10 completed, 3 withdrawn, 2 unknown, 1 recruiting. 17 Phase 1, 11 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 17 | Completed 10, Withdrawn 3, Unknown 2, Recruiting 1, Terminated 1 |
| Phase 2 | 11 | Completed 6, Withdrawn 3, Terminated 1, Unknown 1 |
Follow Osteoarthritis of the Knee: new trials by email Literature Review of Osteoarthritis of the Knee trials Research Report on Osteoarthritis of the Knee
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Assess the Safety and Pharmacokinetics of AVD275 Injection in Patients With Osteoarthritis of the Knee AVD275 Intra-articular Injection - Osteoarthritis of the Knee | Phase 1 | Recruiting | Avidence Therapeutics | 20 | 2026-01-22 | 2026-10-20 |
| Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis Ibuprofen and PRP, Acetaminophen and PRP, Placebo and PRP - Osteoarthritis of the Knee, Degenerative Osteoarthritis | Phase 1 / Phase 2 | Withdrawn | QC Kinetix LLC | 2023-11-01 | 2024-10-09 | |
| Irritation and Sensitization Study of HP-5000 Topical System HP-5000 Topical Patch, HP-5000 Placebo Patch, Saline Patch - Osteoarthritis of the Knee | Phase 1 | Completed | Noven Pharmaceuticals, Inc. | 200 | 2021-06-03 | 2022-08-23 |
| Clinical Study of Umbilical Cord Mesenchymal Stem Cells (UC-MSC) for Treatment of Knee Osteoarthritis Umbilical-cord mesenchymal stromal cells (UC-MSCs), Hyaluronic acid - Osteoarthritis of the Knee | Phase 1 / Phase 2 | Unknown | Liaocheng People's Hospital | 60 | 2018-10-01 | 2018-06-04 |
| Single-Dose Administration Trial of TLC599 in Osteoarthritis of the Knee TLC599 - Osteoarthritis of the Knee | Phase 1 / Phase 2 | Completed | Taiwan Liposome Company | 40 | 2015-06-01 | 2022-05-06 |
| Clinical Study of Umbilical Cord Tissue Mesenchymal Stem Cells (UC-MSC) for Treatment of Osteoarthritis Human umbilical cord tissue-derived mesenchymal stem cells - Osteoarthritis of the Knee | Phase 1 / Phase 2 | Withdrawn | Translational Biosciences | 2014-09-01 | 2017-08-10 | |
| A Study to Evaluate Safety of Three Intra-articular Injections of Ampion in the Knee of Adults With Osteoarthritis Pain 4 mL injection of Ampion, 4 mL injection of Placebo - Osteoarthritis of the Knee | Phase 1 / Phase 2 | Completed | Ampio Pharmaceuticals. Inc. | 47 | 2014-06-01 | 2022-09-30 |
| ADSC Injections for Pain Management of Osteoarthritis in the Human Knee Joint ADSC - Osteoarthritis of the Knee | Phase 1 | Completed | Fodor, Peter B, M.D. | 6 | 2014-03-01 | 2015-06-30 |
| Safety and Feasibility Study of Mesenchymal Trophic Factor (MTF) for Treatment of Osteoarthritis Trophic factors from umbilical cord mesenchymal stem cells - Osteoarthritis of the Knee | Phase 1 / Phase 2 | Withdrawn | Translational Biosciences | 2013-12-01 | 2017-08-10 | |
| Safety, Tolerability, and Efficacy of IA Verapamil in the Treatment of Joint Pain in Subjects With Osteoarthritis of the Knee Verapamil, Placebo - Osteoarthritis of the Knee | Phase 1 / Phase 2 | Terminated | Calosyn Pharma, Inc. | 81 | 2012-04-01 | 2014-09-05 |
