10 completed, 7 recruiting, 5 unknown, 4 not yet recruiting. 16 Not applicable, 3 Phase 2, 2 Phase 3, 1 Phase 1, 1 Phase 4.
Follow Severe Traumatic Brain Injury: new trials by email Literature Review of Severe Traumatic Brain Injury trials Research Report on Severe Traumatic Brain Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Valproic AcId for Traumatic BRAin INjury Trial Valproic Acid (VPA), Standard of care treatment + normal saline - Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury | Phase 2 / Phase 3 | Not yet recruiting | Northwestern University | 432 | 2027-05-01 | 2026-08-13 |
| Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II Optimal cerebral perfusion pressure - Traumatic Brain Injury, Severe Traumatic Brain Injury | Not applicable | Not yet recruiting | Maastricht University Medical Center | 62 | 2027-01-01 | 2026-09-28 |
| The Systemic Nature of Severe Traumatic Brain Injury Severe Traumatic Brain Injury | Not yet recruiting | Corewell Health West | 40 | 2026-12-01 | 2026-10-23 | |
| Vagus Nerve Stimulation in Patients in Comatose State Dual-Site Transcutaneous Auricular Nerve Stimulation (taVNS + taTNS) - Traumatic Brain Injury, Severe Traumatic Brain Injury | Not applicable | Recruiting | Sima Mofakham | 10 | 2026-06-26 | 2026-07-22 |
| SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury SeeMe Multimodal Auditory Command Protocol - Traumatic Brain Injury (TBI) Patients, Severe Traumatic Brain Injury | Not applicable | Recruiting | Stony Brook University | 80 | 2026-03-30 | 2026-05-05 |
| The Örebro Severe Traumatic Brain Injury Registry Severe Traumatic Brain Injury, Severe Brain Injury | Not yet recruiting | András Zoltán Buki | 200 | 2026-02-08 | 2026-02-09 | |
| Feasibility and Safety of Targeting Neutral vs Liberal Fluid Balance in Traumatic Brain Injured Patients- LIMIT-TBI Trial Neutral Fluid Balance Strategy - Traumatic Brain Injury, Severe Traumatic Brain Injury | Phase 2 | Recruiting | Erasme University Hospital | 88 | 2025-07-01 | 2026-06-04 |
| Incidence, Characteristics and Evolution of Cerebral Vasospasm With Clinical Impact in Moderate to Severe Traumatic Brain Injury Complicated by Subarachnoid Hemorrhage at Martinique University Hospital Additional realization of a brain perfusion scan sequence which would allow the radiological diagnosis of CV - SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm | Not applicable | Recruiting | University Hospital Center of Martinique | 154 | 2024-11-06 | 2025-03-31 |
| Ketamine for Sedation in Severe Traumatic Brain Injury Ketamine with propofol, Standard of Care propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam - Severe Traumatic Brain Injury, Intracranial Hypertension | Phase 4 | Suspended | Henry M. Jackson Foundation for the Advancement of Military Medicine | 50 | 2024-09-23 | 2025-07-14 |
| External Lumbar Drainage to Reduce ICP in Severe TBI: a Phase 1 Clinical Trial External Lumbar drainage - Severe Traumatic Brain Injury, Intracranial Hypertension | Not applicable | Recruiting | Brain Trauma Foundation | 30 | 2024-06-24 | 2026-04-22 |
| Cisternostomy Vs Decompressive Craniectomy for Severe Traumatic Brain Injury Decompressive Craniectomy, Cisternostomy - Severe Traumatic Brain Injury | Not applicable | Unknown | University of Health Sciences Lahore | 190 | 2024-05-01 | 2024-04-12 |
| Development and Validation of a Prognostic Model for Neurocritical Patients Using Multimodal Brain Monitoring Acute Brain Injury Coma, Neurocritical Care | Recruiting | Xiangya Hospital of Central South University | 200 | 2024-01-08 | 2026-09-17 | |
| Benchmark Evidence Led by Latin America: Trial of Intracranial Pressure - Pediatrics ICP, CREVICE - Severe Traumatic Brain Injury | Not applicable | Recruiting | University of Washington | 428 | 2023-03-22 | 2025-06-27 |
| Impact of Severe Brain Injury on Neuro-vascular and Endothelial Regulation of Peripheral Microcirculation. Severe Traumatic Brain Injury, Trauma | Unknown | University Hospital, Grenoble | 30 | 2021-08-01 | 2022-11-03 | |
| Prioritization of Cerebral Deoxygenation in Severe Traumatic Brain Injury and Mortality Benefit. Near infrared spectroscopy neuromonitor to prevent cerebral desaturation - Cerebral Hypoxia, Severe Traumatic Brain Injury | Not applicable | Completed | Phramongkutklao College of Medicine and Hospital | 80 | 2021-04-01 | 2024-03-15 |
