26 completed, 7 withdrawn, 5 unknown, 3 recruiting. 14 Phase 2, 9 Not applicable, 5 Phase 4, 3 Phase 3, 2 Phase 1.
Follow Acidosis, Lactic: new trials by email Literature Review of Acidosis, Lactic trials Research Report on Acidosis, Lactic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus) | Phase 1 / Phase 2 | Not yet recruiting | George Washington University | 24 | 2027-03-01 | 2026-10-05 |
| An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM) zagociguat 15mg - Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome) | Phase 2 | Active not recruiting | Tisento Therapeutics | 44 | 2025-08-18 | 2026-10-13 |
| Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning Drug Overdose, Metformin | Recruiting | Centre Hospitalier de Saint-Denis | 50 | 2025-04-11 | 2025-09-25 | |
| Lactic Acidosis and Prior Metformin Treatment Type 2 Diabetes | Recruiting | University Hospital, Strasbourg, France | 100 | 2024-11-06 | 2025-12-23 | |
| A Phase 2b Study of Zagociguat in Patients With MELAS zagociguat 15mg, zagociguat 30mg, Placebo - Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome) | Phase 2 | Completed | Tisento Therapeutics | 43 | 2024-09-10 | 2026-10-23 |
| Comparison of Peripheral Perfusion Indicators and Lactate Levels Sepsis, Shock, Septic | Completed | Gulhane Training and Research Hospital | 192 | 2024-05-01 | 2025-12-05 | |
| OMT-28 in Patients With Primary Mitochondrial Disease (PMD) (PMD-OPTION) OMT-28 - Primary Mitochondrial Disease | Phase 2 | Completed | Omeicos Therapeutics GmbH | 28 | 2023-05-22 | 2026-01-22 |
| Effect of High Velocity/Hyperoxic Breathing Therapy on Blood Lactate Decline High Velocity Therapy - Dyspnea, Lactic Acidosis | Not applicable | Completed | Vapotherm, Inc. | 15 | 2023-03-06 | 2024-10-08 |
| Study of Metformin Overdose Metformin - Metformin Associated Lactic Acidosis | Unknown | Central Hospital, Nancy, France | 50 | 2021-03-01 | 2021-02-21 | |
| Metformin in Diabetic Patients Undergoing Coronary Angiography Metformin - Diabetes Mellitus, Coronary Artery Disease | Phase 4 | Unknown | Humanitas Hospital, Italy | 150 | 2020-01-15 | 2022-04-12 |
| Remote Ischemic Preconditioning During Cardiopulmonary Bypass Inflated cuff, Non inflated cuff - Lactic Acidosis | Not applicable | Withdrawn | Fayoum University | 2018-01-15 | 2021-02-03 | |
| The Threshold of Serum Anion Gap as a Screening Tool for Organic Acidosis Metabolic Acidosis, Critical Illness | Completed | Changi General Hospital | 16475 | 2017-07-01 | 2023-06-15 | |
| Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest Thiamine, placebo - Cardiac Arrest, Shock | Phase 2 | Terminated | Beth Israel Deaconess Medical Center | 41 | 2017-05-01 | 2025-04-10 |
| Alcohol: Thiamine and or Magnesium 1 Magnesium Sulfate, Pabrinex - Alcohol Withdrawal, Lactic Acidosis | Phase 2 / Phase 3 | Completed | Glasgow Royal Infirmary | 127 | 2016-12-16 | 2019-07-31 |
| Thiamine Supplementation in Patients With Septic Shock Thiamine, Placebos - Septic Shock, Shock, Septic | Phase 1 | Withdrawn | The Cleveland Clinic | 2016-11-05 | 2019-03-15 | |
| Investigation of the Correlation Between Plasma Concentration of Linezolid Antibiotic and Treatment Response and Adverse Reactions Myelosuppression, Lactic Acidosis | Unknown | National Taiwan University Hospital | 1000 | 2016-11-01 | 2022-02-10 | |
| Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study Metformin - Renal Insufficiency, Chronic | Phase 2 | Withdrawn | Centre Hospitalier Universitaire, Amiens | 2016-03-16 | 2020-07-15 | |