| Double-Blind, Randomized, Single Dose Escalation Safety Study of Intraarticular Bone Morphogenic Protein (38A BMP-7) in Subjects With Osteoarthritis (OA) of the Knee Bone morphogenetic protein 7 - Osteoarthritis of the Knee | Phase 1 | Completed | Stryker Biotech | 51 | 2010-05-01 | 2012-02-01 |
| A Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Osteoarthritis of the Knee REGN475, Placebo - Osteoarthritis of the Knee | Phase 1 / Phase 2 | Completed | Regeneron Pharmaceuticals | 200 | 2009-08-01 | 2011-12-08 |
| A Phase 1, Double-Blind, Randomized, Single Dose Escalation Safety Study of Intra-articular OP-1 in Subjects With Osteoarthritis of the Knee Intra-articular Injection of OP-1 to affected knee - Osteoarthritis of the Knee | Phase 1 | Completed | Stryker Biotech | 33 | 2007-03-01 | 2010-06-17 |
| Effects of Aquamin F on NSAID Dose Reduction in Osteoarthritis of the Knee Aquamin F, Placebo (maltodextran) - Osteoarthritis of the Knee | Phase 1 / Phase 2 | Completed | Marigot Ltd. | 29 | 2006-01-01 | 2008-09-19 |
| Effects of Aquamin F on Osteoarthritis of the Knee Aquamin F - Osteoarthritis of the Knee | Phase 1 / Phase 2 | Completed | Marigot Ltd. | 70 | 2006-01-01 | 2007-03-26 |
| Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis glucosamine sulphate, ibuprofen, placebo - Osteoarthritis of the Knee | Phase 1 | Unknown | Bispebjerg Hospital | 36 | 2005-02-01 | 2009-01-30 |
| Acupuncture in Osteoarthritis of the Knee Acupuncture - Osteoarthritis of the Knee | Phase 1 / Phase 2 | Completed | Heidelberg University | 125 | 2004-04-01 | 2006-05-15 |
Osteoarthritis, Knee (17) · Osteoarthritis (11) · Joint Diseases (1) · Knee Injuries (1) · Motor Activity (1) · Osteophyte (1) · Pain (1)
Arthritis (17) · Musculoskeletal Diseases (17) · Rheumatic Diseases (17) · Joint Diseases (16) · Osteoarthritis (6) · Behavior (1) · Bone Diseases (1) · Exostoses (1) · Hyperostosis (1) · Leg Injuries (1) · Neurologic Manifestations (1) · Pathological Conditions, Signs and Symptoms (1) · Signs and Symptoms (1) · Wounds and Injuries (1)
Ibuprofen (2) · Acetaminophen (1) · Acupuncture Therapy (1) · Bone Morphogenetic Protein 7 (1) · Glucosamine (1) · Hyaluronic Acid (1) · Sodium Chloride (1) · Verapamil (1) · fasinumab (1)
Marigot Ltd. (2) · Stryker Biotech (2) · Translational Biosciences (2) · Ampio Pharmaceuticals. Inc. (1) · Avidence Therapeutics (1) · Bispebjerg Hospital (1) · Calosyn Pharma, Inc. (1) · Fodor, Peter B, M.D. (1) · Heidelberg University (1) · Liaocheng People's Hospital (1) · Noven Pharmaceuticals, Inc. (1) · QC Kinetix LLC (1) · Regeneron Pharmaceuticals (1) · Taiwan Liposome Company (1)
United States (7) · Panama (2) · Australia (1) · China (1) · Taiwan (1)
Ang Li (1) · Carl Brown, PhD (1) · Dawang Wang, Ph.D. (1) · Frank Brazkiewicz, MD (1) · Howard Levy, M.D. (1) · Johannes Greten, MD (1) · John L Zenk, MD (1) · Jorge Paz-Rodriguez, MD (1) · Kenneth P Barnes, MD, MSc. (1) · Max Karner, MD (1) · Oliver Gerlach, MD (1) · Peter B Fodor, M.D. (1) · Salomon Dayan, MD (1) · Susanne G Petersen, MD (1)
PMID 18279523, PMID 19187557, PMID 19679221, PMID 20932341, PMID 21807137, PMID 27684085