44 completed, 5 withdrawn, 3 terminated, 3 unknown. 56 Phase 2, 11 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 56 | Completed 44, Withdrawn 5, Terminated 3, Unknown 3, Recruiting 1 |
| Phase 1 | 11 | Completed 6, Withdrawn 3, Terminated 1, Unknown 1 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
Follow OSTEOARTHRITIS OF THE KNEE: new trials by email Literature Review of OSTEOARTHRITIS OF THE KNEE trials Research Report on OSTEOARTHRITIS OF THE KNEE
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Analgesic Effects of a Treatment With Cannabis Sativa Extract in Patients With Knee Osteoarthritis - CANOA (Cannabis for Osteoarthritis) Medium Chain Triglyceride solution, Cannabis Sativa - OSTEOARTHRITIS OF THE KNEE | Phase 2 | Completed | Federal University of Latin American Integration | 45 | 2024-01-01 | 2025-07-02 |
| Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis Ibuprofen and PRP, Acetaminophen and PRP, Placebo and PRP - Osteoarthritis of the Knee, Degenerative Osteoarthritis | Phase 1 / Phase 2 | Withdrawn | QC Kinetix LLC | 2023-11-01 | 2024-10-09 | |
| Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee Placebo, Cannabidiol (CBD), Tetrahydrocannabinol (Marinol® or generic equivalent (e.g., dronabinol) - Osteoarthritis, Knee, Osteoarthritis of the Knee | Phase 2 | Recruiting | Steven E Harte, PhD | 200 | 2022-02-22 | 2026-09-04 |
| A Study to Examine the Efficacy and Safety of REGN5069 in Patients With Pain Due to Osteoarthritis of the Knee REGN5069, Matching Placebo - Osteoarthritis of the Knee, Pain | Phase 2 | Terminated | Regeneron Pharmaceuticals | 259 | 2019-05-21 | 2021-07-01 |
| A Phase 2, Open Label, Pharmacokinetic (PK) Study of TLC599 in Subjects With Osteoarthritis of the Knee TLC599, DSP - Osteoarthritis of the Knee | Phase 2 | Completed | Taiwan Liposome Company | 102 | 2019-01-21 | 2024-10-23 |
| A Study of the Efficacy and Safety of CF101 to Patients With Osteoarthritis of the Knee CF101, Placebo - Osteoarthritis of the Knee | Phase 2 | Withdrawn | Can-Fite BioPharma | 2018-11-01 | 2018-02-01 | |
| Clinical Study of Umbilical Cord Mesenchymal Stem Cells (UC-MSC) for Treatment of Knee Osteoarthritis Umbilical-cord mesenchymal stromal cells (UC-MSCs), Hyaluronic acid - Osteoarthritis of the Knee | Phase 1 / Phase 2 | Unknown | Liaocheng People's Hospital | 60 | 2018-10-01 | 2018-06-04 |
| A 4-week Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects With Knee Osteoarthritis Diclofenac Sodium Active Topical Patch 1, Diclofenac Sodium Active Topical Patch 2, Placebo patch - Osteoarthritis of the Knee | Phase 2 | Completed | Noven Pharmaceuticals, Inc. | 289 | 2017-09-07 | 2021-12-23 |
| Phase IIa, Randomized, Double Blinded, Placebo Controlled, Dose Finding Study for TLC599 in OA Patients TLC599 LD group, Normal Saline, TLC599 HD group - Osteoarthritis of the Knee | Phase 2 | Completed | Taiwan Liposome Company | 76 | 2017-03-16 | 2024-04-22 |
| Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes FX006 32 mg, TCA IR 40 mg - Osteoarthritis of the Knee, Type 2 Diabetes Mellitus | Phase 2 | Completed | Pacira Pharmaceuticals, Inc | 33 | 2016-04-01 | 2024-01-24 |
| A Proof-of-Concept Study Assessing NEO6860 in Osteoarthritis Pain NEO6860, NEO6860 placebo, Naproxen - Pain, Osteoarthritis of the Knee | Phase 2 | Completed | Neomed Institute | 54 | 2016-03-01 | 2017-03-13 |
| A Study to Assess the Analgesic Efficacy of ASP7962 in Patients With Pain Due to Osteoarthritis of the Knee ASP7962, Naproxen, Placebo - Osteoarthritis of the Knee, Chronic Lower Back Pain | Phase 2 | Completed | Astellas Pharma Europe B.V. | 215 | 2016-02-16 | 2024-10-31 |
| A Study on the Efficacy of Glucosamine Sulfate Potassium Chloride/Standardized Ginkgo Biloba Leaf Extract in Adults With Osteoarthritis of the Knee. Glucosamine Sulfate Potassium Chloride/Standardized Ginkgo Biloba Extract, Placebo - Osteoarthritis of the Knee | Phase 2 | Completed | KGK Science Inc. | 200 | 2015-11-01 | 2017-08-11 |