| Whole Body Periodic Acceleration on Blood Lactate and Recovery Whole Body Periodic Acceleration - Acidosis, Lactic | Not applicable | Completed | New York Institute of Technology | 32 | 2015-06-01 | 2018-03-29 |
| A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease Cysteamine Bitartrate - Mitochondrial Diseases | Phase 2 | Terminated | Amgen | 22 | 2015-05-19 | 2024-12-27 |
| The Various Effects of Gaseous Albuterol on Serum Lactate Normal Saline, Albuterol - Asthma | Not applicable | Completed | University Medical Center of Southern Nevada | 28 | 2015-04-01 | 2017-08-14 |
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MELAS Syndrome (7) · Diabetes Mellitus (4) · Mitochondrial Diseases (4) · Diabetes Mellitus, Type 2 (3) · Hemorrhage (3) · Metabolism, Inborn Errors (3) · Mitochondrial encephalopathy (3) · Rare Diseases (3) · Shock, Hemorrhagic (3) · Wounds and Injuries (3) · Acidosis (2) · Acquired Immunodeficiency Syndrome (2) · Beriberi (2) · Deafness (2)
Acid-Base Imbalance (47) · Metabolic Diseases (47) · Nutritional and Metabolic Diseases (47) · Acidosis (45) · Pathological Conditions, Signs and Symptoms (23) · Pathologic Processes (19) · Cardiovascular Diseases (11) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Nervous System Diseases (11) · Central Nervous System Diseases (10) · Disease Attributes (10) · Genetic Diseases, Inborn (10) · Signs and Symptoms (10) · Brain Diseases, Metabolic (9) · Neuromuscular Diseases (9)
Dichloroacetic Acid (5) · Metformin (4) · Thiamine (4) · PEG-hemoglobin (3) · Saline Solution (3) · Sodium Chloride (3) · maleimide-polyethylene glycol-modified hemoglobin, MP4 (3) · Riboflavin (2) · polynitroxylated pegylated hemoglobin (2) · Albuterol (1) · Blood Transfusion (1) · Carnitine (1) · Cysteamine (1) · Dietary Supplements (1) · Fenoldopam (1)
Sangart (3) · Tisento Therapeutics (2) · University of Florida (2) · Amgen (1) · Asan Medical Center (1) · Beth Israel Deaconess Medical Center (1) · Central Hospital, Nancy, France (1) · Centre Hospitalier Universitaire, Amiens (1) · Centre Hospitalier de Saint-Denis (1) · Changi General Hospital (1) · Columbia University (1) · Copenhagen University Hospital, Rigshospitalet (1) · Duke University (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Fayoum University (1)
United States (18) · France (9) · Germany (7) · Italy (7) · United Kingdom (7) · Australia (4) · Canada (4) · Austria (3) · Israel (3) · Norway (3) · South Africa (3) · Switzerland (3) · Belgium (2) · Brazil (2) · Croatia (2)
Karim Brohi, MD (3) · Anne Chiaramello, Ph.D. (1) · Arjun B Chatterjee, MD, MS (1) · Bruce Barshop (1) · Bruce Gladden (1) · Cecilia Shikuma (1) · Chang Y Chionh (1) · Darryl C De Vivo, MD (1) · Debra Regier, M.D., Ph.D. (1) · Donogh Maguire, MB BCh (1) · Frank V. Booth, BCh, FACS (1) · Gilles Wandeler, Dr. med. (1) · Han Chu Lee, M.D (1)
PMID 10189326, PMID 10218526, PMID 10371175, PMID 10546860, PMID 10563713, PMID 10634199, PMID 10789605, PMID 10971863, PMID 10988097, PMID 11071184, PMID 11188837, PMID 11216928, PMID 11262215, PMID 11366976, PMID 11399982, PMID 11719381, PMID 11722270, PMID 11737323, PMID 11740189, PMID 11807691, PMID 12008784, PMID 12126821, PMID 12134254, PMID 12172088, PMID 12186514, PMID 12534953, PMID 12553482, PMID 12558340, PMID 12640206, PMID 12741625, PMID 12819520, PMID 12853195, PMID 12859325, PMID 12891060, PMID 12957089, PMID 14518432, PMID 14581998, PMID 14627784, PMID 14991809, PMID 14999610, PMID 15195254, PMID 15197808, PMID 15232720, PMID 15234856, PMID 15272393, PMID 15273954, PMID 15285167, PMID 15316340, PMID 15316342, PMID 15529259
K23HL128814 (1), R01CA125618 (1), U54NS078059 (1), UH3TR003897 (1)