1199 completed, 330 unknown, 184 not yet recruiting, 176 recruiting. 1119 Not applicable, 387 Phase 4, 144 Phase 2, 144 Phase 3, 40 Phase 1.
Follow Postoperative Pain: new trials by email Literature Review of Postoperative Pain trials Research Report on Postoperative Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Postoperative Analgesia Using Ganglion Impar Block After Anal Surgery Ganglion impar block with Bupivacaine., Ganglion impar block with normal saline - Postoperative Pain | Not applicable | Not yet recruiting | University of Alexandria | 60 | 2028-07-01 | 2025-04-03 |
| Psilocybin After Trauma Surgery for Pain Psilocybin (Usona Institute), Postoperative analgesia - Pain Management, Postoperative Pain | Phase 1 | Not yet recruiting | Trent Emerick | 70 | 2027-12-31 | 2026-08-06 |
| ESP Blocks for Posterior Spinal Fusion ESP Block with Bupivacaine, ESP Block with Bupivacaine + Liposomal Bupivacaine - Postoperative Pain | Phase 4 | Not yet recruiting | Duke University | 75 | 2027-10-01 | 2026-08-27 |
| Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery Suzetrigine, Acetaminophen Plus Ibuprofen - Postoperative Pain, Acute Pain | Phase 4 | Not yet recruiting | University of Minnesota | 230 | 2027-04-01 | 2026-09-25 |
| Phase 3 Bunionectomy Study CPL-01, saline placebo - Postoperative Pain, Bunion | Phase 3 | Not yet recruiting | Cali Pharmaceuticals LLC | 112 | 2027-03-01 | 2026-10-21 |
| Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures Vibration tool - Distal Radius Fracture, Radius Fracture Distal | Not applicable | Not yet recruiting | Northwestern University | 100 | 2027-01-01 | 2026-07-10 |
| Evaluation of the Efficacy of Sublingual Sufentanil (Prescribed as Rescue Analgesia for Acute Postoperative Pain) on the Quality of Health Recovery After Surgery: a Randomized, Controlled, Multicenter, Open-label Trial Against an Active Comparator (SUBLIME) Sublingual sufentanil 30 µg (one dose per hour, as needed), Morphine sulfate (10 mg every 4 hours as needed) - Postoperative Pain | Phase 4 | Not yet recruiting | University Hospital, Strasbourg, France | 1150 | 2027-01-01 | 2026-06-03 |
| A Predictive Model for Postoperative Analgesic Requirements After Abdominal Surgery Intravenous Morphine Patient-Controlled Analgesia - Postoperative Pain, Postoperative Analgesia | Not yet recruiting | Chaw Sook Hui | 65 | 2027-01-01 | 2026-09-03 | |
| Study of QL Analgesic Response and Extent Quadratus Lumborum with 1.5% Lidocaine - Acute Pain, Postoperative Pain | Phase 4 | Not yet recruiting | Duke University | 25 | 2027-01-01 | 2026-07-08 |
| Relaxation Exercise Interventions for Individuals Who Have Undergone Urinary Tract Stone Surgery Benson Relaxation Exercise Group, Jacobson Relaxation Exercise Group - Urinary Tract Stone Surgery, Relaxation Exercise | Not applicable | Not yet recruiting | Ondokuz Mayıs University | 120 | 2027-01-01 | 2026-10-14 |
| Postsurgical Pain and Opioid Use in Older Adults: Effects of Mild Cognitive Impairment Mild Cognitive Impairment (MCI), Opioid Use | Not yet recruiting | Miklos Kertai | 552 | 2027-01-01 | 2026-10-21 | |
| Intertransverse Process Block Versus Subcostal Transversus Abdominis Plane Block After Laparoscopic Sleeve Gastrectomy Intertransverse Process Block, The Subcostal Transversus Abdominis Plane Block (TAPB) - Intertransverse Process Block, Subcostal Transverse Abdominis Plane Block | Not applicable | Not yet recruiting | Antalya City Hospital | 60 | 2026-12-30 | 2026-05-15 |
| Intertransverse Process Block Versus External Oblique Intercostal Plane Block After Laparoscopic Sleeve Gastrectomy Intertransverse Process Block, External Oblique Intercostal Plane Block - Intertransverse Process Block, External Oblique Intercostal Plane Block | Not applicable | Not yet recruiting | Antalya City Hospital | 60 | 2026-12-15 | 2026-05-15 |
| SPIP vs ESP Block in Cardiac Surgery Bilateral Superficial Parasternal Intercostal Plane Block, Bilateral Erector Spinae Plane Block, morphine PCA - Cardiac Surgery, Chronic Postsurgical Pain | Not applicable | Not yet recruiting | Ondokuz Mayıs University | 308 | 2026-12-01 | 2026-10-21 |
| Comparison of Serratus Posterior Superior Intercostal Plane Block and Deep Serratus Anterior Plane Block After Video-Assisted Thoracoscopic Surgery Serratus Posterior Superior Intercostal Plane (SPSIP) block, Deep Serratus Anterior Plane Block (Deep SAP) - Postoperative Pain, Video Assisted Thoracic Surgery (VATS) | Not applicable | Not yet recruiting | Antalya City Hospital | 60 | 2026-11-30 | 2026-05-11 |
