84 completed, 19 unknown, 10 recruiting, 7 terminated. 56 Not applicable, 24 Phase 2, 24 Phase 4, 21 Phase 3, 11 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of a Daily Magnesium and Melatonin Supplement on Sleep Quality in People With Nighttime Leg Cramps Magnesium and melatonin based multi-ingredient dietary supplementation, Placebo - Poor Sleep Quality, Leg Cramps, Nocturnal | Not applicable | Recruiting | StudySetGo | 50 | 2026-10-10 | 2026-11-02 |
| Serum Magnesium Levels in Patients Diagnosed With Lipedema Magnesium - Lipedema, Magnesium | Not yet recruiting | Fatih Sultan Mehmet Training and Research Hospital | 128 | 2026-08-16 | 2026-08-21 | |
| Effectiveness and Safety of Benemix® in Constipation Benemix®, a functional food composed of turmeric, onion, magnesium, and lactose-free, skimmed milk powder - Constipation - Functional | Not applicable | Not yet recruiting | Universidad de Antioquia | 80 | 2026-07-01 | 2026-02-23 |
| The Effects of a 6-week Pre-operative Administration of a Microbiome Modulator "WellBiome" Versus Placebo on Cardiac Surgical Outcomes and NHS Cost Savings. 5g of prebiotic fibre and 300mg of magnesium (WellBiome), 5g of maltodextrin - Cardiovascular Diseases (CVD), Cardiovascular Surgery | Not applicable | Recruiting | Hull University Teaching Hospitals NHS Trust | 80 | 2026-04-09 | 2026-06-23 |
| Synbiotic Supplement With Botanical Extracts for Gut Microbiota Balance in Irritable Bowel Syndrome Synbiotic supplement containing probiotic strains, botanical extracts, magnesium, vitamin B1, and L-theanine designed to support gut microbiota balance. - Irritable Bowel Syndrome (IBS) | Not applicable | Not yet recruiting | Iuliu Hatieganu University of Medicine and Pharmacy | 8 | 2026-04-01 | 2026-03-16 |
| The Effect of Magnesium on Post-spinal Headaches Magnesium - Post-spinal Headache | Completed | Haseki Training and Research Hospital | 300 | 2026-04-01 | 2026-11-12 | |
| Effect of Magnesium and Levocarnitine on Metabolic and Clinical Outcomes in Women With Polycystic Ovarian Syndrome (PCOS) Magnesium 500 mg, Levocarnitine 1000 mg, Placebo - Polycystic Ovary Syndrome (PCOS) | Not applicable | Recruiting | Behnood Abbasi | 84 | 2026-01-30 | 2025-12-23 |
| Effect of Opioid-Free Anesthesia (OFA) on Postoperative Pain and Perioperative Nausea and Vomiting in Elective Laparoscopic . opoid free anesthesia - Opioid-Free Anesthesia, Elective Laparoscopic Cholecystectomy | Not applicable | Not yet recruiting | Assiut University | 110 | 2025-12-30 | 2025-12-29 |
| Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines Magnesium, Placebo - Migraine | Phase 3 | Recruiting | Wake Forest University Health Sciences | 100 | 2025-12-16 | 2026-01-22 |
| Omega-3-Based Nutraceutical Supplementation as Adjunctive Therapy in Adults With Otitis Media With Effusion: A Multicenter, Double-Blind, Randomized Placebo-Controlled Trial Omega-3-based nutraceutical combination (Otoair Flogo), Bilastine 20 mg, Placebo Tablet or Capsule - Otits Media With Effusion | Phase 4 | Completed | Isola Tiberina - Gemelli Isola Hospital, Rome, Italy | 501 | 2025-10-01 | 2026-07-23 |
| Comparative Study of Nutraceuticals vs. Conventional Prophylactic Therapy in the Management of Migraine Propranolol 80 mg, Magnesium 400Mg - Migraine, Nutraceuticals | Phase 3 | Not yet recruiting | Fayoum University | 100 | 2025-08-20 | 2025-08-29 |
| Total Intravenous Anesthesia in Patients Undergoing Craniotomy Dexmedetomidine, Fentanyl, Magnesium - Anesthesia | Not applicable | Active not recruiting | Zagazig University | 120 | 2025-08-10 | 2026-08-24 |
| Effect of Preoperative Oral Magnesium on Emergence Agitation Magnesium, Placebo control - Magnesium, Emergence Agitation | Not applicable | Completed | Tanta University | 120 | 2025-07-25 | 2026-04-03 |
| Magnesium Supplementation With Fluoxetine for Cognitive Function in Depression Fluoxetine (drug), Magnesium - Major Depressive Disorder (MDD) | Not applicable | Completed | Hasanuddin University | 40 | 2025-07-01 | 2026-04-09 |
| Prospective Evaluation of Ivosidenib Maintenance Following Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia or High-risk Myelodysplastic Neoplasia With IDH1 (Isocitrate Dehydrogenase 1) Mutation Ivosidenib 250 MG (milligram) - AML, MDS | Phase 2 | Recruiting | Technische Universität Dresden | 76 | 2025-06-17 | 2026-08-26 |
