124 completed, 22 unknown, 13 terminated, 7 withdrawn. 56 Phase 2, 42 Not applicable, 34 Phase 3, 21 Phase 4, 17 Phase 1.
Follow Osteoarthritis of the Knee: new trials by email Literature Review of Osteoarthritis of the Knee trials Research Report on Osteoarthritis of the Knee
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Aerobic Exercise Versus Therapeutic Exercises on Exercise-induced Hypoalgesia in Knee Osteoarthritis Aerobic Exercise, Therapeutic Exercise - Osteoarthritis of the Knee | Not applicable | Recruiting | University of Nove de Julho | 90 | 2026-02-20 | 2026-06-25 |
| Study to Assess the Safety and Pharmacokinetics of AVD275 Injection in Patients With Osteoarthritis of the Knee AVD275 Intra-articular Injection - Osteoarthritis of the Knee | Phase 1 | Recruiting | Avidence Therapeutics | 20 | 2026-01-22 | 2026-10-20 |
| Pilot Study to Identify and Validate Digital Biomarkers in Osteoarthritis of the Knee Syde, The Self-Paced 40-meter Walk Test (SPWT), 30-second chair stand test (30s-CST) - Osteoarthritis of the Knee | Not applicable | Completed | Centre Hospitalier Universitaire de Liege | 43 | 2025-05-14 | 2026-03-24 |
| Shengyu Decoction and Lijin Manipulation for Knee OA: 3D Gait Analysis Traditional Chinese medicine combined with manipulation treatment, Celecoxib capsule - Osteoarthritis of the Knee | Early Phase 1 | Unknown | Xuhui Central Hospital, Shanghai | 94 | 2024-05-01 | 2024-06-11 |
| RObotic-assisted Versus Conventional Knee Endoprosthetic Techniques Robot-assisted total knee arthroplasty, Conventional total knee arthroplasty - Knee Arthroplasty, Total, Robotic-assisted | Not applicable | Recruiting | Danderyd Hospital | 1600 | 2024-03-04 | 2026-09-21 |
| Analgesic Effects of a Treatment With Cannabis Sativa Extract in Patients With Knee Osteoarthritis - CANOA (Cannabis for Osteoarthritis) Medium Chain Triglyceride solution, Cannabis Sativa - OSTEOARTHRITIS OF THE KNEE | Phase 2 | Completed | Federal University of Latin American Integration | 45 | 2024-01-01 | 2025-07-02 |
| Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis Ibuprofen and PRP, Acetaminophen and PRP, Placebo and PRP - Osteoarthritis of the Knee, Degenerative Osteoarthritis | Phase 1 / Phase 2 | Withdrawn | QC Kinetix LLC | 2023-11-01 | 2024-10-09 | |
| A Phase III Study of CLS2901C in Patients With Osteoarthritis of the Knee CLS2901C (human [allogeneic] chondrocyte sheets) - Osteoarthritis of the Knee | Phase 3 | Recruiting | CellSeed Inc. | 96 | 2023-10-20 | 2026-07-09 |
| Different Modalities of Aquatic Physiotherapy in Patients With Knee Osteoarthrosis Low impact immersion, Conventional aquatic physiotherapy, High intensity aquatic physiotherapy - Osteoarthritis of the Knee | Not applicable | Unknown | Federal University of Health Science of Porto Alegre | 15 | 2023-03-30 | 2023-01-20 |
| Intra-Articular Polyacrylamide Hydrogel Injections Improve Pain and Function in Knee Osteoarthritis Polyacrylamide hydrogel 2.5% intra-articular injection - Knee Osteoarthritis, Osteoarthritis | Completed | Feza Korkusuz MD | 387 | 2023-02-11 | 2025-09-25 | |
| Functional and Clinical Outcomes of Hyaluronic Acid and Steroid Injections in Bilateral Knee Osteoarthritis Sodium hyaluronate (hyaluronic acid), Methylprednisolone Acetate Injection - Osteoarthritis (OA) of the Knee, Osteoarthritis | Phase 4 | Completed | Edin Mešanović | 65 | 2023-01-01 | 2024-12-05 |
| Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection Autologous bone marrow aspirate concentrate (BMAC), Corticosteroid injections, Crossover Autologous bone marrow aspirate concentrate (BMAC) - Osteoarthritis of the Knee | Not applicable | Recruiting | Rush University Medical Center | 100 | 2022-07-19 | 2026-08-24 |
| ATTUNE Cementless FB Tibial Base Clinical Study ATTUNE Cementless CR Fixed Bearing, ATTUNE Cementless PS Fixed Bearing - Osteoarthritis of the Knee | Not applicable | Terminated | DePuy Orthopaedics | 80 | 2022-05-09 | 2025-03-04 |
| A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee Marching On for Veterans With Osteoarthritis of the Knee Social Incentives and Gamification to Promote Exercise, Corticosteroid Injection given in A-B order, No Social Incentive applied - Osteoarthritis of the Knee | Phase 3 | Active not recruiting | VA Office of Research and Development | 221 | 2022-03-14 | 2025-03-20 |
| Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee Placebo, Cannabidiol (CBD), Tetrahydrocannabinol (Marinol® or generic equivalent (e.g., dronabinol) - Osteoarthritis, Knee, Osteoarthritis of the Knee | Phase 2 | Recruiting | Steven E Harte, PhD | 200 | 2022-02-22 | 2026-09-04 |
| Identification of Sarcopenia in Knee Osteoarthritis With Ultrasonography and Evaluation of Muscle Architecture Change by Ultrasonography After Isokinetic Exercise Program Knee strengthening exercises with isokinetic dynamometer, Strengthening around the knees with home exercise programe - Osteoarthritis of the Knee, Sarcopenia | Phase 4 | Unknown | Sema Dağcı | 60 | 2021-08-18 | 2021-08-25 |
| Postmarketing Multicenter Study of Intra-Articular DIART ONE / EASYGO ONE for Knee Osteoarthritis Knee Osteoarthritis, Osteoarthritis of the Knee | Completed | Yuria-Pharm | 55 | 2021-08-14 | 2025-04-15 | |
| 3-year, Open-Label Study Evaluating Safety, Tolerability, and Efficacy of Lorecivivint in Knee Osteoarthritis Lorecivivint - Osteoarthritis of the Knee | Phase 3 | Terminated | Biosplice Therapeutics, Inc. | 72 | 2021-07-15 | 2026-03-31 |
| Exploratory Study on Safety of PEEK Knee Prosthesis PEEK Knee Prosthesis - Rheumatoid Arthritis of Knee, Osteoarthritis of the Knee | Not applicable | Unknown | RenJi Hospital | 10 | 2021-06-25 | 2022-09-07 |
| Irritation and Sensitization Study of HP-5000 Topical System HP-5000 Topical Patch, HP-5000 Placebo Patch, Saline Patch - Osteoarthritis of the Knee | Phase 1 | Completed | Noven Pharmaceuticals, Inc. | 200 | 2021-06-03 | 2022-08-23 |
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Osteoarthritis, Knee (175) · Osteoarthritis (72) · Pain (19) · Arthritis (5) · Joint Diseases (5) · Motor Activity (4) · Agnosia (3) · Chronic Pain (3) · Inflammation (3) · Arthralgia (2) · Musculoskeletal Diseases (2) · Osteoarthritis, Hip (2) · Rheumatic Diseases (2) · Atrial Fibrillation (1) · Capillary Malformation-Arteriovenous Malformation (1)
Musculoskeletal Diseases (173) · Rheumatic Diseases (173) · Arthritis (170) · Joint Diseases (170) · Osteoarthritis (103) · Pathological Conditions, Signs and Symptoms (30) · Neurologic Manifestations (28) · Signs and Symptoms (28) · Nervous System Diseases (6) · Pain (6) · Pathologic Processes (5) · Behavior (4) · Neurobehavioral Manifestations (3) · Perceptual Disorders (3) · Cardiovascular Diseases (2)
FX006 (8) · Sodium Chloride (8) · Hyaluronic Acid (7) · Arthroplasty, Replacement, Knee (6) · Celecoxib (6) · Saline Solution (5) · Triamcinolone (5) · Acetaminophen (4) · Glucosamine (4) · Triamcinolone Acetonide (4) · Naproxen (3) · Anti-Inflammatory Agents, Non-Steroidal (2) · Arthroplasty, Replacement (2) · Arthroscopy (2) · Bee Venoms (2)
Pacira Pharmaceuticals, Inc (9) · Ampio Pharmaceuticals. Inc. (5) · Taiwan Liposome Company (4) · PMG Pharm Co., Ltd (3) · Stryker Biotech (3) · AbbVie (prior sponsor, Abbott) (2) · Apimeds, Inc. (2) · Ardabil University of Medical Sciences (2) · Avanos Medical (2) · Carbylan Therapeutics, Inc. (2) · Chong Kun Dang Pharmaceutical (2) · Duke University (2) · Eli Lilly and Company (2) · Endo USA Inc., a Keenova Therapeutics Company (2) · IDEA AG (2)
United States (76) · Canada (14) · Australia (10) · South Korea (7) · United Kingdom (7) · Germany (6) · Israel (6) · Brazil (5) · China (5) · Japan (5) · Denmark (4) · Poland (4) · Czechia (3) · France (3) · Spain (3)
Neil Bodick, MD (6) · Howard Levy, MD (3) · Adam I Perlman, MD, MPH (2) · Carl Brown, PhD (2) · Howard Levy, M.D. (2) · Joshua F. Baker, MD MSCE (2) · Lars Arendt-Nielsen, Dr.Sci.Med. (2) · Marina Jastan, MD (2) · Alejandro Escudero (1) · Alison M Duncan, Ph.D., R.D. (1) · Allyson Morris (1)
PMID 26304646, PMID 27250845, PMID 29156068, PMID 29369450, PMID 29723634, PMID 29780263, PMID 39412672, PMID 18279523, PMID 18669959, PMID 19187557, PMID 19679221, PMID 20338042, PMID 20736233, PMID 20932341, PMID 21174485, PMID 21807137, PMID 21852252, PMID 21908169, PMID 22342928, PMID 22347369, PMID 22571284, PMID 23035641, PMID 23057611, PMID 23088451, PMID 23140091, PMID 23151395, PMID 23542612, PMID 23996292, PMID 24484541, PMID 24498399, PMID 24674732, PMID 24810539, PMID 24919587, PMID 25058311, PMID 25133963, PMID 25887932, PMID 26099553, PMID 26241775, PMID 26506138, PMID 26821189, PMID 26889617, PMID 27029553, PMID 27684085, PMID 28333699, PMID 28549436, PMID 28974919, PMID 29035179, PMID 29088579, PMID 29095245, PMID 29361920
2014 (1), K01DA049219 (1), R01AT004623 (1), R01AT010381 (1), R21AG041942 (1), U19AT003266 (1)