335 completed, 49 recruiting, 47 unknown, 24 terminated. 319 Not applicable, 69 Phase 2, 29 Phase 1, 25 Phase 3, 24 Phase 4.
Follow Posttraumatic Stress Disorder: new trials by email Literature Review of Posttraumatic Stress Disorder trials Research Report on Posttraumatic Stress Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cognitive Training for Functioning in PTSD COGENT (Cognitive ENhancement Training), ST (Sham Training) - Posttraumatic Stress Disorder | Not applicable | Not yet recruiting | VA Office of Research and Development | 176 | 2027-07-01 | 2026-07-16 |
| Assessing Trauma-related Links Between Affective and Metabolic Systems prazosin - Posttraumatic Stress Disorder, Metabolic Syndrome | Phase 4 | Not yet recruiting | VA Office of Research and Development | 70 | 2027-03-01 | 2026-10-15 |
| CHW-Enhanced Trauma Recovery CHW support - Traumatic Injury, Posttraumatic Stress Disorder | Not applicable | Not yet recruiting | Medical University of South Carolina | 100 | 2027-01-01 | 2026-10-01 |
| Mindful RAVANS Study Cala-RAVANS (Model CR-2), Sham - mTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder | Not applicable | Not yet recruiting | Spaulding Rehabilitation Hospital | 20 | 2026-11-01 | 2026-10-14 |
| Testing a Peer-led Trauma-focused Intervention for Significant Others of Those With BPD Trauma Recovery Program (official title TBD) - Posttraumatic Stress Disorder, Family Members | Phase 1 | Not yet recruiting | York University | 60 | 2026-10-01 | 2026-07-29 |
| Focused Ultrasound for PTSD in Veterans Brainsonix Ultrasound Device - Posttraumatic Stress Disorder | Phase 2 | Recruiting | VA Office of Research and Development | 60 | 2026-09-09 | 2026-09-15 |
| Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP) Ketamine, SmartSleep EEG recording headband - Posttraumatic Stress Disorder | Early Phase 1 | Suspended | University of Wisconsin, Madison | 5 | 2026-09-01 | 2026-03-25 |
| Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (RCT) Personalized Stepped Care Cognitive Behavioral Therapy for Children after Trauma (pSC-CBT-CT), Treatment as Usual (TAU) - Trauma, Posttraumatic Stress Disorder | Not applicable | Not yet recruiting | The University of Texas Health Science Center, Houston | 30 | 2026-09-01 | 2026-02-09 |
| A Randomized Controlled Trial of a Web-Based Moral Elevation Intervention for Veterans With PTSD MOVED, Supportive Care Control - Posttraumatic Stress Disorder | Not applicable | Recruiting | VA Office of Research and Development | 250 | 2026-08-10 | 2026-08-19 |
| The Efficacy of a Pharmacological Treatment (Reboxetine Plus Ritalin) Versus Dog-Assisted Therapy in PTSD methylphenidate (Ritalin®), Reboxetine, Placebo - PTSD, Posttraumatic Stress Disorder | Phase 2 | Recruiting | University of Haifa | 160 | 2026-08-01 | 2026-08-18 |
| Early Intervention to Prevent Development of PTSD in Burn Survivors and Their Caregivers Promotion of Emotional Disclosure for Burns (PoED-B), minimally Enhanced Usual Care control (mEUC) - Posttraumatic Stress Disorder, Burns | Not applicable | Not yet recruiting | University of Southern California | 44 | 2026-08-01 | 2026-06-18 |
| Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (Pilot) Personalized Stepped Care Cognitive Behavioral Therapy for Children after Trauma (pSC-CBT-CT) - Trauma, Posttraumatic Stress Disorder | Not applicable | Not yet recruiting | The University of Texas Health Science Center, Houston | 7 | 2026-04-01 | 2026-02-09 |
| Improving Cognitive Rehabilitation Outcomes CCT+MBLT, CCT+ION - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder | Not applicable | Recruiting | VA Office of Research and Development | 144 | 2026-04-01 | 2026-04-24 |
| Biomolecular Characteristics of Reminder-Focused Positive-Psychiatry Reminder Focused Positive Psychiatry, attentional control condition (group process) - Posttraumatic Stress Disorder | Not applicable | Recruiting | University of California, Los Angeles | 60 | 2026-04-01 | 2026-03-27 |
| Self-Help Cognitive Processing Therapy (CPT)/Women Veterans Network (WoVeN) Study Self-Help Cognitive Processing Therapy, Women Veterans Network (WoVeN), Treatment as Usual - Posttraumatic Stress Disorder, Depression | Not applicable | Recruiting | Boston University | 100 | 2026-03-05 | 2026-05-27 |
| CIH Stepped Care for Co-occurring Chronic Pain and PTSD CIH Stepped Care - Chronic Pain, Posttraumatic Stress Disorder | Not applicable | Recruiting | University of Washington | 60 | 2026-02-18 | 2026-02-27 |
