55 completed, 27 recruiting, 13 unknown, 12 terminated. 30 Not applicable, 28 Phase 3, 18 Phase 2, 5 Phase 4, 3 Phase 1.
Follow Status Epilepticus: new trials by email Literature Review of Status Epilepticus trials Research Report on Status Epilepticus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE" Anakinra, Tocilizumab, Standard medical treatment - New Onset Refractory Status Epilepticus, New-Onset Refractory Status Epilepticus | Phase 3 | Not yet recruiting | Yale University | 438 | 2026-12-01 | 2026-08-19 |
| Predictors of Outcomes of Convulsive Status Epilepticus Status Epilepticus, Convulsive Status Epilepticus | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-10-01 | |
| Use of Cognitive Aid Methods in the Management of Status Epilepticus Management of status epilepticus with paper cognitive aids, Management of status epilepticus with digital cognitive aids, Management of status epilepticus with no cognitive aid - Last Year Medical Student | Not applicable | Not yet recruiting | Ankara University | 76 | 2026-05-25 | 2026-05-29 |
| Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT) Levetiracetam (LEV) (60 mg/Kg) + 1 mg/kg Ketamine (KET), Levetiracetam (LEV) (60 mg/Kg) + 3 mg/kg Ketamine (KET), Levetiracetam (LEV) (60 mg/Kg) - Status Epilepticus | Phase 3 | Recruiting | University of Virginia | 770 | 2026-03-06 | 2026-09-17 |
| Targeted Hypothermia Versus Targeted Normothermia After Convulsive Refractory Status Epilepticus Targeted Hypothermia - Convulsive Refractory Status Epilepticus, Status Epilepticus | Phase 3 | Not yet recruiting | Versailles Hospital | 466 | 2026-03-01 | 2026-02-10 |
| Training Program to Improve EEG Competence Training Program - Epilepsy, Status Epilepticus | Not applicable | Completed | University Hospital Marburg | 18 | 2025-11-04 | 2026-07-08 |
| Ketamine for the Treatment of Refractory Status Epilepticus Ketamine, Midazolam - Refractory Status Epilepticus | Phase 4 | Not yet recruiting | Thomas Jefferson University | 50 | 2025-11-01 | 2025-09-16 |
| KD Treatment for Super-refractory Status Epilepticus the ketogenic diet, Standard Medical Therapy - Super-refractory Status Epilepticus | Not applicable | Recruiting | Xuanwu Hospital, Beijing | 84 | 2025-10-20 | 2026-05-15 |
| Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus Perampanel - Refractory Status Epilepticus | Phase 4 | Terminated | Wayne State University | 1 | 2025-10-10 | 2025-10-14 |
| Prehospital Early Administration of Ketamine for Status Epilepticus in Epileptic Kids (PEAK-SEEK) Ketamine, Midazolam - Convulsive Status EPILEPTICUS | Phase 2 / Phase 3 | Recruiting | Sohag University | 668 | 2025-08-03 | 2025-08-05 |
| Levetiracetam Versus Phenobarbital in Benzodiazepines Unresponsive Paediatric Prolonged Seizures Levetiracetam IV, Phenobarbital - Seizure | Not applicable | Recruiting | Ministry of Health and Sports, Myanmar | 180 | 2025-07-22 | 2025-08-01 |
| Simulation Trial of Telemedical Support for Paramedics Video teleconsultation, Audio support - Emergencies, Cardiopulmonary Arrest | Not applicable | Recruiting | Boston Medical Center | 420 | 2025-07-10 | 2026-06-30 |
| Ketamine and Levetiracetam as Second-line Antiseizure Medication for Status Epilepticus in Children Ketamine, Levetiracetam, Placebo - Generalized Convulsive Status Epilepticus | Phase 2 / Phase 3 | Recruiting | Sohag University | 124 | 2025-07-02 | 2025-07-03 |
| Lacosamide Intravenous Injection for Emergency Termination of Status Epilepticus Lacosamide (LCM) - Epilepsy, Status Epilepticus | Not yet recruiting | Second Affiliated Hospital of Guangzhou Medical University | 100 | 2025-06-06 | 2025-05-30 | |
| Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2) anti-seizure medication + sedative agent(s) - Coma, Electrographic Status Epilepticus | Not applicable | Recruiting | University of Twente | 150 | 2025-04-10 | 2026-07-07 |
| Comparison of Intravenous Brivaracetam Versus Levetiracetam in the Management of Status Epilepticus Intravenous brivaracetam, Intravenous levetiracetam - Status Epilepticus | Not applicable | Completed | Muhammad Aamir Latif | 152 | 2025-01-16 | 2025-09-09 |
