240 completed, 73 unknown, 28 recruiting, 26 terminated. 105 Phase 2, 70 Phase 3, 58 Not applicable, 56 Phase 1, 50 Phase 4.
Follow Neutropenia: new trials by email Literature Review of Neutropenia trials Research Report on Neutropenia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Restrictive Versus Standard Antibiotic Treatment During CAR-T Therapy ceftazidime, ciprofloxacin, Standard-of-Care Antibiotic Strategy - Large B-Cell Lymphoma (LBCL), Multiple Myeloma (MM) | Phase 2 | Not yet recruiting | Zealand University Hospital | 150 | 2027-03-01 | 2026-09-25 |
| G-CSF In Neonatal Sepsis With Neutropenia Granulocyte-colony stimulating factor (G-CSF), Standard Sepsis Management - Neonatal Sepsis, Neutropenia | Not applicable | Not yet recruiting | University of Health Sciences Lahore | 52 | 2027-02-15 | 2026-10-22 |
| A Study to Compare the Pharmacokinetics, Pharmacodynamics, Immunogenicity, Safety and Tolerability of Filgrastim Biosimilar and Neupogen Reference Product in Healthy Volunteers Biofilgragen, Neupogen (filgrastim) - Neutropenia (Low White Blood Cell Count) | Phase 1 | Not yet recruiting | BioGeneric Pharma | 50 | 2026-12-15 | 2026-10-20 |
| Acupuncture as add-on to G-CSF for Febrile Neutropenia-related Hospitalization in Doxorubicin-treated Patients With Sarcoma Acupuncture - Febrile Neutropenia, Sarcoma | Not applicable | Not yet recruiting | Shaare Zedek Medical Center | 60 | 2026-12-01 | 2026-04-29 |
| Effects of Resistance Training on Recovery During Hematopoietic Stem Cell Transplantation 8-week Elastic Band Resistance Training Program - Hematologic Malignancies, Hematopoietic Stem Cell Transplantation | Not applicable | Not yet recruiting | Taipei Veterans General Hospital, Taiwan | 86 | 2026-10-12 | 2026-10-14 |
| Correlation Between ANC and Bone Pain in Breast Cancer Patients Receiving Long-Acting G-CSF Breast Cancer, Chemotherapy-Induced Neutropenia | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 132 | 2026-09-30 | 2026-09-08 | |
| Predictive Score in Patients With Hematological Malignancies Colonized by Multidrug-resistant Enterobacteriaceae Hemato-oncologic Patients, Colonization | Not yet recruiting | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 535 | 2026-09-04 | 2026-09-03 | |
| Evaluation of Antibiotic Prophylaxis in Myelodysplastic Syndromes and Acute Myeloid Leukemia (MYELO-CAN:ABX) Levofloxacin, Usual Care - Myeldysplastic Syndrome (MDS), MYELOPROLIFERATIVE DISORDER (P Vera, CMML, ET) | Phase 2 | Not yet recruiting | University of Manitoba | 75 | 2026-09-01 | 2026-06-29 |
| Phase II Study of QLC2519 in Pediatric Solid Tumor Participants Albipagrastim alf - Pediatric Malignant Solid Tumor, Febrile Neutropenia (FN) | Phase 2 | Recruiting | Qilu Pharmaceutical Co., Ltd. | 18 | 2026-06-26 | 2026-07-24 |
| Plasma Host-Microbe Proteomics to Predict Complications in High-risk Febrile Neutropenia Plasma and DNA sample collection for proteomic and genomic analysis - Febrile Neutropenia | Recruiting | Instituto de Investigación Biomédica de Salamanca | 350 | 2026-06-09 | 2026-06-15 | |
| Early Discontinuation of Antibiotics in Paediatric High-risk Febrile Neutropenia Early Discontinuation of Antibiotics, Standard Antibiotic Continuation Strategy - Febrile Neutropenia (FN), Pediatric Cancer | Phase 4 | Not yet recruiting | Hospital Universitari Vall d'Hebron Research Institute | 136 | 2026-06-01 | 2026-05-15 |
| Impact of a Telemonitoring Device on the Occurever at Home in Children at Risk of Chemotherapy-Induced Neutropenia Remote temperature monitoring device, Home temperature monitoring by a nurse - Oncopediatrics, Febrile Neutropenia | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de la Réunion | 30 | 2026-05-01 | 2026-01-20 |
| Letermovir vs Valganciclovir in CMV R+ Kidney Transplant Letermovir, Valganciclovir CMV Prophylaxis - CMV Infection, CMV | Phase 4 | Not yet recruiting | Elisabeth Kincaide | 300 | 2026-05-01 | 2026-05-08 |
| Efficacy of an Empirical Treatment With Amoxicillin-clavulanate (AC) Compared to the Combination Amoxicillin-clavulanate and Ciprofloxacin (AC+C) in the Outpatient Care of Chemotherapy-induced Fever in Adult Haematology Patients. amoxicillin-clavulanate, Amoxicillin-clavulanate ciprofloxacin - C15.378 | Phase 3 | Not yet recruiting | Versailles Hospital | 1526 | 2026-03-01 | 2026-03-19 |
| Antibiotic Duration and Outcomes in High-Risk Febrile Neutropenia Patients Clinical Stability-Driven Antibiotic Discontinuation Strategy, Standard of Care Antibiotic Duration - Bloodstream Infection, Gram Negative Infections | Not applicable | Recruiting | Valeria Cento | 172 | 2026-02-02 | 2026-09-24 |
