30 completed, 6 unknown, 5 not yet recruiting, 2 recruiting. 27 Not applicable, 7 Phase 3, 4 Phase 4, 3 Phase 1.
Follow Toothpastes: new trials by email Literature Review of Toothpastes trials Research Report on Toothpastes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness of Toothpaste Tablets on Plaque, Gingival Health and Caries Experiences Toothpaste Tablet, Conventional Toothpaste - Gingival Inflammation, Dental Caries | Phase 3 | Not yet recruiting | Loma Linda University | 50 | 2026-12-01 | 2026-07-10 |
| Enamel Lesion Detection With New DX Tool BlueCheck, Prevident 5000ppm Booster Plus Toothpaste - Enamel Lesions, Caries | Phase 4 | Not yet recruiting | Colgate Palmolive | 5 | 2026-09-15 | 2026-09-14 |
| Effects of Using Miswak in Addition to Oral Hygiene Products in Patients With Gingivitis Miswak, Toothpaste - Gingivitis; Chronic | Not yet recruiting | Mustafa Kemal University | 36 | 2026-07-04 | 2026-07-08 | |
| Bio-Descaling Toothpaste for Dental Calculus Reduction Bio-Descaling Powder (BDP) Toothpaste, Placebo toothpaste - Dental Calculus, Gingivitis and Periodontal Diseases | Not applicable | Not yet recruiting | Universidad Complutense de Madrid | 100 | 2026-07-01 | 2026-07-08 |
| Study to Investigate Toothpaste on Antibacterial Effects in the Different Regions of the Mouth stannous fluoride toothpaste, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste - Plaque, Gingivitis | Phase 3 | Completed | Colgate Palmolive | 95 | 2026-05-18 | 2026-09-24 |
| The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Sensitive Whitening Toothpaste, Containing 5% KNO3 (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains Over 4 Weeks of Unsupervised Use. Toothpaste - Teeth Staining | Not applicable | Completed | Boka LLC | 100 | 2026-05-11 | 2026-08-13 |
| Real-World Study of a Calcium Sodium Phosphosilicate Anti-Sensitivity Toothpaste for Dentin Hypersensitivity Relief Calcium sodium phosphosilicate (CSPS) Toothpaste - Dentin Sensitivity | Not applicable | Active not recruiting | HALEON | 500 | 2026-03-04 | 2026-07-21 |
| Comparison Between the Effect of Triclosan Toothpaste and Chlorhexidine Mouthwash on Gingival Health in a Group of Fixed Orthodontic Patients: A Randomized Controlled Clinical Trial Triclosan 0.3% toothpaste, sodium fluoride 0.24% toothpaste, Chlorhexidine 0.2% mouthwash - Gingival Inflammation | Phase 4 | Completed | University of Science and Technology, Yemen | 60 | 2026-02-14 | 2026-09-11 |
| Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis. 0.454%Stannous fluoride toothpaste, 0.075% Cetylpyridinium Chloride (CPC) and 0.28% zinc lactatmouthwashe, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste - Plaque | Phase 3 | Completed | Colgate Palmolive | 134 | 2026-01-26 | 2026-05-22 |
| Efficacy of a Toothpaste Containing Hydrogen Peroxide as Compared to a Regular Fluoride Toothpaste Without Hydrogen Peroxide in the Immediate Removal of Tooth Stains After a Single Brushing. Optic White Adv Sparkling White (2%HP) Toothpaste, Colgate Great Regular Flavor Toothpaste - Whitening | Phase 3 | Completed | Colgate Palmolive | 80 | 2025-11-20 | 2025-12-11 |
| The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Whitening Toothpaste (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains) Over 8 Weeks of Unsupervised Use. Toothpaste - Teeth Staining | Not applicable | Completed | Boka LLC | 109 | 2025-09-11 | 2026-08-11 |
| A Clinical Study to Evaluate the Stain Reduction Efficacy of a Non-Fluoride Tooth Whitening Dentifrice Containing Nano-Hydroxyapatite (nHAP) and a High Cleaning Silica Abrasive System Compared to a Commercial Fluoride Non-Whitening Dentifrice as a Negative Control toothpaste - Teeth Color, Teeth Staining | Not applicable | Completed | Boka LLC | 120 | 2025-09-01 | 2026-08-11 |
