15 completed, 3 terminated, 3 unknown. 21 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 21 | Completed 15, Terminated 3, Unknown 3 |
Follow Patent Ductus Arteriosus: new trials by email Literature Review of Patent Ductus Arteriosus trials Research Report on Patent Ductus Arteriosus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimal Dose of Surfactant for Preterm Infants With Respiratory Distress Syndrome PS is stopped when the pressure is equal between bPDA and aPDA., PS is given according to the 2019 European RDS management guideline - Respiratory Distress Syndrome, Newborn, Patent Ductus Arteriosus | Not applicable | Unknown | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | 300 | 2021-08-01 | 2022-10-14 |
| Preliminary Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low-weight Infants Cather closure of patent ductus arteriosus (PDA), Conservative management of patent ductus arteriosus (PDA) - Patent Ductus Arteriosus | Not applicable | Terminated | Nationwide Children's Hospital | 1 | 2020-10-10 | 2024-02-07 |
| Improving Care for Children With Congenital Heart Disease. Biomarker analysis at enrolment, Biomarker analyses throughout the study - Heart Disease Congenital, Ventricular Septal Defect | Not applicable | Completed | Lund University Hospital | 313 | 2020-02-17 | 2026-05-08 |
| Early Treatment Versus Expectant Management of PDA in Preterm Infants Ibuprofen, Paracetamol, Expectant Management - Patent Ductus Arteriosus | Not applicable | Completed | Lviv National Medical University | 208 | 2019-02-15 | 2022-04-13 |
| Feasibility, Efficacy and Safety of IBS ® for Implantaiton in the PDA in Duct-dependent Cyanotic CHD Iron biocorrodable coronary scaffold system - Patent Ductus Arteriosus, Duct-dependent Cyanotic Congenital Heart Disease | Not applicable | Unknown | Lifetech Scientific (Shenzhen) Co., Ltd. | 10 | 2018-12-11 | 2020-03-02 |
| MISA to NRDS：a Multicenter Study in China Minimal Invasive surfactant administration - Bronchopulmonary Dysplasia, Patent Ductus Arteriosus | Not applicable | Completed | Peking University Third Hospital | 237 | 2017-07-01 | 2019-09-06 |
| AMPLATZER Duct Occluder II Additional Sizes ADO II AS (PDA closure) - Patent Ductus Arteriosus | Not applicable | Completed | Abbott Medical Devices | 200 | 2017-06-05 | 2025-02-11 |
| IV Acetaminophen and Patent Ductus Arteriosus Acetaminophen, Ibuprofen - Patent Ductus Arteriosus | Not applicable | Completed | Albany Medical College | 10 | 2017-01-01 | 2019-07-08 |
| Early Treatment Versus Expectative Management of PDA in Preterm Infants Ibuprofen, Expectative Management, Indomethacin - Patent Ductus Arteriosus | Not applicable | Completed | Radboud University Medical Center | 273 | 2016-12-23 | 2023-07-03 |
| Lifetech CeraFlex™ Post-Market Surveillance Study CeraFlex - Patent Foramen Ovale, Atrial Septal Defect | Not applicable | Completed | Lifetech Scientific (Shenzhen) Co., Ltd. | 120 | 2015-10-01 | 2020-03-13 |
| Radiation-Free Heart Catheterization Using MRI MRI guided cardiac catheterization, Magnetic resonance imaging - Aortic Coarctation, Cardiomyopathy | Not applicable | Unknown | Joshua Kanter | 50 | 2015-03-01 | 2024-02-06 |
| Pocket Echocardiography System (PES) for Detection of PDA in Neonates PES first, then FFES - Patent Ductus Arteriosus | Not applicable | Completed | University of Florida | 50 | 2013-02-01 | 2014-04-11 |
| Safety and Effectiveness Study With a New PDA Occluder for Closure of Patent Ductus Arteriosus Occlutech PDA occluder - Patent Ductus Arteriosus | Not applicable | Completed | Occlutech International AB | 50 | 2011-11-01 | 2024-02-15 |
| Safety and Efficacy of Ibuprofen in Term Newborns With Patent Ductus Arteriosus (PDA) Oral Ibuprofen - Patent Ductus Arteriosus | Not applicable | Completed | Hormozgan University of Medical Sciences | 40 | 2011-01-01 | 2012-01-20 |
