36 completed. 36 Phase 1, 13 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 36 | Completed 36 |
| Phase 2 | 13 | Completed 13 |
Follow Respiratory Insufficiency: new trials by email Literature Review of Respiratory Insufficiency trials Research Report on Respiratory Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ENA-001 for Opioid Induced Respiratory Depression ENA-001, Placebo Comparator - Respiratory Depression | Phase 1 | Completed | Enalare Therapeutics Inc. | 62 | 2025-05-14 | 2026-09-16 |
| Pectointercostal Fascial Plane Block (PIFB) Alone Versus PIFB With Rectus Sheath Block (RSB) in Cardiac Surgery Rectus sheath block with bupivacaine - Coronary Artery Disease, Postoperative Pain | Phase 1 | Completed | Medical College of Wisconsin | 62 | 2023-06-19 | 2025-11-17 |
| Alirocumab in Patients with Sepsis Alirocumab, Placebo - Sepsis | Phase 1 | Completed | Jonathan Sevransky | 50 | 2023-01-04 | 2025-03-24 |
| Effect of Respiratory Muscle Training on Lung Function on Quarry Workers in Minia Government Egypt aerobic exercises with electrical treadmill for 30 min and inspiratory muscle training for 10 minutes., - Lung Function Decreased | Phase 1 | Completed | Deraya University | 40 | 2023-01-02 | 2023-11-07 |
| Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation Placebo and Oxycodone, Paroxetine and Oxycodone, Escitalopram and Oxycodone - Hypercapnia, Ventilatory Depression | Phase 1 | Completed | Food and Drug Administration (FDA) | 27 | 2022-09-01 | 2025-05-22 |
| Contrast Enhanced 3D Echocardiographic Quantification of Right Ventricular Volumes in Repaired CHD Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON] - Tetralogy of Fallot, Pulmonary Insufficiency | Phase 1 / Phase 2 | Completed | Nemours Children's Clinic | 25 | 2022-08-23 | 2026-04-27 |
| CONFOCAL-2 Interventional Pilot Study Autoregulation-based precision blood pressure management - Critical Illness, Respiratory Failure | Phase 1 / Phase 2 | Completed | Queen's University | 16 | 2022-07-29 | 2025-12-22 |
| Study of Epigallocatechin-3-gallate (EGCG) for Supportive and Symptomatic Management in Patients With Esophageal Cancer EGCG - Esophageal Obstruction | Phase 1 | Completed | Shandong Cancer Hospital and Institute | 18 | 2021-08-20 | 2024-04-03 |
| Mesenchymal Stromal Cells for the Treatment of SARS-CoV-2 Induced Acute Respiratory Failure (COVID-19 Disease) Mesenchymal Stromal Cells, Supportive Care - Sars-CoV2, Acute Respiratory Distress Syndrome | Phase 1 / Phase 2 | Completed | Baylor College of Medicine | 28 | 2021-02-12 | 2026-10-21 |
| Use of Angiotensin-(1-7) in COVID-19 Angiotensin-(1-7), Placebo - Infection, Coronavirus, Respiratory Failure | Phase 1 / Phase 2 | Completed | Erasme University Hospital | 112 | 2020-08-05 | 2021-11-09 |
| Clinical Study to Investigate the Effect of the Combination of Psychotropic Drugs and an Opioid on Ventilation Oxycodone and Midazolam, Oxycodone, Paroxetine, and Quetiapine - Hypercapnia, Ventilatory Depression | Phase 1 | Completed | Food and Drug Administration (FDA) | 55 | 2020-06-15 | 2024-05-21 |
| Study of Open Label Losartan in COVID-19 Losartan - COVID-19 | Phase 1 | Completed | University of Kansas Medical Center | 34 | 2020-04-04 | 2024-08-02 |
| Single Dose Crossover Study to Compare the Respiratory Drive After Administration of Belbuca, Oxycodone and Placebo. Belbuca 300 µg, Belbuca 600 µg, Belbuca 900 µg - Respiratory Depression | Phase 1 | Completed | BioDelivery Sciences International | 19 | 2019-07-23 | 2021-02-05 |
| Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression Continuous conversational interaction, Remifentanil infusion - Opioid; Intoxication, Perception Disturbance (Acute), Acute Pain | Phase 1 | Completed | University of California, San Francisco | 20 | 2019-04-30 | 2020-03-10 |
