50 completed, 13 recruiting, 9 unknown, 4 terminated. 69 Not applicable, 3 Phase 1, 2 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketosis, Immune Function and Metabolic Adaptation in Response to Short-term Fasting in Critical Illness Delayed nutrition, Standard nutrition, Fasting - Critical Illness, Fasting State | Not applicable | Not yet recruiting | Karolinska University Hospital | 200 | 2026-08-31 | 2026-09-01 |
| The Meta-SHIFT Study: How Metabolic Shift Shapes Human Immunometabolism - a Fasting Trial Fasting - Fasting | Not applicable | Completed | Cornell University | 28 | 2026-06-01 | 2026-09-10 |
| Breaking Fasts Ahead of Cardiac Caths Non-Fasting, Fasting - Stable Angina (SA), Unstable Angina (UA) | Not applicable | Recruiting | University of South Florida | 400 | 2025-10-13 | 2025-12-16 |
| Fastomics: Metabolic and Therapeutic Effects of Prolonged Fasting Fasting - Insulin Resistance, Fasting | Completed | University of Minnesota | 14 | 2025-08-05 | 2026-07-14 | |
| 7-Days Water-Only Fasting or Ketone Supplementation Trial in Prostate Cancer Fasting, Ketone Supplementation - Prostate Cancer, Prostate Cancer Metastatic | Not applicable | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 40 | 2025-06-03 | 2026-06-30 |
| A Study of Time-Restricted Eating in Childhood Cancer Survivors Children's Oncology Group Heart Health Link, Monthly weights, Fasting - Childhood Cancer Survivors | Not applicable | Recruiting | Memorial Sloan Kettering Cancer Center | 300 | 2025-05-27 | 2026-09-03 |
| Interventions for Weight Regain After Bariatric Surgery Diet, Ketogenic diet, Fasting - Obese Patients With Bariatric Surgery, Obese Patients (BMI ≥ 30 kg/m²) | Not applicable | Completed | Medipol University | 43 | 2025-05-12 | 2025-08-01 |
| Preoperative Fasting vs. Not Fasting in Critically Ill Patients Fasting, Not fasting - Critical Illness, Surgical Procedure, Unspecified | Not applicable | Recruiting | Massachusetts General Hospital | 1072 | 2025-04-28 | 2026-06-12 |
| A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors OKN4395, Pembrolizumab, Fasting - Solid Tumours, Sarcoma | Phase 1 | Recruiting | Epkin | 146 | 2025-01-23 | 2026-06-11 |
| Feasibility of Intermittent Fasting During Chemotherapy Fasting - Lymphoma, Cancer | Not applicable | Recruiting | University of Oslo | 40 | 2024-10-31 | 2026-08-20 |
| Investigation of the Relationship Between Peripheral and Central Metabolic Changes Caused by Fasting Fasting - Healthy | Not applicable | Completed | Nils Opel | 12 | 2024-10-04 | 2025-09-17 |
| Guidelines on Long-term Medical Fasting Fasting - Fasting Period, Fasting | Enrolling by invitation | Charite University, Berlin, Germany | 60 | 2024-09-02 | 2026-05-13 | |
| Fasting Effects on Metabolism and Immunity Study in Human Fasting - Fasting | Not applicable | Recruiting | Xuanwu Hospital, Beijing | 30 | 2024-09-01 | 2025-01-22 |
| Thermogenic Silencer Regulatory Factors in Humans Cold Vest Exposure Period, Rewarming Exposure Period, Fasting - Obesity, Metabolic Disease | Not applicable | Active not recruiting | Rockefeller University | 80 | 2024-08-16 | 2026-09-14 |
| Gut Microbiome, Adverse Effects, and Markers Through MEtabolic Reprogramming Fasting - Breast Cancer, Early-stage Breast Cancer | Not applicable | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 30 | 2024-08-08 | 2026-08-21 |
| Dance and Energy Expenditure Among Adults With Parkinson's Fasting, No Intervention - Parkinson Disease | Not applicable | Recruiting | Northeastern University | 60 | 2024-07-01 | 2026-04-13 |
| Weight Loss Interventions to Reduce Cancer Progression in Prostate Cancer Patients Under Active Surveillance Biospecimen Collection, Dietary Intervention, Fasting - Prostate Carcinoma | Not applicable | Completed | Roswell Park Cancer Institute | 20 | 2024-04-24 | 2025-08-06 |
| Intermittent Fasting on Body Fat and Quality of Life Fasting, non fasting - Healthy | Not applicable | Recruiting | Loma Linda University | 70 | 2024-03-11 | 2026-05-06 |
| Effect of Fasting on Patient Outcomes After Wide-Awake, Local Anesthesia-only, No Tourniquet (WALANT) Procedures Non-fasting, Fasting - Surgery, Anesthesia, Local | Not applicable | Recruiting | University of California, Irvine | 134 | 2024-02-22 | 2026-03-12 |
| Exploratory Study Therapeutic Fasting Reduce Physical Limitations, Quality of Life During Aromatase Inhibitor Therapy Fasting - Breast Cancer Patients Treated With Aromatase Inhibitors | Not applicable | Completed | University Hospital Tuebingen | 54 | 2023-12-15 | 2026-03-12 |
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Fasting (43) · Intermittent Fasting (9) · Obesity (6) · Infertility (4) · Insulin Resistance (4) · Arthritis, Rheumatoid (3) · Breast Neoplasms (3) · Hypoglycemia (3) · Ketosis (3) · Motor Activity (3) · Prostatic Neoplasms (3) · Cardiovascular Diseases (2) · Colorectal Neoplasms (2) · Critical Illness (2) · Feeding Behavior (2)
Charite University, Berlin, Germany (7) · Massachusetts General Hospital (6) · IMDEA Food (2) · L-Nutra Inc (2) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · Pennington Biomedical Research Center (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · University of Aarhus (2) · University of Cincinnati (2) · Ain Shams Maternity Hospital (1) · Andreas Michalsen (1) · Anni Rahmawati (1) · Arizona State University (1) · Assistance Publique - Hôpitaux de Paris (1) · Beth Israel Deaconess Medical Center (1)
United States (36) · Germany (13) · China (3) · Denmark (3) · Turkey (Türkiye) (3) · United Kingdom (3) · Egypt (2) · France (2) · Indonesia (2) · Norway (2) · Spain (2) · Sweden (2) · Australia (1) · Brazil (1) · Canada (1)
Andreas Michalsen, Prof. Dr. (6) · Pablo J Fernandez-Marcos, PhD (2) · Abdelmaguid Ramzy (1) · Alexander Nagrebetsky, MD, MSC (1) · Amira S Dieb, MD (1) · Andreas Michalsen, Prof. Dr. med. (1) · Angela M Zivkovic, Ph.D. (1) · Anne Klibanski, MD (1) · Anni Rahmawati, postgraduate (1) · Benjamin H Kaffenberger, MD, MS (1) · Claudia Loeffler, Dr (1) · Colleen S Kraft, MD, MSc (1) · Danielle Friedman, MD (1) · David I Quinn, MD (1)
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