41 completed, 10 terminated, 6 unknown, 3 not yet recruiting. 67 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 67 | Completed 41, Terminated 10, Unknown 6, Not yet recruiting 3, Recruiting 3, Active not recruiting 2, Withdrawn 2 |
Follow Seizures: new trials by email Literature Review of Seizures trials Research Report on Seizures
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolex Epidiolex 100 mg/mL Oral Solution - Dravet Syndrome (DS), Lennox-Gastaut Syndrome (LGS) | Phase 4 | Not yet recruiting | Elizabeth Donner | 25 | 2027-01-01 | 2026-09-11 |
| Study of the Pharmacokinetics, Safety, and Tolerability of ZONISADE in Children 1 Month to 17 Years of Age With Partial-onset Seizures Zonisamide Oral Product - Seizures, Seizures, Focal | Phase 4 | Not yet recruiting | Azurity Pharmaceuticals | 40 | 2026-09-01 | 2026-09-15 |
| Outcomes After Planned Discontinuation of AntiSeizure Medication Discontinue antiseizure medications - Epilepsy | Phase 4 | Recruiting | University of Michigan | 40 | 2026-08-01 | 2026-08-06 |
| Ketamine for the Treatment of Refractory Status Epilepticus Ketamine, Midazolam - Refractory Status Epilepticus | Phase 4 | Not yet recruiting | Thomas Jefferson University | 50 | 2025-11-01 | 2025-09-16 |
| Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus Perampanel - Refractory Status Epilepticus | Phase 4 | Terminated | Wayne State University | 1 | 2025-10-10 | 2025-10-14 |
| Early Post-Traumatic Seizures Prevention Trial (E-PTS Trial) Phenytoin, Levetiracetam, Placebo - Seizures, Traumatic Brain Injuries | Phase 4 | Recruiting | All India Institute of Medical Sciences, Jodhpur | 1260 | 2025-07-23 | 2026-10-29 |
| Comparing Intravenous and Intramuscular Magnesium Sulphate for Preventing Seizure Recurrence in Women With Eclampsia Magnesium Sulphate infusion, Magnesium sulphate intramuscular - Eclampsia, Seizures | Phase 4 | Completed | Nishtar Medical University | 200 | 2025-05-13 | 2025-12-15 |
| Pro-Epileptic Effects of IV Ketamine Ketamine, Midazolam, Propofol - Epilepsy, Seizure | Phase 4 | Completed | Haseki Training and Research Hospital | 300 | 2024-12-01 | 2025-12-15 |
| Open-label Study of Cenobamate Monotherapy in Adult Subjects With Newly Diagnosed or Recurrent Partial-Onset Epilepsy Cenobamate - Focal Onset Seizure | Phase 4 | Active not recruiting | SK Life Science, Inc. | 49 | 2024-10-14 | 2026-10-27 |
| Seizure Rescue Medication (RM) as Part of a Comprehensive Epilepsy Self-management Package of Care SMART RM, Valtoco Nasal Product - Epilepsy | Phase 4 | Active not recruiting | University Hospitals Cleveland Medical Center | 31 | 2024-03-05 | 2026-07-06 |
| Goal-directed vs Preemptive Tranexamic Acid Administration in Non-cardiac Surgery TXA, TEG6 - Arthritis Knee, Spine Fusion | Phase 4 | Unknown | Konkuk University Medical Center | 148 | 2024-02-10 | 2024-05-14 |
| Safety of Simultaneous mRNA COVID-19 Vaccine With Other Childhood Vaccines in Young Children mRNA COVID-19 Vaccine, Routine Childhood Vaccinations - Fever After Vaccination, Fever | Phase 4 | Completed | Duke University | 347 | 2023-10-30 | 2026-05-13 |
| Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits Methylphenidate, Placebo - Epilepsy | Phase 4 | Recruiting | VA Office of Research and Development | 226 | 2023-08-14 | 2026-04-20 |
| A Study to Investigate Behavioral and Other Co-Occurring Outcomes With Epidiolex as Add-On Therapy in Participants Aged 1 to 65 Years of Age With Tuberous Sclerosis Complex Cannabidiol Oral Solution [Epidiolex] - Tuberous Sclerosis Complex Associated Neuropsychiatric Disease | Phase 4 | Completed | Jazz Pharmaceuticals | 79 | 2023-06-29 | 2026-04-27 |
| The Efficacy and Safety of Levetiracetam Versus Fosphenytoin in Convulsive Status Epilepticus Levetiracetam Injection, Fosphenytoin Injection - Status Epilepticus | Phase 4 | Completed | Dhaka Medical College | 62 | 2023-05-15 | 2026-10-07 |
