8 recruiting, 6 completed, 5 not yet recruiting, 3 active not recruiting. 13 Not applicable, 4 Phase 2, 3 Phase 1, 3 Phase 4.
Follow Pain After Surgery: new trials by email Literature Review of Pain After Surgery trials Research Report on Pain After Surgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase I Study of JY1001 Injection JY1001, Placebo - Pain After Surgery | Phase 1 | Not yet recruiting | Jemincare | 48 | 2026-11-01 | 2026-09-30 |
| The Effect of Virtual Reality Headsets on Pain, Anxiety, Patient Satisfaction, and Physiological Parameters in Patients Undergoing Open-Heart Surgery Virtual Reality Glasses - Pain After Surgery, Pain and Anxiety | Not applicable | Recruiting | Dokuz Eylul University | 44 | 2026-09-23 | 2026-11-02 |
| Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA bupivacaine-meloxicam (extended release), Bupivacaine, Ketorolac - Periarticular Block, Osteoarthritis (OA) | Phase 4 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 150 | 2026-09-03 | 2026-10-28 |
| Intraoperative Bupivacaine Injection to Reduce Acute and Chronic Pain After TVT/TVT-O Surgery. Randomized Double-Blind Trial Bupivacain (Postoperative), Placebo - Pain After Surgery, PSP | Not applicable | Not yet recruiting | Hadassah Medical Organization | 60 | 2026-07-01 | 2026-06-23 |
| Comparison Between Paravertebral and Erector Spinal Block Efficacy in Robotic Thoracic Surgeries Paravertebral Nerve Block, ESP block group - Post Operative Analgesia, Regional Anaesthesia | Not applicable | Active not recruiting | Soroka University Medical Center | 60 | 2026-07-01 | 2026-08-24 |
| A Clinical Trial Evaluating the Efficacy and Safety of HSK55718 in Patients for Postoperative Pain Treatment in Abdominal Surgery HSK55718 dose level1, HSK55718 dose level2, HSK55718 dose level 3 - Pain After Surgery | Phase 2 | Recruiting | Haisco Pharmaceutical Group Co., Ltd. | 200 | 2026-05-22 | 2026-05-28 |
| RISS Versus Lower Thoracic ESP Block for Analgesia After Laparoscopic Abdominal Surgery: A Randomized Trial Group A (n=35): Ultrasound-guided RISS block (RISS):, Group B (n=35): Ultrasound-guided lower thoracic ESP block - Pain After Surgery | Not applicable | Not yet recruiting | Misr University for Science and Technology | 70 | 2026-05-20 | 2026-05-18 |
| Impact of NOL - Nociception Level Index Intraoperative Monitoring on Perioperative Outcomes in Spine Surgery - a Quality Improvement Pilot NOL guided intraoperative analgesia - Spine Surgery, Pain After Surgery | Not applicable | Not yet recruiting | Medasense Biometrics Ltd | 100 | 2026-05-01 | 2026-05-27 |
| Virtual Reality as a Method for Pain and Anxiety Control During First Trimester Procedural Abortion VR headset, Usual Care - Abortion, First Trimester, Pain Management | Not applicable | Recruiting | Study Investigator | 72 | 2026-05-01 | 2026-05-06 |
| Comparison of the Analgesic Efficacy of Erector Spinae Plane Block in Breast-Conserving Surgery Versus Serratus Anterior Block Combined With Additional Pecto-Intercostal II Block SAPB + PECS II Technique, Erector Spinae Plane Block - Pain Management in Breast Surgery, Pain After Surgery | Not applicable | Completed | Kayseri City Hospital | 70 | 2026-04-10 | 2026-07-21 |
| Tegileridine for Postoperative Pain After Adolescent Scoliosis Surgery Tegileridine, morphine - Scoliosis; Adolescence, Pain After Surgery | Phase 4 | Recruiting | Peking Union Medical College Hospital | 171 | 2026-04-08 | 2026-10-13 |
| A Clinical Trial Evaluating the Efficacy and Safety of HSK55718 in Patients for Postoperative Pain Treatment in Orthopedic Surgery HSK55718 dose level 1, HSK55718 dose level 2, HSK55718 dose level 3 - Pain After Surgery | Phase 2 | Not yet recruiting | Haisco Pharmaceutical Group Co., Ltd. | 200 | 2026-04-01 | 2026-04-27 |
| Tourniquet Exposure and Risk of Chronic Pain After Severe Limb Trauma Pain, Pain After Surgery | Completed | Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) | 150 | 2026-03-15 | 2026-10-26 | |
