21 completed, 9 recruiting, 9 unknown, 2 not yet recruiting. 16 Not applicable, 7 Phase 2, 4 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 16 | Completed 5, Recruiting 5, Unknown 5, Terminated 1 |
| Phase 2 | 7 | Completed 5, Unknown 2 |
| Phase 1 | 4 | Completed 3, Unknown 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Brain Injury, Chronic: new trials by email Literature Review of Brain Injury, Chronic trials Research Report on Brain Injury, Chronic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury MUSE Stem Cell Therapy - Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients | Not yet recruiting | Healing Hope International | 10 | 2028-01-01 | 2026-03-10 | |
| Scale-Up Evaluation Trial of the Diabetes Prevention Program to Improve Obesity and Cardiometabolic Health After Traumatic Brain Injury Group Lifestyle Balance for People with TBI (GLB-TBI) - Traumatic Brain Injury, Brain Injuries, Traumatic | Not yet recruiting | Baylor Research Institute | 70 | 2026-08-15 | 2026-06-16 | |
| SPIRIT Club Chronic Brain Injury Exercise Platform SPIRIT Club CBI Pathway - Chronic Brain Injury | Not applicable | Recruiting | Ohio State University | 60 | 2025-11-11 | 2026-08-04 |
| Cerebral and Cognitive Impact of Female Professional SoccerPractice Cerebral MRI - Traumatic Chronic Encephalopathy | Not applicable | Recruiting | University Hospital, Strasbourg, France | 80 | 2025-09-13 | 2026-08-20 |
| Visualizing Brain Proteinopathies Using [F-18]Flornaptitril-PET in the Prediction of Clinical Progression of Mild Cognitive Impairment With Either Suspected Chronic Traumatic Encephalopathy or Alzheimer's Disease [F-18]Flornaptitril - Alzheimer Disease, Chronic Traumatic Encephalopathy | Phase 3 | Recruiting | CereMark Pharma, LLC | 230 | 2025-07-01 | 2025-07-30 |
| The DIAGNOSE CTE Research Project-II Chronic Traumatic Encephalopathy (CTE), Alzheimer Disease | Enrolling by invitation | Boston University | 350 | 2025-04-09 | 2026-06-02 | |
| Pilot Study Evaluating brainQuant's Ability to Detect Alterations in White Matter in Diffusion MRI, Indicative of Post-traumatic Lesions Chronic Traumatic Encephalopathy | Recruiting | University Hospital, Strasbourg, France | 80 | 2024-09-10 | 2025-12-24 | |
| Heading in Football: Impact on Neural Blood Biomarkers Head impact exposure - Head Injury, Minor, Concussion, Mild | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 335 | 2024-08-13 | 2025-05-13 | |
| The (Cost)Effectiveness of a Social Robot for Persons With Problems in Daily Structure and Planning in Disability Care Robot Tessa - Brain Injury, Chronic, Intellectual Disability, Mild to Moderate | Not applicable | Completed | Academy Het Dorp | 32 | 2023-11-29 | 2026-07-02 |
| Tau And Connectomics In TES Study [18F] PI-2620 Tau Ligand - Chronic Traumatic Encephalopathy, Traumatic Encephalopathy | Phase 1 | Unknown | Macquarie University, Australia | 12 | 2023-02-03 | 2024-02-28 |
| Cerebral and Cognitive Impact of Professional Soccer Practice MRI - Traumatic Chronic Encephalopathy | Not applicable | Recruiting | University Hospital, Strasbourg, France | 80 | 2022-01-07 | 2025-08-08 |
| Automated Stereognosis to Treat Loss of Tactile Function After Brain Injury ReTrieve Automated Stereognosis System - Stroke, Chronic Brain Injury | Not applicable | Terminated | The University of Texas at Dallas | 3 | 2021-11-15 | 2023-03-06 |
| Qualitative Study Patient & Physician Experiences Botox COVID-19 Chronic Brain Injury, Cerebral Stroke | Completed | East Kent Hospitals University NHS Foundation Trust | 11 | 2021-10-08 | 2022-06-28 | |
| Long-term Follow-up in Severe Traumatic Brain Injury Magnetic Resonance Imaging (MRI) (including functional MRI), Blood sampling (serum/plasma preparation), Cerebrospinal fluid (CSF) - Traumatic Brain Injury, Neurodegenerative Diseases | Unknown | Karolinska University Hospital | 100 | 2021-10-01 | 2022-02-11 | |
| Traumatic Brain Injury and the Gut Microbiome Inulin fructooligosaccharide - Brain Injury, Chronic, Brain Injuries, Traumatic | Not applicable | Completed | Centre for Neuro Skills | 23 | 2021-07-28 | 2022-07-20 |
| Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD) No Intervention is used for this study but all subjects will be asked to complete electroencephalogram (EEG) testing and an MRI scan., No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure. - Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury | Recruiting | VA Office of Research and Development | 800 | 2021-07-01 | 2026-09-01 | |
| The Child in Context Intervention Study Family centered in-home rehabilitation, Control - Rehabilitation, Brain Injuries | Not applicable | Completed | Sunnaas Rehabilitation Hospital | 58 | 2021-05-10 | 2023-12-13 |
| FDDNP Protocol for Visualizing Brain Proteinopathies to Assist in the Diagnosis of Persons With Suspected CTE and AD [F-18]FDDNP-PET - Suspected Chronic Traumatic Encephalopathy (CTE) or Traumatic Encephalopathy Syndrome (TES), Suspected Alzheimer's Disease (AD) | Withdrawn | University of California, Los Angeles | 2021-05-01 | 2021-05-06 | ||
| Cohort Study of Blood Biomarkers for TES Blood tests, Cognitive function tests, head MRI (plain scan and DTI sequence) examination and head PET (FDG-PET, Tau-PET and Amyloid-PET) examination - Chronic Traumatic Encephalopathy, Traumatic Encephalopathy, Chronic | Completed | Tianjin Medical University | 120 | 2021-05-01 | 2026-01-12 | |
| Cross-cultural Adaptation to the Spanish Population and Validation of the Community Balance & Mobility Scale (S-CB&M) Brain Injury, Chronic | Completed | University of Castilla-La Mancha | 100 | 2021-02-09 | 2022-11-04 |
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Chronic Traumatic Encephalopathy (26) · Brain Injuries, Traumatic (22) · Alzheimer Disease (8) · Brain Injuries (8) · Cognitive Dysfunction (6) · Brain Concussion (5) · Neurodegenerative Diseases (4) · Stroke (4) · Dementia (3) · Multiple Sclerosis (3) · Nerve Degeneration (3) · Parkinson Disease (3) · Pick Disease of the Brain (3) · Stress Disorders, Post-Traumatic (3)
Brain Damage, Chronic (45) · Chronic Disease (45) · Disease Attributes (45) · Pathologic Processes (45) · Pathological Conditions, Signs and Symptoms (45) · Trauma, Nervous System (45) · Wounds and Injuries (45) · Central Nervous System Diseases (44) · Nervous System Diseases (44) · Brain Diseases (43) · Craniocerebral Trauma (43) · Brain Injuries (37) · Neurodegenerative Diseases (22) · Mental Disorders (17)
7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (4) · florbetapir (4) · Hyperbaric Oxygenation (2) · Magnetic Resonance Imaging (2) · Blood Specimen Collection (1) · Capsules (1) · Cerebrospinal Fluid Pressure (1) · Cognitive Training (1) · Diffusion Tensor Imaging (1) · Electroencephalography (1) · Exercise (1) · Fish Oils (1) · Genetic Testing (1) · Hematologic Tests (1) · Magnetic Resonance Spectroscopy (1)
University Hospital, Strasbourg, France (3) · Boston University (2) · MD Stem Cells (2) · University of California, Los Angeles (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Academy Het Dorp (1) · Avid Radiopharmaceuticals (1) · Baylor Research Institute (1) · Brent Masel (1) · Brigham and Women's Hospital (1) · Center for Vision Development, New Market, Maryland (1) · Centre for Neuro Skills (1) · CereMark Pharma, LLC (1) · East Kent Hospitals University NHS Foundation Trust (1) · First Affiliated Hospital Xi'an Jiaotong University (1)
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Jeffrey Weiss, MD (2) · Steven Levy, MD (2) · Alexander A Ostanin, MD, PhD (1) · Asaf Gilboa, PhD (1) · Brent E Masel, MD (1) · Brent Masel, MD (1) · Brigitte JF Boon, Prof. Dr. (1) · Chad Yucus, MD (1) · Charles H Tator, M.D (1) · Cristina Lirio-Romero, PhD (1) · Danna Jennings, MD (1) · Dara Dickstein, PhD (1) · Dr. Lambert Abeyatunge, MD: Regenerative Medicine (1)
PMID 23343487, PMID 25848027, PMID 29136240, PMID 30040711, PMID 30969506, PMID 31559169, PMID 33574141, PMID 34384490, PMID 35193666, PMID 36188406, PMID 36351716, PMID 37798671, PMID 38134231, PMID 39283234, PMID 39311542, PMID 42168942
R01NS139383 (1), R44HD112248 (1), U01NS093334 (1)