| A Pilot Study to Test the Efficacy of a Commercial Toothpaste (Cosmetic Product) Toothpaste - Periodontitis | Not applicable | Recruiting | Periotrap Pharmaceuticals GmbH | 28 | 2025-07-28 | 2026-09-01 |
| Hydroxyapatite Toothpastes and Enamel Remineralization: Biorepair® Total Protection Plus Toothpaste, Bioniq® Toothpaste - Enamel Hypomineralization, Tooth Erosion | Not applicable | Recruiting | University of Pavia | 40 | 2025-07-25 | 2026-02-20 |
| Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis Mouthwash, Floss, Toothbrush - Dental Plaque, Gingivitis | Phase 4 | Completed | Colgate Palmolive | 228 | 2025-07-07 | 2025-10-30 |
| Effectiveness of Calcium Silicate and Sodium Fluoride Nanoparticles in The Management of Dentin Hypersensitivity toothpaste - Dentin Hypersensitivity | Not applicable | Not yet recruiting | Minia University | 60 | 2025-05-01 | 2025-05-11 |
| Clinical Investigation of Bleeding Reduction Efficacy on Toothpaste Containing 1.05% Chitosan Toothpaste containing 1.05% Chitosan, Silica-based NaF Toothpaste, Toothpaste with 67% bicarbonate - Bleeding Gum, Gingivitis | Not applicable | Completed | Colgate Palmolive | 134 | 2025-04-29 | 2025-08-15 |
| Comparative Study of CPC+Zn Mouthwash, Dental Floss, and Essential Oils Mouthwash on Plaque and Gingivitis Reduction Mouthwash CPC+Zn+F, Essential oils mouthrinse, Dental floss - Gingival Bleeding, Plaque Induced Gingival Disease | Phase 3 | Completed | Colgate Palmolive | 120 | 2024-09-16 | 2025-04-14 |
| Efficacy of Formulated Eggshell Derived Nano-hydroxyapatite Containing Toothpaste With and Without Addition of Fluoride vs. Conventional Desensitizing Fluoride Containing Toothpaste in Management of Dentin Hypersensitivity Eggshell derived Nano-hydroxyapatite (n-HAp) with a Fluoride containing toothpaste, Eggshell derived Nano-hydroxyapatite (n-HAp) without a Fluoride containing toothpaste - Dentin Hypersensitivity, Fluoride | Phase 1 | Unknown | Cairo University | 39 | 2024-07-01 | 2024-07-10 |
| Evaluation of Toothpaste on Dental Plaque Toothpaste - Dental Plaque | Not applicable | Unknown | Marmara University | 50 | 2023-05-26 | 2023-05-22 |
Showing 20 of 44. Sign in to see all of them.
Gingivitis (11) · Dental Plaque (8) · Dental Caries (4) · Dentin Sensitivity (4) · Tooth Discoloration (4) · Periodontal Diseases (3) · Tooth Erosion (3) · Consumer Behavior (2) · Dental Enamel Hypomineralization (2) · Gingival Hemorrhage (2) · Inflammation (2) · Periodontitis (2) · Plaque, Amyloid (2) · Bronchiolitis Obliterans Syndrome (1) · COVID-19 (1)
Colgate Palmolive (8) · Boka LLC (3) · University of Campinas, Brazil (3) · Loma Linda University (2) · Marmara University (2) · Universidad Complutense de Madrid (2) · University of Pavia (2) · Advantage Dental Services, LLC (1) · Cairo University (1) · Damascus University (1) · Federal University of Paraíba (1) · HALEON (1) · Hospital Israelita Albert Einstein (1) · Minia University (1) · Mucosa Innovations, S.L. (1)
United States (15) · Brazil (7) · Italy (2) · Spain (2) · Turkey (Türkiye) (2) · China (1) · Croatia (1) · Dominican Republic (1) · Germany (1) · India (1) · Iraq (1) · Norway (1) · Switzerland (1) · Syria (1) · Thailand (1)
Livia MA Tenuta, PhD (2) · So Ran Kwon, DDS, MS, PhD (2) · Andrea Scribante, Associate Professor (1) · Andrea Scribante, DDS, PhD (1) · Annette Wiegand, PD Dr. med. dent. (1) · Antonio Moretti, DDS, MS (1) · Cassiano K Rosing, PhD (1) · Chung H Kau, BDS, PhD (1) · Colman McGrath, PhD (1) · David Herrera, Prof. (1) · Debora H Douek, PhD (1) · Domenick T Zero, DDS, MS (1)
PMID 25038509, PMID 26002091, PMID 26820239, PMID 30719933, PMID 31907625, PMID 35570015, PMID 37170260, PMID 38130922, PMID 40657473, PMID 42357830