| Effect of Modifying Magnesium Concentration in Citrate-enriched Dialysate on Hemodialysis-associated Thromboinflammation Hemodialysis using dialysate containing citric acid and magnesium at a concentration of 1.0 mmol/L, Hemodialysis using acetic acid dialysate with magnesium 0.5 mmol/L, Hemodialysis using citric acid dialysate with magnesium 0.75 mmol/L - Hemodialysis, Thromboinflammation | Not applicable | Recruiting | Universitair Ziekenhuis Brussel | 15 | 2025-06-05 | 2025-11-17 |
| Improving Sleep Quality After Total Joint Arthroplasty ( TJA) Melatonin 5 mg, Placebo Oral Tablet, Magnesium 500Mg Oral Tablet - Pain After TJA | Early Phase 1 | Withdrawn | Stanford University | 2025-06-01 | 2025-04-11 | |
| Ivacaftor Impact in an Adolescent Without a Cystic Fibrosis-Associated CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Mutation for Chronic Pancreatitis: Single-Patient Study Tracking Flare Frequency and Health Data Compared to Historical Records. Ivacaftor 150 MG (milligrams) - Chronic Pancreatitis | Active not recruiting | Mission: Cure | 1 | 2025-05-06 | 2025-06-15 | |
| The Effects of Magnesium (Mg) Supplement and Alternate Maxillary Expansion and Constriction (Alt-RAMEC) in Patient With Transverse Maxillary Deficiency (TMD) Oral Magnesium Citrate Supplementation, Micro-implant-Assisted Rapid Palatal Expansion (MARPE) With the Alt-RAMEC Protocol - Magnesium During Orthodontic Expansion, Orthodontic Patients Indicated for Maxillary Expansion | Not applicable | Completed | Universiti Sains Malaysia | 38 | 2025-01-21 | 2026-09-16 |
| Effect of Magnesium Sulfate on Hemodynamics on Laparoscopic Cholecystectomy Patients Placebo, Magnesium - Hemodynamics Instability, Pain After Surgery | Phase 1 / Phase 2 | Completed | Ziauddin University | 60 | 2025-01-06 | 2026-09-02 |
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Pain, Postoperative (9) · Pain (7) · Agnosia (6) · Magnesium Deficiency (6) · Migraine Disorders (5) · Asthma (4) · Osteoporosis (4) · Bone Diseases, Metabolic (3) · Cardiovascular Diseases (3) · Diabetes Mellitus (3) · Emergence Delirium (3) · Hypertension (3) · Obesity (3) · Scoliosis (3) · Sleep Initiation and Maintenance Disorders (3)
Cairo University (3) · Mayo Clinic (3) · National Cancer Institute, Egypt (3) · Ain Shams University (2) · Aristotle University Of Thessaloniki (2) · Assiut University (2) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (2) · Coordinación de Investigación en Salud, Mexico (2) · Fayoum University (2) · Istanbul University (2) · Mahidol University (2) · Spherium Biomed (2) · Stanford University (2) · University Hospital, Clermont-Ferrand (2) · Zagazig University (2)
United States (35) · Egypt (13) · Canada (8) · France (5) · Italy (5) · Turkey (Türkiye) (5) · Brazil (4) · Greece (4) · South Korea (4) · Spain (4) · Mexico (3) · Pakistan (3) · United Kingdom (3) · Bangladesh (2) · Belgium (2)
Umesh Jain, MD (2) · Afifa Siddique, MBBS (1) · Ahmed A Mohamed, MD (1) · Ali Ovayolu, MD (1) · Alison Edelman, M.D., M.P.H (1) · Amany Saleh, MD (1) · Anthony Bier, MD (1) · Arkom Nongnuch, MD (1) · Armin Paravlic, PhD (1) · Ben Chue, MD (1) · Cetina Lucely, MSc (1) · Chad Ruoff, MD (1) · Chris Trigger, DO (1) · Christian Kern, MD, Prof (1)
PMID 17513629, PMID 10389803, PMID 10671850, PMID 12190806, PMID 12198045, PMID 12803269, PMID 14766688, PMID 14980919, PMID 15235946, PMID 16731324, PMID 17202008, PMID 17241503, PMID 17261216, PMID 18044291, PMID 18218147, PMID 18343266, PMID 18640467, PMID 19211496, PMID 19617379, PMID 19696679, PMID 20063223, PMID 20100026, PMID 20304348, PMID 20921313, PMID 21159786, PMID 21527040, PMID 21974483, PMID 2200299, PMID 22096279, PMID 22122960, PMID 23121612, PMID 23669270, PMID 23735418, PMID 23904932, PMID 24105697, PMID 24431032, PMID 24837863, PMID 24975234, PMID 25885838, PMID 27044488, PMID 27381766, PMID 27620816, PMID 28768651, PMID 29324495, PMID 30078167, PMID 30649163, PMID 31303716, PMID 31743503, PMID 31862004, PMID 32644129
2016 (2), 2009 (1), K23RR016047 (1), R01HL069081 (1), U01DC008423 (1), U54HL070871 (1)