| Efficacy and Safety of Oral Versus Intravenous Ibuprofen for PDA Treatment in ELBW Infants oral ibuprofen - Patent Ductus Arteriosus | Not applicable | Completed | Zekai Tahir Burak Women's Health Research and Education Hospital | 70 | 2009-01-01 | 2011-08-09 |
| Early Versus Late Use of Ibuprofen for Patent Ductus Arteriosus (PDA) Closure Ibuprofen - Patent Ductus Arteriosus, Prematurity | Not applicable | Terminated | University of Utah | 15 | 2009-01-01 | 2016-07-04 |
| AMPLATZER Duct Occluder II Clinical Study AMPLATZER Duct Occluder II - Patent Ductus Arteriosus | Not applicable | Completed | Abbott Medical Devices | 192 | 2008-08-01 | 2019-02-04 |
| Feeding During Ibuprofen or Indomethacin Treatment of Preterm Infants feeding, fasting - Patent Ductus Arteriosus | Not applicable | Completed | University of California, San Francisco | 177 | 2008-07-01 | 2012-11-09 |
| Timing of PDA Closure and Respiratory Outcome in Premature Infants Early ibuprofen, Late ibuprofen expectant group (placebo) - Patent Ductus Arteriosus | Not applicable | Terminated | University of Miami | 105 | 2007-11-01 | 2014-02-05 |
| Closure of Patent Ductus Arteriosus With Indomethacin or Ibuprofen in Extreme Low Birth Weight Infants Ibuprofen - Patent Ductus Arteriosus | Not applicable | Completed | Taipei Medical University Hospital | 110 | 2007-02-01 | 2013-01-03 |
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Ductus Arteriosus, Patent (21) · Premature Birth (4) · Bronchopulmonary Dysplasia (3) · Heart Septal Defects, Atrial (3) · Aortic Coarctation (1) · Aortic Valve Stenosis (1) · Aortopulmonary Septal Defect (1) · Cardiomyopathies (1) · Cardiovascular Diseases (1) · Enterocolitis, Necrotizing (1) · Foramen Ovale, Patent (1) · Heart Defects, Congenital (1) · Heart Septal Defects, Ventricular (1) · Leukomalacia, Periventricular (1) · Respiratory Distress Syndrome (1)
Cardiovascular Abnormalities (21) · Congenital Abnormalities (21) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (21) · Heart Diseases (21) · Cardiovascular Diseases (20) · Heart Defects, Congenital (20) · Female Urogenital Diseases and Pregnancy Complications (4) · Obstetric Labor Complications (4) · Obstetric Labor, Premature (4) · Pregnancy Complications (4) · Urogenital Diseases (4) · Heart Septal Defects (3) · Infant, Newborn, Diseases (3) · Infant, Premature, Diseases (3) · Lung Diseases (3)
Ibuprofen (7) · Acetaminophen (2) · Conservative Treatment (2) · Cyclooxygenase Inhibitors (2) · Angptl4 protein, mouse (1) · Indomethacin (1) · Magnetic Resonance Imaging (1) · Watchful Waiting (1) · acetylamino propylidene diphosphonic acid (1)
Abbott Medical Devices (2) · Lifetech Scientific (Shenzhen) Co., Ltd. (2) · Albany Medical College (1) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (1) · Hormozgan University of Medical Sciences (1) · Joshua Kanter (1) · Lund University Hospital (1) · Lviv National Medical University (1) · Nationwide Children's Hospital (1) · Occlutech International AB (1) · Peking University Third Hospital (1) · Radboud University Medical Center (1) · Taipei Medical University Hospital (1) · University of California, San Francisco (1) · University of Florida (1)
United States (10) · China (2) · Malaysia (2) · Belgium (1) · France (1) · Germany (1) · Iran (1) · Ireland (1) · Italy (1) · Netherlands (1) · Sweden (1) · Switzerland (1) · Turkey (Türkiye) (1) · Ukraine (1) · Vietnam (1)
Alwi Mazeni, Dr (1) · Carl H Backes, MD (1) · Curt DeGroff, MD (1) · D Sc Lim, MD (1) · Dmytro Dobryanskyy, MD, PhD (1) · Evan Zahn, MD (1) · Gary Chan, MD (1) · Hamidreza Mahboobi, MD (1) · Henning Clausen, MD (1) · Ilene RS Sosenko, MD (1) · Joshua Kanter, MD (1) · Kevin Walsh, Professor (1) · Omer Erdeve (1) · Ronald Clyman, M.D. (1) · Tsu-Fu Yeh, MD, PhD (1)
PMID 22284563, PMID 23472765, PMID 24321538, PMID 28874164, PMID 30077184, PMID 32433821, PMID 34147090, PMID 34526095, PMID 36477458, PMID 37587183, PMID 37659585, PMID 42637114
2019 (1)