| Andes Virus DNA Vaccine for the Prevention of Hantavirus Pulmonary Syndrome Using the PharmaJet Stratis(R) Needle-Free Injection Delivery Device Andes virus DNA vaccine, Placebo - Hantavirus Pulmonary Infection, Immunisation | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 48 | 2019-02-19 | 2022-11-22 |
| Lung and Diaphragm-Protective Ventilation by Means of Assessing Respiratory Work Lung- and Diaphragm-Protective Ventilation - Diaphragm Injury, Lung Injury | Phase 1 | Completed | University Health Network, Toronto | 23 | 2019-02-01 | 2024-12-10 |
| Predictors of Opioid-Induced Respiratory Depression (OIRD) Remifentanil, Oxygen, Carbon dioxide - Respiratory Depression | Phase 1 | Completed | Duke University | 30 | 2015-04-01 | 2020-03-10 |
| Nebulized Hypertonic Saline for Mechanically Ventilated Children Hypertonic saline (3%), Placebo (0.9% saline) - Respiratory Failure | Phase 1 / Phase 2 | Completed | University Hospitals Cleveland Medical Center | 18 | 2013-10-01 | 2016-06-28 |
| A Comparison of Mometasone Nasal Spray, Nasonex Nasal Spray, Nasonex Nasal Spray Suspension, & Placebo for Treatment of Seasonal Allergies for Safety, Efficacy, & Superiority in 1520 Male & Female Volunteers Mometasone Furoate Monohydrate Nasal Spray, 50 μg/act., Nasonex® Nasal Spray, 50 μg/actuation, Nasonex® Nasal Spray Suspnsn, 50 μg/actuation - Treatment of the Signs and Symptoms of Seasonal Allergic Rhinitis | Phase 1 | Completed | Mylan Pharmaceuticals Inc | 1307 | 2013-09-01 | 2014-04-09 |
| Testing the Feasibility of Patient Controlled Sedation for Ventilated ICU Patients Dexmedetomidine - Acute Respiratory Failure, Anxiety | Phase 1 / Phase 2 | Completed | University of Minnesota | 15 | 2013-03-01 | 2018-03-13 |
Showing 20 of 36. Sign in to see all of them.
Nasal Obstruction (6) · Airway Obstruction (3) · Sneezing (3) · Apnea (2) · COVID-19 (2) · Heart Failure (2) · Hypercapnia (2) · Pain, Postoperative (2) · Pulmonary Atelectasis (2) · Respiratory Aspiration (2) · Rhinitis, Allergic (2) · Rhinitis, Allergic, Seasonal (2) · Acute Pain (1) · Anxiety Disorders (1)
Respiration Disorders (36) · Respiratory Tract Diseases (36) · Pathological Conditions, Signs and Symptoms (18) · Signs and Symptoms (14) · Pathologic Processes (8) · Signs and Symptoms, Respiratory (8) · Infections (7) · Airway Obstruction (6) · Lung Diseases (6) · Neurologic Manifestations (6) · Nose Diseases (6) · Otorhinolaryngologic Diseases (6) · Pain (5) · Cardiovascular Diseases (4)
Oxycodone (3) · Dexmedetomidine (2) · Interactive Ventilatory Support (2) · Paroxetine (2) · Saline Solution (2) · Acetaminophen (1) · Bupivacaine (1) · Buprenorphine (1) · Carbon Dioxide (1) · Diphenhydramine (1) · Escitalopram (1) · Exercise (1) · Influenza Vaccines (1) · Losartan (1) · Midazolam (1)
Food and Drug Administration (FDA) (2) · 5i Sciences, Inc. (1) · Bayer (1) · Baylor College of Medicine (1) · Baylor Research Institute (1) · BioDelivery Sciences International (1) · Deraya University (1) · Drexel University (1) · Duke University (1) · Enalare Therapeutics Inc. (1) · Erasme University Hospital (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Faes Farma, S.A. (1) · Insel Gruppe AG, University Hospital Bern (1) · Johnson & Johnson Consumer and Personal Products Worldwide (1)
United States (22) · Canada (2) · Germany (2) · Australia (1) · Brazil (1) · China (1) · Egypt (1) · France (1) · Ireland (1) · Sweden (1) · Switzerland (1) · United Kingdom (1)
Ana Martins Valle (1) · Anatole D Martin, Ph D, PT (1) · Andrea Gabrielli, MD (1) · Anita K Simonds, MD (1) · Anne Castro (1) · Carlos Sanabria, MD (1) · Craig Weinert, MD (1) · David MacLeod, MB BS (1) · Edward S Schulman, MD (1) · Elisabeth Kruse, PhD (1) · Elosie Harman, MD (1) · Ewan Goligher, MD, PhD (1) · Filippo Annoni (1) · Gunilla Hedlin, Prof. Dr. (1)
PMID 21385346, PMID 22661448, PMID 25212533, PMID 26962013, PMID 27110692, PMID 30850876, PMID 32658300, PMID 32978722, PMID 33651243, PMID 35524938, PMID 36038890, PMID 36219407, PMID 37380156, PMID 39231898, PMID 39986981, PMID 41849255
2009 (2), R21NR012795 (1), R44DA057133 (1)