28 completed, 5 unknown, 3 terminated, 1 recruiting. 14 Phase 2, 11 Not applicable, 7 Phase 3, 5 Phase 4, 3 Phase 1.
Follow Acetylcarnitine: new trials by email Literature Review of Acetylcarnitine trials Research Report on Acetylcarnitine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Acetyl L-Carnitine Supplementation on Clinical, Metabolic and Inflammatory Symptoms in Obese, Diabetic, Postmenopausal Women With Osteoarthritis Acetyl-l-carnitine, Placebo - Osteoarthritis, Type 2 Diabetes | Not applicable | Completed | Khyber Medical University Peshawar | 100 | 2025-12-01 | 2026-09-17 |
| Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS Acetyl-l-carnitine, Placebo - Amyotrophic Lateral Sclerosis | Phase 2 / Phase 3 | Recruiting | Mario Negri Institute for Pharmacological Research | 246 | 2025-03-26 | 2026-10-06 |
| The Effects of Acetyl-L-Carnitine and Myo/Chiro-Inositol in Patients With PCOS metformin - Infertility, Female, PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries | Not applicable | Completed | Khyber Medical University Peshawar | 120 | 2023-07-15 | 2026-02-09 |
| Preventive Effect of Acetyl-L-carnitine on Oxaliplatin-induced Peripheral Neuropathy Acetyl-L-carnitine - Acetylcarnitine, Chemotherapy-induced Peripheral Neuropathy | Phase 2 | Unknown | Nanfang Hospital, Southern Medical University | 100 | 2022-11-01 | 2022-11-01 |
| Comparison of Acetyl- L- Carnitine& Folic Acid Versus Coenzyme Q10& Folic Acid on Semen& Hormonal Parameters& Semen Oxidative Status in Patients of Primary Infertility. A Double Blind Randomized Clinical Trial Acetyl-l-carnitine, folic acid - Infertility | Phase 2 | Completed | Khyber Medical University Peshawar | 86 | 2022-08-06 | 2022-11-30 |
| Efficacy and Safety of Acetyl L-Carnitine in COVID-19 Patients With Mild-to-Moderate Disease Acetyl L-Carnitine - Covid19 | Not applicable | Unknown | Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo | 100 | 2020-12-15 | 2020-11-17 |
| Effectiveness of N-acetyl Cysteine, Acetyl L- Carnitine and Medicated Paraffin Oil in Aluminium Phosphide Poisoning N-acetyl cysteine, acetyl L-carnitine, medicated paraffin oil - the Study Focus to Improve the Standard of Care Used for Aluminuim Phosphide Poisoning and to Save Patients With the Minimal Organ Damage | Phase 4 | Unknown | Cairo University | 100 | 2020-10-01 | 2020-08-12 |
| Effects of Triple Drug Cocktail Therapy on Metabolic, Endocrine Alterations and Perceived Stress in Patients With Poly Cystic Ovary Syndrome Metformin (1000 mg daily), Pioglitazone (30 mg daily), Acetyl-L-carnitine (3 gm daily), Metformin, pioglitazone and placebo - PCOS | Phase 2 | Completed | Khyber Medical University Peshawar | 147 | 2019-10-15 | 2020-02-05 |
| Adding Antioxidants Into Human Sequential Culture Media System Antioxidants - Culture Media, Blastocyst | Not applicable | Completed | Vitrolife | 128 | 2016-12-01 | 2018-12-03 |
| Comparisons of Human Embryonic Development Using Single Medium With and Without the Addition of Antioxidants Acetyl-L-carnitine (ALC), N-acetyl-L-cysteine (NAC) and α-lipoic acid (ALA) - Culture Media, Blastocyst | Not applicable | Completed | Fertilitetscentrum AB | 128 | 2016-11-01 | 2018-02-22 |
| Assessment the Efficacy of Acetyl-L-carnitine in Patient With Alzheimer's Disease Acetyl-L-Carnitine, Placebo of Acetyl-L-Carnitine - Alzheimer Disease | Phase 4 | Completed | Dong-A ST Co., Ltd. | 265 | 2016-04-01 | 2021-04-14 |
| Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome Acetyl-l-carnitine, placebo - Carpal Tunnel Syndrome, Compression Neuropathy | Phase 2 / Phase 3 | Completed | University of Alberta | 20 | 2015-09-01 | 2017-10-27 |