| Study to Characterize the PK and Local Extent and Duration of Exposure From FX006 in Patients With OA of the Knee FX006 32 mg, TCA IR 40 - Osteoarthritis of the Knee | Phase 2 | Completed | Pacira Pharmaceuticals, Inc | 81 | 2015-11-01 | 2024-01-24 |
| Single-Dose Administration Trial of TLC599 in Osteoarthritis of the Knee TLC599 - Osteoarthritis of the Knee | Phase 1 / Phase 2 | Completed | Taiwan Liposome Company | 40 | 2015-06-01 | 2022-05-06 |
| Clinical Study of Umbilical Cord Tissue Mesenchymal Stem Cells (UC-MSC) for Treatment of Osteoarthritis Human umbilical cord tissue-derived mesenchymal stem cells - Osteoarthritis of the Knee | Phase 1 / Phase 2 | Withdrawn | Translational Biosciences | 2014-09-01 | 2017-08-10 | |
| A Study to Evaluate Safety of Three Intra-articular Injections of Ampion in the Knee of Adults With Osteoarthritis Pain 4 mL injection of Ampion, 4 mL injection of Placebo - Osteoarthritis of the Knee | Phase 1 / Phase 2 | Completed | Ampio Pharmaceuticals. Inc. | 47 | 2014-06-01 | 2022-09-30 |
| A Study to Evaluate the Safety and Efficacy of Topically Applied TV-45070 (Ointment) in Participants With Primary Osteoarthritis (OA) Affecting a Single Knee TV-45070, Placebo - Osteoarthritis of the Knee | Phase 2 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 389 | 2014-04-14 | 2021-11-09 |
| Study of FX006 vs Normal Saline in Patients With Osteoarthritis of the Knee FX006 32 mg, Placebo, FX006 16 mg - Osteoarthritis of the Knee | Phase 2 | Completed | Pacira Pharmaceuticals, Inc | 310 | 2014-04-01 | 2024-01-24 |
| A Study to Evaluate the Efficacy and Safety of X0002 Spray in Subjects With Osteoarthritis X0002, Placebo - Osteoarthritis of the Knee | Phase 2 | Completed | Lina Xu | 216 | 2014-02-01 | 2018-02-07 |
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Osteoarthritis, Knee (56) · Osteoarthritis (34) · Pain (13) · Agnosia (2) · Arthritis (2) · Joint Diseases (2) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1) · Inflammation (1) · Knee Injuries (1) · Musculoskeletal Diseases (1) · Rheumatic Diseases (1)
Musculoskeletal Diseases (55) · Rheumatic Diseases (55) · Arthritis (54) · Joint Diseases (54) · Osteoarthritis (22) · Neurologic Manifestations (14) · Pathological Conditions, Signs and Symptoms (14) · Signs and Symptoms (14) · Nervous System Diseases (2) · Neurobehavioral Manifestations (2) · Perceptual Disorders (2) · Connective Tissue Diseases (1) · Endocrine System Diseases (1) · Glucose Metabolism Disorders (1) · Leg Injuries (1)
FX006 (6) · Sodium Chloride (4) · Hyaluronic Acid (3) · Naproxen (3) · Triamcinolone (3) · Intercellular Signaling Peptides and Proteins (2) · Oxycodone (2) · Saline Solution (2) · Triamcinolone Acetonide (2) · ARRY-371797 (1) · Acetaminophen (1) · Acupuncture Therapy (1) · Analgesics, Opioid (1) · Atorvastatin (1) · Bee Venoms (1)
Pacira Pharmaceuticals, Inc (6) · Taiwan Liposome Company (3) · AbbVie (prior sponsor, Abbott) (2) · Ampio Pharmaceuticals. Inc. (2) · KGK Science Inc. (2) · Marigot Ltd. (2) · Meir Medical Center (2) · Regeneron Pharmaceuticals (2) · Translational Biosciences (2) · Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (1) · Apimeds, Inc. (1) · Ardabil University of Medical Sciences (1) · Astellas Pharma Europe B.V. (1) · Ben-Gurion University of the Negev (1) · Calosyn Pharma, Inc. (1)
United States (31) · Canada (7) · Israel (5) · Australia (4) · Taiwan (3) · Panama (2) · Poland (2) · Spain (2) · Austria (1) · Belgium (1) · Brazil (1) · Chile (1) · China (1) · Czechia (1) · Georgia (1)
Neil Bodick, MD (5) · Adam I Perlman, MD, MPH (1) · Brian M. Berman, MD (1) · Bruce Berger, MD (1) · Bruce G. Rankin, D.O., C.P.I (1) · Carl Brown, PhD (1) · Chongxi Yu, Ph.D. (1) · Christopher MH Kim, M.D. (1) · Dale Wilson, MD (1) · Dan A Chiche, MD (1) · Dawang Wang, Ph.D. (1) · Eisenberg Elon, MD (1) · Ernest A. Kopecky, PhD, MBA (1) · Francisney P Nascimento, 1 (1)
PMID 18279523, PMID 19187557, PMID 22347369, PMID 23035641, PMID 24498399, PMID 25887932, PMID 26099553, PMID 26506138, PMID 27684085, PMID 29088579, PMID 30203101, PMID 31356878, PMID 35189943, PMID 41487518
2014 (1), K01DA049219 (1), R01AT010381 (1), U19AT003266 (1)