| Transversalis Fascia Plane Block Versus M-TAPA Block After Laparoscopic Inguinal Hernia Repair Transversalis Fascia Plane Block, M TAPA block - Transversalis Fascia Plane Block, Mtapa Block | Not applicable | Not yet recruiting | Antalya City Hospital | 60 | 2026-11-30 | 2026-06-01 |
| Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Hysterectomy Intertransverse Process Block, M-TAPA Block - Intertransverse Process Block, Mtapa Block | Not applicable | Not yet recruiting | Antalya City Hospital | 60 | 2026-11-18 | 2026-05-20 |
| Intertransverse Process Block Versus M-TAPA Block After Laparoscopic Cholecystectomy Intertransverse Process Block, M-TAPA Block - Intertransverse Process Block, Mtapa Block | Not applicable | Not yet recruiting | Antalya City Hospital | 60 | 2026-11-15 | 2026-06-16 |
| SPSIP vs ESP Block for Analgesia After Rib Fracture Surgery Erector Spinae Plane Block (ESP), Serratus Posterior Superior Intercostal Plane (SPSIP) - Rib Fracture, Postoperative Pain | Not applicable | Not yet recruiting | Antalya City Hospital | 60 | 2026-11-15 | 2026-05-11 |
| Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery Suzetrigine, Opioid Analgesics (Tramadol or Oxycodone), Scheduled Acetaminophen and Ibuprofen - Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI) | Phase 4 | Not yet recruiting | University of California, Los Angeles | 120 | 2026-11-01 | 2026-09-15 |
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Pain, Postoperative (2041) · Agnosia (186) · Pain (152) · Postoperative Nausea and Vomiting (78) · Acute Pain (61) · Postoperative Complications (49) · Anxiety Disorders (38) · Hernia, Inguinal (35) · Breast Neoplasms (30) · Chronic Pain (30) · Neuralgia (16) · Patient Satisfaction (16) · Shoulder Pain (16) · Emergence Delirium (15) · Hip Fractures (15)
Pathological Conditions, Signs and Symptoms (2041) · Neurologic Manifestations (2040) · Pathologic Processes (2040) · Signs and Symptoms (2040) · Postoperative Complications (1992) · Pain (1889) · Nervous System Diseases (268) · Neurobehavioral Manifestations (206) · Perceptual Disorders (188) · Signs and Symptoms, Digestive (91) · Mental Disorders (86) · Musculoskeletal Diseases (79) · Nausea (76) · Vomiting (76) · Wounds and Injuries (72)
Bupivacaine (191) · Ropivacaine (97) · Sodium Chloride (97) · Acetaminophen (78) · Saline Solution (76) · Dexamethasone (70) · Dexmedetomidine (57) · Lidocaine (54) · Morphine (53) · Ketamine (46) · Tramadol (35) · Fentanyl (33) · Ibuprofen (33) · Dental Occlusion (31) · Magnesium Sulfate (28)
Assiut University (66) · Cairo University (54) · Ain Shams University (30) · Kocaeli University (21) · Cukurova University (19) · Tanta University (17) · Seoul National University Hospital (15) · Pacira Pharmaceuticals, Inc (14) · Ondokuz Mayıs University (13) · TC Erciyes University (12) · Ataturk University (11) · Aydin Adnan Menderes University (11) · Heron Therapeutics (11) · Ankara City Hospital Bilkent (10) · Antalya City Hospital (10)
Turkey (Türkiye) (496) · United States (319) · Egypt (227) · China (93) · Denmark (69) · Canada (48) · South Korea (43) · Italy (38) · France (32) · Pakistan (32) · Greece (30) · Brazil (28) · Spain (26) · Belgium (24) · Thailand (23)
XiaoFeng Shen, MD (5) · Arzu Karaveli (4) · David Prior (4) · Ebru Biricik (4) · Guolin Wang, MD (4) · Hala S Abdel-Ghaffar, MD (4) · Musa Zengin, MD (4) · Stanley SC Wong, MBBS (4) · Brian M Ilfeld, M.D., M.S. (3) · Dmitri Lissin, MD (3) · Erol Onel, MD (3) · Fatma Acil, M.D. (3) · Giuseppe Pascarella, MD (3)
PMID 26225500, PMID 22900785, PMID 30063657, PMID 11756886, PMID 23471754, PMID 24012235, PMID 24535604, PMID 25032676, PMID 27501016, PMID 32871021, PMID 10486687, PMID 10794256, PMID 12355695, PMID 12567343, PMID 14984863, PMID 16703549, PMID 17678782, PMID 19606021, PMID 19819416, PMID 20071021, PMID 21519308, PMID 22412772, PMID 22510183, PMID 22792007, PMID 23121612, PMID 24216403, PMID 24322571, PMID 24404359, PMID 24445643, PMID 25500688, PMID 25582785, PMID 25774458, PMID 26397443, PMID 28030701, PMID 28759502, PMID 28802593, PMID 29670771, PMID 31145215, PMID 31663286, PMID 33082286, PMID 34196965, PMID 34284613, PMID 34290085, PMID 34559941, PMID 35143011, PMID 35422388, PMID 38148266, PMID 38537393, PMID 10467917, PMID 10551571
2014 (5), 2017 (4), 2019 (4), 2005 (3), 2018 (3), 2008 (2), R01HD089458 (2), 2009 (1), 2016 (1), 2023 (1), 2025 (1), P01HD033988 (1), R01AG098934 (1), R21AT004708 (1), R44DA049640 (1)