| Prolonged Exposure Therapy to Treat Posttraumatic Stress Disorder in Pregnant Patients Prolonged exposure therapy + incentives for therapy session attendance - Posttraumatic Stress Disorder, Pregnancy | Not applicable | Recruiting | University of Vermont | 30 | 2026-02-05 | 2026-05-13 |
| Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD) Modular Cognitive Processing Therapy, Modular Prolonged Exposure Therapy, Step Down Treatment - Posttraumatic Stress Disorder, PTSD | Not applicable | Recruiting | The University of Texas Health Science Center at San Antonio | 302 | 2025-12-12 | 2025-12-19 |
| Adaptation of Written Exposure Therapy in Substance Treatment Written Exposure Therapy, Treatment as Usual - Posttraumatic Stress Disorder, Substance Use Disorders | Not applicable | Completed | Potomac Health Foundations | 26 | 2025-11-21 | 2026-06-29 |
| Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD) Psilocybin, MDMA - Posttraumatic Stress Disorder | Phase 1 | Recruiting | Johns Hopkins University | 40 | 2025-09-17 | 2026-09-04 |
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Stress Disorders, Post-Traumatic (498) · Depression (78) · Anxiety Disorders (53) · Wounds and Injuries (41) · Substance-Related Disorders (24) · Sleep Initiation and Maintenance Disorders (20) · Brain Injuries, Traumatic (19) · Depressive Disorder, Major (19) · Alcoholism (15) · Panic Disorder (14) · Generalized Anxiety Disorder (12) · Combat Disorders (10) · Obsessive-Compulsive Disorder (9) · Phobia, Social (9) · Stress Disorders, Traumatic (9)
Mental Disorders (495) · Trauma and Stressor Related Disorders (493) · Stress Disorders, Traumatic (489) · Behavior (118) · Behavioral Symptoms (91) · Nervous System Diseases (56) · Chemically-Induced Disorders (43) · Pathological Conditions, Signs and Symptoms (37) · Central Nervous System Diseases (28) · Brain Diseases (27) · Signs and Symptoms (27) · Mood Disorders (26) · Wounds and Injuries (25) · Trauma, Nervous System (24) · Craniocerebral Trauma (23)
Therapeutics (38) · Cognitive Behavioral Therapy (18) · N-Methyl-3,4-methylenedioxyamphetamine (15) · 2-cyclohexylidenhydrazo-4-phenyl-thiazole (7) · Implosive Therapy (7) · Prazosin (7) · Propranolol (7) · Sertraline (7) · Sugars (6) · Ketamine (5) · Mindfulness (5) · Motivational Interviewing (5) · Psychotherapy (5) · Ethanol (4) · Exercise (4)
VA Office of Research and Development (58) · University of Konstanz (14) · Medical University of South Carolina (13) · Resilient Pharmaceuticals (13) · University of Washington (11) · US Department of Veterans Affairs (9) · Duke University (8) · The University of Texas Health Science Center at San Antonio (8) · Weill Medical College of Cornell University (7) · Massachusetts General Hospital (6) · University of Pennsylvania (5) · Yale University (5) · Centre Hospitalier Universitaire Vaudois (4) · Emory University (4) · Research Foundation for Mental Hygiene, Inc. (4)
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Daniel F Gros, PhD MA BS (3) · Douglas Zatzick, MD (3) · James S Gordon, MD (3) · JoAnn Difede, PhD (3) · Lori L Davis, MD (3) · Michael C Mithoefer, MD (3) · Michele Bedard-Gilligan, PhD (3) · Adam P. McGuire, PhD (2) · Alexander Neumeister, MD (2) · Alison A Salloum, PhD (2) · Antje Horsch, DClinPsych (2) · Antje Horsch, PhD (2) · Ariel J Lang, PhD (2) · Avi Avital, PhD (2) · Bessel van der Kolk, M.D. (2)
PMID 31065731, PMID 31572236, PMID 32500209, PMID 37795783, PMID 35141873, PMID 38767196, PMID 32077948, PMID 35901423, PMID 36987703, PMID 40811121, PMID 14629992, PMID 16281252, PMID 16367493, PMID 16551156, PMID 17602023, PMID 17716102, PMID 18373017, PMID 18956449, PMID 19366490, PMID 19434621, PMID 19480669, PMID 19576299, PMID 20122374, PMID 20520307, PMID 20633428, PMID 20643699, PMID 20873910, PMID 21132846, PMID 21208581, PMID 21303552, PMID 21308886, PMID 21344046, PMID 21360528, PMID 21458165, PMID 21720194, PMID 21793047, PMID 21908494, PMID 21912931, PMID 21923756, PMID 21955037, PMID 22040192, PMID 22115887, PMID 22538773, PMID 22549276, PMID 22790114, PMID 23006898, PMID 23118021, PMID 23172889, PMID 23295710, PMID 23376868
2019 (3), 2023 (2), R01AA028776 (2), 1IK2CX000918-01A1 (1), 1IK2CX001397-01A2 (1), 1IK2CX001774-01 (1), 1IK2RX001298-01A2 (1), 1IK2RX002762-01A1 (1), 1IK2RX003520-01A2 (1), 2017 (1), 5KL2TR002387-02 (1), F32AA029865 (1), I01CX000857 (1), I01CX001784 (1), I01RX001783 (1)