87 completed, 52 unknown, 23 recruiting, 15 terminated. 84 Not applicable, 12 Phase 3, 8 Phase 2, 7 Phase 4, 3 Phase 1.
Follow Intracranial Hypertension: new trials by email Literature Review of Intracranial Hypertension trials Research Report on Intracranial Hypertension
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage (DECIDE-SAH) Decompressive craniectomy - Aneurysmal Subarachnoid Hemorrhage | Not yet recruiting | University Hospital, Essen | 10000 | 2026-11-01 | 2026-10-14 | |
| Comparison of Hyperosmolar Agent in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Ultrasonography Mannitol (20%), Hypertonic Saline ( 3% Sodium Chloride Saline) - TBI (Traumatic Brain Injury), ICP (Intracranial Pressure) Increase | Not applicable | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-08-25 |
| TCD and ONSD for Early Risk Stratification of Traumatic Brain Injury Transcranial Doppler and Optic Nerve Sheath Diameter Assessment - Traumatic Brain Injury | Not yet recruiting | Assiut University | 60 | 2026-10-01 | 2026-09-15 | |
| Bedside Ultrasound Measurement of Optic Nerve Sheath Diameter for Detecting Raised Intracranial Pressure Intracranial Hypertension, Increased Intracranial Pressure | Not yet recruiting | Assiut University | 85 | 2026-10-01 | 2026-09-02 | |
| Non-Invasive Triage for Intracranial Hypertension in Prehospital Care Brain4care non-invasive intracranial pressure monitor, Optic nerve sheath diameter ultrasound - Intracranial Hypertension, Acute Brain Injury | Not applicable | Not yet recruiting | Juliana Caldas | 180 | 2026-09-01 | 2026-08-05 |
| Stenting Of Symptomatic Cerebral siNus stenosIs With the laserCut Self-expanding SILANCE Stent SILANCE Stent Implantation - Idiopathic Intracranial Hypertension (IIH) | Not applicable | Not yet recruiting | Acandis GmbH | 99 | 2026-09-01 | 2026-05-01 |
| Assessment of Optic Sheat Diameter (ONSD) and Eyeball Transverse Diameter (ETD) Ratio Measurement From Ocular Ultrasound Low Pressure Group, High Pressure Group - Optic Nerve Sheath Diameter Measurement, Intracranial Pressure Increase | Not yet recruiting | Gaziantep City Hospital | 68 | 2026-08-30 | 2026-08-25 | |
| Tirzepatide in Idiopathic Intracranial Hypertension Trial Tirzepatide, Tirzepatide Placebo - Idiopathic Intracranial Hypertension (IIH) | Phase 4 | Recruiting | Duke University | 60 | 2026-08-25 | 2026-09-15 |
| Strategies for Weaning From External Ventricular Drainage Direct clamping of external ventricular drain, Progressive (gradual) weaning of external ventricular drain - Subarachnoid Hemorrhage, Hydrocephalus | Not applicable | Not yet recruiting | University Hospital, Angers | 170 | 2026-07-01 | 2026-06-05 |
| Eptinezumab for Chronic Headache in Idiopathic Intracranial Hypertension Eptinezumab, Placebo - Idiopathic Intracranial Hypertension (IIH) | Phase 3 | Not yet recruiting | Rigmor Højland Jensen | 96 | 2026-06-22 | 2026-06-12 |
| TCD and ONSD for Noninvasive Assessment of Increased ICP in TBI Transcranial Doppler (TCD), Optic Nerve Sheath Diameter (ONSD) Ultrasound - Intracranial Pressure Increase, Traumatic Brain Injuries | Active not recruiting | Ain Shams University | 40 | 2026-06-07 | 2026-09-11 | |
| Idiopathic Intracranial Hypertension: Prognostic Factors and Multidisciplinary Management lumbo-peritoneal shunt, Conservative Management: Centered on lifestyle modifications for weight reduction, alongside targeted medical therapies including carbonic anhydrase inhibitors (e.g., acetazolamide) and/or topiramate. - Idiopathic Intracranial Hypertension | Not applicable | Active not recruiting | Sohag University | 30 | 2026-06-01 | 2026-07-21 |
| Effects of Extracorporeal Circulation Techniques on Cerebral Perfusion in CABG Surgery Intracranial Hypertension | Recruiting | Kartal Kosuyolu High Speciality Training and Research Hospital | 70 | 2026-05-01 | 2026-08-05 | |
| Effect of Central Venous Catheterization on Brain Pressure in Acute Brain Injury Patients Acute Brain Injury, Traumatic Brain Injury | Active not recruiting | Beijing Tiantan Hospital | 120 | 2026-03-01 | 2026-07-15 | |
| Venous Stenting Evaluation in Patients With Intracranial Hypertension Under Long-term Acetazolamide Acetazolamide, Stent (Tentos 4F or Precise ProRX) - Idiopathic Intracranial Hypertension (IIH) | Not applicable | Recruiting | University Hospital, Montpellier | 114 | 2026-01-05 | 2026-03-06 |
| Non-invasive Intracranial Pressure Monitoring in Brain Tumor Patients Ocular Sonography - Brain Neoplasm, Intracranial Pressure Increase | Not yet recruiting | Tanta University | 60 | 2026-01-01 | 2025-12-16 | |
