6 unknown, 2 completed, 2 terminated, 2 withdrawn. 13 Phase 2, 2 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Unknown 6, Completed 2, Terminated 2, Withdrawn 2, Recruiting 1 |
| Phase 3 | 2 | Terminated 1, Unknown 1 |
| Phase 1 | 1 | Unknown 1 |
Follow Patent Ductus Arteriosus: new trials by email Literature Review of Patent Ductus Arteriosus trials Research Report on Patent Ductus Arteriosus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Precision Dosing of Oral Ibuprofen for PDA, A Pilot RCT Standard Dose - Ibuprofen oral suspension, Precision Dose - Ibuprofen oral suspension - Patent Ductus Arteriosus, Preterm | Phase 2 | Recruiting | Hamilton Health Sciences Corporation | 26 | 2024-07-04 | 2025-08-27 |
| Assessment of Therapeutic Effect of Rectal Vs. Intravenous Paracetamol in The Treatment of Patent Ductus Arteriosus (PDA) in Neonates Paracetamol - Patent Ductus Arteriosus | Phase 1 / Phase 2 | Unknown | Soha mahmoud Hussien mahdy | 100 | 2024-03-01 | 2024-02-13 |
| Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus Paracetamol, Ibuprofen - Patent Ductus Arteriosus | Phase 2 | Unknown | Assiut University | 56 | 2023-12-01 | 2023-12-01 |
| PAIR (Paracetamol and Ibuprofen Research) Pilot Trial Paracetamol injection, Ibuprofen injection - Patent Ductus Arteriosus | Phase 2 / Phase 3 | Unknown | Manchester University NHS Foundation Trust | 32 | 2021-09-03 | 2023-10-30 |
| Addition of Acetaminophen in Standard PDA Management Intravenous Ibuprofen, Intravenous Ibuprofen + Oral Acetaminophen - Patent Ductus Arteriosus | Phase 2 | Withdrawn | University of Florida | 2021-04-01 | 2021-06-24 | |
| Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus Ibuprofen and acetaminophen, Ibuprofen and placebo - Patent Ductus Arteriosus, Preterm Infant | Phase 2 | Terminated | University of South Alabama | 1 | 2018-12-15 | 2026-04-30 |
| Paracetamol Treatment of the Borderline Significant PDA Paracetamol drops, Placebo - Patent Ductus Arteriosus | Phase 2 | Unknown | Shaare Zedek Medical Center | 80 | 2016-06-01 | 2016-07-06 |
| Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus pharmacologic treatment of the PDA, no pharmacologic treatment of the PDA, NSAID - Patent Ductus Arteriosus, Surgery | Phase 2 | Completed | University of California, San Francisco | 202 | 2013-12-01 | 2018-11-30 |
| Paracetamol and Patent Ductus Arteriosus (PDA) Paracetamol, NSAID, D5W - Patent Ductus Arteriosus | Phase 2 | Unknown | Shaare Zedek Medical Center | 80 | 2012-04-01 | 2012-12-19 |
| Second Course of Therapy for Resistant Patent Ductus Arteriosus (PDA) Indomethacin, Ibuprofen - Patent Ductus Arteriosus | Phase 2 | Withdrawn | Shaare Zedek Medical Center | 2010-06-01 | 2012-06-07 | |
| An Escalating Dose Indomethacin for the Treatment of Persistent Patent Ductus Arteriosus (PDA) In Preterm Infants Indomethacin - Patent Ductus Arteriosus | Phase 2 / Phase 3 | Terminated | University of Calgary | 9 | 2008-08-01 | 2016-08-18 |
| Treating the Resistant Patent Ductus Arteriosus (PDA) Indomethacin, Pentoxifylline - Patent Ductus Arteriosus | Phase 2 | Unknown | Shaare Zedek Medical Center | 68 | 2008-03-01 | 2008-02-15 |
| Comparison of 2 Different Indomethacin Dosing Protocols to Treat Infants Delivered at <28 Weeks Gestation With a Persistent Patent Ductus Arteriosus indomethacin (two different dosing regimens) - Patent Ductus Arteriosus | Phase 2 | Completed | University of California, San Francisco | 100 | 2003-08-01 | 2008-06-04 |
Ductus Arteriosus, Patent (13) · Premature Birth (3) · Enterocolitis, Necrotizing (2) · Bronchopulmonary Dysplasia (1) · Intestinal Perforation (1)
Cardiovascular Abnormalities (13) · Cardiovascular Diseases (13) · Congenital Abnormalities (13) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (13) · Heart Defects, Congenital (13) · Heart Diseases (13) · Female Urogenital Diseases and Pregnancy Complications (3) · Obstetric Labor Complications (3) · Obstetric Labor, Premature (3) · Pregnancy Complications (3) · Urogenital Diseases (3) · Digestive System Diseases (2) · Enterocolitis (2) · Gastroenteritis (2) · Gastrointestinal Diseases (2)
Acetaminophen (6) · Ibuprofen (4) · Indomethacin (4) · Anti-Inflammatory Agents, Non-Steroidal (2) · Pentoxifylline (1)
Shaare Zedek Medical Center (4) · University of California, San Francisco (2) · Assiut University (1) · Hamilton Health Sciences Corporation (1) · Manchester University NHS Foundation Trust (1) · Soha mahmoud Hussien mahdy (1) · University of Calgary (1) · University of Florida (1) · University of South Alabama (1)
Israel (4) · United States (3) · Canada (2) · United Kingdom (2) · Sweden (1) · Turkey (Türkiye) (1)
Cathy Hammerman, MD (4) · Amuchou S Soraisham, MD, DM (1) · Arin Mukherjee, MRCPCH (1) · Fabien Eyal, MD (1) · Ronald Clyman, M.D. (1) · Ronald Clyman, MD (1) · Samira Samiee-Zafarghandy, MD, FRCPC (1) · Sanket D Shah, MD (1)
PMID 16322159, PMID 19217726, PMID 22065264, PMID 26283668, PMID 26951240, PMID 30340932, PMID 30850756, PMID 31255386, PMID 41550606, PMID 8618179