16507156, PMID 16570523, PMID 17617901, PMID 17698886, PMID 17720019, PMID 18353115, PMID 18477932, PMID 19017409, PMID 19114908, PMID 19664253, PMID 20332511, PMID 20646908, PMID 21093515, PMID 21182783, PMID 21246318, PMID 21371308, PMID 21615299, PMID 21659748, PMID 21827677, PMID 21864392, PMID 21929764, PMID 227054, PMID 22961865, PMID 23036432, PMID 23374652, PMID 23525934, PMID 23681364, PMID 24108526, PMID 24200239, PMID 24329115, PMID 24794878, PMID 24838355
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