| Optic Nerve Ultrasound for Assessing Cerebral Inflammation and Intracranial Hypertension in Cerebral Pathologies Optic Nerve Sheath Diameter - Meningitis, Meningitis/Encephalitis | Recruiting | Spitalul Clinic de Boli Infecțioase și tropicale "Dr. Victor Babeș" | 200 | 2025-12-01 | 2026-01-12 | |
| Conservative vs Interventional Management of Postsurgical CSF Pseudomeningocele Lumbar Drainage, Pseudomeningocele Puncture, Puncture with Fibrin Glue Application - CSF Leak, CSF Pressure Increased | Not applicable | Recruiting | Charles University, Czech Republic | 60 | 2025-11-01 | 2026-05-29 |
| Intracranial Venous Stenting Evaluation in Patients With Idiopathic Intracranial Hypertension in the Early Phase Best medical care, Intervention (stenting) - Idiopathic Intracranial Hypertension (IIH) | Not applicable | Recruiting | University Hospital, Montpellier | 114 | 2025-09-19 | 2025-10-03 |
| Different Intraperitoneal Pressures on Optic Nerve Sheath Diameter in Laparoscopic Surgeries Low pressure group, Normal pressure group - Intracranial Pressure Increase, Abdominal Pain | Not applicable | Completed | Diskapi Yildirim Beyazit Education and Research Hospital | 99 | 2025-08-30 | 2026-10-15 |
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Pseudotumor Cerebri (51) · Brain Injuries, Traumatic (37) · Brain Injuries (13) · Hydrocephalus (12) · Subarachnoid Hemorrhage (12) · Papilledema (11) · Brain Edema (10) · Headache (10) · Posterior Leukoencephalopathy Syndrome (7) · Stroke (7) · Brain Neoplasms (6) · Cerebral Hemorrhage (6) · Tinnitus (5) · Vision Disorders (5)
Central Nervous System Diseases (212) · Brain Diseases (211) · Nervous System Diseases (211) · Wounds and Injuries (50) · Trauma, Nervous System (49) · Craniocerebral Trauma (47) · Pathological Conditions, Signs and Symptoms (45) · Brain Injuries (33) · Cardiovascular Diseases (28) · Vascular Diseases (27) · Pathologic Processes (26) · Cerebrovascular Disorders (25) · Signs and Symptoms (23) · Neurologic Manifestations (20)
Mannitol (11) · Saline Solution, Hypertonic (8) · Acetazolamide (7) · Spinal Puncture (6) · Ultrasonography, Doppler, Transcranial (6) · Ultrasonography (5) · Sodium Lactate (4) · Decompressive Craniectomy (3) · Dexmedetomidine (3) · Stents (3) · Ketamine (2) · Pressure (2) · Saline Solution (2) · semaglutide (2) · 2-(1-(5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl)-3-piperidyl)acetic acid (1)
Assiut University (6) · HeadSense Medical (5) · Capital Medical University (4) · Duke University (4) · Dunjin Chen (4) · Copenhagen University Hospital, Rigshospitalet (3) · University Hospital, Montpellier (3) · University of Birmingham (3) · Bagcilar Training and Research Hospital (2) · Beijing Tiantan Hospital (2) · Beth Israel Deaconess Medical Center (2) · Centre Hospitalier Universitaire, Amiens (2) · Danish Headache Center (2) · Institut d'Anesthesiologie des Alpes Maritimes (2) · Integra LifeSciences Corporation (2)
United States (44) · Turkey (Türkiye) (26) · France (20) · China (14) · Egypt (12) · United Kingdom (12) · Italy (9) · Canada (8) · Germany (8) · Denmark (7) · Spain (6) · Switzerland (6) · Netherlands (5) · Israel (4) · South Korea (4)
Andres M Rubiano, MD (2) · Bradley Dengler, MD (2) · Dunjin Chen (2) · Gunnar Bentsen, MD (2) · Luigi V Berra, MD (2) · Michael Wall, MD (2) · Abdelhakeem A Essa, Ass. prof. (1) · Achikam Oren-Grinberg, MD (1) · Alexa N Bramall, MD (1) · Alexandra Sinclair, MBChB (1) · Alexandra Sinclair, MbChb PhD (1) · Alice Y Chang, MD (1) · Andreas Raabe, MD (1)
PMID 12455560, PMID 15145991, PMID 21505900, PMID 27654000, PMID 28255904, PMID 36240084, PMID 38355918, PMID 40353282, PMID 10627774, PMID 11077095, PMID 11160468, PMID 12234639, PMID 12670853, PMID 12794404, PMID 14238966, PMID 14505162, PMID 14669535, PMID 14872049, PMID 15226070, PMID 15230741, PMID 15243684, PMID 15644669, PMID 15661943, PMID 16206972, PMID 16703877, PMID 16816807, PMID 16997419, PMID 17041512, PMID 17186320, PMID 17210899, PMID 17384377, PMID 17522793, PMID 18173315, PMID 18275454, PMID 18395321, PMID 18477382, PMID 18495051, PMID 18807008, PMID 18947918, PMID 19167786, PMID 1931224, PMID 19372001, PMID 19715392, PMID 19726011, PMID 19934980, PMID 20466698, PMID 20714759, PMID 21323404, PMID 21523461, PMID 21680652
U10EY025990 (2), 2008 (1), 2014 (1), 2018 (1), 2025 (1), R01NS061860 (1), R03EB019352 (1), U01NS081041 (1), U10EY017281 (1), U10EY017387 (1)