43 completed, 21 unknown, 10 terminated, 4 active not recruiting. 21 Not applicable, 13 Phase 2, 9 Phase 3, 7 Phase 4, 3 Phase 1.
Follow Patent Ductus Arteriosus: new trials by email Literature Review of Patent Ductus Arteriosus trials Research Report on Patent Ductus Arteriosus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HeartR™ PDA Occluder Post-Market Follow-Up Study HeartR™ PDA Occluder - Patent Ductus Arteriosus | Recruiting | Lifetech Scientific (Shenzhen) Co., Ltd. | 140 | 2025-04-30 | 2026-06-15 | |
| PDA for Kidneys Study Near Infrared Spectroscopy - Patent Ductus Arteriosus, Congenital Heart Disease | Active not recruiting | University of Wisconsin, Madison | 27 | 2024-12-19 | 2026-09-21 | |
| NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation Pilot NeoDoppler - CE certified - Preterm, Patent Ductus Arteriosus | Recruiting | St. Olavs Hospital | 180 | 2024-10-20 | 2026-04-23 | |
| Precision Dosing of Oral Ibuprofen for PDA, A Pilot RCT Standard Dose - Ibuprofen oral suspension, Precision Dose - Ibuprofen oral suspension - Patent Ductus Arteriosus, Preterm | Phase 2 | Recruiting | Hamilton Health Sciences Corporation | 26 | 2024-07-04 | 2025-08-27 |
| The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease Thiamine - Congenital Heart Disease, Thiamine Deficiency | Early Phase 1 | Completed | Universitas Sumatera Utara | 86 | 2024-05-01 | 2026-03-24 |
| Assessment of Therapeutic Effect of Rectal Vs. Intravenous Paracetamol in The Treatment of Patent Ductus Arteriosus (PDA) in Neonates Paracetamol - Patent Ductus Arteriosus | Phase 1 / Phase 2 | Unknown | Soha mahmoud Hussien mahdy | 100 | 2024-03-01 | 2024-02-13 |
| Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus Paracetamol, Ibuprofen - Patent Ductus Arteriosus | Phase 2 | Unknown | Assiut University | 56 | 2023-12-01 | 2023-12-01 |
| PUFAs in Preterm Infants Necrotizing Enterocolitis, Intraventricular Hemorrhage | Unknown | The First Hospital of Jilin University | 600 | 2023-09-21 | 2023-09-21 | |
| Liver Regional Oxygen Saturation in Preterm Patent Ductus Arteriosus near-infrared spectroscopy based cerebral/somatic oximeter system (INVOS™ system manufactured by Medtronics) - Patent Ductus Arteriosus, Circulation | Completed | Seoul St. Mary's Hospital | 40 | 2023-01-13 | 2025-05-30 | |
| Post Marketing Clinical Follow Up Study to Evaluate Efficacy and Safety of the Occlutech PDA Occluder in Patients With Patent Ductus Arteriosus Defects Occlutech® PDA Occluder - Patent Ductus Arteriosus | Recruiting | Occlutech International AB | 255 | 2021-12-20 | 2026-08-12 | |
| PAIR (Paracetamol and Ibuprofen Research) Pilot Trial Paracetamol injection, Ibuprofen injection - Patent Ductus Arteriosus | Phase 2 / Phase 3 | Unknown | Manchester University NHS Foundation Trust | 32 | 2021-09-03 | 2023-10-30 |
| Optimal Dose of Surfactant for Preterm Infants With Respiratory Distress Syndrome PS is stopped when the pressure is equal between bPDA and aPDA., PS is given according to the 2019 European RDS management guideline - Respiratory Distress Syndrome, Newborn, Patent Ductus Arteriosus | Not applicable | Unknown | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | 300 | 2021-08-01 | 2022-10-14 |
| Aminoglycosides and Duct echocardiography - Patent Ductus Arteriosus | Unknown | Carmel Medical Center | 60 | 2021-07-01 | 2021-02-09 | |
| Effect of PDA Closure on the Left Ventricular Remodeling speckle tracking echocardiography - Congenital Heart Defect, Patent Ductus Arteriosus | Unknown | Ahmed Mohamed Moheb El-Din | 48 | 2021-07-01 | 2021-07-16 | |
| Addition of Acetaminophen in Standard PDA Management Intravenous Ibuprofen, Intravenous Ibuprofen + Oral Acetaminophen - Patent Ductus Arteriosus | Phase 2 | Withdrawn | University of Florida | 2021-04-01 | 2021-06-24 | |
| Clinical Profile of Neonates Having Patent Ductus Arteriosus echocardiography - Patent Ductus Arteriosus | Unknown | Assiut University | 30 | 2021-04-01 | 2021-03-05 | |
| Preliminary Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low-weight Infants Cather closure of patent ductus arteriosus (PDA), Conservative management of patent ductus arteriosus (PDA) - Patent Ductus Arteriosus | Not applicable | Terminated | Nationwide Children's Hospital | 1 | 2020-10-10 | 2024-02-07 |