| Using Mindfulness in an Enhanced Recovery After Surgery Protocol to Support Recovery After Colorectal Surgery Mindfulness Intervention - Pain After Surgery, Anxiety After Surgery | Not applicable | Recruiting | University Hospitals Cleveland Medical Center | 50 | 2026-02-20 | 2026-04-13 |
| Effect of Intraoperative Morphine on Postoperative Pain After CABG In this study, morphine administration, which is routinely and frequently used in our operating room for patients undergoing CABG, was applied as an additional intervention - Cardiac Surgery Patient, Postoperative Pain | Phase 4 | Recruiting | Istanbul University - Cerrahpasa | 60 | 2026-02-01 | 2026-03-16 |
| Preoperative Opioid Tapering Before Spine Surgery Opioid tapering with CBT and education, Opioid tapering with education alone - Opioid Consumption, Postoperative, Pain After Surgery | Not applicable | Recruiting | Thomas Jefferson University | 45 | 2025-12-01 | 2026-03-24 |
| Melatonin on Post Operative Pain After CS Melatonin 5 mg, Melatonin 10 mg, Placebo - Pain Management, Pain After Surgery | Not applicable | Completed | Benha University | 60 | 2025-10-10 | 2026-07-14 |
| Effect of the Superficial Cervical Plexus Block in the Hypotensive Anesthesia of Ear Surgery. nerve block with bupivacaine 0.25% - Pain After Surgery | Not applicable | Active not recruiting | Ain Shams University | 46 | 2025-04-01 | 2025-11-21 |
| Effect of Magnesium Sulfate on Hemodynamics on Laparoscopic Cholecystectomy Patients Placebo, Magnesium - Hemodynamics Instability, Pain After Surgery | Phase 1 / Phase 2 | Completed | Ziauddin University | 60 | 2025-01-06 | 2026-09-02 |
| Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks Low, non-weight based dose of Dexamethasone and Dexmedetomidine in peripheral nerve blocks, Ropivacaine with low, non weight based Dexamethasone additive - Postoperative Pain, Nausea and Vomiting, Postoperative | Phase 1 / Phase 2 | Active not recruiting | University of Arizona | 100 | 2024-10-10 | 2026-02-13 |
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Pain (8) · Agnosia (6) · Pain, Postoperative (4) · Anxiety Disorders (3) · Postoperative Nausea and Vomiting (2) · Chronic Pain (1) · Constipation (1) · Depression (1) · Dizziness (1) · Opioid-Related Disorders (1) · Osteoarthritis (1) · Patient Satisfaction (1) · Personal Satisfaction (1) · Phantom Limb (1) · Pneumoperitoneum (1)
Neurologic Manifestations (14) · Pathological Conditions, Signs and Symptoms (14) · Signs and Symptoms (14) · Nervous System Diseases (7) · Neurobehavioral Manifestations (7) · Perceptual Disorders (7) · Pathologic Processes (6) · Postoperative Complications (6) · Behavior (3) · Mental Disorders (3) · Pain (3) · Musculoskeletal Diseases (2) · Nausea (2) · Signs and Symptoms, Digestive (2) · Vomiting (2)
Morphine (3) · Bupivacaine (1) · Dexamethasone (1) · Dexmedetomidine (1) · Educational Status (1) · Ketorolac (1) · Lidocaine (1) · Magnesium (1) · Magnesium Sulfate (1) · Melatonin (1) · Nerve Block (1) · Pharmaceutical Preparations (1) · Postoperative Period (1) · Ropivacaine (1) · Saposins (1)
Haisco Pharmaceutical Group Co., Ltd. (2) · Ain Shams University (1) · Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) (1) · Benha University (1) · Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) (1) · Dokuz Eylul University (1) · Hadassah Medical Organization (1) · Haseki Training and Research Hospital (1) · Istanbul University - Cerrahpasa (1) · Jemincare (1) · Kayseri City Hospital (1) · Medasense Biometrics Ltd (1) · Misr University for Science and Technology (1) · Peking Union Medical College Hospital (1) · Sennur Kula Şahin (1)
United States (6) · Turkey (Türkiye) (5) · China (3) · Egypt (3) · Israel (1) · Pakistan (1) · Ukraine (1)
Ahmed SK Elkhodary, Lecturer (1) · Andrew Waligora, MD (1) · Berna Caliskan (1) · Dr Asma A Salam, MBBS, FCPS (1) · Emily Steinhagen, MD (1) · Ling Lan, Doctor (1) · Manar M ElKholy, Profesor (1) · Mohamed Abdelaziz Taha, Assist. Prof. (1) · Ronald Tang, MD (1)
PMID 17513629, PMID 18376170, PMID 19617379, PMID 22096279, PMID 23904932, PMID 25885838, PMID 29858144, PMID 30169476, PMID 31303716, PMID 31862004, PMID 39726901, PMID 40161212