9 completed, 5 recruiting, 3 terminated, 1 active not recruiting. 20 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 20 | Completed 9, Recruiting 5, Terminated 3, Active not recruiting 1, Unknown 1, Withdrawn 1 |
| Phase 1 | 2 | Completed 1, Terminated 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Post-Concussion Syndrome: new trials by email Literature Review of Post-Concussion Syndrome trials Research Report on Post-Concussion Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 34 | 2026-10-01 | 2026-09-30 |
| HBOT Effects on First Responders' Cognition and Well-Being Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 54 | 2026-09-11 | 2026-10-01 |
| Long-Term Outcomes Following HBOT Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, Post-Concussive Symptoms | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 35 | 2026-06-18 | 2026-07-28 |
| Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy Hyperbaric Oxygen Therapy - TBI Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 54 | 2025-10-01 | 2025-10-09 |
| Personalized Brain Stimulation to Treat Chronic Concussive Symptoms Active cTBS, Inactive/Sham cTBS, Imaginal exposure - Post-Concussion Syndrome, Concussion, Brain | Phase 2 | Recruiting | University of California, Los Angeles | 75 | 2024-03-06 | 2026-02-24 |
| Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms Hyperbaric oxygen at 1.5 ATA, Sham treatment - Persistent Post-concussive Syndrome, Concussion Post Syndrome | Phase 2 | Completed | Essentia Health | 20 | 2022-06-28 | 2026-10-15 |
| Efficacy and Tolerability of Erenumab in the Prophylactic Treatment of Persistent Post-Traumatic Headache AMG 334 - Post-Traumatic Headache, Mild Traumatic Brain Injury | Phase 2 | Completed | Danish Headache Center | 100 | 2019-04-05 | 2020-02-10 |
| Sildenafil Treatment for Mild TBI Sildenafil Citrate, Placebo oral capsule - Vascular System Injuries, Concussion, Brain | Phase 2 | Terminated | University of Texas Southwestern Medical Center | 22 | 2018-07-25 | 2020-11-19 |
| Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury Hyperbaric Oxygen, Minimal pressure air - Brain Injury, Chronic | Phase 2 | Completed | Lindell Weaver | 49 | 2017-09-06 | 2022-08-04 |
| Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin prazosin hydrochloride, placebo - Posttraumatic Headache, Combat Disorders | Phase 1 / Phase 2 | Completed | VA Office of Research and Development | 89 | 2016-01-04 | 2026-03-30 |
| Ibuprofen Versus Acetaminophen for Treatment of Mild Traumatic Brain Injury Ibuprofen, Acetaminophen - Brain Concussion | Phase 2 | Withdrawn | Northwestern University | 2015-05-01 | 2020-11-13 | |
| Brain Stimulation for Mild Traumatic Brain Injury Frontal Stimulation, Temporal Stimulation, Sham Stimulation - Traumatic Brain Injury, Post-Concussion Symptoms | Phase 2 | Active not recruiting | University of Sao Paulo General Hospital | 20 | 2014-10-01 | 2024-01-30 |
| PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin Melatonin, Sugar pill - Post-concussion Syndrome, Post-concussive Symptoms | Phase 2 / Phase 3 | Unknown | University of Calgary | 99 | 2013-09-01 | 2017-04-18 |
| Sildenafil for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury. Sildenafil - Traumatic Brain Injury, Post-concussive Syndrome | Phase 2 | Completed | Uniformed Services University of the Health Sciences | 59 | 2013-01-01 | 2016-01-01 |
| mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms Hyperbaric oxygen (HBO2) at 1.5 atms, Sham control 1.2 atms - Traumatic Brain Injury With Brief Loss of Consciousness, Post-Concussion Syndrome | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 71 | 2012-09-11 | 2018-11-21 |
| Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI) hyperbaric oxygen, sham hyperbaric air - Post-concussive Symptoms, Traumatic Brain Injury | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 79 | 2011-02-01 | 2014-09-05 |
| Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI) Hyperbaric Oxygen Therapy - Mild Traumatic Brain Injury, Post-Concussive Syndrome | Phase 2 | Completed | Virginia Commonwealth University | 60 | 2010-06-01 | 2013-08-27 |
| Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol Atorvastatin, Placebo - Traumatic Brain Injury, Post-traumatic Stress Disorder | Phase 2 | Terminated | Baylor College of Medicine | 52 | 2010-02-01 | 2017-01-09 |
| An Intervention Program to Reduce to the Risk of Persistent Symptoms After Concussion Treatment as usual, Cognitive-behavioural therapy - Mild Traumatic Brain Injury | Phase 2 | Completed | University of British Columbia | 28 | 2009-06-01 | 2018-11-06 |
| Evaluation of Two Treatments for Chronic Post Concussion Syndrome Psychoeducation, Relaxation Training, Interoceptive Exposure - Post Concussion Syndrome, Head Injury | Phase 1 / Phase 2 | Terminated | Simon Fraser University | 10 | 2008-04-01 | 2014-01-22 |
Brain Injuries, Traumatic (11) · Brain Concussion (10) · Stress Disorders, Post-Traumatic (6) · Combat Disorders (3) · Headache (3) · Anxiety Disorders (2) · Craniocerebral Trauma (2) · Depression (2) · Post-Traumatic Headache (2) · Autonomic Nervous System Diseases (1) · Brain Injuries (1) · Brain Injury, Chronic (1) · Charcot-Marie-Tooth disease, Type 1F (1) · Dizziness (1)
Head Injuries, Closed (20) · Nervous System Diseases (20) · Trauma, Nervous System (20) · Wounds and Injuries (20) · Wounds, Nonpenetrating (20) · Brain Diseases (18) · Central Nervous System Diseases (18) · Craniocerebral Trauma (18) · Brain Injuries (17) · Brain Concussion (10) · Mental Disorders (8) · Stress Disorders, Traumatic (8) · Trauma and Stressor Related Disorders (8) · Brain Injuries, Traumatic (6) · Pathological Conditions, Signs and Symptoms (5)
Hyperbaric Oxygenation (7) · Sildenafil Citrate (2) · Acetaminophen (1) · Atorvastatin (1) · Cognitive Behavioral Therapy (1) · Ibuprofen (1) · Implosive Therapy (1) · Melatonin (1) · Oxyhemoglobins (1) · Prazosin (1) · Relaxation Therapy (1) · Sugars (1) · Therapeutics (1) · erenumab (1)
Summit Hyperbarics and Wellness (4) · U.S. Army Medical Research and Development Command (2) · Baylor College of Medicine (1) · Danish Headache Center (1) · Essentia Health (1) · Lindell Weaver (1) · Northwestern University (1) · Simon Fraser University (1) · Uniformed Services University of the Health Sciences (1) · University of British Columbia (1) · University of Calgary (1) · University of California, Los Angeles (1) · University of Sao Paulo General Hospital (1) · University of Texas Southwestern Medical Center (1) · VA Office of Research and Development (1)
United States (15) · Canada (3) · Brazil (1) · Denmark (1)
Steve Wyman, MD (2) · Alex P Chapman, Ph.D. (1) · Alice Rose (1) · Allen E Thornton, Ph.D. (1) · Allen Thornton (1) · Brad Hallam (1) · Brett Hart, MD (1) · Claudia S Robertson, MD (1) · Cynthia L Mayer, DO (1) · David Cox, Ph.D. (1) · David X Cifu, MD (1) · Demetrios N. Kyriacou, MD,PhD (1) · Eric Wassermann, MD (1) · Heather Underwood (1) · Justin O Alicea (1)
PMID 31394602, PMID 31394603, PMID 25401463, PMID 28006970, PMID 28512443, PMID 28768069, PMID 28768070, PMID 28768071, PMID 28768072, PMID 28768073, PMID 28768075, PMID 28771392, PMID 29734566, PMID 30098189, PMID 30099354, PMID 31394600, PMID 31394601, PMID 32217739, PMID 32493206, PMID 32772826, PMID 34873185
1IK2RX001136-01A2 (1), 2018 (1)