93 completed, 32 unknown, 22 recruiting, 15 terminated. 107 Not applicable, 38 Phase 2, 11 Phase 3, 9 Phase 4, 7 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dynamic Treatment Regimes for Opioid Use Disorder Medication for opioid use disorder, psychotherapy - Opioid Use Disorder | Phase 2 | Not yet recruiting | Brigham and Women's Hospital | 75 | 2028-07-01 | 2025-11-04 |
| Reestablishing Normal Gut-brain Interaction in Anorexia Nervose With Normal Gut Microbiota Psychotherapy as usual combined with single dose normal gut microbiota, Psychotherapy treatment as usual (TAU) - Anorexia Nervosa | Phase 1 | Not yet recruiting | Haukeland University Hospital | 36 | 2026-12-01 | 2026-09-24 |
| Augmenting Parent Management Training for Child Temper Outbursts Using a Digital Tool Psychotherapy - Disruptive Behavior Disorders, Conduct Disorder | Recruiting | National Institute of Mental Health (NIMH) | 200 | 2026-10-27 | 2026-10-22 | |
| Psychotherapy for Irritability in Youth: Comparing Active Treatment to Nonactive Psychoeducation Supportive Psychotherapy Psychotherapy - Irritability, Disruptive Mood Dysregulation Disorder | Recruiting | National Institute of Mental Health (NIMH) | 410 | 2026-10-27 | 2026-10-22 | |
| Psilocybin With Psychotherapy for Improving Chronic Pain in Cancer Patients Requiring Opioids Biospecimen Collection, Functional Magnetic Resonance Imaging, Interview - Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm | Phase 2 | Not yet recruiting | Roswell Park Cancer Institute | 20 | 2026-09-15 | 2026-08-12 |
| Sibling Caregiver CMC Pilot Study Mental health assessment and diagnosis, psychotherapy, and treatment - Children With Medical Complexity (CMC), Siblings | Not applicable | Not yet recruiting | The Hospital for Sick Children | 63 | 2026-09-01 | 2026-08-12 |
| Women Who Are Victims of Violence: Treatment of PTSD Through Reactivation of Traumatic Memories Using Propranolol Propranolol, Psychotherapy - Post-Traumatic Stress Disorder, PTSD | Phase 3 | Not yet recruiting | University Hospital, Toulouse | 70 | 2026-09-01 | 2026-08-28 |
| Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic Malignancies Psychotherapy, Psilocybin, Survey Administration - Anxiety, Depression | Phase 2 | Active not recruiting | University of Washington | 18 | 2026-05-19 | 2026-07-31 |
| Modular Intervention for Depression Study Modular Intervention for Depression Therapy (MIND Therapy), Psychotherapy as Usual (TAU) - Major Depression | Not applicable | Recruiting | Pontificia Universidad Catolica de Chile | 150 | 2026-05-01 | 2026-05-12 |
| CARED : A Novel Rapid Treatment Paradigm for Depression Intermittent Theta Burst Stimulation (iTBS), Transcranial Alternating Current Stimulation (tACS), Psychotherapy - Major Depressive Disorder | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 30 | 2026-04-14 | 2026-06-25 |
| Healing ALS Registry Observational Study (HAROS) Education about treatment options, Dietary Supplements: Vitamins, Minerals, Herbs, etc., Meditation, Prayer, Talk Therapy, Affirmations, Journaling, etc. - Amyotrophic Lateral Sclerosis (ALS), Motor Neuron Disease (MND) | Recruiting | Healing Advocates Registry and Ministry | 1000 | 2026-01-26 | 2026-06-24 | |
| Ketamine-Enhanced Therapy for Individuals With Alcohol Use Disorder and Depression: A Pilot Study (KET-DUAL) Ketamine, Cognitive Behavioural Therapy - Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD) | Phase 1 / Phase 2 | Not yet recruiting | South West Sydney Local Health District | 20 | 2025-12-10 | 2025-11-25 |
| Does Psychotherapy Change the Gut Microbiome in Women of Child-bearing Age? Psychotherapy - Chronic Stress | Not applicable | Active not recruiting | University of Nebraska | 30 | 2025-12-01 | 2026-10-05 |
| Development And Evaluation of An Adaptive Web-Based Intervention for COPD Tiered whole health support for people living with COPD - COPD (Chronic Obstructive Pulmonary Disease) | Not applicable | Not yet recruiting | University of Colorado, Denver | 60 | 2025-12-01 | 2025-05-08 |
| Impact of Therapeutic Exercise Integrated With Psychotherapy and Education in Patients With Depression Psychotherapy, Graded activity combined with exercise and education - Depression Disorder | Not applicable | Not yet recruiting | MarcoMateoRiera | 112 | 2025-12-01 | 2025-11-28 |
| Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression Psychotherapy - Depression - Major Depressive Disorder, Childhood Traumas | Not applicable | Recruiting | St. Joseph's Healthcare Hamilton | 50 | 2025-10-25 | 2026-07-14 |
| Disposition Kinetics of Dolutegravir Among People Living With HIV With Major Depression in Nigeria Fluoxetine, Cognitive-behavioral therapy - Depression, HIV | Phase 4 | Not yet recruiting | University of Ibadan | 168 | 2025-08-14 | 2025-08-08 |
| MDMA-Assisted Psychotherapy for Treatment Resistant PTSD in Adolescents MDMA, Psychotherapy - PTSD, Post Traumatic Stress Disorder, Adolescents | Phase 2 | Withdrawn | University of California, Los Angeles | 2025-07-01 | 2025-04-10 | |
| Τhe Combination of Pharmacotherapy With RECOVERYTRSGR and RECOVERYTRSBDGR. Group A: (Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol,anxiolytics: clonazepam, stedon, tavor antidepressants: seropram),, Group B (Pharmacotherapy and TAU) (Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol, clonazepam, stedon, tavor, antidepressants,, Group C (Pharmacotherapy and Psychotherapy) Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol, clonazepam, stedon, tavor, lithium, depakine - Treatment Resistant Schizophrenia, Treatment Resistant Bipolar Disorder | Phase 4 | Active not recruiting | Dr. Stavroula Rakitzi | 84 | 2025-06-04 | 2026-05-01 |
| Dose Optimization of MDMA-Assisted Therapy for PTSD Midomafetamine, Psychotherapy - Posttraumatic Stress Disorder | Phase 2 | Recruiting | Bronx VA Medical Center | 60 | 2025-06-03 | 2026-10-08 |
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Depression (40) · Stress Disorders, Post-Traumatic (23) · Anxiety Disorders (19) · Depressive Disorder, Major (18) · Mental Disorders (11) · Obsessive-Compulsive Disorder (10) · Depressive Disorder (6) · Emotional Regulation (6) · Bipolar Disorder (5) · Anorexia Nervosa (4) · Chronic Pain (4) · Fibromyalgia (4) · Behavior (3) · Binge-Eating Disorder (3) · Generalized Anxiety Disorder (3)
Modum Bad (5) · Resilient Pharmaceuticals (5) · New York State Psychiatric Institute (4) · Emory University (3) · NYU Langone Health (3) · National Institute of Mental Health (NIMH) (3) · Ohio State University (3) · University Hospital Heidelberg (3) · University of California, Los Angeles (3) · Brigham and Women's Hospital (2) · Cybin IRL Limited (2) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (2) · Hannover Medical School (2) · Haukeland University Hospital (2) · Icahn School of Medicine at Mount Sinai (2)
United States (75) · Canada (12) · Norway (10) · Germany (9) · France (7) · Israel (7) · China (6) · Spain (6) · Brazil (5) · Denmark (4) · Italy (4) · United Kingdom (4) · Pakistan (3) · Switzerland (3) · Chile (2)
Antoni Font Guiteras, PhD (2) · Esther Margarit de Miguel, Msc (2) · Melissa A Brotman, Ph.D. (2) · Ulrike Dinger-Ehrenthal, Prof. Dr. (2) · Aage Indahl, Prof.Dr (1) · Alan J Budney, Ph.D. (1) · Alan Schatzberg, MD (1) · Ali J. Zarrabi, MD (1) · Amir Inamdar, MBBS, DNB, MFPM (1) · Amir Inamdar, MBBS,DNB,MFPM (1) · Amy Lehrner, PhD (1) · Anna E Odom, Ph.D. (1) · Anna Van Meter, PhD (1) · Anne M Myhre, MD Phd (1)
PMID 31065731, PMID 31572236, PMID 32500209, PMID 33884617, PMID 13688369, PMID 1438661, PMID 14639062, PMID 15315995, PMID 15608541, PMID 17135984, PMID 17135985, PMID 17135986, PMID 17135987, PMID 17135988, PMID 17135989, PMID 17450048, PMID 17907854, PMID 17909125, PMID 18030086, PMID 18164940, PMID 18291293, PMID 18391133, PMID 18974308, PMID 19465880, PMID 19723787, PMID 19877976, PMID 20215935, PMID 20396993, PMID 21041614, PMID 21674151, PMID 21865014, PMID 21943381, PMID 22065252, PMID 22116638, PMID 22123153, PMID 22273276, PMID 22401479, PMID 23132334, PMID 23357439, PMID 23357440, PMID 23588951, PMID 23594060, PMID 23656847, PMID 23760393, PMID 23809145, PMID 23971683, PMID 24239154, PMID 24337537, PMID 24462230, PMID 24550805
2016 (1), 2019 (1), 2025 (1), 2KL2TR001870 (1), K01DA061975 (1), K24MH122514 (1), K43TW011995 (1), P30CA138292 (1), R01CA085566 (1), R01DA023526 (1), R01DK025568 (1), R01MH069867 (1), R01MH069915 (1), R01MH073719 (1), R01MH081864 (1)