| A Study to Evaluate the Efficacy and Safety of Perampanel Monotherapy in Untreated Participants With Focal Onset Seizures With or Without Focal to Bilateral Tonic-clonic Seizures Perampanel - Epilepsy | Phase 4 | Completed | Eisai Korea Inc. | 125 | 2022-10-19 | 2025-03-07 |
| Comparing the Efficacy of Intranasal Midazolam Versus Intravenous Diazepam for Control of Seizures in Children IV diazepam, I/N Midazolam - Seizures | Phase 4 | Unknown | Shaheed Zulfiqar Ali Bhutto Medical University | 60 | 2021-05-30 | 2021-05-13 |
| Correlation of Serum Level of Perampanel (PER) Level to Cerebrospinal Fluid (CSF) Levels of PER Perampanel - Epilepsy, Seizures | Phase 4 | Unknown | Carilion Clinic | 25 | 2019-11-01 | 2021-09-16 |
| Comparison of Efficacy of Phenytoin With Levetireacetam for the Management of Children With Status Epilepticus intravenous levetireacetam - Status Epilepticus | Phase 4 | Unknown | ayesha tariq | 244 | 2019-07-25 | 2021-04-02 |
| Memantine for Epileptic Encephalopathy Memantine Hydrochloride 10 mg - Epileptic Encephalopathy, Childhood-Onset | Phase 4 | Completed | Kenneth Myers, MD | 30 | 2019-02-07 | 2022-03-11 |
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Epilepsy (25) · Epilepsies, Partial (7) · Status Epilepticus (5) · Brain Injuries, Traumatic (3) · Nervous System Diseases (3) · Seizures, Febrile (3) · Brain Neoplasms (2) · Conversion Disorder (2) · Depression (2) · Epilepsy, Tonic-Clonic (2) · Fever (2) · Intracranial Aneurysm (2) · Lennox Gastaut Syndrome (2) · Psychogenic Nonepileptic Seizures (2)
Pathological Conditions, Signs and Symptoms (67) · Signs and Symptoms (67) · Neurologic Manifestations (66) · Nervous System Diseases (64) · Central Nervous System Diseases (39) · Brain Diseases (38) · Epilepsy (7) · Cardiovascular Diseases (5) · Mental Disorders (5) · Neoplasms (5) · Pathologic Processes (5) · Vascular Diseases (5) · Cerebrovascular Disorders (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4)
Levetiracetam (11) · Phenytoin (7) · perampanel (4) · Lacosamide (3) · Midazolam (3) · Oxcarbazepine (3) · Topiramate (3) · Cannabidiol (2) · Diazepam (2) · Influenza Vaccines (2) · Ketamine (2) · Melatonin (2) · Methylphenidate (2) · Pregabalin (2) · Sertraline (2)
Duke University (3) · GlaxoSmithKline (2) · Novartis (2) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (2) · Rhode Island Hospital (2) · Tanta University (2) · UCB Pharma (2) · University of Cincinnati (2) · University of Michigan (2) · Ain Shams University (1) · All India Institute of Medical Sciences, Bhubaneswar (1) · All India Institute of Medical Sciences, Jodhpur (1) · Astellas Pharma Global Development, Inc. (1) · Azurity Pharmaceuticals (1) · Boston Children's Hospital (1)
United States (35) · Canada (6) · Finland (4) · France (4) · South Korea (4) · Egypt (3) · Italy (3) · Russia (3) · Spain (3) · Switzerland (3) · Turkey (Türkiye) (3) · United Kingdom (3) · Argentina (2) · Austria (2) · Bangladesh (2)
W. Curt LaFrance, Jr., MD, MPH (2) · Aashit Shah, MD (1) · Aditya S Pandey, MD (1) · Amira Darwish (1) · Amira Darwish, MD (1) · Andrew Yeates (1) · Antonio A Lazzari, MD (1) · Beth A Leeman-Markowski, MD (1) · Carol C Base, RN, MS (1) · Debra Houry, MD (1)
PMID 10431771, PMID 10908900, PMID 11207795, PMID 12428025, PMID 15380560, PMID 16344515, PMID 1744641, PMID 18070841, PMID 18595663, PMID 19652140, PMID 20739647, PMID 22342434, PMID 22417223, PMID 24655096, PMID 24989152, PMID 25616485, PMID 26875743, PMID 28597842, PMID 29028517, PMID 29870458, PMID 29945898, PMID 32029684, PMID 32690786, PMID 33957739, PMID 35844168, PMID 36256600, PMID 37363462, PMID 38293492, PMID 39564442, PMID 42435131, PMID 6317805, PMID 7044473, PMID 7783877, PMID 8635421, PMID 9578017, PMID 9595992
2009 (1), 2023 (1), K23AG081463 (1), K23MH066835 (1), K23NS045902 (1)