| Effect of Acetyl-L-carnitine on Chronic Pancreatitis acetyl-L-carnitine 1000mg 2X per day for 3 months - Chronic Pancreatitis | Early Phase 1 | Terminated | Karin High | 3 | 2015-08-01 | 2017-03-10 |
| An Open-label Study of the Effects of Acetyl-L-Carnitine on Cardiovascular Outcomes in Friedreich's Ataxia Acetyl-L-Carnitine - Friedreich's Ataxia | Not applicable | Unknown | University of South Florida | 20 | 2013-08-01 | 2016-04-12 |
| Effect of Acetyl-L-carnitine in Migraine Acetyl-L-carnitine - Migraine | Phase 4 | Completed | Norwegian University of Science and Technology | 72 | 2013-04-01 | 2022-04-13 |
| Sympathetic Heart Innervation in Patients With Tako-Tsubo Cardiomyopathy Placebo, alpha-lipoic acid, L-acetyl carnitine - Apical Ballooning Syndrome, Nervous System Diseases, Sympathetic | Phase 4 | Completed | University of Campania Luigi Vanvitelli | 90 | 2011-12-01 | 2016-01-27 |
| Therapy for Chronic Fatigue Syndrome: A Presumptive Mitochondrial Disorder Nutraceuticals - Chronic Fatigue Syndrome | Withdrawn | Columbia University | 2011-11-01 | 2016-10-14 | ||
| Acetyl-L-carnitine in Combination With a Cisplatin-containing Chemotherapy as First Line Treatment of Advanced or Metastatic Non Small Cell Lung Cancer Acetylcarnitine, Placebo - Non Small Cell Lung Cancer | Phase 3 | Terminated | Mario Negri Institute for Pharmacological Research | 107 | 2011-04-01 | 2015-04-24 |
| Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS) Progressive exercise, Neuromuscular electrical stimulation delivered using the electrical therapy device EMPI 300 PV, Modified paleolithic diet - Multiple Sclerosis | Phase 1 | Completed | University of Iowa | 38 | 2010-10-01 | 2018-06-26 |
| Alpha-lipoic Acid/L-acetyl Carnitine for Progressive Supranuclear Palsy alpha-lipoic acid and L-acetyl carnitine - Progressive Supranuclear Palsy | Phase 1 / Phase 2 | Completed | Weill Medical College of Cornell University | 11 | 2010-09-14 | 2017-05-30 |
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Depression (3) · Diabetes Mellitus, Type 2 (3) · Fatigue (2) · HIV Infections (2) · Hepatic Encephalopathy (2) · Peripheral Nervous System Diseases (2) · Alzheimer Disease (1) · Amyotrophic Lateral Sclerosis (1) · Anemia, Sickle Cell (1) · Autonomic Nervous System Diseases (1) · Bipolar Disorder (1) · Brain Injuries, Traumatic (1) · COVID-19 (1) · Carcinoma, Non-Small-Cell Lung (1) · Carpal Tunnel Syndrome (1)
University of Catania (6) · Khyber Medical University Peshawar (4) · Mario Negri Institute for Pharmacological Research (4) · Amen Clinics, Inc. (1) · Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo (1) · Bayer (1) · Cairo University (1) · Columbia University (1) · Dong-A ST Co., Ltd. (1) · Fertilitetscentrum AB (1) · Indiana University (1) · Karin High (1) · Lee's Pharmaceutical Limited (1) · Mclean Hospital (1) · Nanfang Hospital, Southern Medical University (1)
Italy (11) · United States (11) · Pakistan (4) · United Kingdom (2) · Australia (1) · Belgium (1) · Canada (1) · China (1) · Egypt (1) · France (1) · Germany (1) · Japan (1) · Netherlands (1) · Norway (1) · Puerto Rico (1)
A Yoshida, MD, PhD (1) · Alfred Slonim, MD (1) · Antonio Cascio, MD, PhD (1) · Ashutosh Lal, M.D. (1) · Brian P Brennan, MD (1) · Bruce N. Ames, Ph.D. (1) · Chunlin Wang (1) · Claire Henchcliffe, MD DPhil (1) · Daniel G Amen, MD (1) · Dr Mohsin Shah, PhD (1) · Dr Safia Bibi, PhD* (1) · Dr Zia Ullah, PhD (1) · Elisabetta Pupillo, PharmD (1)
PMID 24105751, PMID 10411196, PMID 10856474, PMID 19620516, PMID 21304145, PMID 21310833, PMID 21615001, PMID 23733756, PMID 25601916, PMID 27079660, PMID 28105133, PMID 34047916, PMID 39847053
2008 (1), R21AT004493 (1)