| Efficacy Comparison Between Levetiracetam and Valproic Acid in Pediatric Patients With Status Epilepticus Levetiracetam, Valproic acid - Status Epilepticus | Not applicable | Completed | RESnTEC, Institute of Research | 138 | 2024-11-01 | 2025-07-04 |
| Multicenter Retrospective Study of Isoflurane in Refractory and Super-Refractory Status Epilepticus Isoflurane - Refractory Status Epilepticus | Completed | Hopital of Melun | 66 | 2024-06-30 | 2025-09-26 | |
| Patient-reported Outcome and Patient-reported Experience After Status Epilepticus Patient Reported Outcomes, Patient Satisfaction | Recruiting | Versailles Hospital | 145 | 2024-05-25 | 2026-07-07 | |
| PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest Perampanel, Placebo - Heart Arrest, Seizures | Phase 2 | Recruiting | University of California, San Francisco | 52 | 2024-05-20 | 2026-07-29 |
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Seizures (27) · Epilepsy (22) · Heart Arrest (9) · Coma (6) · Brain Injuries, Traumatic (5) · Subarachnoid Hemorrhage (5) · Cerebral Hemorrhage (4) · Ischemic Stroke (4) · Encephalitis (3) · Epilepsia Partialis Continua (3) · Stroke (3) · Brain Diseases (2) · Consciousness Disorders (2) · Emergencies (2)
Nervous System Diseases (119) · Pathological Conditions, Signs and Symptoms (119) · Signs and Symptoms (119) · Neurologic Manifestations (118) · Seizures (92) · Central Nervous System Diseases (37) · Brain Diseases (35) · Cardiovascular Diseases (16) · Vascular Diseases (10) · Cerebrovascular Disorders (9) · Heart Diseases (9) · Pathologic Processes (9) · Neurobehavioral Manifestations (8) · Wounds and Injuries (7) · Immune System Diseases (6)
Levetiracetam (13) · Lorazepam (11) · Valproic Acid (9) · Ketamine (8) · Midazolam (7) · Phenytoin (4) · Clonazepam (3) · Diazepam (3) · Lacosamide (3) · Phenobarbital (3) · Propofol (3) · Thiopental (3) · Transcranial Direct Current Stimulation (3) · fosphenytoin (3) · ganaxolone (3)
Assistance Publique - Hôpitaux de Paris (5) · Sohag University (5) · University Hospital, Basel, Switzerland (5) · Marinus Pharmaceuticals (4) · Versailles Hospital (4) · Assiut University (3) · University Hospital Marburg (3) · University of California, San Francisco (3) · Xuanwu Hospital, Beijing (3) · All India Institute of Medical Sciences (2) · Boston Children's Hospital (2) · Boston Medical Center (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Kamuzu University of Health Sciences (2) · Mayo Clinic (2)
United States (40) · France (16) · Switzerland (9) · Canada (8) · Egypt (7) · Belgium (6) · China (6) · United Kingdom (6) · Italy (5) · Germany (4) · Pakistan (4) · Finland (3) · Japan (3) · Netherlands (3) · Poland (3)
Abdelrahim A Sadek, MD, PhD (3) · James Chamberlain, MD (3) · Raoul Sutter, PD Dr. med (3) · Edilberto Amorim, MD (2) · Robert Silbergleit, MD (2) · Tehnaz Boyle, MD PhD (2) · Adam Ostendorf, MD (1) · Alberto Pinzon, M.D., Ph.D. (1) · Alfred Meurs, MD, PhD (1) · Amira Darwish, MD (1) · Andrea O. Rossetti, MD (1) · Anna Rosati, MD, PhD (1) · Atifa Mazhar (1)
PMID 12628059, PMID 16698412, PMID 16844492, PMID 16861095, PMID 16886975, PMID 17199030, PMID 20878265, PMID 21275979, PMID 21967361, PMID 21967362, PMID 22335736, PMID 22506949, PMID 24001080, PMID 24070982, PMID 24756515, PMID 25616473, PMID 26384469, PMID 26627366, PMID 26971488, PMID 27311915, PMID 27325409, PMID 27993298, PMID 28002714, PMID 28295226, PMID 29356811, PMID 30232735, PMID 31161706, PMID 31774955, PMID 32203691, PMID 32446674, PMID 32618687, PMID 32913029, PMID 33336359, PMID 33567109, PMID 33625371, PMID 33664203, PMID 33742783, PMID 34032604, PMID 34286464, PMID 34454654, PMID 35067230, PMID 35168989, PMID 35196426, PMID 35217351, PMID 35235003, PMID 35718575, PMID 35748707, PMID 35987977, PMID 36333039, PMID 36533915
2017 (1), 2018 (1), 2019 (1), K02NS096058 (1), K23HL145126 (1), R01HD115574 (1), RC3NS070658 (1), U01NS056975 (1), U01NS088034 (1)