| Low-Dose Liposomal Amphotericin B for Invasive Fungal Infection Prophylaxis in Neutropenic Children Liposomal Amphotericin B (LAmB) - Thalassemia, Hematopoietic Stem Cell Transplantation | Recruiting | Haikou Affiliated Hospital of Central South University Xiangya School of Medicine | 30 | 2026-02-01 | 2026-07-24 | |
| the Efficacy of Leucogen in Preventing the Risk of Ribociclib-Associated Neutropenia in Early Breast Cancer Treat Regimen - Leucogen, Ribociclib | Phase 2 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 97 | 2026-01-07 | 2026-09-28 |
| Levofloxacin Prophylaxis to Prevent First Febrile Neutropenia in Pediatric ALL During Induction Phase Levofloxacin, Placebo - Neutropenic Fever, Acute Lymphoblastic Leukemia | Phase 4 | Terminated | Gadjah Mada University | 49 | 2026-01-01 | 2026-10-01 |
| Early Versus Late Stopping of Antibiotics in Adults With High-risk Hematological Malignancies/Receiving Cellular Therapies and Fever Early antibiotic cessation alert - Leukemia, CART Therapy | Not applicable | Recruiting | Peter MacCallum Cancer Centre, Australia | 214 | 2025-12-03 | 2025-12-15 |
| Efficacy of Empirical Anti-Infective Therapy in Neutropenic Febrile Patients. Carbapenems, Anti-Gram-positive agent, Antifungal agent - Febrile Neutropenia | Recruiting | Shanxi Bethune Hospital | 20 | 2025-09-22 | 2025-10-02 |
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Febrile Neutropenia (143) · Breast Neoplasms (53) · Neoplasms (53) · Fever (44) · Infections (34) · Hematologic Neoplasms (32) · Leukemia (30) · Leukemia, Myeloid, Acute (30) · Thrombocytopenia (29) · Anemia (22) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (22) · Lymphoma (18) · Multiple Myeloma (17) · Mycoses (17)
Hemic and Lymphatic Diseases (409) · Agranulocytosis (408) · Leukocyte Disorders (408) · Cytopenia (401) · Leukopenia (399) · Hematologic Diseases (393) · Neoplasms (169) · Neoplasms by Site (118) · Pathological Conditions, Signs and Symptoms (107) · Neoplasms by Histologic Type (92) · Immune System Diseases (77) · Infections (75) · Pathologic Processes (64) · Skin and Connective Tissue Diseases (63)
pegfilgrastim (39) · Filgrastim (36) · Cyclophosphamide (14) · Cefepime (11) · Ciprofloxacin (11) · Meropenem (10) · Vancomycin (10) · Docetaxel (9) · Granulocyte Colony-Stimulating Factor (8) · Piperacillin, Tazobactam Drug Combination (8) · pegylated granulocyte colony-stimulating factor (8) · Amphotericin B (7) · Cytarabine (7) · Etoposide (7) · liposomal amphotericin B (7)
Amgen (16) · National Heart, Lung, and Blood Institute (NHLBI) (13) · Pfizer (11) · National Cancer Institute (NCI) (8) · EVIVE Biotechnology (7) · Sandoz (6) · Assistance Publique - Hôpitaux de Paris (5) · National Institute of Allergy and Infectious Diseases (NIAID) (5) · Asan Medical Center (4) · Children's Oncology Group (4) · Insel Gruppe AG, University Hospital Bern (4) · M.D. Anderson Cancer Center (4) · Memorial Sloan Kettering Cancer Center (4) · Merck Sharp & Dohme LLC (4) · Spectrum Pharmaceuticals, Inc (4)
United States (122) · China (45) · France (34) · South Korea (20) · Germany (19) · Canada (18) · Spain (16) · Australia (15) · Italy (15) · Switzerland (14) · Israel (13) · Netherlands (12) · Belgium (11) · Russia (11) · United Kingdom (11)
Danielle M Townsley, M.D. (4) · Thomas J. Walsh, MD (4) · Aaron Cumpston, PharmD, BCOP (2) · Binghe XU, MD (2) · Christa Koenig, MD (2) · Cynthia E Dunbar, M.D. (2) · David H McDermott, M.D. (2) · Junning Cao, Professor (2) · Lei Li, M.D. (2) · Mark J. Ratain, MD (2) · Matthew M Hsieh, M.D. (2)
PMID 29958797, PMID 29674506, PMID 23317527, PMID 28637287, PMID 29419434, PMID 30900158, PMID 33789616, PMID 34724566, PMID 10091805, PMID 12084168, PMID 12660125, PMID 15459300, PMID 15718314, PMID 15761020, PMID 15770833, PMID 15806544, PMID 15814645, PMID 16096770, PMID 16382125, PMID 16932345, PMID 17008536, PMID 17170128, PMID 17251531, PMID 17317205, PMID 17339189, PMID 17470691, PMID 17573453, PMID 17621407, PMID 18156492, PMID 18165618, PMID 18322708, PMID 18616811, PMID 18619375, PMID 18827613, PMID 19208097, PMID 19467544, PMID 19596586, PMID 20038732, PMID 20045791, PMID 20118030, PMID 20163377, PMID 20231680, PMID 20232087, PMID 20410061, PMID 20431381, PMID 20435233, PMID 20953908, PMID 21394050, PMID 21831685, PMID 21835955
2014 (4), 2016 (2), 2018 (2), 2023 (2), U10CA095861 (2), 2005 (1), 2025 (1), P01CA075606 (1), P30AI060354 (1), P30CA012197 (1), P30CA015083 (1), P30CA016086 (1), P30CA016672 (1), P30CA036727 (1), R01HD061265 (1)