| Ibuprofen vs Expectant Management for hsPDA in Preterm Infants: Retrospective Cohort Ibuprofen - Patent Ductus Arteriosus, Infant, Premature | Completed | Shengjing Hospital | 541 | 2020-06-01 | 2026-04-16 | |
| Population Pharmacokinetics and Dosage Individualization of Paracetamol and Ibuprofen in Children With PDA Paracetamol, Ibuprofen - Patent Ductus Arteriosus | Unknown | Shandong University | 500 | 2020-05-25 | 2020-05-21 | |
| Amplatzer Piccolo Occluder Japan Post-marketing Database Surveillance Amplatzer Piccolo Occluder - Patent Ductus Arteriosus | Active not recruiting | Abbott Medical Devices | 70 | 2020-04-01 | 2026-10-06 |
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Ductus Arteriosus, Patent (86) · Premature Birth (28) · Bronchopulmonary Dysplasia (7) · Heart Defects, Congenital (6) · Enterocolitis, Necrotizing (5) · Heart Septal Defects, Atrial (5) · Apnea (2) · Bradycardia (2) · Heart Septal Defects, Ventricular (2) · Hypertension, Pulmonary (2) · Leukomalacia, Periventricular (2) · Respiratory Distress Syndrome (2) · Sepsis (2) · Aortic Coarctation (1) · Aortic Valve Stenosis (1)
Cardiovascular Abnormalities (86) · Congenital Abnormalities (86) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (86) · Heart Diseases (86) · Cardiovascular Diseases (85) · Heart Defects, Congenital (80) · Female Urogenital Diseases and Pregnancy Complications (28) · Obstetric Labor Complications (28) · Obstetric Labor, Premature (28) · Pregnancy Complications (28) · Urogenital Diseases (28) · Respiratory Tract Diseases (13) · Lung Diseases (11) · Infant, Newborn, Diseases (9) · Infant, Premature, Diseases (7)
Ibuprofen (27) · Acetaminophen (18) · Indomethacin (9) · Echocardiography (3) · Spectroscopy, Near-Infrared (3) · Anti-Inflammatory Agents, Non-Steroidal (2) · Conservative Treatment (2) · Cyclooxygenase Inhibitors (2) · Watchful Waiting (2) · Angptl4 protein, mouse (1) · Injections (1) · Magnetic Resonance Imaging (1) · Pentoxifylline (1) · Sodium Chloride (1) · Thiamine (1)
Shaare Zedek Medical Center (7) · Albany Medical College (4) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (4) · University of Florida (4) · Abbott Medical Devices (3) · Lifetech Scientific (Shenzhen) Co., Ltd. (3) · University of California, San Francisco (3) · University of Utah (3) · Zekai Tahir Burak Women's Health Research and Education Hospital (3) · Assiut University (2) · Nationwide Children's Hospital (2) · Occlutech International AB (2) · Ahmed Mohamed Moheb El-Din (1) · Ain Shams University (1) · Alan Fujii (1)
United States (29) · Israel (7) · Turkey (Türkiye) (6) · China (5) · France (5) · Italy (5) · Canada (4) · United Kingdom (4) · Germany (3) · Sweden (3) · Indonesia (2) · Malaysia (2) · Switzerland (2) · Tunisia (2) · Algeria (1)
Cathy Hammerman, MD (5) · Carl H Backes, MD (2) · Ronald Clyman, M.D. (2) · Silvia Martini, MD (2) · Adelina Pellicer, PhDMD (1) · Alan M Fujii, MD (1) · Alwi Mazeni, Dr (1) · Amish Jain, MBBS, PhD (1) · Amuchou S Soraisham, MD, DM (1) · Arin Mukherjee, MRCPCH (1) · Curt DeGroff, MD (1) · D Sc Lim, MD (1) · Dan L Stewart, MD (1) · Daniel K Benjamin, MD PhD MPH (1) · Dmytro Dobryanskyy, MD, PhD (1)
PMID 22065264, PMID 26283668, PMID 16322159, PMID 17564958, PMID 18628265, PMID 19047225, PMID 19217726, PMID 19902266, PMID 19956811, PMID 20336076, PMID 20336077, PMID 20368313, PMID 21094951, PMID 21760564, PMID 22284563, PMID 23258386, PMID 23472765, PMID 24223740, PMID 24321538, PMID 24359938, PMID 24854626, PMID 25653299, PMID 26168357, PMID 26244949, PMID 26672023, PMID 26951240, PMID 28395364, PMID 28874164, PMID 29695206, PMID 29943734, PMID 30077184, PMID 30340932, PMID 30850756, PMID 30940676, PMID 31211764, PMID 31255386, PMID 31519154, PMID 32433821, PMID 33301630, PMID 33307111, PMID 33952559, PMID 34147090, PMID 34293369, PMID 34526095, PMID 34675131, PMID 36477458, PMID 36519620, PMID 37587183, PMID 37659585, PMID 41364689
2019 (1), R01HL145032 (1), UG1HD112079 (1), UG1HD112097 (1), UG1HD112100 (1)