| Vestibular Rehabilitation and Severe Traumatic Brain Injury Vestibular Rehabilitation (VR), Conventional Neurorehabilitation - Severe Traumatic Brain Injury, Gait Disorders, Neurologic | Not applicable | Completed | I.R.C.C.S. Fondazione Santa Lucia | 30 | 2020-06-01 | 2021-06-22 |
| Aquatic Sequential Preparatory Approach and Severe Traumatic Brain Injury Aquatic Training, Conventional Training - Traumatic Brain Injury, Severe Traumatic Brain Injury | Not applicable | Completed | I.R.C.C.S. Fondazione Santa Lucia | 20 | 2019-09-01 | 2020-05-12 |
| Randomized Control Trial to Compare Standard Monitoring and Plethysmographic Variability Index-Guided Fluid Therapy In 64 Severe Traumatic Brain Injury Patients, Aged 18 to 60 Years Old Undergoing Emergency Craniotomies Plethymographic Variability Index, Standard Monitoring - Severe Traumatic Brain Injury | Not applicable | Completed | Universiti Sains Malaysia | 64 | 2019-05-29 | 2020-12-11 |
| Identification of Predictive Neuroinflammatory Biomarkers of Neuro-radiological Evolution in Severe Traumatic Brain Injury Biological Collection - Severe Traumatic Brain Injury | Not applicable | Unknown | Assistance Publique - Hôpitaux de Paris | 80 | 2018-10-15 | 2018-10-23 |
| The Effect of Closed Suction System on the Incidence of Ventilator-associated Pneumonia. Closed suction systems, Conventional suction system - Severe Traumatic Brain Injury, Pancreatic Diseases | Not applicable | Completed | Northern State Medical University | 40 | 2018-02-01 | 2022-04-08 |
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Brain Injuries, Traumatic (27) · Intracranial Hypertension (4) · Subarachnoid Hemorrhage (4) · Brain Injuries (3) · Coma (2) · Wounds and Injuries (2) · Accidental Injuries (1) · Cerebral Hemorrhage (1) · Cerebral Infarction (1) · Coma, Post-Head Injury (1) · Consciousness Disorders (1) · Encephalitis (1) · Gait Disorders, Neurologic (1) · Hypothermia (1) · Hypoxia (1)
Brain Diseases (27) · Central Nervous System Diseases (27) · Craniocerebral Trauma (27) · Nervous System Diseases (27) · Trauma, Nervous System (27) · Wounds and Injuries (25) · Brain Injuries (24) · Pathological Conditions, Signs and Symptoms (12) · Signs and Symptoms (8) · Cardiovascular Diseases (6) · Cerebrovascular Disorders (6) · Pathologic Processes (6) · Vascular Diseases (6) · Hemorrhage (5) · Intracranial Hemorrhages (5)
Acetaminophen (1) · Decompressive Craniectomy (1) · Dexmedetomidine (1) · Fentanyl (1) · Hydromorphone (1) · Ibuprofen (1) · Ketamine (1) · Lorazepam (1) · Midazolam (1) · Modafinil (1) · Morphine (1) · Propofol (1) · Saline Solution (1) · Transcranial Magnetic Stimulation (1) · Valproic Acid (1)
University of Washington (3) · I.R.C.C.S. Fondazione Santa Lucia (2) · András Zoltán Buki (1) · Assistance Publique - Hôpitaux de Paris (1) · Brain Trauma Foundation (1) · Corewell Health West (1) · Emory University (1) · Erasme University Hospital (1) · Henry M. Jackson Foundation for the Advancement of Military Medicine (1) · Kessler Foundation (1) · Maastricht University Medical Center (1) · Northern State Medical University (1) · Northwestern University (1) · Phramongkutklao College of Medicine and Hospital (1) · Sima Mofakham (1)
United States (13) · France (3) · Italy (3) · Netherlands (2) · Australia (1) · Belgium (1) · China (1) · Colombia (1) · Denmark (1) · El Salvador (1) · Guatemala (1) · Honduras (1) · India (1) · Malaysia (1) · New Zealand (1)
Bradley Dengler, MD (2) · Brenda Everett (1) · Elie P Elovic, M.D. (1) · Elizabeth A Steensma, MD, FACS (1) · Gregory Hawryluk, MD PhD (1) · Halinder S Mangat, MD MSc (1) · Hasan Alam, MD (1) · Jamshid Ghajar, MD PhD (1) · Jean-Luc Cracowksi, Pr (1) · Michael J Bell, MD (1) · Miriam Treggiari, MD (1) · Natallia Lapitskaya, MD (1) · Odette A Harris, MD, MPH (1)
PMID 25603012, PMID 27226973, PMID 28440675, PMID 29028696, PMID 29253420, PMID 31306264, PMID 33668311, PMID 34839268, PMID 34879500, PMID 36600643, PMID 37409817, PMID 37955439, PMID 38717237, PMID 39246040, PMID 41420823, PMID 42431819
R61MH138612 (2), R01HD106273 (1), R01NS061860 (1), U01NS081041 (1)